Presenilins mediate a dual intramembranous γ-secretase cleavage of Notch-1

EMBO Journal

Volumn 21, Issue 20, 2002, Pages 5408-5416

  Okochi, Masayasu ^a   Steiner, Harald ^a   Fukumori, Akio ^a   Tanii, Hisashi ^a   Tomita, Taisuke ^a   Tanaka, Toshihisa ^a   Iwatsubo, Takeshi ^a   Kudo, Takashi ^a   Takeda, Masatoshi ^a   Haass, Christian ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Notch signaling; Notch 1 peptide; Presenilin; Site 4 cleavage; secretase

Indexed keywords

AMYLOID BETA PROTEIN; GAMMA SECRETASE; NOTCH RECEPTOR; PRESENILIN 1;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN PROCESSING; PROTEIN SECRETION; PROTEIN STRUCTURE; SEQUENCE ANALYSIS;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; BINDING SITES; CELL LINE; CELL MEMBRANE; ENDOPEPTIDASES; HUMANS; MEMBRANE PROTEINS; MICE; MOLECULAR SEQUENCE DATA; MUTATION; PEPTIDE FRAGMENTS; PRESENILIN-1; RECEPTOR, NOTCH1; RECEPTORS, CELL SURFACE; SEQUENCE HOMOLOGY, AMINO ACID; TRANSCRIPTION FACTORS;

ANIMALIA;

EID: 18644367748     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/cdf541     Document Type: Article

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