Presenilin-dependent intramembrane cleavage of ephrin-BI

Molecular Neurodegeneration

Volumn 1, Issue 1, 2006, Pages

  Tomita, Taisuke ^a   Tanaka, Sayaka ^a   Morohashi, Yuichi ^a   Iwatsubo, Takeshi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 33847014741     PISSN: None     EISSN: 17501326     Source Type: Journal    
DOI: 10.1186/1750-1326-1-2     Document Type: Article

References (42)

1. Tomita T, Iwatsubo T: The inhibition of γ-secretase as a therapeutic approach to Alzheimer's disease. Drug News Perspect 2004, 17:321-325.
2. Takasugi N, Tomita T, Hayashi I, Tsuruoka M, Niimura M, Takahashi Y, Thinakaran G, Iwatsubo T: The role of presenilin cofactors in the γ-secretase complex. Nature 2003, 422:438-441.
3. Kopan R, Ilagan MX: γ-Secretase: proteasome of the membrane? Nat Rev Mol Cell 2004, 5:499-504.
4. De Strooper B, Annaert W, Cupers P, Saftig P, Craessaerts K, Mumm JS, Schroeter EH, Schrijvers V, Wolfe MS, Ray WJ, Goate A, Kopan R: A presenilin-I-dependent γ-secretase-like protease mediates release of Notch intracellular domain. Nature 1999, 398:518-522.
5. Landman N, Kim TW: Got RIP? Presenilin-dependent intramembrane proteolysis in growth factor receptor signaling. Cytokine Growth Factor Rev 2004, 15:337-351.
6. Herreman A, Serneels L, Annaert W, Collen D, Schoonjans L, De Strooper B: Total inactivation of γ-secretase activity in presenilin-deficient embryonic stem cells. Nat Cell Biol 2000, 2:461-462.
7. Blobel CP: ADAMs: key components in EGFR signalling and development. Nat Rev Mol Cell Biol 2005, 6:32-43.
8. Yong VW: Metalloproteinases: Mediators of Pathology and Regeneration in the CMS. Nat Rev Neurosci 2005, 6(21):931-44.
9. Hattori M, Osterfield M, Flanagan JG: Regulated cleavage of a contact-mediated axon repellent. Science 2000, 289:1360-1365.
10. Yu C, Kim SH, Ikeuchi T, Xu H, Gasparini L, Wang R, Sisodia SS: Characterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment y. Evidence for distinct mechanisms involved in γ-secretase processing of the APP and Notchl transmembrane domains. J Biol Chem 2001, 276:43756-43760.
11. Gu Y, Misonou H, Sato T, Dohmae N, Takio K, Ihara Y: Distinct intramembrane cleavage of the β-amyloid precursor protein family resembling γ-secretase-like cleavage of Notch. J Biol Chem 2001, 276:35235-35238.
12. Kopan R, Schroeter EH, Weintraub H, Nye JS: Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain. Proc Natl Acad Sci USA 1996, 93:1683-1688.
13. Ni CY, Yuan H, Carpenter G: Role of the ErbB-4 carboxyl terminus in γ-secretase cleavage. J Biol Chem 2003, 278:4561-4565.
14. Kullander K, Klein R: Mechanisms and functions of eph and ephrin signaling. Nat Rev Mol Cell Biol 2002, 3:475-486.
15. Davy A, Soriano P: Ephrin signaling in vivo: look both ways. Dev Dyn 2005, 232:1-10.
16. Cowan CA, Henkemeyer M: The SH2/SH3 adaptor Grb4 transduces B-ephrin reverse signals. Nature 2001, 413:174-179.
17. Palmer A, Zimmer M, Erdmann KS, Eulenburg V, Porthin A, Heumann R, Deutsch U, Klein R: EphrinB phosphorylation and reverse signaling: regulation by Src kinases and PTP-BL phosphatase. Mol Cell 2002, 9:725-737.
18. Tanaka M, Kamata R, Sakai R: Phosphorylation of ephrin-BI via the interaction with claudin following cell-cell contact formation. EMBO J 2005, 24:3700-3711.
19. Zimmer M, Palmer A, Kohler J, Klein R: EphB-ephrinB bi-directional endocytosis terminates adhesion allowing contact mediated repulsion. Nat Cell Biol 2003, 5:869-878.
20. Marston DJ, Dickinson S, Nobes CD: Rac-dependent trans-endocytosis of ephrinBs regulates Eph-ephrin contact repulsion. Nat Cell Biol 2003, 5:879-888.
21. Jarriault S, Brou C, Logeat F, Schroeter EH, Kopan R, Israel A: Signalling downstream of activated mammalian Notch. Nature 1995, 377:355-358.
22. Cao X, Sudhof TC: A transcriptionally active complex of APP with Fe65 and histone acetyltransferase Tip60. Science 2001, 293:115-120.
23. Komuro A, Nagai M, Navin NE, Sudol M: WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus. J Biol Chem 2003, 278:33334-33341.
24. Song J: Tyrosine phosphorylation of the well packed ephrinB cytoplasmic β-hairpin for reverse signaling. Structural consequences and binding properties. J Biol Chem 2003, 278:24714-24720.
25. Bong YS, Park YH, Lee HS, Mood K, Ishimura A, Daar IO: Tyr-298 in ephrinBI is critical for an interaction with the Grb4 adaptor protein. Biochem J 2004, 377:499-507.
26. Su Z, Xu P, Ni F: Single phosphorylation of Tyr304 in the cytoplasmic tail of ephrin B2 confers high-affinity and bifunctional binding to both the SH2 domain of Grb4 and the PDZ domain of the PDZ-RGS3 protein. Eur J Biochem 2004, 271:1725-1736.
27. Twigg SR, Kan R, Babbs C, Bochukova EG, Robertson SP, Wall SA, Morriss-Kay GM, Wilkie AO: Mutations of ephrin-BI (EFNBI), a marker of tissue boundary formation, cause craniofrontonasal syndrome. Proc Natl Acad Sci USA 2004, 101:8652-8657.
28. Wieland l, Jakubiczka S, Muschke P, Cohen M, Thiele H, Gerlach KL, Adams RH, Wieacker P: Mutations of the ephrin-BI gene cause craniofrontonasal syndrome. Am J Hum Genet 2004, 74:1209-1215.
29. Compagni A, Logan M, Klein R, Adams RH: Control of Skeletal Patterning by EphrinBI-EphB Interactions. Dev Cell 2003. 5:217-230.
30. Davy A, Aubin J, Soriano P: Ephrin-BI forward and reverse signaling are required during mouse development. Genes Dev 2004, 18:572-583.
31. Wieland I, Reardon W, Jakubiczka S, Franco B, Kress W, Vincent-Delorme C, Thierry P, Edwards M, Konig R, Rusu C, Schweiger S, Thompson E, Tinschert S, Stewart F, Wieacker P: Twenty-six novel EFNBI mutations in familial and sporadic craniofrontonasal syndrome (CFNS). Hum Mutat 2005, 26:113-118.
32. Parent AT, Barnes NY, Taniguchi Y, Thinakaran G, Sisodia SS: Presenilin attenuates receptor-mediated signaling and synaptic function, J Neurosci 2005, 25:1540-1549.
33. Chong SW, Jiang YJ: Off limits - integrins holding boundaries in somitogenesis. Trends Cell Biol 2005, 15:453-457.
34. Takahashi Y: Common mechanisms for boundary formation in somitogenesis and brain development: shaping the 'chic' chick. Int J Dev Biol 2005, 49:221-230.
35. Fischer A, Schumacher N, Maier M, Sendtner M, Gessler M: The Notch target genes Heyl and Hey2 are required for embryonic vascular development. Genes Dev 2004, 18:901-911.
36. Tomita T, Maruyama K, Saido TC, Kume H, Shinozaki K, Tokuhiro S, Capell A, Walter J. Grunberg J, Haass C, Iwatsubo T, Obata K: The presenilin 2 mutation (NI 4II) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid β protein ending at the 42nd (or 43rd) residue. Proc Natl Acad Sci USA 1997, 94:2025-2030.
37. Watanabe N, Tomita T, Sato C, Kitamura T, Morohashi Y, Iwatsubo T: Pen-2 is incorporated into the γ-secretase complex through binding to transmembrane domain 4 of presenilin I. J Biol Chem 2005, 280:41967-41975.
38. Kan T, Tominari Y, Rikimaru K, Morohashi Y, Natsugari H, Tomita T, Iwatsubo T, Fukuyama T: Parallel synthesis of DAPT derivatives and their γ-secretase-inhibitory activity. Bioorg Med Chem Lett 2004, 14:1983-1985.
39. Tomita T, Tokuhiro S, Hashimoto T, Aiba K, Saido TC, Maruyama K, Iwatsubo T: Molecular dissection of domains in mutant presenilin 2 that mediate overproduction of amyloidogenic forms of amyloid β peptides. Inability of truncated forms of PS2 with familial Alzheimer's disease mutation to increase secretion of Aβ42. J Biol Chem 1998, 273:21153-21160.
40. Tomita T, Takikawa R, Koyama A, Morohashi Y, Takasugi N, Saido TC, Maruyama K, Iwatsubo T: C terminus of presenilin is required for overproduction of amyloidogenic Aβ42 through stabilization and endoproteolysis of presenilin. J Neurosci 1999, 19:10627- 10634.
41. Iwata H, Tomita T, Maruyama K, Iwatsubo T: Subcellular compartment and molecular subdomain of β-amyloid precursor protein relevant to the Aβ42-promoting effects of Alzheimer mutant presenilin 2. J Biol Chem 2001, 276:21678-21685.
42. Morohashi Y, Hatano N, Ohya S, Takikawa R, Watabiki T, Takasugi N, Imaizumi Y, Tomita T, Iwatsubo T: Molecular cloning and characterization of CALP/KChlP4, a novel EF-hand protein interacting with presenilin 2 and voltage-gated potassium channel subunit Kv4. J Biol Chem 2002, 277:14965-14975.