Transport-dependent proteolysis of SREBP: Relocation of Site-1 protease from Golgi to ER obviates the need for SREBP transport to Golgi

Cell

Volumn 99, Issue 7, 1999, Pages 703-712

  DeBose Boyd, Russell A ^a   Brown, Michael S ^a   Li, Wei Ping ^a   Nohturfft, Axel ^a   Goldstein, Joseph L ^a   Espenshade, Peter J ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BREFELDIN A; CHOLESTEROL; MEMBRANE PROTEIN; PROTEINASE; STEROL REGULATORY ELEMENT BINDING PROTEIN;

ANIMAL CELL; ARTICLE; ENDOPLASMIC RETICULUM; ENZYME ACTIVE SITE; GOLGI COMPLEX; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN INTERACTION; PROTEIN PROCESSING; PROTEIN TRANSPORT;

EID: 0033599028     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(00)81668-2     Document Type: Article

References (37)

1. Bollag, D.M., and Edelstein, S.J. (1991). Protein Methods (New York: Wiley-Liss, Inc.), pp. 1-230.
2. Brown, M.S., and Goldstein, J.L. (1997). The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell 89, 331-340.
3. Brown, M.S., and Goldstein, J.L. (1999). A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood. Proc. Natl. Acad. Sci. USA 96, 11041-11048.
4. Cheng, D., Espenshade, P.J., Slaughter, C.A., Jaen, J.C., Brown, M.S., and Goldstein, J.L. (1999). Secreted Site-1 protease cleaves peptides corresponding to luminal loop of sterol regulatory element-binding proteins. J. Biol. Chem. 274, 22805-22812.
5. Duncan, E.A., Brown, M.S., Goldstein, J.L., and Sakai, J. (1997). Cleavage site for sterol-regulated protease localized to a Leu-Ser bond in lumenal loop of sterol regulatory element binding protein-2. J. Biol. Chem. 272, 12778-12785.
6. Edwards, P.A., and Ericsson, J. (1999). Sterols and isoprenoids: signaling molecules derived from the cholesterol biosynthetic pathway. Annu. Rev. Biochem. 68, 157-185.
7. Espenshade, P.J., Cheng, D., Goldstein, J.L., and Brown, M.S. (1999). Autocatalytic processing of Site-1 protease removes propeptide and permits cleavage of sterol regulatory element-binding proteins. J. Biol. Chem. 274, 22795-22804.
8. Goldstein, J.L., Basu, S.K., and Brown, M.S. (1983). Receptor-mediated endocytosis of LDL in cultured cells. Methods Enzymol. 98, 241-260.
9. Haass, C., and De Strooper, B. (1999). The presenilins in Alzheimer's disease - proteolysis holds the key. Science 286, 916-919.
10. Harlow, E., and Lane, D. (1999). Using Antibodies: A Laboratory Manual (New York: Cold Spring Harbor), pp. 1-495.
11. Hua, X., Nohturfft, A., Goldstein, J.L., and Brown, M.S. (1996a). Sterol resistance in CHO cells traced to point mutation in SREBP cleavage activating protein (SCAP). Cell 87, 415-426.
12. Hua, X., Sakai, J., Brown, M.S., and Goldstein, J.L. (1996b). Regulated cleavage of sterol regulatory element binding proteins (SREBPs) requires sequences on both sides of the endoplasmic reticulum membrane. J. Biol. Chem. 271, 10379-10384.
13. Kornfeld, R., and Kornfeld, S. (1985). Assembly of asparagine-linked oligosaccharides. Annu. Rev. Biochem. 54, 631-664.
14. Lippincott-Schwartz, J., Yuan, L.C., Bonifacino, J.S., and Klausner, R.D. (1989). Rapid redistribution of Golgi proteins into the ER in cells treated with brefeldin A: evidence for membrane cycling from Golgi to ER. Cell 56, 801-813.
15. Metherall, J.E., Goldstein, J.L., Luskey, K.L., and Brown, M.S. (1989). Loss of transcriptional repression of three sterol-regulated genes in mutant hamster cells. J. Biol. Chem. 264, 15634-15641.
16. Munro, S., and Pelham, H.R.B. (1987). A C-terminal signal prevents secretion of luminal ER proteins. Cell 48, 899-907.
17. Naruse, S., Thinakaran, G., Luo, J.-J., Kusiak, J.W., Tomita, T., Iwatsubo, T., Qian, X., Ginty, D.D., Price, D.L., Borchelt, D.R., et al. (1998). Effects of PS1 deficiency on membrane protein trafficking in neurons. Neuron 21, 1213-1221.
18. Nohturfft, A., Hua, X., Brown, M.S., and Goldstein, J.L. (1996). Recurrent G-to-A substitution in a single codon of SREBP cleavage-activating protein causes sterol resistance in three mutant CHO cell lines. Proc. Natl. Acad. Sci. USA 93, 13709-13714.
19. Nohturfft, A., Brown, M.S., and Goldstein, J.L. (1998a). Topology of SREBP cleavage-activating protein, a polytopic membrane protein with a sterol-sensing domain. J. Biol. Chem. 273, 17243-17250.
20. Nohturfft, A., Brown, M.S., and Goldstein, J.L. (1998b). Sterols regulate processing of carbohydrate chains of wild-type SREBP cleavage-activating protein (SCAP), but not sterol-resistant mutants Y298C or D443N. Proc. Natl. Acad. Sci. USA 95, 12848-12853.
21. Nohturfft, A., DeBose-Boyd, R.A., Scheek, S., Goldstein, J.L., and Brown, M.S. (1999). Sterols regulate cycling of SREBP cleavage-activating protein (SCAP) between endoplasmic reticulum and Golgi. Proc. Natl. Acad. Sci. USA 96, 11235-11240.
22. Pelham, H.R.B. (1992). The secretion of proteins by cells. Proc. R. Soc. Med. 250, 1-10.
23. Rawson, R.B., Zelenski, N.G., Nijhawan, D., Ye, J., Sakai, J., Hasan, M.T., Chang, T.-Y., Brown, M.S., and Goldstein, J.L. (1997). Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs. Mol. Cell 1, 47-57.
24. Rawson, R.B., Cheng, D., Brown, M.S., and Goldstein, J.L. (1998). Isolation of cholesterol-requiring mutant CHO cells with defects in cleavage of sterol regulatory element binding proteins at Site-1. J. Biol. Chem. 273, 28261-28269.
25. Rawson, R.B., DeBose-Boyd, R., Goldstein, J.L., and Brown, M.S. (1999). Failure to cleave sterol regulatory element-binding proteins (SREBPs) causes cholesterol auxotrophy in Chinese hamster ovary cells with genetic absence of SREBP cleavage-activating protein. J. Biol. Chem. 274, 28549-28556.
26. Ridgway, N.D., and Lagace, T.A. (1995). Brefeldin A renders Chinese hamster ovary cells insensitive to transcriptional suppression by 25-hydroxycholesterol. J. Biol. Chem. 270, 8023-8031.
27. Sakai, J., Duncan, E.A., Rawson, R.B., Hua, X., Brown, M.S., and Goldstein, J.L. (1996). Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment. Cell 85, 1037-1046.
28. Sakai, J., Nohturfft, A., Cheng, D., Ho, Y.K., Brown, M.S., and Goldstein, J.L. (1997). Identification of complexes between the COOH-terminal domains of sterol regulatory element binding proteins (SREBPs) and SREBP cleavage-activating protein (SCAP). J. Biol. Chem. 272, 20213-20221.
29. Sakai, J., Nohturfft, A., Goldstein, J.L., and Brown, M.S. (1998a). Cleavage of sterol regulatory element binding proteins (SREBPs) at site-1 requires interaction with SREBP cleavage-activating protein. Evidence from in vivo competition studies. J. Biol. Chem. 273, 5785-5793.
30. Sakai, J., Rawson, R.B., Espenshade, P.J., Cheng, D., Seegmiller, A.C., Goldstein, J.L., and Brown, M.S. (1998b). Molecular identification of the sterol-regulated luminal protease that cleaves SREBPs and controls lipid composition of animal cells. Mol. Cell 2, 505-514.
31. Selkoe, D.J. (1996). Amyloid β-protein and the genetics of Alzheimer's disease. J. Biol. Chem. 271, 18295-19298.
32. Springer, S., Spang, A., and Schekman, R. (1999). A primer on vesicle budding. Cell 97, 145-148.
33. Thinakaran, G., Regard, J.B., Bouton, C.M.L., Harris, C.L., Price, D.L., Borchelt, D.R., and Sisodia, S.S. (1998). Stable association of presenilin derivatives and absence of presenilin interactions with APP. Neurobiol. Dis. 4, 438-453.
34. Wang, X., Sato, R., Brown, M.S., Hua, X., and Goldstein, J.L. (1994). SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis. Cell 77, 53-62.
35. Weidemann, A., Paliga, K., Durrwang, U., Czech, C., Evin, G., Masters, C.L., and Beyreuther, K. (1997). Formation of stable complexes between two Alzheimer's disease gene products: presenilin-2 and β-amyloid precursor protein. Nat. Med. 3, 328-332.
36. Wolfe, M.S., Xia, W., Ostaszewski, B.L., Diehl, T.S., Kimberly, W.T., and Selkoe, D.J. (1999). Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and y-secretase activity. Nature 398, 513-517.
37. Xia, W., Zhang, J., Perez, R., Koo, E.H., and Selkoe, D.J. (1997). Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease. Proc. Natl. Acad. Sci. USA 94, 8208-8213.