Signal peptide peptidase dependent cleavage of type II transmembrane substrates releases intracellular and extracellular signals

European Journal of Pharmacology

Volumn 540, Issue 1-3, 2006, Pages 10-17

  Dev, Kumlesh K ^a   Chatterjee, Sandipan ^a   Osinde, Maribel ^a   Stauffer, Daniela ^a   Morgan, Hannah ^a   Kobialko, Monika ^a   Dengler, Uwe ^a   Rueeger, Heinrich ^a   Martoglio, Bruno ^a   Rovelli, Giorgio ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Secretase inhibitor; I CLiP (intramembrane cleaving protease); Reporter gene assay; S2P (Site 2 protease) cleavage; SPP (single peptide peptidase) splice variant

Indexed keywords

[2 [2 (3,5 DIFLUOROPHENYL)ACETYLAMINO] 5 METHYL 6 OXO 6,7 DIHYDRO 5H DIBENZO[B,D]AZEPIN 7 YL]PROPIONAMIDE; [[1 BENZYL 4 [1 (7 CHLORO 2 OXO 5 PHENYL 2,3 DIHYDRO 1H BENZO[E][1,4]DIAZEPIN 3 YLCARBAMOYL)ETHYLCARBOMOYL] 2 HYDROXY 5 PHENYLPENTYL]CARBAMIC ACID TERT BUTYL ESTER]; BENZYLOXYCARBONYLLEUCINELEUCYL 2 KETONE; CARBAMIC ACID DERIVATIVE; CORE PROTEIN; ENZYME INHIBITOR; GAMMA SECRETASE INHIBITOR; GLYCINE DERIVATIVE; KETONE DERIVATIVE; LY 411575; N 1055; N [N (3,5 DIFLUOROPHENACETYL)ALANYL] S PHENYLGLYCINE TERT BUTYL ESTER; PROPIONAMIDE DERIVATIVE; PROTEIN PRECURSOR; SIGNAL PEPTIDASE; SIGNAL PEPTIDASE INHIBITOR; SIGNAL PEPTIDE; UNCLASSIFIED DRUG; WO 9822494; WO 9828268;

ANIMAL CELL; ARTICLE; CELL ASSAY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DATA ANALYSIS; EMBRYO; ENZYME REGULATION; ENZYME SUBSTRATE COMPLEX; EXTRACELLULAR SPACE; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; IC 50; INTRACELLULAR SPACE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DEGRADATION; SIGNAL PROCESSING; VIRUS CORE;

AMINO ACID SEQUENCE; ANIMALS; ASPARTIC ACID ENDOPEPTIDASES; ASPARTIC ENDOPEPTIDASES; BINDING SITES; CELL LINE; CHO CELLS; CRICETINAE; CRICETULUS; DIPEPTIDES; ENDOPLASMIC RETICULUM; EXTRACELLULAR SPACE; HEPACIVIRUS; HUMANS; INTRACELLULAR SPACE; LUCIFERASES; MOLECULAR SEQUENCE DATA; MUTATION; PROTEASOME ENDOPEPTIDASE COMPLEX; RECOMBINANT FUSION PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; SUBSTRATE SPECIFICITY; TRANSFECTION; VIRAL PROTEINS;

EID: 33745000693     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2006.04.011     Document Type: Article

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