Intramembrane proteolysis: Theme and variations

Science

Volumn 305, Issue 5687, 2004, Pages 1119-1123

  Wolfe, Michael S ^a   Kopan, Raphael ^b  

^a Brigham and Women's Hospital Center for Neurologic Diseases   (United States)

^b WASHINGTON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; CHEMICAL BONDS; HYDROLYSIS; POLYPEPTIDES;

PEPTIDE BONDS; PROTEASES;

BIOLOGICAL MEMBRANES;

MEMBRANE PROTEIN; PEPTIDE; PROTEINASE; WATER;

CELLS AND CELL COMPONENTS; MEMBRANE;

AMINO ACID SEQUENCE; CATALYSIS; CELL MEMBRANE; CHEMICAL BOND; ENZYME SUBSTRATE; HYDROLYSIS; MEMBRANE BIOLOGY; PATHOPHYSIOLOGY; PREDICTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN FUNCTION; REVIEW; SOLUBILITY;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; BINDING SITES; CATALYSIS; CELL MEMBRANE; DROSOPHILA PROTEINS; ENDOPEPTIDASES; HUMANS; HYDROLYSIS; HYDROPHOBICITY; MEMBRANE PROTEINS; METALLOENDOPEPTIDASES; SOLUBILITY;

EID: 4143084775     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1096187     Document Type: Review

References (75)

1. A. J. Barrett, J. F. Woessner, N. D. Rawlings, Eds., Handbook of Proteolytic Enzymes (Academic Press, New York, 1998).
2. M. S. Wolfe, J. De Los Angeles, D. D. Miller, W. Xia, D. J. Selkoe, Biochemistry 38, 11223 (1999).
3. M. S. Brown, J. L. Goldstein, Cell 89, 331 (1997).
4. A. Nohturfft, R. A. DeBose-Boyd, S. Scheek, J. L. Goldstein, M. S. Brown, Proc. Natl. Acad. Sci. U.S.A. 96, 11235 (1999).
5. R. B. Rawson, Nature Rev. Mol. Cell Biol. 4, 631 (2003).
6. J. Sakai et al., Mol. Cell 2, 505 (1998).
7. E. A. Duncan, U. P. Dave, J. Sakai, J. L. Goldstein, M. S. Brown, J. Biol. Chem. 273, 17801 (1998).
8. R. B. Rawson et al., Mol. Cell 1, 47 (1997).
9. N. G. Zelenski, R. B. Rawson, M. S. Brown, J. L. Goldstein, J. Biol. Chem. 274, 21973 (1999).
10. D. Z. Rudner, P. Fawcett, R. Losick, Proc. Natl. Acad. Sci. U.S.A. 96, 14765 (1999).
11. K. Kanehara, Y. Akiyama, K. Ito, Gene 281, 71 (2001).
12. J. Ye, U. P. Dave, N. V. Grishin, J. L. Goldstein, M. S. Brown, Proc. Natl. Acad. Sci. U.S.A. 97, 5123 (2000).
13. J. Hardy, D. J. Selkoe, Science 297, 353 (2002).
14. B. De Strooper et al., Nature 391, 387 (1998).
15. M. S. Wolfe et al., Biochemistry 38, 4720 (1999).
16. M. S. Wolfe et al., Nature 398, 513 (1999).
17. G. Thinakaran et al., J. Biol. Chem. 272, 28415 (1997).
18. G. Yu et al., J. Biol. Chem. 273, 16470 (1998).
19. A. Capell et al., J. Biol. Chem. 273, 3205 (1998).
20. J. Zhang et al., J. Biol. Chem. 273, 12436 (1998).
21. H. Laudon et al., J. Neurochem. 89, 44 (2004).
22. Y. M. Li et al., Nature 405, 689 (2000).
23. W. P. Esler et al., Nature Cell Biol. 2, 428 (2000).
24. D. Levitan, I. Greenwald, Nature 377, 351 (1995).
25. S. Artavanis-Tsakonas, M. D. Rand, R. J. Lake, Science 284, 770 (1999).
26. F. Logeat et al., Proc. Natl. Acad. Sci. U.S.A. 95, 8108 (1998).
27. C. Brou et al., Mol. Cell 5, 207 (2000).
28. J. S. Mumm et al., Mol. Cell 5, 197 (2000).
29. B. De Strooper et al., Nature 398, 518 (1999).
30. E. H. Schroeter, J. A. Kisslinger, R. Kopan, Nature 393, 382 (1998).
31. S. S. Huppert et al., Nature 405, 966 (2000).
32. X. Cao, T. C. Sudhof, Science 293, 115 (2001).
33. X. Cao, T. C. Sudhof, J. Biol. Chem., 279, 24601 (2004).
34. C. Goutte, W. Hepler, K. M. Mickey, J. R. Priess, Development 127, 2481 (2000).
35. R. Francis et al., Dev. Cell 3, 85 (2002).
36. C. Goutte, M. Tsunozaki, V. A. Hale, J. R. Priess, Proc. Natl. Acad. Sci. U.S.A. 99, 775 (2002).
37. G. Yu et al., Nature 407, 48 (2000).
38. H. M. Chung, G. Struhl, Nature Cell Biol. 3, 1129 (2001).
39. N. Takasugi et al., Nature 422, 438 (2003).
40. W. T. Kimberly et al., Proc. Natl. Acad. Sci. U.S.A. 100, 6382 (2003).
41. W. P. Esler et al., Proc. Natl. Acad. Sci. U.S.A. 99, 2720 (2002).
42. D. Edbauer et al., Nature Cell Biol. 5, 486 (2003).
43. M. J. LaVoie et al., J. Biol. Chem. 278, 37213 (2003).
44. Y. Hu, M. E. Fortini, J. Cell Biol. 161, 685 (2003).
45. P. C. Fraering et al., Biochemistry 43, 323 (2004).
46. S. Prokop, K. Shirotani, D. Edbauer, C. Haass, H. Steiner, J. Biol. Chem. 279, 23255 (2004).
47. B. De Strooper, Neuron 38, 9 (2003).
48. P. Marambaud et al., Cell 114, 635 (2003).
49. O. Berezovska, P. Ramdya, M. S. Wolfe, B. Bacskai, B. T. Hyman, J. Neurosci. 23, 4560 (2003).
50. C. Das et al., J. Am. Chem. Soc. 125, 11794 (2003).
51. A. Y. Kornilova, C. Das, M. S. Wolfe, J. Biol. Chem. 278, 16470 (2003).
52. W. G. Annaert et al., Neuron 32, 579 (2001).
53. E. H. Schroeter et al., Proc. Natl. Acad. Sci. U.S.A. 100, 13075 (2003).
54. Y. M. Li et al., Proc. Natl. Acad. Sci. U.S.A. 97, 6138 (2000).
55. H. Steiner et al., J. Biol. Chem. 277, 39062 (2002).
56. M. R. Farmery et al., J. Biol. Chem. 278, 24277 (2003).
57. O. Nyabi et al., J. Biol. Chem. 278, 43430 (2003).
58. M. K. Lemberg, F. A. Bland, A. Weihofen, V. M. Braud, B. Martoglio, J. Immunol. 167, 6441 (2001).
59. J. McLauchlan, M. K. Lemberg, G. Hope, B. Martoglio, EMBO J. 21, 3980 (2002).
60. A. Weihofen, K. Binns, M. K. Lemberg, K. Ashman, B. Martoglio, Science 296, 2215 (2002).
61. C. P. Ponting et al., Hum. Mol. Genet. 11, 1037 (2002).
62. A. Weihofen et al., J. Biol. Chem. 278, 16528 (2003).
63. A. C. Nyborg et al. J. Biol. Chem. 279, 15153 (2004).
64. T. Golde, personal communication.
65. M. K. Lemberg, B. Martoglio, Mol. Cell 10, 735 (2002).
66. J. R. Lee, S. Urban, C. F. Garvey, M. Freeman, Cell 107, 161 (2001).
67. S. Urban, J. R. Lee, M. Freeman, Cell 107, 173 (2001).
68. S. Urban, M. Freeman, Mol. Cell 11, 1425 (2003).
69. S. Urban, D. Schlieper, M. Freeman, Curr. Biol. 12, 1507 (2002).
70. K. Esser, B. Tursun, M. Ingenhoven, G. Michaelis, E. Pratje J. Mol. Biol. 323, 835 (2002).
71. G. A. McQuibban, S. Saurya, M. Freeman, Nature 423, 537 (2003).
72. M. Herlan, F. Vogel, C. Bornhovd, W. Neupert, A. S. Reichert, J. Biol. Chem. 278, 27781 (2003).
73. O. Loh, S. Urban, M. Freeman, Curr. Biol. 14, 236 (2004).
74. Single-letter abbreviations for the amino acid residues are as follows: A, Ala; C, Cys, D, Asp; E, Glu; F, Phe; G, Gly; H, His; I, Ile; K, Lys; L, Leu; M, Met; N, Asn; P, Pro; Q, Gln; R, Arg; S, Ser; T, Thr; V, Val; W, Trp; and Y, Tyr.
75. We thank S. Urban for helpful comments on the manuscript. Supported by NIH and the Alzheimer's Association.