Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the α-secretase ADAM 10

Proceedings of the National Academy of Sciences of the United States of America

Volumn 98, Issue 10, 2001, Pages 5815-5820

  Kojro, Elzbieta ^a   Gimpl, Gerald ^a   Lammich, Sven ^a   März, Winfried ^b   Fahrenholz, Falk ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b UNIVERSITY OF FREIBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADAM 10; ALPHA SECRETASE; AMYLOID PRECURSOR PROTEIN; CHOLESTEROL; DISINTEGRIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; METALLOPROTEINASE; METHYL BETA CYCLODEXTRIN; MEVINOLIN; PHORBOL ESTER; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; CHOLESTEROL BLOOD LEVEL; ENZYME ACTIVITY; ENZYME RELEASE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; INTERNALIZATION; MEMBRANE FLUIDITY; NEUROPROTECTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN METABOLISM; PROTEIN PROCESSING;

ADAM PROTEINS; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANTICHOLESTEREMIC AGENTS; CELL COMPARTMENTATION; CELL MEMBRANE; CHOLESTEROL; ENDOCYTOSIS; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LOVASTATIN; MEMBRANE FLUIDITY; MEMBRANE PROTEINS; METALLOENDOPEPTIDASES;

EID: 0035826909     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.081612998     Document Type: Article

References (49)

1. Esch, F. S., Keim, P. S., Beattie, E. C., Blacher, R. W., Culwell, A. R., Oltersdorf, T., McClure, D. & Ward, P. J. (1990) Science 248, 1122-1124.
2. Palmert, M. R., Podlisny, M. B., Witker, D. S., Oltersdorf, T., Younkin, S. H., Selkoe, D. L. & Younkin, S. G. (1998) Proc. Natl. Acad. Sci. USA 86, 6338-6342.
3. Buxbaum, J. D., Liu, K. N., Luo, Y., Slack, J.L., Stocking, K. L., Peschon, J. J., Johnson, R. S., Castner, B. J., Cerretti, D. P. & Black, R. A. (1998) J. Biol. Chem. 273, 27765-27767.
4. Lammich, S., Kojro, E., Postina, R., Gilbert, S., Pfeiffer, R., Jasionowski, M., Haass, C. & Fahrenholz, F. (1999) Proc. Natl. Acad. Sci. USA 96, 3922-3927.
5. Koike, H., Tomioka, S., Sorimachi, H., Saido, T. C., Maruyama, K., Okuyama, A., Fujisawa-Sehara, A., Ohno, S., Suzuki, K. & Ishiura, S. (1999) Biochem. J. 343, 371-375.
6. De Strooper, B. & Annaert, W. (2000) J. Cell. Sci. 113, 1857-1870.
7. Araki, W., Kitaguchi, N., Tokushima, Y., Ishii, K., Aratake, H., Shimohama, S., Nakamura, S. & Kimura, J. (1991) Biochem. Biophys. Res. Commun. 181, 265-271.
8. Small, D. H., Nurcombe, V., Reed, G., Clarris, H., Moir, R., Beyreuther, K. & Masters, C. L. (1994) J. Neurosci. 14, 2117-2127.
9. Morimoto, T., Ohsawa, I., Takamura, C. Ishiguro, M. & Kohsaka, S. (1998) J. Neurosci. Res. 51, 185-195.
10. Rossjohn, J., Cappai, R., Feil S. C., Henry, A., McKinstry, W. J., Galatis, D., Hesse, L., Multhaup, G., Beyreuther, K., Masters, C. L. & Parker, M. W. (1999) Nat. Struct. Biol. 6, 327-331.
11. Furukawa, K. S., Barger, E., Blalock, E. & Mattson, M. (1996) Nature (London) 379, 74-78.
12. Guo, Q., Robinson, N. & Mattson, M. P. (1998) J. Biol. Chem. 273, 12341-12351.
13. Meziane, H., Dodart, J. C., Mathis, C., Little, S., Clemens, J., Paul, S. M. & Ungerer, A. (1998) Proc. Natl. Acad. Sci. USA 95, 12683-12688.
14. Dartigues, J. F. & Letenneur, L. (2000) Curr. Opin. Neurol. 13, 385-389.
15. Sing, C. F. & Davignon, J. (1985) Am. J. Hum. Genet. 37, 268-286.
16. Bodovitz, S. & Klein, W. L. (1996) J. Biol. Chem. 271, 4436-4440.
17. Racchi, M., Baetta, R., Salvietti, N., Ianna, P., Franceschini, G., Paoletti, R., Fumagalli, R., Govoni, S., Trabucchi, M. & Soma, M. (1997) Biochem. J. 322, 893-898.
18. Galbete, J. L., Rodriguez-Martin, T., Peressini, E., Modena, P., Bianchi, R. & Forloni, G. (2000) Biochem. J. 348, 307-313.
19. Simons, M., Keller, P., De Strooper, B., Beyreuther, K., Dotti, C. G. & Simons, K. (1998) Proc. Natl. Acad. Sci. USA 95, 6460-6464.
20. Refolo, L. M., Pappolla, M. A., Malester, B., LaFrancois, J., Bryant-Thomas, T., Wang, R., Tint, G. S., Sambamurti, K. & Duff, K. (2000) Neurobiol. Dis. 7, 321-331.
21. Marcinkiewicz, M. & Seidah, N. G. (2000) J. Neurochem. 75, 2133-2143.
22. Cutts, J. L. & Melnykovych, G. (1988) Biochim. Biophys. Acta 961, 65-72.
23. Klein, U., Gimpl, G. & Fahrenholz, F. (1995) Biochemistry 34, 13784-13793.
24. Gimpl, G., Burger, K. & Fahrenholz, F. (1997) Biochemistry 36, 10959-10974.
25. Bradford, M. M. (1976) Anal. Biochem. 72, 248-254.
26. Steiner, H., Capell, A., Pesold, B., Citron, M., Kloetzel, P., Selkoe, D. I., Romig, H., Mendla, K. & Haass, C. (1998) J .Biol. Chem. 273, 32322-32331.
27. Harder, T., Scheiffele, P., Verkade, P. & Simons, K. (1998) J. Cell. Biol. 141, 929-942.
28. Bligh, E. D. & Dyer, W. J. (1959) Can. J. Biochem. Physiol. 37, 911-917.
29. Subtil, A., Gaidarow, I., Kobylarz, K., Lampson, M. A., Keen, J. H. & McGraw, T. E. (1999) Proc. Natl. Acad. Sci. USA 96, 6775-6780.
30. Rodal, S. K., Skretting, G., Garred, O., Vilhardt, F., van Deurs, B. & Sandvig, K. (1999) Mol. Biol. Cell. 10, 961-974.
31. Perez, R. G., Soriano, S., Hayes, J. D., Ostaszewski, B., Xia, W., Selkoe, D. J., Chen, X., Stokin, G. B. & Koo, H. (1999) J. Biol. Chem. 274, 18851-18856.
32. Ikezu, T., Trapp, B. D., Song, K. S., Schlegel, A., Lisanti, M. P. & Okamoto, T. (1998) J. Biol. Chem. 273, 10485-10495.
33. Simons, K. & Ikonen, E. (1997) Nature (London) 387, 569-572.
34. Rothberg, K. G., Heuser, J. E., Donzell, W. C., Ying, Y. S., Glenney, J. R. & Anderson, R. G. W. (1992) Cell 68, 673-682.
35. Smart, E. J., Ying, Y.S., Conrad, P. A. & Anderson, R. G. W. (1994) J. Cell Biol. 127, 1185-1197.
36. Moebius, F. F., Fitzky, B. U. & Glossmann, H. (2000) Trends Endocrinol. Metab. 11, 106-114.
37. Shivers, B. D., Hilbich, C., Multhaup, G., Salbaum, M., Beyreuther, K. & Seeburg, P. H. (1988) EMBO J. 7, 1365-1370.
38. Nordstedt, C., Caporaso, G. L., Thyberg, J., Gandy, S. E. & Greengard, P. (1993) J. Biol. Chem. 268, 608-612.
39. Yamazaki, T., Koo, E. H. & Selkoe, D. J. (1996) J. Cell. Sci. 109, 999-1008.
40. Haass, C., Koo, E. H., Mellon, A., Hung, A. Y. & Selkoe, D. J. (1992) Nature (London) 357, 500-503.
41. Parvathy, S., Hussain, I., Karran, E. H., Turner, A. J. & Hooper, N. M. (1999) Biochemistry 38, 9728-9734.
42. Lee, S. J., Liyanage, U., Bickel, P. E., Xia, W., Lansbury, P. T. & Kosik, S. S. (1998) Nat. Med. 4, 730-734.
43. Bouillot, C., Prochiantz, A., Rougon, G. & Allinquant, B. (1996) J. Biol. Chem. 271, 7640-7644.
44. Parkin, E. T., Hussain, I. & Hooper, N. M. (1997) J. Neurochem. 69, 2179-2188.
45. Huse, J. T., Pijak, D. S., Leslie, G. J., Lee, V. M. Y. & Doms, R. W. (2000) J. Biol. Chem. 275, 33729-33737.
46. Weisgraber, K. H. & Mahley, R. W. (1996) FASEB J. 10, 1485-1494.
47. Michikawa, M., Fan, Q. W., Isobe, I. & Yanagisawa, K. (2000) J. Neurochem. 74, 1008-1016.
48. Seheki, A., Terasaki, T., Tamai, I. & Tsuji, A. (1994) Pharm. Res. 11, 305-311.
49. Jick, H., Zornberg, G. L., Jick, S. S., Seshadri, S. & Drachman, D. A. (2000) Lancet 356, 1627-1631.