Enzymatic analysis of a rhomboid intramembrane protease implicates transmembrane helix 5 as the lateral substrate gate

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 20, 2007, Pages 8257-8262

  Baker, Rosanna P ^a   Young, Keith ^a   Feng, Liang ^b   Shi, Yigong ^b   Urban, Sinisa ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b PRINCETON UNIVERSITY   (United States)

Author keywords

Cell signaling; Presenilin; Signal peptide peptidase; Site 2 protease

Indexed keywords

MEMBRANE ENZYME; MUTANT PROTEIN; PROTEINASE; DNA BINDING PROTEIN; ESCHERICHIA COLI PROTEIN; GLPG PROTEIN, E COLI; MEMBRANE PROTEIN; PEPTIDE HYDROLASE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DISULFIDE BOND; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME ENGINEERING; ENZYME STRUCTURE; ENZYME SUBSTRATE; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; BINDING SITE; CHEMISTRY; ENZYME SPECIFICITY; ENZYMOLOGY; ESCHERICHIA COLI; GENETICS; METABOLISM; MUTATION; PROTEIN ENGINEERING; PROTEIN PROCESSING; PROTEIN SECONDARY STRUCTURE;

BINDING SITES; DNA-BINDING PROTEINS; ENDOPEPTIDASES; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; MEMBRANE PROTEINS; MUTANT PROTEINS; MUTATION; PEPTIDE HYDROLASES; PROTEIN ENGINEERING; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, SECONDARY; SUBSTRATE SPECIFICITY;

EID: 34347250499     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0700814104     Document Type: Article

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