-
1
-
-
84856397577
-
Digoxin inhibits development of hypoxic pulmonary hypertension in mice
-
Abud EM, Maylor J, Undem C, Punjabi A, Zaiman AL, Myers AC, Sylvester JT, Se-menza GL, Shimoda LA. Digoxin inhibits development of hypoxic pulmonary hypertension in mice. Proc Natl Acad Sci USA 109: 1239-1244,2012.
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, pp. 1239-1244
-
-
Abud, E.M.1
Maylor, J.2
Undem, C.3
Punjabi, A.4
Zaiman, A.L.5
Myers, A.C.6
Sylvester, J.T.7
Se-Menza, G.L.8
Shimoda, L.A.9
-
2
-
-
33745274488
-
Role of ETS transcription factors in the hypoxia-inducible factor-2 target gene selection
-
Aprelikova O, Wood M, Tackett S, Chandramouli GV, Barrett JC. Role of ETS transcription factors in the hypoxia-inducible factor-2 target gene selection. Cancer Res 66: 5641-5647, 2006.
-
(2006)
Cancer Res
, vol.66
, pp. 5641-5647
-
-
Aprelikova, O.1
Wood, M.2
Tackett, S.3
Chandramouli, G.V.4
Barrett, J.C.5
-
3
-
-
0032104119
-
Molecular identification of the role of voltage-gated K channels, Kv1.5 and Kv21, in hypoxic pulmonary vasoconstriction and control of resting membrane potential in rat pulmonary artery myocytes
-
Archer SL, Souil E, Dinh-Xuan AT, Schremmer B, Mercier JC, ElYaagoubi A, Nguyen-Huu L, Reeve HL, Hampl V. Molecular identification of the role of voltage-gated K channels, Kv1.5 and Kv21, in hypoxic pulmonary vasoconstriction and control of resting membrane potential in rat pulmonary artery myocytes. J Clin Invest 101: 2319-2330, 1998.
-
(1998)
J Clin Invest
, vol.101
, pp. 2319-2330
-
-
Archer, S.L.1
Souil, E.2
Dinh-Xuan, A.T.3
Schremmer, B.4
Mercier, J.C.5
Elyaagoubi, A.6
Nguyen-Huu, L.7
Reeve, H.L.8
Hampl, V.9
-
4
-
-
65249155915
-
Molecular signatures of obstructive sleep apnea in adults: A review and perspective
-
Arnardottir ES, Mackiewicz M, Gislason T, Teff KL, Pack AI. Molecular signatures of obstructive sleep apnea in adults: a review and perspective. Sleep 32: 447-470, 2009.
-
(2009)
Sleep
, vol.32
, pp. 447-470
-
-
Arnardottir, E.S.1
Mackiewicz, M.2
Gislason, T.3
Teff, K.L.4
Pack, A.I.5
-
5
-
-
0031974606
-
Monocyte activation in angiogenesis and collateral growth in the rabbit hindlimb
-
Arras M, Ito WD, Scholz D, Winkler B, Schaper J, Schaper W. Monocyte activation in angiogenesis and collateral growth in the rabbit hindlimb.J Clin Invest 101: 40-50, 1998.
-
(1998)
J Clin Invest
, vol.101
, pp. 40-50
-
-
Arras, M.1
Ito, W.D.2
Scholz, D.3
Winkler, B.4
Schaper, J.5
Schaper, W.6
-
6
-
-
0346216146
-
Effects of hypoxia and intracellular iron chelation on hypoxia-inducible factor-1α and -1β in the rat carotid body and glomus cells
-
Baby SM, Roy A, Mokashi AM, Lahiri S. Effects of hypoxia and intracellular iron chelation on hypoxia-inducible factor-1α and -1β in the rat carotid body and glomus cells. Histochem Cell Biol 120: 343-352,2003.
-
(2003)
Histochem Cell Biol
, vol.120
, pp. 343-352
-
-
Baby, S.M.1
Roy, A.2
Mokashi, A.M.3
Lahiri, S.4
-
7
-
-
37349025432
-
FOXO3α is activated in response to hypoxic stress and inhibits HIF1-induced apoptosis via regulation of CITED2
-
Bakker WJ, Harris IS, Mak TW. FOXO3α is activated in response to hypoxic stress and inhibits HIF1-induced apoptosis via regulation of CITED2. Mol Cell 28: 941-953,2007.
-
(2007)
Mol Cell
, vol.28
, pp. 941-953
-
-
Bakker, W.J.1
Harris, I.S.2
Mak, T.W.3
-
8
-
-
0030738644
-
Blood pressure response to chronic episodic hypoxia: Role of the sympathetic nervous system
-
Bao G, Metreveli N, Li R, Taylor A, Fletcher EC. Blood pressure response to chronic episodic hypoxia: role of the sympathetic nervous system. J Appl Physiol 83: 95-101, 1997.
-
(1997)
J Appl Physiol
, vol.83
, pp. 95-101
-
-
Bao, G.1
Metreveli, N.2
Li, R.3
Taylor, A.4
Fletcher, E.C.5
-
9
-
-
0023636579
-
Time-dependent effect of hypoxia on carotid body chemosensory function
-
Barnard P, Andronikou S, Pokorski M, Smatresk N, Mokashi A, Lahiri S. Time-dependent effect of hypoxia on carotid body chemosensory function. J Appl Physiol 63: 685-691, 1987.
-
(1987)
J Appl Physiol
, vol.63
, pp. 685-691
-
-
Barnard, P.1
Andronikou, S.2
Pokorski, M.3
Smatresk, N.4
Mokashi, A.5
Lahiri, S.6
-
10
-
-
34547468520
-
Two routes to functional adaptation: Tibetan and Andean high-altitude natives
-
Beall CM. Two routes to functional adaptation: Tibetan and Andean high-altitude natives. Proc Natl Acad Sci USA 104 Suppl 1: 8655-8660, 2007.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, Issue.SUPPL. 1
, pp. 8655-8660
-
-
Beall, C.M.1
-
11
-
-
77954926596
-
Natural selecαtion on EPAS1 (HIF2α) associated with low hemoglobin concentration in Tibetan highlanders
-
Beall CM, Cavalleri GL, Deng L, Elston RC, Gao Y, Knight J, Li C, Li JC, Liang Y, McCormack M, Montgomery HE, Pan H, Robbins PA, Shianna KV, Tam SC, Tsering N, Veeramah KR, Wang W, Wangdui P, Weale ME, Xu Y, Xu Z, Yang L, Zaman MJ, Zeng C, Zhang L, Zhang X, Zhaxi P, Zheng YT. Natural selecαtion on EPAS1 (HIF2α) associated with low hemoglobin concentration in Tibetan highlanders. Proc Natl Acad Sci USA 107: 11459-11464,2010.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 11459-11464
-
-
Beall, C.M.1
Cavalleri, G.L.2
Deng, L.3
Elston, R.C.4
Gao, Y.5
Knight, J.6
Li, C.7
Li, J.C.8
Liang, Y.9
McCormack, M.10
Montgomery, H.E.11
Pan, H.12
Robbins, P.A.13
Shianna, K.V.14
Tam, S.C.15
Tsering, N.16
Veeramah, K.R.17
Wang, W.18
Wangdui, P.19
Weale, M.E.20
Xu, Y.21
Xu, Z.22
Yang, L.23
Zaman, M.J.24
Zeng, C.25
Zhang, L.26
Zhang, X.27
Zhaxi, P.28
Zheng, Y.T.29
more..
-
12
-
-
0026049416
-
Enhancer element at the 3-flanking region controls transcriptional response to hypoxia in the human erythropoietin gene
-
Beck I, Ramirez S, Weinmann R, Caro J. Enhancer element at the 3-flanking region controls transcriptional response to hypoxia in the human erythropoietin gene. J Biol Chem 266: 15563-15566, 1991.
-
(1991)
J Biol Chem
, vol.266
, pp. 15563-15566
-
-
Beck, I.1
Ramirez, S.2
Weinmann, R.3
Caro, J.4
-
13
-
-
33846794822
-
The NOX family of ROS-generating NADPH oxidases: Physiology and pathophysiology
-
Bedard K, Krause KH. The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol Rev 87: 245-313, 2007.
-
(2007)
Physiol Rev
, vol.87
, pp. 245-313
-
-
Bedard, K.1
Krause, K.H.2
-
14
-
-
66349121718
-
Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains
-
Bellot G, Garcia-Medina R, Gounon P, Chiche J, Roux D, PouyssegurJ, Mazure NM. Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains. Mol Cell Biol 29: 2570-2581, 2009.
-
(2009)
Mol Cell Biol
, vol.29
, pp. 2570-2581
-
-
Bellot, G.1
Garcia-Medina, R.2
Gounon, P.3
Chiche, J.4
Roux, D.5
Pouyssegur, J.6
Mazure, N.M.7
-
15
-
-
0033435198
-
Induction of hypoxia-inducible factor-1 (HIF-1) and its target genes following focal ischaemia in rat brain
-
Bergeron M, Yu AY, Solway KE, Semenza GL, Sharp FR. Induction of hypoxia-inducible factor-1 (HIF-1) and its target genes following focal ischaemia in rat brain. Eur J Neurosci 11:4159-4170, 1999.
-
(1999)
Eur J Neurosci
, vol.11
, pp. 4159-4170
-
-
Bergeron, M.1
Yu, A.Y.2
Solway, K.E.3
Semenza, G.L.4
Sharp, F.R.5
-
16
-
-
0022751328
-
Expression of the erythropoietin gene
-
Beru N, McDonald J, Lacombe C, Goldwasser E. Expression of the erythropoietin gene. Mol Cell Biol 6: 2571-2575, 1986.
-
(1986)
Mol Cell Biol
, vol.6
, pp. 2571-2575
-
-
Beru, N.1
McDonald, J.2
Lacombe, C.3
Goldwasser, E.4
-
17
-
-
0032900610
-
Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1
-
Bhattacharya S, Michels CL, Leung MK, Arany ZP, Kung AL, Livingston DM. Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1. Genes Dev 13:64-75, 1999.
-
(1999)
Genes Dev
, vol.13
, pp. 64-75
-
-
Bhattacharya, S.1
Michels, C.L.2
Leung, M.K.3
Arany, Z.P.4
Kung, A.L.5
Livingston, D.M.6
-
18
-
-
76249086956
-
Identifying positive selection candidate loci for high-altitude adaptation in Andean populations
-
Bigham AW, Mao X, Mei R, Brutsaert T, Wilson MJ, Julian CG, Parra EJ, Akey JM, Moore LG, Shriver MD. Identifying positive selection candidate loci for high-altitude adaptation in Andean populations. Hum Genomics 4: 79-90, 2009.
-
(2009)
Hum Genomics
, vol.4
, pp. 79-90
-
-
Bigham, A.W.1
Mao, X.2
Mei, R.3
Brutsaert, T.4
Wilson, M.J.5
Julian, C.G.6
Parra, E.J.7
Akey, J.M.8
Moore, L.G.9
Shriver, M.D.10
-
19
-
-
0033837398
-
Carotid body mechanisms in acclimatization to hypoxia
-
Bisgard GE. Carotid body mechanisms in acclimatization to hypoxia. Respir Physiol 121: 237-246, 2000.
-
(2000)
Respir Physiol
, vol.121
, pp. 237-246
-
-
Bisgard, G.E.1
-
20
-
-
43249108443
-
Abnormal sympathoadrenal development and systemic hypotension in PHD3- /- mice
-
Bishop T, Gallagher D, Pascual A, Lygate CA, de Bono JP, Nicholls LG, Ortega-Saenz P, Oster H, Wijeyekoon B, Sutherland AI, Grosfeld A, Aragones J, Schneider M, van Geyte K, Teixeira D, Diez-Juan A, Lopez-Barneo J, Channon KM, Maxwell PH, Pugh CW, Davies AM, Carmeliet P, Ratcliffe PJ. Abnormal sympathoadrenal development and systemic hypotension in PHD3- /- mice. Mol Cell Biol 28: 3386-3400, 2008.
-
(2008)
Mol Cell Biol
, vol.28
, pp. 3386-3400
-
-
Bishop, T.1
Gallagher, D.2
Pascual, A.3
Lygate, C.A.4
de Bono, J.P.5
Nicholls, L.G.6
Ortega-Saenz, P.7
Oster, H.8
Wijeyekoon, B.9
Sutherland, A.I.10
Grosfeld, A.11
Aragones, J.12
Schneider, M.13
van Geyte, K.14
Teixeira, D.15
Diez-Juan, A.16
Lopez-Barneo, J.17
Channon, K.M.18
Maxwell, P.H.19
Pugh, C.W.20
Davies, A.M.21
Carmeliet, P.22
Ratcliffe, P.J.23
more..
-
21
-
-
0022751115
-
Anemia induces accumulation of erythropoietin mRNA in the kidney and liver
-
Bondurant MC, Koury MJ. Anemia induces accumulation of erythropoietin mRNA in the kidney and liver. Mol Cell Biol 6: 2731-2733, 1986.
-
(1986)
Mol Cell Biol
, vol.6
, pp. 2731-2733
-
-
Bondurant, M.C.1
Koury, M.J.2
-
22
-
-
33745155785
-
An abnormal mitochondrial-hypoxia inducible factor-1 α-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: Similarities to human pulmonary arterial hypertension
-
Bonnet S, Michelakis ED, Porter CJ, Andrade-Navarro MA, Thebaud B, Haromy A, Harry G, Moudgil R, McMurtry MS, Weir EK, Archer SL. An abnormal mitochondrial-hypoxia inducible factor-1 α-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: similarities to human pulmonary arterial hypertension. Circulation 113: 2630-2641, 2006.
-
(2006)
Circulation
, vol.113
, pp. 2630-2641
-
-
Bonnet, S.1
Michelakis, E.D.2
Porter, C.J.3
Andrade-Navarro, M.A.4
Thebaud, B.5
Haromy, A.6
Harry, G.7
Moudgil, R.8
McMurtry, M.S.9
Weir, E.K.10
Archer, S.L.11
-
23
-
-
37349115260
-
Effects of aging and hypoxia-inducible factor-1 activity on angiogenic cell mobilization and recovery of perfusion after limb ischemia
-
Bosch-Marce M, Okuyama H, Wesley JB, Sarkar K, Kimura H, Liu YV, Zhang H, Strazza M, Rey S, Savino L, Zhou YF, McDonald KR, Na Y, Vandiver S, Rabi A, Shaked Y, Kerbel R, Lavallee T, Semenza GL. Effects of aging and hypoxia-inducible factor-1 activity on angiogenic cell mobilization and recovery of perfusion after limb ischemia. Circ Res 101: 1310-1318, 2007.
-
(2007)
Circ Res
, vol.101
, pp. 1310-1318
-
-
Bosch-Marce, M.1
Okuyama, H.2
Wesley, J.B.3
Sarkar, K.4
Kimura, H.5
Liu, Y.V.6
Zhang, H.7
Strazza, M.8
Rey, S.9
Savino, L.10
Zhou, Y.F.11
McDonald, K.R.12
Na, Y.13
Vandiver, S.14
Rabi, A.15
Shaked, Y.16
Kerbel, R.17
Lavallee, T.18
Semenza, G.L.19
-
24
-
-
33747366672
-
Cell-specific regulation of hypoxia-inducible factor (HIF)-1 α and HIF-2α stabilization and transactivation in agraded oxygen environment
-
Bracken CP, Fedele AO, Linke S, Balrak W, Lisy K, Whitelaw ML, Peet DJ. Cell-specific regulation of hypoxia-inducible factor (HIF)-1 α and HIF-2α stabilization and transactivation in agraded oxygen environment. J Biol Chem 281: 22575-22585,2006.
-
(2006)
J Biol Chem
, vol.281
, pp. 22575-22585
-
-
Bracken, C.P.1
Fedele, A.O.2
Linke, S.3
Balrak, W.4
Lisy, K.5
Whitelaw, M.L.6
Peet, D.J.7
-
25
-
-
78449267006
-
Divergent roles of reactive oxygen species in the responses of perinatal adrenal chromaffin cells to hypoxic challenges
-
Brown ST, Buttigieg J, Nurse CA. Divergent roles of reactive oxygen species in the responses of perinatal adrenal chromaffin cells to hypoxic challenges. Respir Physiol Neurobiol 174: 252-258, 2010.
-
(2010)
Respir Physiol Neurobiol
, vol.174
, pp. 252-258
-
-
Brown, S.T.1
Buttigieg, J.2
Nurse, C.A.3
-
26
-
-
67649494709
-
Hypoxia inducible factor (HIF)-2 α is required for the development of the catecholaminergic phenotype of sympathoadrenal cells
-
Brown ST, Kelly KF, Daniel JM, Nurse CA. Hypoxia inducible factor (HIF)-2 α is required for the development of the catecholaminergic phenotype of sympathoadrenal cells. J Neurochem 110: 622-630, 2009.
-
(2009)
J Neurochem
, vol.110
, pp. 622-630
-
-
Brown, S.T.1
Kelly, K.F.2
Daniel, J.M.3
Nurse, C.A.4
-
27
-
-
47249162090
-
2-sensitive adrenomedullary chromaffin cell line
-
Brown ST, Nurse CA. Induction of HIF-2α is dependent on mitochondrial O2 consumption in an O2-sensitive adrenomedullary chromaffin cell line. Am J Physiol Cell Physiol 294: C1305-C1312, 2008.
-
(2008)
Am J Physiol Cell Physiol
, vol.294
-
-
Brown, S.T.1
Nurse, C.A.2
-
28
-
-
0035834409
-
Aconserved family of prolyl-4-hydroxylases that modify HIF
-
Bruick RK, McKnight SL. Aconserved family of prolyl-4-hydroxylases that modify HIF. Science 294: 1337-1340,2001.
-
(2001)
Science
, vol.294
, pp. 1337-1340
-
-
Bruick, R.K.1
McKnight, S.L.2
-
29
-
-
24144444133
-
Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation
-
Brunelle JK, Bell EL, Quesada NM, Vercauteren K, Tiranti V, Zeviani M, Scarpulla RC, Chandel NS. Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation. Cell Metab 1: 409-414, 2005.
-
(2005)
Cell Metab
, vol.1
, pp. 409-414
-
-
Brunelle, J.K.1
Bell, E.L.2
Quesada, N.M.3
Vercauteren, K.4
Tiranti, V.5
Zeviani, M.6
Scarpulla, R.C.7
Chandel, N.S.8
-
30
-
-
85047691081
-
Heterozygous deficiency of hypoxia-inducible factor-2 α protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia
-
Brusselmans K, Compernolle V, Tjwa M, Wiesener MS, Maxwell PH, Collen D, Carmeliet P. Heterozygous deficiency of hypoxia-inducible factor-2 α protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia. J Clin Invest 111: 1519-1527, 2003.
-
(2003)
J Clin Invest
, vol.111
, pp. 1519-1527
-
-
Brusselmans, K.1
Compernolle, V.2
Tjwa, M.3
Wiesener, M.S.4
Maxwell, P.H.5
Collen, D.6
Carmeliet, P.7
-
31
-
-
1642484223
-
2 with microelectrodes
-
Buerk DG. Measuring tissue Po2 with microelectrodes. Methods Enzymol 381: 665-690, 2004.
-
(2004)
Methods Enzymol
, vol.381
, pp. 665-690
-
-
Buerk, D.G.1
-
32
-
-
66749191478
-
ATP channels: Role of a7 nicotinic acetylcholine receptor and hypoxia-inducible factor-2α
-
Buttigieg J, Brown S, Holloway AC, Nurse CA. Chronic nicotine blunts hypoxic sensitivity in perinatal rat adrenal chromaffin cells via upregulation of KATP channels: role of a7 nicotinic acetylcholine receptor and hypoxia-inducible factor-2α. J Neurosci 29: 7137-7147, 2009.
-
(2009)
J Neurosci
, vol.29
, pp. 7137-7147
-
-
Buttigieg, J.1
Brown, S.2
Holloway, A.C.3
Nurse, C.A.4
-
33
-
-
43249114882
-
Chronic nicotine in utero selectively suppresses hypoxic sensitivity in neonatal rat adrenal chromaffin cells
-
Buttigieg J, Brown S, Zhang M, Lowe M, Holloway AC, Nurse CA. Chronic nicotine in utero selectively suppresses hypoxic sensitivity in neonatal rat adrenal chromaffin cells. FASEBJ 22: 1317-1326,2008.
-
(2008)
FASEBJ
, vol.22
, pp. 1317-1326
-
-
Buttigieg, J.1
Brown, S.2
Zhang, M.3
Lowe, M.4
Holloway, A.C.5
Nurse, C.A.6
-
34
-
-
0038163900
-
Hearts from rodents exposed to intermittent hypoxia or erythropoietin are protected against ischemia-reperfusion injury
-
Cai Z, Manalo DJ, Wei G, Rodriguez ER, Fox-Talbot K, Lu H, Zweier JL, Semenza GL. Hearts from rodents exposed to intermittent hypoxia or erythropoietin are protected against ischemia-reperfusion injury. Circulation 108: 79-85, 2003.
-
(2003)
Circulation
, vol.108
, pp. 79-85
-
-
Cai, Z.1
Manalo, D.J.2
Wei, G.3
Rodriguez, E.R.4
Fox-Talbot, K.5
Lu, H.6
Zweier, J.L.7
Semenza, G.L.8
-
35
-
-
2442587705
-
Phosphatidylinositol-3-kinase signaling is required for erythro-poietin-mediated acute protection against myocardial ischemia/reperfusion injury
-
Cai Z, Semenza GL. Phosphatidylinositol-3-kinase signaling is required for erythro-poietin-mediated acute protection against myocardial ischemia/reperfusion injury. Circulation 109: 2050-2053,2004.
-
(2004)
Circulation
, vol.109
, pp. 2050-2053
-
-
Cai, Z.1
Semenza, G.L.2
-
36
-
-
38849182762
-
Complete loss of ischaemic preconditioning-induced cardioprotection in mice with partial deficiency of HIF-1 α
-
Cai Z, Zhong H, Bosch-Marce M, Fox-Talbot K, Wang L, Wei C, Trush MA, Semenza GL. Complete loss of ischaemic preconditioning-induced cardioprotection in mice with partial deficiency of HIF-1 α. Cardiovasc Res 77: 463-470, 2008.
-
(2008)
Cardiovasc Res
, vol.77
, pp. 463-470
-
-
Cai, Z.1
Zhong, H.2
Bosch-Marce, M.3
Fox-Talbot, K.4
Wang, L.5
Wei, C.6
Trush, M.A.7
Semenza, G.L.8
-
37
-
-
0035575975
-
Differential effects of physiologically relevant hypoxic conditions on T lymphocyte development and effector functions
-
Caldwell CC, Kojima H, Lukashev D, Armstrong J, Farber M, Apasov SG, Sitkovsky MV. Differential effects of physiologically relevant hypoxic conditions on T lymphocyte development and effector functions. J Immunol 167: 6140-6149, 2001.
-
(2001)
J Immunol
, vol.167
, pp. 6140-6149
-
-
Caldwell, C.C.1
Kojima, H.2
Lukashev, D.3
Armstrong, J.4
Farber, M.5
Apasov, S.G.6
Sitkovsky, M.V.7
-
38
-
-
33645504221
-
Hypoxic induction of an HIF-1 α dependent bFGF autocrine loop drives angiogenesis in human endothelial cells
-
Calvani M, Rapisarda A, Uranchimeg B, Shoemaker RH, Melillo G. Hypoxic induction of an HIF-1 α dependent bFGF autocrine loop drives angiogenesis in human endothelial cells. Blood 107: 2705-2712, 2006.
-
(2006)
Blood
, vol.107
, pp. 2705-2712
-
-
Calvani, M.1
Rapisarda, A.2
Uranchimeg, B.3
Shoemaker, R.H.4
Melillo, G.5
-
39
-
-
34848903331
-
Chronic hypoxia up-regulates a 1HT-type channels and low-threshold catecholamine secretion in rat chromaffin cells
-
Carabelli V, Marcantoni A, Comunanza V, de Luca A, Diaz J, Borges R, Carbone E. Chronic hypoxia up-regulates a 1HT-type channels and low-threshold catecholamine secretion in rat chromaffin cells.J Physiol 584: 149-165, 2007.
-
(2007)
J Physiol
, vol.584
, pp. 149-165
-
-
Carabelli, V.1
Marcantoni, A.2
Comunanza, V.3
de Luca, A.4
Diaz, J.5
Borges, R.6
Carbone, E.7
-
40
-
-
0032581277
-
Role of HIF-1 α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
-
Carmeliet P, Dor Y, Herbert JM, Fukumura D, Brusselmans K, Dewerchin M, Nee-man M, Bono F, Abramovitch R, Maxwell P, Koch CJ, Ratcliffe P, Moons L, Jain RK, Collen D, Keshert E. Role of HIF-1 α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature 394: 485-490, 1998.
-
(1998)
Nature
, vol.394
, pp. 485-490
-
-
Carmeliet, P.1
Dor, Y.2
Herbert, J.M.3
Fukumura, D.4
Brusselmans, K.5
Dewerchin, M.6
Nee-Man, M.7
Bono, F.8
Abramovitch, R.9
Maxwell, P.10
Koch, C.J.11
Ratcliffe, P.12
Moons, L.13
Jain, R.K.14
Collen, D.15
Keshert, E.16
-
41
-
-
4043184065
-
Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1
-
Ceradini DJ, Kulkarni AR, Callaghan MJ, Tepper OM, Bastidas N, Kleinman ME, Capla JM, Galiano RD, Levine JP, Gurtner GC. Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1. Nat Med 10: 858-864, 2004.
-
(2004)
Nat Med
, vol.10
, pp. 858-864
-
-
Ceradini, D.J.1
Kulkarni, A.R.2
Callaghan, M.J.3
Tepper, O.M.4
Bastidas, N.5
Kleinman, M.E.6
Capla, J.M.7
Galiano, R.D.8
Levine, J.P.9
Gurtner, G.C.10
-
42
-
-
22544464403
-
Coordinate regulation of the oxygen-dependent degradation domains of hypoxia-inducible factor 1 α
-
Chan DA, Sutphin PD, Yen SE, Giaccia AJ. Coordinate regulation of the oxygen-dependent degradation domains of hypoxia-inducible factor 1 α. Mol Cell Biol 25: 6415-6426, 2005.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 6415-6426
-
-
Chan, D.A.1
Sutphin, P.D.2
Yen, S.E.3
Giaccia, A.J.4
-
43
-
-
70349478990
-
MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1/2
-
Chan SY, Zhang YY, Hemann C, Mahoney CE, Zweier JL, Loscalzo J. MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1/2. Cell Metab 10: 273-284, 2009.
-
(2009)
Cell Metab
, vol.10
, pp. 273-284
-
-
Chan, S.Y.1
Zhang, Y.Y.2
Hemann, C.3
Mahoney, C.E.4
Zweier, J.L.5
Loscalzo, J.6
-
44
-
-
0034661990
-
Role of oxidants in NF-kappa B activation and TNF-α gene transcription induced by hypoxia and endotoxin
-
Chandel NS, Trzyna WC, McClintock DS, Schumacker PT. Role of oxidants in NF-kappa B activation and TNF-α gene transcription induced by hypoxia and endotoxin. J Immunol 165: 1013-1021, 2000.
-
(2000)
J Immunol
, vol.165
, pp. 1013-1021
-
-
Chandel, N.S.1
Trzyna, W.C.2
McClintock, D.S.3
Schumacker, P.T.4
-
45
-
-
0036083763
-
Role of endothelin andendothelin A-type receptor in adaptation of the carotid body to chronic hypoxia
-
Chen J, He L, Dinger B, Stensaas L, Fidone S. Role of endothelin andendothelin A-type receptor in adaptation of the carotid body to chronic hypoxia. Am J Physiol Lung Cell Mol Physiol 282: L1314-L1323, 2002.
-
(2002)
Am J Physiol Lung Cell Mol Physiol
, vol.282
-
-
Chen, J.1
He, L.2
Dinger, B.3
Stensaas, L.4
Fidone, S.5
-
46
-
-
34447570574
-
Effect of the endothelin receptor antagonist bosentan on chronic hypoxia-induced morphological and physiological changes in rat carotid body
-
Chen J, He L, Liu X, Dinger B, Stensaas L, Fidone S. Effect of the endothelin receptor antagonist bosentan on chronic hypoxia-induced morphological and physiological changes in rat carotid body. Am J Physiol Lung Cell Mol Physiol 292: L1257-L1262,2007.
-
(2007)
Am J Physiol Lung Cell Mol Physiol
, vol.292
-
-
Chen, J.1
He, L.2
Liu, X.3
Dinger, B.4
Stensaas, L.5
Fidone, S.6
-
47
-
-
79954609893
-
Hypoxia increases sirtuin 1 expression in a hypoxia-inducible factor-dependent manner
-
Chen R, Dioum EM, Hogg RT, Gerard RD, Garcia JA. Hypoxia increases sirtuin 1 expression in a hypoxia-inducible factor-dependent manner.J Biol Chem 286: 13869-13878, 2011.
-
(2011)
J Biol Chem
, vol.286
, pp. 13869-13878
-
-
Chen, R.1
Dioum, E.M.2
Hogg, R.T.3
Gerard, R.D.4
Garcia, J.A.5
-
48
-
-
0032891708
-
Induction and nuclear translocation of hypoxia-inducible factor-1 (HIF-1): Heterodimerization with ARNT is not necessary for nuclear accumulation of HIF-1α
-
Chilov D, Camenisch G, Kvietikova I, Ziegler U, Gassmann M, Wenger RH. Induction and nuclear translocation of hypoxia-inducible factor-1 (HIF-1): heterodimerization with ARNT is not necessary for nuclear accumulation of HIF-1α. J Cell Sci 112: 1203-1212, 1999.
-
(1999)
J Cell Sci
, vol.112
, pp. 1203-1212
-
-
Chilov, D.1
Camenisch, G.2
Kvietikova, I.3
Ziegler, U.4
Gassmann, M.5
Wenger, R.H.6
-
49
-
-
77957810983
-
Stabilization of hypoxia-inducible factor-1 α protein in hypoxia occurs independently of mitochondrial reactive oxygen species production
-
Chua YL, Dufour E, Dassa EP, Rustin P, Jacobs HT, Taylor CT, Hagen T. Stabilization of hypoxia-inducible factor-1 α protein in hypoxia occurs independently of mitochondrial reactive oxygen species production.J Biol Chem 285: 31277-31284, 2010.
-
(2010)
J Biol Chem
, vol.285
, pp. 31277-31284
-
-
Chua, Y.L.1
Dufour, E.2
Dassa, E.P.3
Rustin, P.4
Jacobs, H.T.5
Taylor, C.T.6
Hagen, T.7
-
50
-
-
0037083845
-
A dominant-negative isoform lacking exons 11 and 12 of the human hypoxia-inducible factor-1 α gene
-
Chun YS, Choi E, Kim TY, Kim MS, Park JW. A dominant-negative isoform lacking exons 11 and 12 of the human hypoxia-inducible factor-1 α gene. Biochem J 362: 71-79, 2002.
-
(2002)
Biochem J
, vol.362
, pp. 71-79
-
-
Chun, Y.S.1
Choi, E.2
Kim, T.Y.3
Kim, M.S.4
Park, J.W.5
-
51
-
-
0035205085
-
Anew HIF-1 α variant induced by zinc ion suppresses HIF-1-mediated hypoxic responses
-
Chun YS, Choi E, Yeo EJ, Lee JH, Kim MS, Park JW. Anew HIF-1 α variant induced by zinc ion suppresses HIF-1-mediated hypoxic responses. J Cell Sci 114: 4051-4061, 2001.
-
(2001)
J Cell Sci
, vol.114
, pp. 4051-4061
-
-
Chun, Y.S.1
Choi, E.2
Yeo, E.J.3
Lee, J.H.4
Kim, M.S.5
Park, J.W.6
-
52
-
-
0346059588
-
Phorbol ester stimulates the nonhypoxic induction of a novel hypoxia-inducible factor 1 α isoform: Implications for tumor promotion
-
Chun YS, Lee KH, Choi E, Bae SY, Yeo EJ, Huang LE, Kim MS, Park JW. Phorbol ester stimulates the nonhypoxic induction of a novel hypoxia-inducible factor 1 α isoform: implications for tumor promotion. Cancer Res 63: 8700-8707, 2003.
-
(2003)
Cancer Res
, vol.63
, pp. 8700-8707
-
-
Chun, Y.S.1
Lee, K.H.2
Choi, E.3
Bae, S.Y.4
Yeo, E.J.5
Huang, L.E.6
Kim, M.S.7
Park, J.W.8
-
53
-
-
0000121357
-
Pathophysiology of sleep apnea
-
edited by Saunders N, Sullivan C. New York: Dekker
-
Cistulli P, Sullivan C. Pathophysiology of sleep apnea. In: Sleep and Breathing, edited by Saunders N, Sullivan C. New York: Dekker, 1994, p. 405-448.
-
(1994)
Sleep and Breathing
, pp. 405-448
-
-
Cistulli, P.1
Sullivan, C.2
-
54
-
-
55449137328
-
Vascular endothelial growth factor-A specifies formation of native collaterals and regulates collateral growth in ischemia
-
Clayton JA, Chalothorn D, Faber JE. Vascular endothelial growth factor-A specifies formation of native collaterals and regulates collateral growth in ischemia. Circ Res 103: 1027-1036,2008.
-
(2008)
Circ Res
, vol.103
, pp. 1027-1036
-
-
Clayton, J.A.1
Chalothorn, D.2
Faber, J.E.3
-
55
-
-
14844348832
-
Perinatal exposure to nicotine causes deficits associated with a loss of nicotinic receptor function
-
Cohen G, Roux JC, Grailhe R, Malcolm G, Changeux JP, Lagercrantz H. Perinatal exposure to nicotine causes deficits associated with a loss of nicotinic receptor function. Proc Natl Acad Sci USA 102: 3817-3821, 2005.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 3817-3821
-
-
Cohen, G.1
Roux, J.C.2
Grailhe, R.3
Malcolm, G.4
Changeux, J.P.5
Lagercrantz, H.6
-
56
-
-
78449267271
-
Cell redox state and hypoxic pulmonary vasoconstriction: Recent evidence and possible mechanisms
-
Connolly MJ, Aaronson PI. Cell redox state and hypoxic pulmonary vasoconstriction: recent evidence and possible mechanisms. Respir Physiol Neurobiol 174: 165-174, 2010.
-
(2010)
Respir Physiol Neurobiol
, vol.174
, pp. 165-174
-
-
Connolly, M.J.1
Aaronson, P.I.2
-
57
-
-
0025329308
-
Enhancement by hypoxia of human erythropoietin gene transcription in vitro
-
Costa-Giomi P, Caro J, Weinmann R. Enhancement by hypoxia of human erythropoietin gene transcription in vitro. J Biol Chem 265: 10185-10188, 1990.
-
(1990)
J Biol Chem
, vol.265
, pp. 10185-10188
-
-
Costa-Giomi, P.1
Caro, J.2
Weinmann, R.3
-
58
-
-
70649084123
-
Emerging roles of microRNAs in the molecular responses to hypoxia
-
Crosby ME, Devlin CM, Glazer PM, Calin GA, Ivan M. Emerging roles of microRNAs in the molecular responses to hypoxia. Curr Pharm Des 15: 3861-3866, 2009.
-
(2009)
Curr Pharm Des
, vol.15
, pp. 3861-3866
-
-
Crosby, M.E.1
Devlin, C.M.2
Glazer, P.M.3
Calin, G.A.4
Ivan, M.5
-
59
-
-
0141643358
-
Hypoxia up-regulates prolyl hydroxylase activity: A feedback mechanism that limits HIF-1 responses during reoxy-genation
-
D'Angelo G, Duplan E, Boyer N, Vigne P, Frelin C. Hypoxia up-regulates prolyl hydroxylase activity: a feedback mechanism that limits HIF-1 responses during reoxy-genation. J Biol Chem 278: 38183-38187, 2003.
-
(2003)
J Biol Chem
, vol.278
, pp. 38183-38187
-
-
D'Angelo, G.1
Duplan, E.2
Boyer, N.3
Vigne, P.4
Frelin, C.5
-
60
-
-
0037180452
-
DeisenhoferJ. Structure of factor-inhibiting hypoxia-inducible factor 1: An asparaginyl hydroxylase involved in the hypoxic response pathway
-
Dann CE 3rd, Bruick RK, DeisenhoferJ. Structure of factor-inhibiting hypoxia-inducible factor 1: an asparaginyl hydroxylase involved in the hypoxic response pathway. Proc Natl Acad Sci USA 99: 15351-15356, 2002.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 15351-15356
-
-
Dann, C.E.1
Bruick, R.K.2
-
61
-
-
33645735151
-
The oxygen sensor factor-inhibiting hypoxia-inducible factor-1 controls expression of distinct genes through the bifunctional transcriptional character of hypoxia-inducible factor-1 α
-
Dayan F, Roux D, Brahimi-Horn MC, Pouyssegur J, Mazure NM. The oxygen sensor factor-inhibiting hypoxia-inducible factor-1 controls expression of distinct genes through the bifunctional transcriptional character of hypoxia-inducible factor-1 α. Cancer Res 66: 3688-3698, 2006.
-
(2006)
Cancer Res
, vol.66
, pp. 3688-3698
-
-
Dayan, F.1
Roux, D.2
Brahimi-Horn, M.C.3
Pouyssegur, J.4
Mazure, N.M.5
-
62
-
-
0038492596
-
Induction of T-type calcium channel gene expression by chronic hypoxia
-
Del Toro R, Levitsky KL, Lopez-Barneo J, Chiara MD. Induction of T-type calcium channel gene expression by chronic hypoxia. J Biol Chem 278: 22316-22324, 2003.
-
(2003)
J Biol Chem
, vol.278
, pp. 22316-22324
-
-
Del Toro, R.1
Levitsky, K.L.2
Lopez-Barneo, J.3
Chiara, M.D.4
-
63
-
-
0020022637
-
Mediation of ventilatory adaptations
-
Dempsey JA, Forster HV. Mediation of ventilatory adaptations. Physiol Rev 62: 262-346, 1982.
-
(1982)
Physiol Rev
, vol.62
, pp. 262-346
-
-
Dempsey, J.A.1
Forster, H.V.2
-
64
-
-
77952775655
-
Pulmonary artery smooth muscle hypertrophy: Roles of glycogen synthase kinase-3/3 and p70 ribosomal S6 kinase
-
Deng H, Hershenson MB, Lei J, Anyanwu AC, Pinsky DJ, Bentley JK. Pulmonary artery smooth muscle hypertrophy: roles of glycogen synthase kinase-3/3 and p70 ribosomal S6 kinase. Am J Physiol Lung Cell Mol Physiol 298: L793-L803, 2010.
-
(2010)
Am J Physiol Lung Cell Mol Physiol
, vol.298
-
-
Deng, H.1
Hershenson, M.B.2
Lei, J.3
Anyanwu, A.C.4
Pinsky, D.J.5
Bentley, J.K.6
-
65
-
-
0021364843
-
The enlarged carotid body of the chronically hypoxic and chronically hypoxic and hypercapnic rat: A morphometric analysis
-
Dhillon DP, Barer GR, Walsh M. The enlarged carotid body of the chronically hypoxic and chronically hypoxic and hypercapnic rat: a morphometric analysis. QJ Exp Physiol 69: 301-317, 1984.
-
(1984)
QJ Exp Physiol
, vol.69
, pp. 301-317
-
-
Dhillon, D.P.1
Barer, G.R.2
Walsh, M.3
-
66
-
-
17444413362
-
Oxygen and life span: Chronic hypoxia as a model for studying HIF-1 α, VEGF and NOS during aging
-
Di Giulio C, Bianchi G, Cacchio M, Artese L, Rapino C, Macri MA, Di Ilio C. Oxygen and life span: chronic hypoxia as a model for studying HIF-1 α, VEGF and NOS during aging. Respir Physiol Neurobiol 147: 31-38,2005.
-
(2005)
Respir Physiol Neurobiol
, vol.147
, pp. 31-38
-
-
Di Giulio, C.1
Bianchi, G.2
Cacchio, M.3
Artese, L.4
Rapino, C.5
Macri, M.A.6
Di Ilio, C.7
-
67
-
-
0032071253
-
Does chronic hypoxia increase rat carotid body nitric oxide?
-
Di Giulio C, Grilli A, De Lutiis MA, Di Natale F, Sabatino G, Felaco M. Does chronic hypoxia increase rat carotid body nitric oxide? Comp Biochem Physiol A Mol Integr Physiol 120: 243-247, 1998.
-
(1998)
Comp Biochem Physiol a Mol Integr Physiol
, vol.120
, pp. 243-247
-
-
Di Giulio, C.1
Grilli, A.2
de Lutiis, M.A.3
Di Natale, F.4
Sabatino, G.5
Felaco, M.6
-
68
-
-
77953505608
-
Reciprocal regulation of Rac1 and PAK-1 by HIF-1 α: A positive-feedback loop promoting pulmonary vascular remodeling
-
Diebold I, Petry A, Djordjevic T, Belaiba RS, Fineman J, Black S, Schreiber C, Fratz S, Hess J, Kietzmann T, Gorlach A. Reciprocal regulation of Rac1 and PAK-1 by HIF-1 α: a positive-feedback loop promoting pulmonary vascular remodeling. Antioxid Redox Signal 13:399-412,2010.
-
(2010)
Antioxid Redox Signal
, vol.13
, pp. 399-412
-
-
Diebold, I.1
Petry, A.2
Djordjevic, T.3
Belaiba, R.S.4
Fineman, J.5
Black, S.6
Schreiber, C.7
Fratz, S.8
Hess, J.9
Kietzmann, T.10
Gorlach, A.11
-
69
-
-
66749129781
-
Regulation of hypoxia-inducible factor 2α signaling by the stress-responsive deacety-lase sirtuin 1
-
Dioum EM, Chen R, Alexander MS, Zhang Q, Hogg RT, Gerard RD, Garcia JA Regulation of hypoxia-inducible factor 2α signaling by the stress-responsive deacety-lase sirtuin 1. Science 324: 1289-1293,2009.
-
(2009)
Science
, vol.324
, pp. 1289-1293
-
-
Dioum, E.M.1
Chen, R.2
Alexander, M.S.3
Zhang, Q.4
Hogg, R.T.5
Gerard, R.D.6
Garcia, J.A.7
-
70
-
-
47249111254
-
HIF-2α-haploinsufficient mice have blunted retinal neovascularization due to impaired expression of a proangiogenic gene battery
-
Dioum EM, Clarke SL, Ding K, Repa JJ, Garcia JA. HIF-2α-haploinsufficient mice have blunted retinal neovascularization due to impaired expression of a proangiogenic gene battery. Invest Ophthalmol Vis Sci 49: 2714-2720, 2008.
-
(2008)
Invest Ophthalmol Vis Sci
, vol.49
, pp. 2714-2720
-
-
Dioum, E.M.1
Clarke, S.L.2
Ding, K.3
Repa, J.J.4
Garcia, J.A.5
-
71
-
-
0034890091
-
Hypoxic release of calcium from the sarcoplasmic reticulum of pulmonary artery smooth muscle
-
Dipp M, Nye PC, Evans AM. Hypoxic release of calcium from the sarcoplasmic reticulum of pulmonary artery smooth muscle. Am J Physiol Lung Cell Mol Physiol 281: L318-L325, 2001.
-
(2001)
Am J Physiol Lung Cell Mol Physiol
, vol.281
-
-
Dipp, M.1
Nye, P.C.2
Evans, A.M.3
-
72
-
-
0032476059
-
Hypoxia regulates beta-enolase and pyruvate kinase-M promoters by modulating Sp1/Sp3 binding to a conserved GC element
-
Discher DJ, Bishopric NH, Wu X, Peterson CA, Webster KA. Hypoxia regulates beta-enolase and pyruvate kinase-M promoters by modulating Sp1/Sp3 binding to a conserved GC element. J Biol Chem 273: 26087-26093, 1998.
-
(1998)
J Biol Chem
, vol.273
, pp. 26087-26093
-
-
Discher, D.J.1
Bishopric, N.H.2
Wu, X.3
Peterson, C.A.4
Webster, K.A.5
-
73
-
-
27144528715
-
Inhibition of mitochondrial respiration elevates oxygen concentration but leaves regulation of hypoxia-inducible factor (HIF) intact
-
Doege K, Heine S, Jensen I, Jelkmann W, Metzen E. Inhibition of mitochondrial respiration elevates oxygen concentration but leaves regulation of hypoxia-inducible factor (HIF) intact. Blood 106: 2311-2317, 2005.
-
(2005)
Blood
, vol.106
, pp. 2311-2317
-
-
Doege, K.1
Heine, S.2
Jensen, I.3
Jelkmann, W.4
Metzen, E.5
-
74
-
-
0035378480
-
NishiyamaJ. Up-regulation of apoptosis inhibitory protein IAP-2 by hypoxia. Hif-1-independent mechanisms
-
Dong Z, Venkatachalam MA, Wang J, Patel Y, Saikumar P, Semenza GL, Force T, NishiyamaJ. Up-regulation of apoptosis inhibitory protein IAP-2 by hypoxia. Hif-1-independent mechanisms. J Biol Chem 276: 18702-18709, 2001.
-
(2001)
J Biol Chem
, vol.276
, pp. 18702-18709
-
-
Dong, Z.1
Venkatachalam, M.A.2
Wang, J.3
Patel, Y.4
Saikumar, P.5
Semenza, G.L.6
Force, T.7
-
75
-
-
0026575755
-
Age-dependent expression of the erythropoietin gene in rat liver and kidneys
-
Eckardt KU, Ratcliffe PJ, Tan CC, Bauer C, Kurtz A. Age-dependent expression of the erythropoietin gene in rat liver and kidneys. J Clin Invest 89: 753-760, 1992.
-
(1992)
J Clin Invest
, vol.89
, pp. 753-760
-
-
Eckardt, K.U.1
Ratcliffe, P.J.2
Tan, C.C.3
Bauer, C.4
Kurtz, A.5
-
76
-
-
47649128513
-
Hypoxia-inducible factor-1 is central to cardioprotection: A new paradigm for ischemic preconditioning
-
Eckle T, Kohler D, Lehmann R, El Kasmi K, Eltzschig HK. Hypoxia-inducible factor-1 is central to cardioprotection: a new paradigm for ischemic preconditioning. Circulation 118: 166-175,2008.
-
(2008)
Circulation
, vol.118
, pp. 166-175
-
-
Eckle, T.1
Kohler, D.2
Lehmann, R.3
El Kasmi, K.4
Eltzschig, H.K.5
-
77
-
-
34247343418
-
Cardioprotection by ecto-5-nucleotidase (CD73) and A2B adenosine receptors
-
Eckle T, Krahn T, Grenz A, Kohler D, Mittelbronn M, Ledent C, Jacobson MA, Osswald H, Thompson LF, Unertl K, Eltzschig HK. Cardioprotection by ecto-5-nucleotidase (CD73) and A2B adenosine receptors. Circulation 115: 1581-1590, 2007.
-
(2007)
Circulation
, vol.115
, pp. 1581-1590
-
-
Eckle, T.1
Krahn, T.2
Grenz, A.3
Kohler, D.4
Mittelbronn, M.5
Ledent, C.6
Jacobson, M.A.7
Osswald, H.8
Thompson, L.F.9
Unertl, K.10
Eltzschig, H.K.11
-
78
-
-
33744954065
-
Concordant regulation of gene expression by hypoxia and 2-oxoglutarate-dependentdioxygenase inhibition: The role of HIF-1α
-
Elvidge GP, Glenny L, Appelhoff RJ, Ratcliffe PJ, Ragoussis J, Gleadle JM. Concordant regulation of gene expression by hypoxia and 2-oxoglutarate-dependentdioxygenase inhibition: the role of HIF-1α, HIF-2α, and other pathways.J Biol Chem 281: 15215-15226, 2006.
-
(2006)
HIF-2α, and Other Pathways.J Biol Chem
, vol.281
, pp. 15215-15226
-
-
Elvidge, G.P.1
Glenny, L.2
Appelhoff, R.J.3
Ratcliffe, P.J.4
Ragoussis, J.5
Gleadle, J.M.6
-
79
-
-
0031000736
-
A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1 α regulates the VEGF expression and is potentially involved in lung and vascular development
-
Ema M, Taya S, Yokotani N, Sogawa K, Matsuda Y, Fujii-Kuriyama Y. A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1 α regulates the VEGF expression and is potentially involved in lung and vascular development. Proc Natl Acad Sci USA 94: 4273-4278, 1997.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 4273-4278
-
-
Ema, M.1
Taya, S.2
Yokotani, N.3
Sogawa, K.4
Matsuda, Y.5
Fujii-Kuriyama, Y.6
-
80
-
-
17944375360
-
C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
-
Epstein AC, Gleadle JM, McNeill LA, Hewitson KS, O'Rourke J, Mole DR, Mukherji M, Metzen E, Wilson MI, Dhanda A, Tian YM, Masson N, Hamilton DL, Jaakkola P, Barstead R, Hodgkin J, Maxwell PH, Pugh CW, Schofield CJ, Ratcliffe PJ. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell 107: 43-54, 2001.
-
(2001)
Cell
, vol.107
, pp. 43-54
-
-
Epstein, A.C.1
Gleadle, J.M.2
McNeill, L.A.3
Hewitson, K.S.4
O'Rourke, J.5
Mole, D.R.6
Mukherji, M.7
Metzen, E.8
Wilson, M.I.9
Dhanda, A.10
Tian, Y.M.11
Masson, N.12
Hamilton, D.L.13
Jaakkola, P.14
Barstead, R.15
Hodgkin, J.16
Maxwell, P.H.17
Pugh, C.W.18
Schofield, C.J.19
Ratcliffe, P.J.20
more..
-
81
-
-
0034682741
-
2 sensor and NO signaling functions
-
Eu JP, Sun J, Xu L, Stamler JS, Meissner G. The skeletal muscle calcium release channel: coupled O2 sensor and NO signaling functions. Cell 102: 499-509, 2000.
-
(2000)
Cell
, vol.102
, pp. 499-509
-
-
Eu, J.P.1
Sun, J.2
Xu, L.3
Stamler, J.S.4
Meissner, G.5
-
82
-
-
0037024639
-
Hypoxia activates multiple transcriptional pathways in mouse pheochromocytoma cells
-
Evinger MJ, Cikos S, Nwafor-Anene V, Powers JF, Tischler AS. Hypoxia activates multiple transcriptional pathways in mouse pheochromocytoma cells. Ann NY Acad Sci 971: 61-65, 2002.
-
(2002)
Ann NY Acad Sci
, vol.971
, pp. 61-65
-
-
Evinger, M.J.1
Cikos, S.2
Nwafor-Anene, V.3
Powers, J.F.4
Tischler, A.S.5
-
83
-
-
0033566693
-
Reciprocal positive regulation of hypoxia-inducible factor 1 α and insulin-like growth factor 2
-
Feldser D, Agani F, Iyer NV, Pak B, Ferreira G, Semenza GL. Reciprocal positive regulation of hypoxia-inducible factor 1 α and insulin-like growth factor 2. Cancer Res 59: 3915-3918, 1999.
-
(1999)
Cancer Res
, vol.59
, pp. 3915-3918
-
-
Feldser, D.1
Agani, F.2
Iyer, N.V.3
Pak, B.4
Ferreira, G.5
Semenza, G.L.6
-
84
-
-
77749291806
-
Hypoxia inducible-factor 1α regulates the metabolic shift of pulmonary hypertensive endothelial cells
-
Fijalkowska I, Xu W, Comhair SA, Janocha AJ, Mavrakis LA, Krishnamachary B, Zhen L, Mao T, Richter A, Erzurum SC, Tuder RM. Hypoxia inducible-factor 1α regulates the metabolic shift of pulmonary hypertensive endothelial cells. Am J Pathol 176: 1130-1138, 2010.
-
(2010)
Am J Pathol
, vol.176
, pp. 1130-1138
-
-
Fijalkowska, I.1
Xu, W.2
Comhair, S.A.3
Janocha, A.J.4
Mavrakis, L.A.5
Krishnamachary, B.6
Zhen, L.7
Mao, T.8
Richter, A.9
Erzurum, S.C.10
Tuder, R.M.11
-
85
-
-
53549085960
-
CSB protein is (a direct target of HIF-1 and) a critical mediator of the hypoxic response
-
Filippi S, Latini P, Frontini M, Palitti F, Egly JM, Proietti-De-Santis L. CSB protein is (a direct target of HIF-1 and) a critical mediator of the hypoxic response. EMBO J 27: 2545-2556, 2008.
-
(2008)
EMBO J
, vol.27
, pp. 2545-2556
-
-
Filippi, S.1
Latini, P.2
Frontini, M.3
Palitti, F.4
Egly, J.M.5
Proietti-De-Santis, L.6
-
86
-
-
0026505363
-
The central organization of carotid body afferent projections to the brainstem of the rat
-
Finley JC, Katz DM. The central organization of carotid body afferent projections to the brainstem of the rat. Brain Res 572: 108-116, 1992.
-
(1992)
Brain Res
, vol.572
, pp. 108-116
-
-
Finley, J.C.1
Katz, D.M.2
-
87
-
-
0343683375
-
HRF, a putative basic helix-loop-helix-PAS-domain transcription factor is closely related to hypoxia-inducible factor-1 α and developmentally expressed in blood vessels
-
Flamme I, Frohlich T, von Reutern M, Kappel A, Damert A, Risau W. HRF, a putative basic helix-loop-helix-PAS-domain transcription factor is closely related to hypoxia-inducible factor-1 α and developmentally expressed in blood vessels. Mech Dev 63: 51-60, 1997.
-
(1997)
Mech Dev
, vol.63
, pp. 51-60
-
-
Flamme, I.1
Frohlich, T.2
von Reutern, M.3
Kappel, A.4
Damert, A.5
Risau, W.6
-
88
-
-
0035103272
-
Physiological consequences of intermittent hypoxia: Systemic blood pressure
-
Fletcher EC. Physiological consequences of intermittent hypoxia: systemic blood pressure. J Appl Physiol 90: 1600-1605, 2001.
-
(2001)
J Appl Physiol
, vol.90
, pp. 1600-1605
-
-
Fletcher, E.C.1
-
89
-
-
75149117810
-
Hypoxia inducible factors regulate pluripotency and proliferation in human embryonic stem cells cultured at reduced oxygen tensions
-
Forristal CE, Wright KL, Hanley NA, Oreffo RO, Houghton FD. Hypoxia inducible factors regulate pluripotency and proliferation in human embryonic stem cells cultured at reduced oxygen tensions. Reproduction 139: 85-97, 2010.
-
(2010)
Reproduction
, vol.139
, pp. 85-97
-
-
Forristal, C.E.1
Wright, K.L.2
Hanley, N.A.3
Oreffo, R.O.4
Houghton, F.D.5
-
90
-
-
0029761644
-
Activation of vascular endothelial growth factorgene transcription by hypoxia-inducible factor 1
-
Forsythe JA, Jiang BH, Iyer NV, Agani F, Leung SW, Koos RD, Semenza GL. Activation of vascular endothelial growth factorgene transcription by hypoxia-inducible factor 1. Mol Cell Biol 16: 4604-4613, 1996.
-
(1996)
Mol Cell Biol
, vol.16
, pp. 4604-4613
-
-
Forsythe, J.A.1
Jiang, B.H.2
Iyer, N.V.3
Agani, F.4
Leung, S.W.5
Koos, R.D.6
Semenza, G.L.7
-
91
-
-
71949097961
-
Sustained hypoxia leads to the emergence of cells with enhanced growth, migratory, and promitogenic potentials within the distal pulmonary artery wall
-
Frid MG, Li M, Gnanasekharan M, Burke DL, Fragoso M, Strassheim D, Sylman JL, Stenmark KR. Sustained hypoxia leads to the emergence of cells with enhanced growth, migratory, and promitogenic potentials within the distal pulmonary artery wall. Am J Physiol Lung Cell Mol Physiol 297: L1059-L1072, 2009.
-
(2009)
Am J Physiol Lung Cell Mol Physiol
, vol.297
-
-
Frid, M.G.1
Li, M.2
Gnanasekharan, M.3
Burke, D.L.4
Fragoso, M.5
Strassheim, D.6
Sylman, J.L.7
Stenmark, K.R.8
-
92
-
-
0037064010
-
Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells
-
Fukuda R, Hirota K, Fan F, Jung YD, Ellis LM, Semenza GL. Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells. J Biol Chem 277: 38205-38211,2002.
-
(2002)
J Biol Chem
, vol.277
, pp. 38205-38211
-
-
Fukuda, R.1
Hirota, K.2
Fan, F.3
Jung, Y.D.4
Ellis, L.M.5
Semenza, G.L.6
-
93
-
-
0038375038
-
2 is mediated by hypoxia-inducible factor 1
-
Fukuda R, Kelly B, Semenza GL. Vascular endothelial growth factorgene expression in colon cancer cells exposed to prostaglandin E2 is mediated by hypoxia-inducible factor 1. Cancer Res 63: 2330-2334, 2003.
-
(2003)
Cancer Res
, vol.63
, pp. 2330-2334
-
-
Fukuda, R.1
Kelly, B.2
Semenza, G.L.3
-
94
-
-
33947724515
-
HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells
-
Fukuda R, Zhang H, Kim JW, Shimoda L, Dang CV, Semenza GL. HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells. Cell 129: 111-122, 2007.
-
(2007)
Cell
, vol.129
, pp. 111-122
-
-
Fukuda, R.1
Zhang, H.2
Kim, J.W.3
Shimoda, L.4
Dang, C.V.5
Semenza, G.L.6
-
95
-
-
0041471553
-
Hypoxia-inducible factor-1: A molecular hint of physiological changes in the carotid body during long-term hypoxemia?
-
Fung ML. Hypoxia-inducible factor-1: a molecular hint of physiological changes in the carotid body during long-term hypoxemia? Curr Drug Targets Cardiovasc Haematol Disord 3: 254-259, 2003.
-
(2003)
Curr Drug Targets Cardiovasc Haematol Disord
, vol.3
, pp. 254-259
-
-
Fung, M.L.1
-
96
-
-
0035896558
-
Hypoxia inhibits G1/S transition through regulation of p27 expression
-
Gardner LB, Li Q, Park MS, Flanagan WM, Semenza GL, Dang CV. Hypoxia inhibits G1/S transition through regulation of p27 expression. J Biol Chem 276: 7919-7926, 2001.
-
(2001)
J Biol Chem
, vol.276
, pp. 7919-7926
-
-
Gardner, L.B.1
Li, Q.2
Park, M.S.3
Flanagan, W.M.4
Semenza, G.L.5
Dang, C.V.6
-
97
-
-
66749190028
-
Cardiovascular disease in obstructive sleep apnoea syndrome: The role of intermittent hypoxia and inflammation
-
Garvey JF, Taylor CT, McNicholas WT. Cardiovascular disease in obstructive sleep apnoea syndrome: the role of intermittent hypoxia and inflammation. Eur RespirJ 33: 1195-1205, 2009.
-
(2009)
Eur RespirJ
, vol.33
, pp. 1195-1205
-
-
Garvey, J.F.1
Taylor, C.T.2
McNicholas, W.T.3
-
98
-
-
0034879150
-
Transcriptional regulation of the BCL-X gene by NF-kappaB is an element of hypoxic responses in the rat brain
-
Glasgow JN, Qiu J, Rassin D, Grafe M, Wood T, Perez-Pol JR. Transcriptional regulation of the BCL-X gene by NF-kappaB is an element of hypoxic responses in the rat brain. Neurochem Res 26: 647-659, 2001.
-
(2001)
Neurochem Res
, vol.26
, pp. 647-659
-
-
Glasgow, J.N.1
Qiu, J.2
Rassin, D.3
Grafe, M.4
Wood, T.5
Perez-Pol, J.R.6
-
99
-
-
0024273450
-
Regulation of the erythropoietin gene: Evidence that the oxygen sensor is a heme protein
-
Goldberg MA, Dunning SP, Bunn HF. Regulation of the erythropoietin gene: evidence that the oxygen sensor is a heme protein. Science 242: 1412-1415, 1988.
-
(1988)
Science
, vol.242
, pp. 1412-1415
-
-
Goldberg, M.A.1
Dunning, S.P.2
Bunn, H.F.3
-
100
-
-
0025972125
-
Erythropoietin mRNA levels are governed by both the rate of gene transcription and posttranscriptional events
-
Goldberg MA, Gaut CC, Bunn HF. Erythropoietin mRNA levels are governed by both the rate of gene transcription and posttranscriptional events. Blood 77: 271-277, 1991.
-
(1991)
Blood
, vol.77
, pp. 271-277
-
-
Goldberg, M.A.1
Gaut, C.C.2
Bunn, H.F.3
-
101
-
-
0242408897
-
The regulated expression of erythropoietin by two human hepatoma cell lines
-
Goldberg MA, Glass GA, Cunningham JM, Bunn HF. The regulated expression of erythropoietin by two human hepatoma cell lines. Proc Natl Acad Sci USA 84: 7972-7976, 1987.
-
(1987)
Proc Natl Acad Sci USA
, vol.84
, pp. 7972-7976
-
-
Goldberg, M.A.1
Glass, G.A.2
Cunningham, J.M.3
Bunn, H.F.4
-
102
-
-
0034629304
-
Identification of alternative spliced variants of human hypoxia-inducible factor-1 α
-
Gothie E, Richard DE, Berra E, Pages G, Pouyssegur J. Identification of alternative spliced variants of human hypoxia-inducible factor-1 α. J Biol Chem 275: 6922-6927, 2000.
-
(2000)
J Biol Chem
, vol.275
, pp. 6922-6927
-
-
Gothie, E.1
Richard, D.E.2
Berra, E.3
Pages, G.4
Pouyssegur, J.5
-
103
-
-
33645514937
-
Antioxidant vitamin C improves endothelial function in obstructive sleep apnea
-
Grebe M, Eisele HJ, Weissmann N, Schaefer C, Tillmanns H, Seeger W, Schulz R. Antioxidant vitamin C improves endothelial function in obstructive sleep apnea. Am J Respir Crit Care Med 173: 897-901, 2006.
-
(2006)
Am J Respir Crit Care Med
, vol.173
, pp. 897-901
-
-
Grebe, M.1
Eisele, H.J.2
Weissmann, N.3
Schaefer, C.4
Tillmanns, H.5
Seeger, W.6
Schulz, R.7
-
104
-
-
33847796951
-
Acute postnatal ablation of Hif-2α results in anemia
-
Gruber M, Hu CJ, Johnson RS, Brown EJ, Keith B, Simon MC. Acute postnatal ablation of Hif-2α results in anemia. Proc Natl Acad Sci USA 104: 2301-2306, 2007.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 2301-2306
-
-
Gruber, M.1
Hu, C.J.2
Johnson, R.S.3
Brown, E.J.4
Keith, B.5
Simon, M.C.6
-
105
-
-
30344437303
-
VEGF-induced adult neovascularization: Recruitment, retention, and role of accessory cells
-
Grunewald M, Avraham I, Dor Y, Bachar-Lustig E, Itin A, Jung S, Chimenti S, Landsman L, Abramovitch R, Keshet E. VEGF-induced adult neovascularization: recruitment, retention, and role of accessory cells. Cell 124: 175-189, 2006.
-
(2006)
Cell
, vol.124
, pp. 175-189
-
-
Grunewald, M.1
Avraham, I.2
Dor, Y.3
Bachar-Lustig, E.4
Itin, A.5
Jung, S.6
Chimenti, S.7
Landsman, L.8
Abramovitch, R.9
Keshet, E.10
-
106
-
-
27644561755
-
Hypoxia requires notch signaling to maintain the undifferentiated cell state
-
Gustafsson MV, Zheng X, Pereira T, Gradin K, Jin S, Lundkvist J, Ruas JL, Poellinger L, Lendahl U, Bondesson M. Hypoxia requires notch signaling to maintain the undifferentiated cell state. Dev Cell 9: 617-628, 2005.
-
(2005)
Dev Cell
, vol.9
, pp. 617-628
-
-
Gustafsson, M.V.1
Zheng, X.2
Pereira, T.3
Gradin, K.4
Jin, S.5
Lundkvist, J.6
Ruas, J.L.7
Poellinger, L.8
Lendahl, U.9
Bondesson, M.10
-
107
-
-
24144493814
-
Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing
-
Guzy RD, Hoyos B, Robin E, Chen H, Liu L, Mansfield KD, Simon MC, Hammerling U, Schumacker PT. Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing. Cell Metab 1: 401-408, 2005.
-
(2005)
Cell Metab
, vol.1
, pp. 401-408
-
-
Guzy, R.D.1
Hoyos, B.2
Robin, E.3
Chen, H.4
Liu, L.5
Mansfield, K.D.6
Simon, M.C.7
Hammerling, U.8
Schumacker, P.T.9
-
108
-
-
0348134741
-
Redistribution of intracellular oxygen in hypoxia by nitric oxide: Effect on HIF-1 α
-
Hagen T, Taylor CT, Lam F, Moncada S. Redistribution of intracellular oxygen in hypoxia by nitric oxide: effect on HIF-1 α. Science 302: 1975-1978, 2003.
-
(2003)
Science
, vol.302
, pp. 1975-1978
-
-
Hagen, T.1
Taylor, C.T.2
Lam, F.3
Moncada, S.4
-
109
-
-
70350380469
-
From polyps to people: A highly familiar response to hypoxia
-
Hampton-Smith RJ, Peet DJ. From polyps to people: a highly familiar response to hypoxia. Ann NY Acad Sci 1177: 19-29, 2009.
-
(2009)
Ann NY Acad Sci
, vol.1177
, pp. 19-29
-
-
Hampton-Smith, R.J.1
Peet, D.J.2
-
110
-
-
0033370832
-
Differential signaling pathways of HO-1 gene expression in pulmonary and systemic vascular cells
-
Hartsfield CL, Alam J, Choi AM. Differential signaling pathways of HO-1 gene expression in pulmonary and systemic vascular cells. Am J Physiol Lung Cell Mol Physiol 277: L1133-L1141, 1999.
-
(1999)
Am J Physiol Lung Cell Mol Physiol
, vol.277
-
-
Hartsfield, C.L.1
Alam, J.2
Choi, A.M.3
-
111
-
-
0021943571
-
Comparative pathology of the enlarged carotid body
-
Heath D, Smith P, Fitch R, Harris P. Comparative pathology of the enlarged carotid body. J Comp Pathol 95: 259-271, 1985.
-
(1985)
J Comp Pathol
, vol.95
, pp. 259-271
-
-
Heath, D.1
Smith, P.2
Fitch, R.3
Harris, P.4
-
112
-
-
0034797791
-
Hypoxic upregulation of TNF receptor type 2 expression involves NF-IL-6 and is independent of HIF-1 or HIF-2
-
Hehlgans T, Seitz C, Lewis C, Mannel DN. Hypoxic upregulation of TNF receptor type 2 expression involves NF-IL-6 and is independent of HIF-1 or HIF-2.J Interferon Cytokine Res 21: 757-762, 2001.
-
(2001)
J Interferon Cytokine Res
, vol.21
, pp. 757-762
-
-
Hehlgans, T.1
Seitz, C.2
Lewis, C.3
Mannel, D.N.4
-
113
-
-
75149165633
-
Prolyl hydroxylases 2 and 3 αct in gliomas as protective negative feedback regulators of hypoxia-inducible factors
-
Henze AT, Riedel J, Diem T, Wenner J, Flamme I, Pouyseggur J, Plate KH, Acker T. Prolyl hydroxylases 2 and 3 αct in gliomas as protective negative feedback regulators of hypoxia-inducible factors. Cancer Res 70: 357-366, 2010.
-
(2010)
Cancer Res
, vol.70
, pp. 357-366
-
-
Henze, A.T.1
Riedel, J.2
Diem, T.3
Wenner, J.4
Flamme, I.5
Pouyseggur, J.6
Plate, K.H.7
Acker, T.8
-
114
-
-
34047255064
-
Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates
-
Hewitson KS, Lienard BM, McDonough MA, Clifton IJ, Butler D, Soares AS, Oldham NJ, McNeill LA, Schofield CJ. Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates. J Biol Chem 282: 3293-3301, 2007.
-
(2007)
J Biol Chem
, vol.282
, pp. 3293-3301
-
-
Hewitson, K.S.1
Lienard, B.M.2
McDonough, M.A.3
Clifton, I.J.4
Butler, D.5
Soares, A.S.6
Oldham, N.J.7
McNeill, L.A.8
Schofield, C.J.9
-
115
-
-
0043234538
-
Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor
-
Hirsila M, Koivunen P, Gunzler V, Kivirikko KI, Myllyharju J. Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor. J Biol Chem 278: 30772-30780, 2003.
-
(2003)
J Biol Chem
, vol.278
, pp. 30772-30780
-
-
Hirsila, M.1
Koivunen, P.2
Gunzler, V.3
Kivirikko, K.I.4
Myllyharju, J.5
-
116
-
-
0025906014
-
Cloning of a factor required for activity of the Ah (dioxin) receptor
-
Hoffman EC, Reyes H, Chu FF, Sander F, Conley LH, Brooks BA, Hankinson O. Cloning of a factor required for activity of the Ah (dioxin) receptor. Science 252: 954-958, 1991.
-
(1991)
Science
, vol.252
, pp. 954-958
-
-
Hoffman, E.C.1
Reyes, H.2
Chu, F.F.3
Sander, F.4
Conley, L.H.5
Brooks, B.A.6
Hankinson, O.7
-
117
-
-
0030887045
-
Characterization of a subset of the basic-helix-loop-helix-PAS super-family that interacts with components of the dioxin signaling pathway
-
Hogenesch JB, Chan WKJ, Ackiw VH, Brown RC, Gu YZ, Pray-Grant M, Perdew GH, Bradfield CA. Characterization of a subset of the basic-helix-loop-helix-PAS super-family that interacts with components of the dioxin signaling pathway. J Biol Chem 272: 8581-8593, 1997.
-
(1997)
J Biol Chem
, vol.272
, pp. 8581-8593
-
-
Hogenesch, J.B.1
Chan, W.K.J.2
Ackiw, V.H.3
Brown, R.C.4
Gu, Y.Z.5
Pray-Grant, M.6
Perdew, G.H.7
Bradfield, C.A.8
-
118
-
-
33750630119
-
Recruitment of HIF-1 α and HIF-2α to common target genes is differentially regulated in neuroblastoma: HIF-2α promotes an aggressive phenotype
-
Holmquist-Mengelbier L, Fredlund E, Lofstedt T, Noguera R, Navarro S, Nilsson H, Pietras A, Vallon-Christersson J, Borg A, Gradin K, Poellinger L, Pahlman S. Recruitment of HIF-1 α and HIF-2α to common target genes is differentially regulated in neuroblastoma: HIF-2α promotes an aggressive phenotype. Cancer Cell 10: 413-423, 2006.
-
(2006)
Cancer Cell
, vol.10
, pp. 413-423
-
-
Holmquist-Mengelbier, L.1
Fredlund, E.2
Lofstedt, T.3
Noguera, R.4
Navarro, S.5
Nilsson, H.6
Pietras, A.7
Vallon-Christersson, J.8
Borg, A.9
Gradin, K.10
Poellinger, L.11
Pahlman, S.12
-
119
-
-
37349071022
-
Endothelin-1 and serotonin are involved in activation of RhoA/Rho kinase signaling in the chronically hypoxic hypertensive rat pulmonary circulation
-
Homma N, Nagaoka T, Morio Y, Ota H, Gebb SA, Karoor V, McMurtry IF, Oka M. Endothelin-1 and serotonin are involved in activation of RhoA/Rho kinase signaling in the chronically hypoxic hypertensive rat pulmonary circulation. J Cardiovasc Pharmacol 50: 697-702, 2007.
-
(2007)
J Cardiovasc Pharmacol
, vol.50
, pp. 697-702
-
-
Homma, N.1
Nagaoka, T.2
Morio, Y.3
Ota, H.4
Gebb, S.A.5
Karoor, V.6
McMurtry, I.F.7
Oka, M.8
-
120
-
-
77949535410
-
Negative feedback control of HIF-1 through REDD1-regulated ROS suppresses tumorigenesis
-
Horak P, Crawford AR, Vadysirisack DD, Nash ZM, DeYoung MP, Sgroi D, Ellisen LW. Negative feedback control of HIF-1 through REDD1-regulated ROS suppresses tumorigenesis. Proc Natl Acad Sci USA 107: 4675-4680, 2010.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 4675-4680
-
-
Horak, P.1
Crawford, A.R.2
Vadysirisack, D.D.3
Nash, Z.M.4
Deyoung, M.P.5
Sgroi, D.6
Ellisen, L.W.7
-
121
-
-
0023738152
-
Localization by kainic acid lesions of neurones transmitting the carotid chemoreceptor stimulus for respiration in rat
-
Housley GD, Sinclair JD. Localization by kainic acid lesions of neurones transmitting the carotid chemoreceptor stimulus for respiration in rat. J Physiol 406:99-114, 1988.
-
(1988)
J Physiol
, vol.406
, pp. 99-114
-
-
Housley, G.D.1
Sinclair, J.D.2
-
122
-
-
35848938945
-
The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1α and HIF-2α
-
Hu CJ, Sataur A, Wang L, Chen H, Simon MC. The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1α and HIF-2α. Mol Biol Cell 18:4528-4542,2007.
-
(2007)
Mol Biol Cell
, vol.18
, pp. 4528-4542
-
-
Hu, C.J.1
Sataur, A.2
Wang, L.3
Chen, H.4
Simon, M.C.5
-
123
-
-
0345491599
-
Differential roles of hypoxia-inducible factor 1 α (HIF-1 α) and HIF-2α in hypoxic gene regulation
-
Hu CJ, Wang LY, Chodosh LA, Keith B, Simon MC. Differential roles of hypoxia-inducible factor 1 α (HIF-1 α) and HIF-2α in hypoxic gene regulation. Mol Cell Biol 23: 9361-9374, 2003.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 9361-9374
-
-
Hu, C.J.1
Wang, L.Y.2
Chodosh, L.A.3
Keith, B.4
Simon, M.C.5
-
124
-
-
0032576971
-
Hypoxia regulates expression of the endothelin-1 gene through a proximal hypoxia-inducible factor-1 binding site on the antisense strand
-
Hu J, Discher DJ, Bishopric NH, Webster KA. Hypoxia regulates expression of the endothelin-1 gene through a proximal hypoxia-inducible factor-1 binding site on the antisense strand. Biochem Biophys Res Commun 245: 894-899, 1998.
-
(1998)
Biochem Biophys Res Commun
, vol.245
, pp. 894-899
-
-
Hu, J.1
Discher, D.J.2
Bishopric, N.H.3
Webster, K.A.4
-
125
-
-
0032493368
-
2-dependent degradation domain via the ubiquitin-proteasome pathway
-
Huang LE, Gu J, Schau M, Bunn HF. Regulation of hypoxia-inducible factor 1α is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway. Proc Natl Acad Sci USA 95: 7987-7992, 1998.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 7987-7992
-
-
Huang, L.E.1
Gu, J.2
Schau, M.3
Bunn, H.F.4
-
126
-
-
0035849720
-
Blockade of NF-kappaB activity in human prostate cancer cells is associated with suppression of angiogenesis, invasion, and metastasis
-
Huang S, Pettaway CA, Uehara H, Bucana CD, Fidler IJ. Blockade of NF-kappaB activity in human prostate cancer cells is associated with suppression of angiogenesis, invasion, and metastasis. Oncogene 20: 4188-4197, 2001.
-
(2001)
Oncogene
, vol.20
, pp. 4188-4197
-
-
Huang, S.1
Pettaway, C.A.2
Uehara, H.3
Bucana, C.D.4
Fidler, I.J.5
-
127
-
-
0036789574
-
Regulation of hypoxia-inducible factor 1α expression and function by the mammalian target of rapamycin
-
Hudson CC, Liu M, Chiang GG, Otterness DM, Loomis DC, Kaper F, Giaccia AJ, Abraham RT. Regulation of hypoxia-inducible factor 1α expression and function by the mammalian target of rapamycin. Mol Cell Biol 22: 7004-7014, 2002.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 7004-7014
-
-
Hudson, C.C.1
Liu, M.2
Chiang, G.G.3
Otterness, D.M.4
Loomis, D.C.5
Kaper, F.6
Giaccia, A.J.7
Abraham, R.T.8
-
128
-
-
1642443175
-
Microximetry: Simultaneous determination of oxygen consumption and free radical production using electron paramagnetic resonance spectroscopy
-
Ilangovan G, Zweier JL, Kuppusamy P. Microximetry: simultaneous determination of oxygen consumption and free radical production using electron paramagnetic resonance spectroscopy. Methods Enzymol 381: 747-762, 2004.
-
(2004)
Methods Enzymol
, vol.381
, pp. 747-762
-
-
Ilangovan, G.1
Zweier, J.L.2
Kuppusamy, P.3
-
129
-
-
0030049584
-
Tubulogenesis in Drosophila: A requirement forthe trachealess gene product
-
Isaac DD, Andrew DJ. Tubulogenesis in Drosophila: a requirement forthe trachealess gene product. Genes Dev 10: 103-117, 1996.
-
(1996)
Genes Dev
, vol.10
, pp. 103-117
-
-
Isaac, D.D.1
Andrew, D.J.2
-
130
-
-
0037119415
-
Hsp90 regulates avon Hippel Lindau-independent hypoxia-inducible factor-1 α-degradative pathway
-
Isaacs JS, Jung YJ, Mimnaugh EG, Martinez A, Cuttitta F, Neckers LM. Hsp90 regulates avon Hippel Lindau-independent hypoxia-inducible factor-1 α-degradative pathway. J Biol Chem 277: 29936-29944, 2002.
-
(2002)
J Biol Chem
, vol.277
, pp. 29936-29944
-
-
Isaacs, J.S.1
Jung, Y.J.2
Mimnaugh, E.G.3
Martinez, A.4
Cuttitta, F.5
Neckers, L.M.6
-
131
-
-
23644448721
-
HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: Novel role of fumarate in regulation of HIF stability
-
Isaacs JS, Jung YJ, Mole DR, Lee S, Torres-Cabala C, Chung YL, Merino M, Trepel J, Zbar B, Toro J, Ratcliffe PJ, Linehan WM, Neckers L. HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability. Cancer Cell 8: 143-153, 2005.
-
(2005)
Cancer Cell
, vol.8
, pp. 143-153
-
-
Isaacs, J.S.1
Jung, Y.J.2
Mole, D.R.3
Lee, S.4
Torres-Cabala, C.5
Chung, Y.L.6
Merino, M.7
Trepel, J.8
Zbar, B.9
Toro, J.10
Ratcliffe, P.J.11
Linehan, W.M.12
Neckers, L.13
-
132
-
-
1942533543
-
Aryl hydrocarbon nuclear translocator (ARNT) promotes oxygen-independent stabilization of hypoxia-inducible factor-1 α by modulating an Hsp90-dependent regulatory pathway
-
Isaacs JS, Jung YJ, Neckers L. Aryl hydrocarbon nuclear translocator (ARNT) promotes oxygen-independent stabilization of hypoxia-inducible factor-1 α by modulating an Hsp90-dependent regulatory pathway. J Biol Chem 279: 16128-16135, 2004.
-
(2004)
J Biol Chem
, vol.279
, pp. 16128-16135
-
-
Isaacs, J.S.1
Jung, Y.J.2
Neckers, L.3
-
133
-
-
0037108807
-
Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor
-
Ivan M, Haberberger T, Gervasi DC, Michelson KS, Gunzler V, Kondo K, Yang H, Sorokina I, Conaway RC, Conaway JW, Kaelin WG Jr. Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor. Proc Natl Acad Sci USA 99: 13459-13464, 2002.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 13459-13464
-
-
Ivan, M.1
Haberberger, T.2
Gervasi, D.C.3
Michelson, K.S.4
Gunzler, V.5
Kondo, K.6
Yang, H.7
Sorokina, I.8
Conaway, R.C.9
Conaway, J.W.10
Kaelin Jr., W.G.11
-
134
-
-
0035917313
-
2 sensing
-
Ivan M, Kondo K, Yang H, Kim W, Valiando J, Ohh M, Salic A, Asara JM, Lane WS, Kaelin WG Jr. HIFα targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science 292: 464-468, 2001.
-
(2001)
Science
, vol.292
, pp. 464-468
-
-
Ivan, M.1
Kondo, K.2
Yang, H.3
Kim, W.4
Valiando, J.5
Ohh, M.6
Salic, A.7
Asara, J.M.8
Lane, W.S.9
Kaelin Jr., W.G.10
-
135
-
-
15444342958
-
2 homeostasis by hypoxia-inducible factor 1 α
-
Iyer NV, Kotch LE, Agani F, Leung SW, Laughner E, Wenger RH, Gassmann M, Gearhart JD, Lawler AM, Yu AY, Semenza GL. Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 α. Genes Dev 12: 149-162, 1998.
-
(1998)
Genes Dev
, vol.12
, pp. 149-162
-
-
Iyer, N.V.1
Kotch, L.E.2
Agani, F.3
Leung, S.W.4
Laughner, E.5
Wenger, R.H.6
Gassmann, M.7
Gearhart, J.D.8
Lawler, A.M.9
Yu, A.Y.10
Semenza, G.L.11
-
136
-
-
0032167784
-
The human hypoxia-inducible factor 1α gene: HIF1α structure and evolutionary conservation
-
Iyer NV, Leung SW, Semenza GL. The human hypoxia-inducible factor 1α gene: HIF1α structure and evolutionary conservation. Genomics 52: 159-165, 1998.
-
(1998)
Genomics
, vol.52
, pp. 159-165
-
-
Iyer, N.V.1
Leung, S.W.2
Semenza, G.L.3
-
137
-
-
0035917808
-
2-regulated prolyl hydroxylation
-
Jaakkola P, Mole DR, Tian YM, Wilson MI, Gielbert J, Gaskell SJ, Kriegsheim A, Hebestreit HF, Mukherji M, Schofield CJ, Maxwell PH, Pugh CW, Ratcliffe PJ. Targeting of HIF-α to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 292: 468-472, 2001.
-
(2001)
Science
, vol.292
, pp. 468-472
-
-
Jaakkola, P.1
Mole, D.R.2
Tian, Y.M.3
Wilson, M.I.4
Gielbert, J.5
Gaskell, S.J.6
Kriegsheim, A.7
Hebestreit, H.F.8
Mukherji, M.9
Schofield, C.J.10
Maxwell, P.H.11
Pugh, C.W.12
Ratcliffe, P.J.13
-
138
-
-
0026526168
-
Erythropoietin: Structure, control of production, and function
-
Jelkmann W. Erythropoietin: structure, control of production, and function. Physiol Rev 72: 449-489, 1992.
-
(1992)
Physiol Rev
, vol.72
, pp. 449-489
-
-
Jelkmann, W.1
-
139
-
-
34250330368
-
Hypoxia-inducible factor-1 α inhibits self-renewal of mouse embryonic stem cells in vitro via negative regulation of the leukemia inhibitory factor-STAT3 pathway
-
Jeong CH, Lee HJ, Cha JH, Kim JH, Kim KR, Yoon DK, Kim KW. Hypoxia-inducible factor-1 α inhibits self-renewal of mouse embryonic stem cells in vitro via negative regulation of the leukemia inhibitory factor-STAT3 pathway.J Biol Chem 282: 13672-13679, 2007.
-
(2007)
J Biol Chem
, vol.282
, pp. 13672-13679
-
-
Jeong, C.H.1
Lee, H.J.2
Cha, J.H.3
Kim, J.H.4
Kim, K.R.5
Yoon, D.K.6
Kim, K.W.7
-
140
-
-
0032504751
-
Hypoxia induces high-mobility-group protein I(Y) and transcription of the cyclooxygenase-2 gene in human vascular endothelium
-
Ji YS, Xu Q, Schmedtje JF Jr. Hypoxia induces high-mobility-group protein I(Y) and transcription of the cyclooxygenase-2 gene in human vascular endothelium. Circ Res 83: 295-304, 1998.
-
(1998)
Circ Res
, vol.83
, pp. 295-304
-
-
Ji, Y.S.1
Xu, Q.2
Schmedtje Jr., J.F.3
-
141
-
-
0030659531
-
V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: Involvement of HIF-1 in tumor progression
-
Jiang BH, Agani F, Passaniti A, Semenza GL. V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: involvement of HIF-1 in tumor progression. Cancer Res 57: 5328-5335, 1997.
-
(1997)
Cancer Res
, vol.57
, pp. 5328-5335
-
-
Jiang, B.H.1
Agani, F.2
Passaniti, A.3
Semenza, G.L.4
-
142
-
-
0029944965
-
Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1
-
Jiang BH, Rue E, Wang GL, Roe R, Semenza GL. Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1. J Biol Chem 271: 17771-17778, 1996.
-
(1996)
J Biol Chem
, vol.271
, pp. 17771-17778
-
-
Jiang, B.H.1
Rue, E.2
Wang, G.L.3
Roe, R.4
Semenza, G.L.5
-
144
-
-
0030787469
-
Transactivation and inhibitory domains of hypoxia-inducible factor 1α. Modulation of transcriptional activity by oxygen tension
-
Jiang BH, Zheng JZ, Leung SW, Roe R, Semenza GL. Transactivation and inhibitory domains of hypoxia-inducible factor 1α. Modulation of transcriptional activity by oxygen tension. J Biol Chem 272: 19253-19260, 1997.
-
(1997)
J Biol Chem
, vol.272
, pp. 19253-19260
-
-
Jiang, B.H.1
Zheng, J.Z.2
Leung, S.W.3
Roe, R.4
Semenza, G.L.5
-
145
-
-
0034940761
-
The Caenorhabditis elegans hif-1 gene encodes a bHLH-PAS protein that is required for adaptation to hypoxia
-
Jiang H, Guo R, Powell-Coffman JA. The Caenorhabditis elegans hif-1 gene encodes a bHLH-PAS protein that is required for adaptation to hypoxia. Proc Natl Acad Sci USA 98: 7916-7921, 2001.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 7916-7921
-
-
Jiang, H.1
Guo, R.2
Powell-Coffman, J.A.3
-
146
-
-
33646581046
-
+ hemangiocytes
-
+ hemangiocytes. Nat Med 12: 557-567, 2006.
-
(2006)
Nat Med
, vol.12
, pp. 557-567
-
-
Jin, D.K.1
Shido, K.2
Kopp, H.G.3
Petit, I.4
Shmelkov, S.V.5
Young, L.M.6
Hooper, A.T.7
Amano, H.8
Avecilla, S.T.9
Heissig, B.10
Hattori, K.11
Zhang, F.12
Hicklin, D.J.13
Wu, Y.14
Zhu, Z.15
Dunn, A.16
Salari, H.17
Werb, Z.18
Hackett, N.R.19
Crystal, R.G.20
Lyden, D.21
Rafii, S.22
more..
-
147
-
-
0033967276
-
Expression of angiogenic growth factors in paragangliomas
-
Jyung RW, LeClair EE, Bernat RA, Kang TS, Ung F, McKenna MJ, Tuan RS.
-
(2000)
Laryngoscope
, vol.110
, pp. 161-167
-
-
Jyung, R.W.1
Leclair, E.E.2
Bernat, R.A.3
Kang, T.S.4
Ung, F.5
McKenna, M.J.6
Tuan, R.S.7
-
148
-
-
33746123520
-
Direct transcriptional up-regulation of cyclooxygenase-2 by hypoxia-inducible factor (HIF)-1 promotes colorectal tumor cell survival and enhances HIF-1 transcriptional activity during hypoxia
-
Kaidi A, Qualtrough D, Williams AC, Paraskeva C. Direct transcriptional up-regulation of cyclooxygenase-2 by hypoxia-inducible factor (HIF)-1 promotes colorectal tumor cell survival and enhances HIF-1 transcriptional activity during hypoxia. Cancer Res 66: 6683-6691,2006.
-
(2006)
Cancer Res
, vol.66
, pp. 6683-6691
-
-
Kaidi, A.1
Qualtrough, D.2
Williams, A.C.3
Paraskeva, C.4
-
149
-
-
0033525830
-
Regulation of the hypoxia-inducible transcription factor 1 α by the ubiquitin-proteasome pathway
-
Kallio PJ, Wilson WJ, O'Brien S, Makino Y, Poellinger L. Regulation of the hypoxia-inducible transcription factor 1 α by the ubiquitin-proteasome pathway.J Biol Chem 274:6519-6525, 1999.
-
(1999)
J Biol Chem
, vol.274
, pp. 6519-6525
-
-
Kallio, P.J.1
Wilson, W.J.2
O'Brien, S.3
Makino, Y.4
Poellinger, L.5
-
150
-
-
0034641615
-
Activation of HIF1 α ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex
-
Kamura T, Sato S, Iwai K, Czyzyk-Krzeska M, Conaway RC, Conaway JW. Activation of HIF1 α ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex. Proc Natl Acad Sci USA 97: 10430-10435, 2000.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 10430-10435
-
-
Kamura, T.1
Sato, S.2
Iwai, K.3
Czyzyk-Krzeska, M.4
Conaway, R.C.5
Conaway, J.W.6
-
151
-
-
0037342849
-
Chemoreflexes-physiology and clinical implications
-
Kara T, Narkiewicz K, Somers VK. Chemoreflexes-physiology and clinical implications. Acta Physiol Scand 177: 377-384, 2003.
-
(2003)
Acta Physiol Scand
, vol.177
, pp. 377-384
-
-
Kara, T.1
Narkiewicz, K.2
Somers, V.K.3
-
152
-
-
1642453685
-
Nitric oxide induces hypoxia-inducible factor 1 αctivation that is dependent on MAPK and phosphatidylinositol 3-kinase signaling
-
Kasuno K, Takabuchi S, Fukuda K, Kizaka-Kondoh S, Yodoi J, Adachi T, Semenza GL, Hirota K. Nitric oxide induces hypoxia-inducible factor 1 αctivation that is dependent on MAPK and phosphatidylinositol 3-kinase signaling. J Biol Chem 279: 2550-2558, 2004.
-
(2004)
J Biol Chem
, vol.279
, pp. 2550-2558
-
-
Kasuno, K.1
Takabuchi, S.2
Fukuda, K.3
Kizaka-Kondoh, S.4
Yodoi, J.5
Adachi, T.6
Semenza, G.L.7
Hirota, K.8
-
153
-
-
0344874751
-
Cell type-specific regulation of angiogenic growth factor gene expression and induction of angiogenesis in nonischemic tissue by a con-stitutively active form of hypoxia-inducible factor 1
-
Kelly BD, Hackett SF, Hirota K, Oshima Y, Cai Z, Berg-Dixon S, Rowan A, Yan Z, Campochiaro PA, Semenza GL. Cell type-specific regulation of angiogenic growth factor gene expression and induction of angiogenesis in nonischemic tissue by a con-stitutively active form of hypoxia-inducible factor 1. Circ Res 93: 1074-1081, 2003.
-
(2003)
Circ Res
, vol.93
, pp. 1074-1081
-
-
Kelly, B.D.1
Hackett, S.F.2
Hirota, K.3
Oshima, Y.4
Cai, Z.5
Berg-Dixon, S.6
Rowan, A.7
Yan, Z.8
Campochiaro, P.A.9
Semenza, G.L.10
-
154
-
-
33745164962
-
Oxygen-sensitive reset of hypoxia-inducible factor transactivation response: Prolyl hydroxylases tune the biological nor-moxic set point
-
Khanna S, Roy S, Maurer M, Ratan RR, Sen CK. Oxygen-sensitive reset of hypoxia-inducible factor transactivation response: prolyl hydroxylases tune the biological nor-moxic set point. Free Radic Biol Med 40: 2147-2154, 2006.
-
(2006)
Free Radic Biol Med
, vol.40
, pp. 2147-2154
-
-
Khanna, S.1
Roy, S.2
Maurer, M.3
Ratan, R.R.4
Sen, C.K.5
-
155
-
-
0037016064
-
Transient limb ischemia induces remote ischemic preconditioning in vivo
-
Kharbanda RK, Mortensen UM, White PA, Kristiansen SB, Schmidt MR, Hoschtitzky JA, Vogel M, Sorensen K, Redington AN, MacAllister R. Transient limb ischemia induces remote ischemic preconditioning in vivo. Circulation 106: 2881-2883, 2002.
-
(2002)
Circulation
, vol.106
, pp. 2881-2883
-
-
Kharbanda, R.K.1
Mortensen, U.M.2
White, P.A.3
Kristiansen, S.B.4
Schmidt, M.R.5
Hoschtitzky, J.A.6
Vogel, M.7
Sorensen, K.8
Redington, A.N.9
Macallister, R.10
-
156
-
-
33644614520
-
HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
-
Kim JW, Tchernyshyov I, Semenza GL, Dang CV. HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. Cell Metab 3: 177-185, 2006.
-
(2006)
Cell Metab
, vol.3
, pp. 177-185
-
-
Kim, J.W.1
Tchernyshyov, I.2
Semenza, G.L.3
Dang, C.V.4
-
157
-
-
77952863907
-
Human enhancer of filamentation 1 is a mediator of hypoxia-inducible factor-1 α-mediated migration in colorectal carcinoma cells
-
Kim SH, Xia D, Kim SW, Holla V, Menter DG, Dubois RN. Human enhancer of filamentation 1 is a mediator of hypoxia-inducible factor-1 α-mediated migration in colorectal carcinoma cells. Cancer Res 70: 4054-4063, 2010.
-
(2010)
Cancer Res
, vol.70
, pp. 4054-4063
-
-
Kim, S.H.1
Xia, D.2
Kim, S.W.3
Holla, V.4
Menter, D.G.5
Dubois, R.N.6
-
158
-
-
0033975850
-
Hypoxia response element of the human vascular endothelial growth factor gene mediates transcriptional regulation by nitric oxide: Control of hypoxia-inducible factor-1 activity by nitric oxide
-
Kimura H, Weisz A, Kurashima Y, Hashimoto K, Ogura T, D'Acquisto F, Addeo R, Makuuchi M, Esumi H. Hypoxia response element of the human vascular endothelial growth factor gene mediates transcriptional regulation by nitric oxide: control of hypoxia-inducible factor-1 activity by nitric oxide. Blood 95: 189-197, 2000.
-
(2000)
Blood
, vol.95
, pp. 189-197
-
-
Kimura, H.1
Weisz, A.2
Kurashima, Y.3
Hashimoto, K.4
Ogura, T.5
D'Acquisto, F.6
Addeo, R.7
Makuuchi, M.8
Esumi, H.9
-
159
-
-
0037154262
-
Defective carotid body function and impaired ventilatory responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1 α
-
Kline DD, Peng YJ, Manalo DJ, Semenza GL, Prabhakar NR. Defective carotid body function and impaired ventilatory responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1 α. Proc Natl Acad Sci USA 99: 821-826, 2002.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 821-826
-
-
Kline, D.D.1
Peng, Y.J.2
Manalo, D.J.3
Semenza, G.L.4
Prabhakar, N.R.5
-
160
-
-
79957440998
-
The hypoxia-associated factor switches cells from HIF-1 α- to HIF-2α-dependent signaling promoting stem cell characteristics, aggressive tumor growth and invasion
-
Koh MY, Lemos R Jr, Liu X, Powis G. The hypoxia-associated factor switches cells from HIF-1 α- to HIF-2α-dependent signaling promoting stem cell characteristics, aggressive tumor growth and invasion. Cancer Res 71: 4015-4027, 2011.
-
(2011)
Cancer Res
, vol.71
, pp. 4015-4027
-
-
Koh, M.Y.1
Lemos Jr., R.2
Liu, X.3
Powis, G.4
-
161
-
-
1642315195
-
Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases
-
Koivunen P, Hirsila M, Gunzler V, Kivirikko KI, Myllyharju J, Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases. J Biol Chem 279: 9899-9904, 2004.
-
(2004)
J Biol Chem
, vol.279
, pp. 9899-9904
-
-
Koivunen, P.1
Hirsila, M.2
Gunzler, V.3
Kivirikko, K.I.4
Myllyharju, J.5
-
162
-
-
33947520506
-
Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: Possible links between cell metabolism and stabilization of HIF
-
Koivunen P, Hirsila M, Remes AM, Hassinen IE, Kivirikko KI, Myllyharju J. Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF. J Biol Chem 282: 4524-4532, 2007.
-
(2007)
J Biol Chem
, vol.282
, pp. 4524-4532
-
-
Koivunen, P.1
Hirsila, M.2
Remes, A.M.3
Hassinen, I.E.4
Kivirikko, K.I.5
Myllyharju, J.6
-
163
-
-
34548616504
-
Identification of Pur α as a new hypoxia response factor responsible for coordinated induction of the beta 2 integrin family
-
Kong T, Scully M, Shelley CS, Colgan SP. Identification of Pur α as a new hypoxia response factor responsible for coordinated induction of the beta 2 integrin family. J Immunol 179: 1934-1941,2007.
-
(2007)
J Immunol
, vol.179
, pp. 1934-1941
-
-
Kong, T.1
Scully, M.2
Shelley, C.S.3
Colgan, S.P.4
-
164
-
-
3142631736
-
HIF-1 α induces cell cycle arrest by functionally counteracting Myc
-
Koshiji M, Kageyama Y, Pete EA, Horikawa I, Barrett JC, Huang LE. HIF-1 α induces cell cycle arrest by functionally counteracting Myc. EMBOJ 23: 1949-1956, 2004.
-
(2004)
EMBOJ
, vol.23
, pp. 1949-1956
-
-
Koshiji, M.1
Kageyama, Y.2
Pete, E.A.3
Horikawa, I.4
Barrett, J.C.5
Huang, L.E.6
-
165
-
-
15244344206
-
HIF-1 α induces genetic instability by transcriptionally downregulating MutSa expression
-
Koshiji M, To KK, Hammer S, Kumamoto K, Harris AL, Modrich P, Huang LE. HIF-1 α induces genetic instability by transcriptionally downregulating MutSa expression. Mol Cell 17: 793-803, 2005.
-
(2005)
Mol Cell
, vol.17
, pp. 793-803
-
-
Koshiji, M.1
To, K.K.2
Hammer, S.3
Kumamoto, K.4
Harris, A.L.5
Modrich, P.6
Huang, L.E.7
-
166
-
-
33748703089
-
Cyclosporin A inhibits hypoxia-induced pulmonary hypertension and right ventricle hypertrophy
-
Koulmann N, Novel-Chate V, Peinnequin A, Chapot R, Serrurier B, Simler N, Richard H, Ventura-Clapier R, Bigard X. Cyclosporin A inhibits hypoxia-induced pulmonary hypertension and right ventricle hypertrophy. Am J Respir Crit Care Med 174: 699-705, 2006.
-
(2006)
Am J Respir Crit Care Med
, vol.174
, pp. 699-705
-
-
Koulmann, N.1
Novel-Chate, V.2
Peinnequin, A.3
Chapot, R.4
Serrurier, B.5
Simler, N.6
Richard, H.7
Ventura-Clapier, R.8
Bigard, X.9
-
167
-
-
0025912710
-
Localization of cells producing erythropoietin in murine liver by in situ hybridization
-
Koury ST, Bondurant MC, Koury MJ, Semenza GL. Localization of cells producing erythropoietin in murine liver by in situ hybridization. Blood 77: 2497-2503, 1991.
-
(1991)
Blood
, vol.77
, pp. 2497-2503
-
-
Koury, S.T.1
Bondurant, M.C.2
Koury, M.J.3
Semenza, G.L.4
-
168
-
-
0024322837
-
Quantitation of erythropoi-etin-producing cells in kidneys of mice by in situ hybridization: Correlation with hematocrit, renal erythropoietin mRNA, and serum erythropoietin concentration
-
Koury ST, Koury MJ, Bondurant MC, Caro J, Graber SE. Quantitation of erythropoi-etin-producing cells in kidneys of mice by in situ hybridization: correlation with hematocrit, renal erythropoietin mRNA, and serum erythropoietin concentration. Blood 74: 645-651, 1989.
-
(1989)
Blood
, vol.74
, pp. 645-651
-
-
Koury, S.T.1
Koury, M.J.2
Bondurant, M.C.3
Caro, J.4
Graber, S.E.5
-
169
-
-
20944432353
-
Hypoxia-driven proliferation of human pulmonary artery fibroblasts: Cross-talk between HIF-1 α and an autocrine angiotensin system
-
Krick S, Hanze J, Eul B, Savai R, Seay U, Grimminger F, Lohmeyer J, Klepetko W, Seeger W, Rose F. Hypoxia-driven proliferation of human pulmonary artery fibroblasts: cross-talk between HIF-1 α and an autocrine angiotensin system. FASEBJ 19: 857-859, 2005.
-
(2005)
FASEBJ
, vol.19
, pp. 857-859
-
-
Krick, S.1
Hanze, J.2
Eul, B.3
Savai, R.4
Seay, U.5
Grimminger, F.6
Lohmeyer, J.7
Klepetko, W.8
Seeger, W.9
Rose, F.10
-
170
-
-
73549088729
-
Regulation of the histone demethylase JMJD1α by hypoxia-inducible factor 1 α enhances hypoxic gene expression and tumor growth
-
Krieg AJ, Rankin EB, Chan D, Razorenova O, Fernandez S, Giaccia AJ. Regulation of the histone demethylase JMJD1α by hypoxia-inducible factor 1 α enhances hypoxic gene expression and tumor growth. Mol Cell Biol 30: 344-353, 2010.
-
(2010)
Mol Cell Biol
, vol.30
, pp. 344-353
-
-
Krieg, A.J.1
Rankin, E.B.2
Chan, D.3
Razorenova, O.4
Fernandez, S.5
Giaccia, A.J.6
-
171
-
-
33746847626
-
Chronic intermittent hypoxia induces hypoxia-evoked catecholamine efflux in adult rat adrenal medulla via oxidative stress
-
Kumar GK, Rai V, Sharma SD, Ramakrishnan DP, Peng YJ, Souvannakitti D, Prabhakar NR. Chronic intermittent hypoxia induces hypoxia-evoked catecholamine efflux in adult rat adrenal medulla via oxidative stress. J Physiol 575: 229-239, 2006.
-
(2006)
J Physiol
, vol.575
, pp. 229-239
-
-
Kumar, G.K.1
Rai, V.2
Sharma, S.D.3
Ramakrishnan, D.P.4
Peng, Y.J.5
Souvannakitti, D.6
Prabhakar, N.R.7
-
172
-
-
84862002022
-
Peripheral chemoreceptors: Function and plasticity of the carotid body
-
Kumar P, Prabhakar N. Peripheral chemoreceptors: function and plasticity of the carotid body. Comprehensive Physiology 2: 141-219, 2012.
-
(2012)
Comprehensive Physiology
, vol.2
, pp. 141-219
-
-
Kumar, P.1
Prabhakar, N.2
-
173
-
-
0036150703
-
Hypoxia-inducible factor-1 α/vascular endothelial growth factor pathway for adventitial vasa vasorum formation in hypertensive rat aorta
-
Kuwahara F, Kai H, Tokuda K, Shibata R, Kusaba K, Tahara N, Niiyama H, Nagata T, Imaizumi T. Hypoxia-inducible factor-1 α/vascular endothelial growth factor pathway for adventitial vasa vasorum formation in hypertensive rat aorta. Hypertension 39: 46-50, 2002.
-
(2002)
Hypertension
, vol.39
, pp. 46-50
-
-
Kuwahara, F.1
Kai, H.2
Tokuda, K.3
Shibata, R.4
Kusaba, K.5
Tahara, N.6
Niiyama, H.7
Nagata, T.8
Imaizumi, T.9
-
174
-
-
0029819995
-
Impaired ventilatory responses to hypoxia and hypercapnia in mutant mice deficient in endothelin-1
-
Kuwaki T, Cao WH, Kurihara Y, Kurihara H, Ling GY, Onodera M, Ju KH, Yazaki Y, Kumada M. Impaired ventilatory responses to hypoxia and hypercapnia in mutant mice deficient in endothelin-1. Am J Physiol Regul Integr Comp Physiol 270: R1279-R1286, 1996.
-
(1996)
Am J Physiol Regul Integr Comp Physiol
, vol.270
-
-
Kuwaki, T.1
Cao, W.H.2
Kurihara, Y.3
Kurihara, H.4
Ling, G.Y.5
Onodera, M.6
Ju, K.H.7
Yazaki, Y.8
Kumada, M.9
-
175
-
-
0032052761
-
Oxygen sensing and the transcriptional regulation of oxygen-responsive genes in yeast
-
Kwast KE, Burke PV, Poyton RO. Oxygen sensing and the transcriptional regulation of oxygen-responsive genes in yeast. J Exp Biol 201: 1177-1195, 1998.
-
(1998)
J Exp Biol
, vol.201
, pp. 1177-1195
-
-
Kwast, K.E.1
Burke, P.V.2
Poyton, R.O.3
-
176
-
-
0000815086
-
Sympathoadrenal mechanism during development
-
edited by Pollard R, FoxW. Philadelphia, PA: Saunders
-
Lagercrantz H, Marcus C. Sympathoadrenal mechanism during development. In: Fetal and Neonatal Physiology, edited by Pollard R, FoxW. Philadelphia, PA: Saunders, 1992.
-
(1992)
Fetal and Neonatal Physiology
-
-
Lagercrantz, H.1
Marcus, C.2
-
177
-
-
0017840703
-
A quantitative study of some ultrastructural features of the type I cells in the carotid bodies of rats living at a simulated altitude of 4300 metres
-
Laidler P, Kay JM. A quantitative study of some ultrastructural features of the type I cells in the carotid bodies of rats living at a simulated altitude of 4300 metres. J Neurocytol 7: 183-192, 1978.
-
(1978)
J Neurocytol
, vol.7
, pp. 183-192
-
-
Laidler, P.1
Kay, J.M.2
-
178
-
-
0038022867
-
Chronic hypoxia activates a local angiotensin-generating system in rat carotid body
-
Lam SY, Leung PS. Chronic hypoxia activates a local angiotensin-generating system in rat carotid body. Mol Cell Endocrinol 203: 147-153, 2003.
-
(2003)
Mol Cell Endocrinol
, vol.203
, pp. 147-153
-
-
Lam, S.Y.1
Leung, P.S.2
-
179
-
-
84863989372
-
Differential expressions and roles of hypoxia-inducible factor-1 α, -2 α and -3 α in the rat carotid body during chronic and intermittent hypoxia
-
Lam SY, Tipoe GL, Liong EC, Fung ML. Differential expressions and roles of hypoxia-inducible factor-1 α, -2 α and -3 α in the rat carotid body during chronic and intermittent hypoxia. Histol Histopathol 23: 271-280, 2008.
-
(2008)
Histol Histopathol
, vol.23
, pp. 271-280
-
-
Lam, S.Y.1
Tipoe, G.L.2
Liong, E.C.3
Fung, M.L.4
-
180
-
-
0037097861
-
FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor
-
Lando D, Peet DJ, Gorman JJ, Whelan DA, Whitelaw ML, Bruick RK. FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor. Genes Dev 16: 1466-1471,2002.
-
(2002)
Genes Dev
, vol.16
, pp. 1466-1471
-
-
Lando, D.1
Peet, D.J.2
Gorman, J.J.3
Whelan, D.A.4
Whitelaw, M.L.5
Bruick, R.K.6
-
181
-
-
0036469038
-
Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch
-
Lando D, Peet DJ, Whelan DA, Gorman JJ, Whitelaw ML. Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch. Science 295: 858-861, 2002.
-
(2002)
Science
, vol.295
, pp. 858-861
-
-
Lando, D.1
Peet, D.J.2
Whelan, D.A.3
Gorman, J.J.4
Whitelaw, M.L.5
-
183
-
-
66149180568
-
An Akt/hypoxia-inducible factor-1 α/platelet-derived growth factor-BB autocrine loop mediates hy-poxia-induced chemoresistance in liver cancer cells and tumorigenic hepatic progenitor cells
-
Lau CK, Yang ZF, Ho DW, Ng MN, Yeoh GC, Poon RT, Fan ST. An Akt/hypoxia-inducible factor-1 α/platelet-derived growth factor-BB autocrine loop mediates hy-poxia-induced chemoresistance in liver cancer cells and tumorigenic hepatic progenitor cells. Clin Cancer Res 15: 3462-3471, 2009.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 3462-3471
-
-
Lau, C.K.1
Yang, Z.F.2
Ho, D.W.3
Ng, M.N.4
Yeoh, G.C.5
Poon, R.T.6
Fan, S.T.7
-
184
-
-
0035012605
-
HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1 α (HIF-1 α) synthesis: Novel mechanism for HIF-1-mediated vascular endothelial growth factor expression
-
Laughner E, Taghavi P, Chiles K, Mahon PC, Semenza GL. HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1 α (HIF-1 α) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression. Mol Cell Biol 21: 3995-4004, 2001.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 3995-4004
-
-
Laughner, E.1
Taghavi, P.2
Chiles, K.3
Mahon, P.C.4
Semenza, G.L.5
-
185
-
-
0037470162
-
Structure of human FIH-1 reveals a unique active site pocket and interaction sites for HIF-1 and von Hippel-Lindau
-
Lee C, Kim SJ, Jeong DG, Lee SM, Ryu SE. Structure of human FIH-1 reveals a unique active site pocket and interaction sites for HIF-1 and von Hippel-Lindau.J Biol Chem 278: 7558-7563, 2003.
-
(2003)
J Biol Chem
, vol.278
, pp. 7558-7563
-
-
Lee, C.1
Kim, S.J.2
Jeong, D.G.3
Lee, S.M.4
Ryu, S.E.5
-
186
-
-
6044219806
-
Non-hypoxic transcriptional activation of the aryl hydrocarbon receptor nuclear translocator in concert with a novel hypoxia-inducible factor-1 α isoform
-
Lee KH, Park JW, Chun YS. Non-hypoxic transcriptional activation of the aryl hydrocarbon receptor nuclear translocator in concert with a novel hypoxia-inducible factor-1 α isoform. Nucleic Acids Res 32: 5499-5511, 2004.
-
(2004)
Nucleic Acids Res
, vol.32
, pp. 5499-5511
-
-
Lee, K.H.1
Park, J.W.2
Chun, Y.S.3
-
187
-
-
77951938407
-
Downregulation of a tumor suppressor RECK by hypoxia through recruitment of HDAC1 and HIF-1 α to reverse HRE site in the promoter
-
Lee KJ, Lee KY, Lee YM. Downregulation of a tumor suppressor RECK by hypoxia through recruitment of HDAC1 and HIF-1 α to reverse HRE site in the promoter. Biochim Biophys Acta 1803: 608-616, 2010.
-
(2010)
Biochim Biophys Acta
, vol.1803
, pp. 608-616
-
-
Lee, K.J.1
Lee, K.Y.2
Lee, Y.M.3
-
188
-
-
0031041377
-
Hypoxia-inducible factor-1 mediates transcriptional activation of the heme oxygenase-1 gene in response to hypoxia
-
Lee PJ, Jiang BH, Chin BY, Iyer NV, Alam J, Semenza GL, Choi AM. Hypoxia-inducible factor-1 mediates transcriptional activation of the heme oxygenase-1 gene in response to hypoxia. J Biol Chem 272: 5375-5381, 1997.
-
(1997)
J Biol Chem
, vol.272
, pp. 5375-5381
-
-
Lee, P.J.1
Jiang, B.H.2
Chin, B.Y.3
Iyer, N.V.4
Alam, J.5
Semenza, G.L.6
Choi, A.M.7
-
189
-
-
0034594876
-
Early expression of angiogenesis factors in acute myocardial ischemia and infarction
-
Lee SH, Wolf PL, Escudero R, Deutsch R, Jamieson SW, Thistlethwaite PA. Early expression of angiogenesis factors in acute myocardial ischemia and infarction. N Engl J Med 342: 626-633, 2000.
-
(2000)
N Engl J Med
, vol.342
, pp. 626-633
-
-
Lee, S.H.1
Wolf, P.L.2
Escudero, R.3
Deutsch, R.4
Jamieson, S.W.5
Thistlethwaite, P.A.6
-
190
-
-
70449602451
-
Regulation of HIF-1α and VEGF by miR-20b tunes tumor cells to adapt to the alteration of oxygen concentration
-
Lei Z, Li B, Yang Z, Fang H, Zhang GM, Feng ZH, Huang B. Regulation of HIF-1α and VEGF by miR-20b tunes tumor cells to adapt to the alteration of oxygen concentration. PLoS One 4: e7629, 2009.
-
(2009)
PLoS One
, vol.4
-
-
Lei, Z.1
Li, B.2
Yang, Z.3
Fang, H.4
Zhang, G.M.5
Feng, Z.H.6
Huang, B.7
-
191
-
-
0031457720
-
Hypertension caused by chronic intermittent hypoxia-influence of chemoreceptors and sympathetic nervous system
-
Lesske J, Fletcher EC, Bao G, Unger T. Hypertension caused by chronic intermittent hypoxia-influence of chemoreceptors and sympathetic nervous system. J Hypertens 15: 1593-1603, 1997.
-
(1997)
J Hypertens
, vol.15
, pp. 1593-1603
-
-
Lesske, J.1
Fletcher, E.C.2
Bao, G.3
Unger, T.4
-
192
-
-
34047272690
-
Regulation of HIF-1 α stability through S-nitrosylation
-
Li F, Sonveaux P, Rabbani ZN, Liu S, Yan B, Huang Q, Vujaskovic Z, Dewhirst MW, Li CY. Regulation of HIF-1 α stability through S-nitrosylation. Mol Cell 26: 63-74, 2007.
-
(2007)
Mol Cell
, vol.26
, pp. 63-74
-
-
Li, F.1
Sonveaux, P.2
Rabbani, Z.N.3
Liu, S.4
Yan, B.5
Huang, Q.6
Vujaskovic, Z.7
Dewhirst, M.W.8
Li, C.Y.9
-
193
-
-
33646775277
-
Altered metabolic responses to intermittent hypoxia in mice with partial deficiency of hypoxia-inducible factor-1 α
-
Li J, Bosch-Marce M, Nanayakkara A, Savransky V, Fried SK, Semenza GL, Polotsky VY. Altered metabolic responses to intermittent hypoxia in mice with partial deficiency of hypoxia-inducible factor-1 α. Physiol Genomics 25: 450-457, 2006.
-
(2006)
Physiol Genomics
, vol.25
, pp. 450-457
-
-
Li, J.1
Bosch-Marce, M.2
Nanayakkara, A.3
Savransky, V.4
Fried, S.K.5
Semenza, G.L.6
Polotsky, V.Y.7
-
194
-
-
30444442692
-
Inhibition of hypoxia-inducible factor activity in endothelial cells disrupts embryonic cardiovascular development
-
Licht AH, Muller-Holtkamp F, Flamme I, Breier G. Inhibition of hypoxia-inducible factor activity in endothelial cells disrupts embryonic cardiovascular development. Blood 107: 584-590, 2006.
-
(2006)
Blood
, vol.107
, pp. 584-590
-
-
Licht, A.H.1
Muller-Holtkamp, F.2
Flamme, I.3
Breier, G.4
-
195
-
-
74949098819
-
Evaluation of postnatal arteriogenesis and angiogenesis in a mouse model of hind-limb ischemia
-
Limbourg A, Korff T, Napp LC, Schaper W, Drexler H, Limbourg FP. Evaluation of postnatal arteriogenesis and angiogenesis in a mouse model of hind-limb ischemia. Nat Protoc 4: 1737-1746,2009.
-
(2009)
Nat Protoc
, vol.4
, pp. 1737-1746
-
-
Limbourg, A.1
Korff, T.2
Napp, L.C.3
Schaper, W.4
Drexler, H.5
Limbourg, F.P.6
-
196
-
-
0026047960
-
Protection against infarction afforded by preconditioning is mediated by A1 αdenosine receptors in rabbit heart
-
Liu GS, Thornton J, Van Winkle DM, Stanley AW, Olsson RA, Downey JM. Protection against infarction afforded by preconditioning is mediated by A1 αdenosine receptors in rabbit heart. Circulation 84: 350-356, 1991.
-
(1991)
Circulation
, vol.84
, pp. 350-356
-
-
Liu, G.S.1
Thornton, J.2
van Winkle, D.M.3
Stanley, A.W.4
Olsson, R.A.5
Downey, J.M.6
-
197
-
-
33846254999
-
2-independent and HSP90 inhibitor-induced degradation of HIF-1 α
-
Liu YV, Baek JH, Zhang H, Diez R, Cole RN, Semenza GL. RACK1 competes with HSP90 for binding to HIF-1 α and is required for O2-independent and HSP90 inhibitor-induced degradation of HIF-1 α. Mol Cell 25: 207-217, 2007.
-
(2007)
Mol Cell
, vol.25
, pp. 207-217
-
-
Liu, Y.V.1
Baek, J.H.2
Zhang, H.3
Diez, R.4
Cole, R.N.5
Semenza, G.L.6
-
198
-
-
37549028456
-
Calcineurin promotes hypoxia-inducible factor 1 α expression by dephosphory-lating RACK1 and blocking RACK1 dimerization
-
Liu YV, Hubbi ME, Pan F, McDonald KR, Mansharamani M, Cole RN, Liu JO, Semenza GL. Calcineurin promotes hypoxia-inducible factor 1 α expression by dephosphory-lating RACK1 and blocking RACK1 dimerization. J Biol Chem 282: 37064-37073, 2007.
-
(2007)
J Biol Chem
, vol.282
, pp. 37064-37073
-
-
Liu, Y.V.1
Hubbi, M.E.2
Pan, F.3
McDonald, K.R.4
Mansharamani, M.5
Cole, R.N.6
Liu, J.O.7
Semenza, G.L.8
-
199
-
-
0000655498
-
Identification of a hypoxia response element in the transferrin receptor gene
-
Lok CN, Ponka P. Identification of a hypoxia response element in the transferrin receptor gene. J Biol Chem 274: 24147-24152, 1999.
-
(1999)
J Biol Chem
, vol.274
, pp. 24147-24152
-
-
Lok, C.N.1
Ponka, P.2
-
200
-
-
2642565248
-
Therapeutic angiogenesis and vasculogenesis for ischemic disease. Part I: Angiogenic cytokines
-
Losordo DW, Dimmeler S. Therapeutic angiogenesis and vasculogenesis for ischemic disease. Part I: angiogenic cytokines. Circulation 109: 2487-2491, 2004.
-
(2004)
Circulation
, vol.109
, pp. 2487-2491
-
-
Losordo, D.W.1
Dimmeler, S.2
-
201
-
-
29644442625
-
Reversible inactivation of HIF-1 prolyl hydroxylases allows cell metabolism to control basal HIF-1
-
Lu H, Dalgard CL, Mohyeldin A, McFate T, Tait AS, Verma A. Reversible inactivation of HIF-1 prolyl hydroxylases allows cell metabolism to control basal HIF-1.J Biol Chem 280: 41928-41939, 2005.
-
(2005)
J Biol Chem
, vol.280
, pp. 41928-41939
-
-
Lu, H.1
Dalgard, C.L.2
Mohyeldin, A.3
McFate, T.4
Tait, A.S.5
Verma, A.6
-
202
-
-
0037189542
-
Hypoxia-inducible factor 1 αctivation by aerobic glycolysis implicates the Warburg effect in carcinogenesis
-
Lu H, Forbes RA, Verma A. Hypoxia-inducible factor 1 αctivation by aerobic glycolysis implicates the Warburg effect in carcinogenesis.J Biol Chem 277: 23111-23115,2002.
-
(2002)
J Biol Chem
, vol.277
, pp. 23111-23115
-
-
Lu, H.1
Forbes, R.A.2
Verma, A.3
-
203
-
-
33749512970
-
Cutting edge: Hypoxia-inducible factor 1α and its activation-inducible short isoform I.1 negatively regulate functions of CD4+ and CD8+ T lymphocytes
-
Lukashev D, Klebanov B, Kojima H, Grinberg A, Ohta A, Berenfeld L, Wenger RH, Sitkovsky M. Cutting edge: hypoxia-inducible factor 1α and its activation-inducible short isoform I.1 negatively regulate functions of CD4+ and CD8+ T lymphocytes.J Immunol 177: 4962-4965, 2006.
-
(2006)
J Immunol
, vol.177
, pp. 4962-4965
-
-
Lukashev, D.1
Klebanov, B.2
Kojima, H.3
Grinberg, A.4
Ohta, A.5
Berenfeld, L.6
Wenger, R.H.7
Sitkovsky, M.8
-
204
-
-
51749103723
-
Preferential expression of the novel alternative isoform I.3 of hypoxia-inducible factor 1 α in activated human T lymphocytes
-
Lukashev D, Sitkovsky M. Preferential expression of the novel alternative isoform I.3 of hypoxia-inducible factor 1 α in activated human T lymphocytes. Hum Immunol 69: 421-425, 2008.
-
(2008)
Hum Immunol
, vol.69
, pp. 421-425
-
-
Lukashev, D.1
Sitkovsky, M.2
-
205
-
-
79957567239
-
Pyruvate kinase M2 IsaPHD3-stimulated coactivatorfor hypoxia-inducible factor 1
-
Luo W, Hu H, Chang R, Zhong J, Knabel M, O'Meally R, Cole RN, Pandey A, Semenza GL. Pyruvate kinase M2 IsaPHD3-stimulated coactivatorfor hypoxia-inducible factor 1. Cell 145: 732-744, 2011.
-
(2011)
Cell
, vol.145
, pp. 732-744
-
-
Luo, W.1
Hu, H.2
Chang, R.3
Zhong, J.4
Knabel, M.5
O'Meally, R.6
Cole, R.N.7
Pandey, A.8
Semenza, G.L.9
-
206
-
-
77950473770
-
Hsp70 and CHIP selectively mediate ubiquitination and degradation of hypoxia-inducible factor (HIF)-1 α but not HIF-2α
-
Luo W, Zhong J, Chang R, Hu H, Pandey A, Semenza GL. Hsp70 and CHIP selectively mediate ubiquitination and degradation of hypoxia-inducible factor (HIF)-1 α but not HIF-2α.J Biol Chem 285: 3651-3663, 2010.
-
(2010)
J Biol Chem
, vol.285
, pp. 3651-3663
-
-
Luo, W.1
Zhong, J.2
Chang, R.3
Hu, H.4
Pandey, A.5
Semenza, G.L.6
-
207
-
-
0035887011
-
FIH-1: A novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity
-
Mahon PC, Hirota K, Semenza GL. FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity. Genes Dev 15: 2675-2686,2001.
-
(2001)
Genes Dev
, vol.15
, pp. 2675-2686
-
-
Mahon, P.C.1
Hirota, K.2
Semenza, G.L.3
-
208
-
-
0035969508
-
Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression
-
Makino Y, Cao R, Svensson K, Bertilsson G, Asman M, Tanaka H, Cao Y, Berkenstam A, Poellinger L. Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression. Nature 414: 550-554, 2001.
-
(2001)
Nature
, vol.414
, pp. 550-554
-
-
Makino, Y.1
Cao, R.2
Svensson, K.3
Bertilsson, G.4
Asman, M.5
Tanaka, H.6
Cao, Y.7
Berkenstam, A.8
Poellinger, L.9
-
209
-
-
0037031808
-
Inhibitory PAS domain protein (IPAS) is a hypoxia-inducible splicing variant of the hypoxia-inducible fac-tor-3α locus
-
Makino Y, Kanopka A, Wilson WJ, Tanaka H, Poellinger L. Inhibitory PAS domain protein (IPAS) is a hypoxia-inducible splicing variant of the hypoxia-inducible fac-tor-3α locus. J Biol Chem 277: 32405-32408, 2002.
-
(2002)
J Biol Chem
, vol.277
, pp. 32405-32408
-
-
Makino, Y.1
Kanopka, A.2
Wilson, W.J.3
Tanaka, H.4
Poellinger, L.5
-
210
-
-
34347265260
-
Transcriptional up-regulation of inhibitory PAS domain protein gene expression by hypoxia-inducible factor 1 (HIF-1): A negative feedback regulatory circuit in HIF-1-mediated signaling in hypoxic cells
-
Makino Y, Uenishi R, Okamoto K, Isoe T, Hosono O, Tanaka H, Kanopka A, Poellinger L, Haneda M, Morimoto C. Transcriptional up-regulation of inhibitory PAS domain protein gene expression by hypoxia-inducible factor 1 (HIF-1): a negative feedback regulatory circuit in HIF-1-mediated signaling in hypoxic cells. J Biol Chem 282: 14073-14082,2007.
-
(2007)
J Biol Chem
, vol.282
, pp. 14073-14082
-
-
Makino, Y.1
Uenishi, R.2
Okamoto, K.3
Isoe, T.4
Hosono, O.5
Tanaka, H.6
Kanopka, A.7
Poellinger, L.8
Haneda, M.9
Morimoto, C.10
-
211
-
-
11244315697
-
Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1
-
Manalo DJ, Rowan A, Lavoie T, Natarajan L, Kelly BD, Ye SQ, Garcia JG, Semenza GL. Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1. Blood 105: 659-669, 2005.
-
(2005)
Blood
, vol.105
, pp. 659-669
-
-
Manalo, D.J.1
Rowan, A.2
Lavoie, T.3
Natarajan, L.4
Kelly, B.D.5
Ye, S.Q.6
Garcia, J.G.7
Semenza, G.L.8
-
212
-
-
24144447915
-
Mitochondrial dysfunction resultingfrom loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-a activation
-
Mansfield KD, Guzy RD, Pan Y, Young RM, Cash TP, Schumacker PT, Simon MC. Mitochondrial dysfunction resultingfrom loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-a activation. Cell Metab 1: 393-399,2005.
-
(2005)
Cell Metab
, vol.1
, pp. 393-399
-
-
Mansfield, K.D.1
Guzy, R.D.2
Pan, Y.3
Young, R.M.4
Cash, T.P.5
Schumacker, P.T.6
Simon, M.C.7
-
213
-
-
0027163384
-
Cardiac stress protein elevation 24 hours after brief ischemia or heat stress is associated with resistance to myocardial infarction
-
Marber MS, Latchman DS, Walker JM, Yellon DM. Cardiac stress protein elevation 24 hours after brief ischemia or heat stress is associated with resistance to myocardial infarction. Circulation 88: 1264-1272, 1993.
-
(1993)
Circulation
, vol.88
, pp. 1264-1272
-
-
Marber, M.S.1
Latchman, D.S.2
Walker, J.M.3
Yellon, D.M.4
-
214
-
-
0036162264
-
Isoform-specific expression of hypoxia-inducible factor-1 α during the late stages of mouse spermiogenesis
-
Marti HH, Katschinski DM, Wagner KF, Schaffer L, Stier B, Wenger RH. Isoform-specific expression of hypoxia-inducible factor-1 α during the late stages of mouse spermiogenesis. Mol Endocrinol 16: 234-243, 2002.
-
(2002)
Mol Endocrinol
, vol.16
, pp. 234-243
-
-
Marti, H.H.1
Katschinski, D.M.2
Wagner, K.F.3
Schaffer, L.4
Stier, B.5
Wenger, R.H.6
-
215
-
-
0031957221
-
Cardiac hypertrophy in chronically anemic fetal sheep: Increased vascularization is associated with increased myocardial expression of vascular endothelial growth factor and hypoxia-inducible factor 1
-
Martin C, Yu AY, Jiang BH, Davis L, Kimberly D, Hohimer AR, Semenza GL. Cardiac hypertrophy in chronically anemic fetal sheep: increased vascularization is associated with increased myocardial expression of vascular endothelial growth factor and hypoxia-inducible factor 1.AmJ Obstet Gynecol 178: 527-534, 1998.
-
(1998)
AmJ Obstet Gynecol
, vol.178
, pp. 527-534
-
-
Martin, C.1
Yu, A.Y.2
Jiang, B.H.3
Davis, L.4
Kimberly, D.5
Hohimer, A.R.6
Semenza, G.L.7
-
216
-
-
0035903468
-
Independent function of two destruction domains in hypoxia-inducible factor-α chains activated by prolyl hydroxy-lation
-
Masson N, Willam C, Maxwell PH, Pugh CW, Ratcliffe PJ. Independent function of two destruction domains in hypoxia-inducible factor-α chains activated by prolyl hydroxy-lation. EMBOJ 20: 5197-5206, 2001.
-
(2001)
EMBOJ
, vol.20
, pp. 5197-5206
-
-
Masson, N.1
Willam, C.2
Maxwell, P.H.3
Pugh, C.W.4
Ratcliffe, P.J.5
-
217
-
-
66449124596
-
HIF-2α, but not HIF-1α, promotes iron absorption in mice
-
Mastrogiannaki M, Matak P, Keith B, Simon MC, Vaulont S, Peyssonnaux C. HIF-2α, but not HIF-1α, promotes iron absorption in mice. J Clin Invest 119: 1159-1166, 2009.
-
(2009)
J Clin Invest
, vol.119
, pp. 1159-1166
-
-
Mastrogiannaki, M.1
Matak, P.2
Keith, B.3
Simon, M.C.4
Vaulont, S.5
Peyssonnaux, C.6
-
218
-
-
0032920658
-
Induction of interleukin (IL)-6 by hypoxia is mediated by nuclear factor (NF)-kappa B and NF-IL6 in cardiac myocytes
-
Matsui H, Ihara Y, Fujio Y, Kunisada K, Akira S, Kishimoto T, Yamauchi-Takihara K. Induction of interleukin (IL)-6 by hypoxia is mediated by nuclear factor (NF)-kappa B and NF-IL6 in cardiac myocytes. Cardiovasc Res 42: 104-112, 1999.
-
(1999)
Cardiovasc Res
, vol.42
, pp. 104-112
-
-
Matsui, H.1
Ihara, Y.2
Fujio, Y.3
Kunisada, K.4
Akira, S.5
Kishimoto, T.6
Yamauchi-Takihara, K.7
-
219
-
-
0033587146
-
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
-
Maxwell PH, Wiesener MS, Chang GW, Clifford SC, Vaux EC, Cockman ME, Wykoff CC, Pugh CW, Maher ER, Ratcliffe PJ. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 399: 271-275, 1999.
-
(1999)
Nature
, vol.399
, pp. 271-275
-
-
Maxwell, P.H.1
Wiesener, M.S.2
Chang, G.W.3
Clifford, S.C.4
Vaux, E.C.5
Cockman, M.E.6
Wykoff, C.C.7
Pugh, C.W.8
Maher, E.R.9
Ratcliffe, P.J.10
-
220
-
-
0037837724
-
Multiple splice variants of the human HIF-3α locus are targets of the von Hippel-Lindau E3 ubiquitin ligase complex
-
Maynard MA, Qi H, Chung J, Lee EH, Kondo Y, Hara S, Conaway RC, Conaway JW, Ohh M. Multiple splice variants of the human HIF-3α locus are targets of the von Hippel-Lindau E3 ubiquitin ligase complex. J Biol Chem 278: 11032-11040, 2003.
-
(2003)
J Biol Chem
, vol.278
, pp. 11032-11040
-
-
Maynard, M.A.1
Qi, H.2
Chung, J.3
Lee, E.H.4
Kondo, Y.5
Hara, S.6
Conaway, R.C.7
Conaway, J.W.8
Ohh, M.9
-
221
-
-
0036174191
-
Repression of α-fetoprotein gene expression under hypoxic conditions in human hepatoma cells: Characterization of a negative hypoxia response element that mediates opposite effects of hypoxia inducible factor-1 and c-Myc
-
Mazure NM, Chauvet C, Bois-Joyeux B, Bernard MA, Nacer-Cherif H, Danan JL. Repression of α-fetoprotein gene expression under hypoxic conditions in human hepatoma cells: characterization of a negative hypoxia response element that mediates opposite effects of hypoxia inducible factor-1 and c-Myc. Cancer Res 62: 1158-1165, 2002.
-
(2002)
Cancer Res
, vol.62
, pp. 1158-1165
-
-
Mazure, N.M.1
Chauvet, C.2
Bois-Joyeux, B.3
Bernard, M.A.4
Nacer-Cherif, H.5
Danan, J.L.6
-
222
-
-
0034967417
-
Expression of heme oxygenase in the oxygen-sensing regions of the rostral ventrolateral medulla
-
Mazza E, Thakkar-Varia S, Tozzi CA, Neubauer JA. Expression of heme oxygenase in the oxygen-sensing regions of the rostral ventrolateral medulla. J Appl Physiol 91: 379-385, 2001.
-
(2001)
J Appl Physiol
, vol.91
, pp. 379-385
-
-
Mazza, E.1
Thakkar-Varia, S.2
Tozzi, C.A.3
Neubauer, J.A.4
-
223
-
-
53049087909
-
Pyruvate dehydrogenase complex activity controls metabolic and malignant phenotype in cancer cells
-
McFate T, Mohyeldin A, Lu H, Thakar J, Henriques J, Halim ND, Wu H, Schell MJ, Tsang TM, Teahan O, Zhou S, Califano JA, Jeoung NH, Harris RA, Verma A. Pyruvate dehydrogenase complex activity controls metabolic and malignant phenotype in cancer cells.J Biol Chem 283: 22700-22708, 2008.
-
(2008)
J Biol Chem
, vol.283
, pp. 22700-22708
-
-
McFate, T.1
Mohyeldin, A.2
Lu, H.3
Thakar, J.4
Henriques, J.5
Halim, N.D.6
Wu, H.7
Schell, M.J.8
Tsang, T.M.9
Teahan, O.10
Zhou, S.11
Califano, J.A.12
Jeoung, N.H.13
Harris, R.A.14
Verma, A.15
-
224
-
-
0036846033
-
Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the β-car-bon of asparagine-803
-
McNeill LA, Hewitson KS, Claridge TD, Seibel JF, Horsfall LE, Schofield CJ. Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the β-car-bon of asparagine-803. BiochemJ 367: 571-575, 2002.
-
(2002)
BiochemJ
, vol.367
, pp. 571-575
-
-
McNeill, L.A.1
Hewitson, K.S.2
Claridge, T.D.3
Seibel, J.F.4
Horsfall, L.E.5
Schofield, C.J.6
-
225
-
-
0037124173
-
The use of dioxygen by HIF prolyl hydroxylase (PHD1)
-
McNeill LA, Hewitson KS, Gleadle JM, Horsfall LE, Oldham NJ, Maxwell PH, Pugh CW, Ratcliffe PJ, Schofield CJ. The use of dioxygen by HIF prolyl hydroxylase (PHD1). Bioorg Med Chem Lett 12: 1547-1550,2002.
-
(2002)
Bioorg Med Chem Lett
, vol.12
, pp. 1547-1550
-
-
McNeill, L.A.1
Hewitson, K.S.2
Gleadle, J.M.3
Horsfall, L.E.4
Oldham, N.J.5
Maxwell, P.H.6
Pugh, C.W.7
Ratcliffe, P.J.8
Schofield, C.J.9
-
226
-
-
0030911247
-
Functional requirement of the hypoxia-responsive element in the activation of the inducible nitric oxide synthase promoter by the iron chelator desferoxamine
-
Melillo G, Taylor LS, Brooks A, Musso T, Cox GW, Varesio L. Functional requirement of the hypoxia-responsive element in the activation of the inducible nitric oxide synthase promoter by the iron chelator desferoxamine.J Biol Chem 272: 12236-12243, 1997.
-
(1997)
J Biol Chem
, vol.272
, pp. 12236-12243
-
-
Melillo, G.1
Taylor, L.S.2
Brooks, A.3
Musso, T.4
Cox, G.W.5
Varesio, L.6
-
227
-
-
0042469448
-
Nitric oxide impairs normoxic degradation of HIF-1 α by inhibition of prolyl hydroxylases
-
Metzen E, Zhou J, Jelkmann W, Fandrey J, Brune B. Nitric oxide impairs normoxic degradation of HIF-1 α by inhibition of prolyl hydroxylases. Mol Biol Cell 14: 3470-3481,2003.
-
(2003)
Mol Biol Cell
, vol.14
, pp. 3470-3481
-
-
Metzen, E.1
Zhou, J.2
Jelkmann, W.3
Fandrey, J.4
Brune, B.5
-
228
-
-
0037080541
-
Dichloroacetate, a metabolic modulator, prevents and reverses chronic hypoxic pulmonary hypertension in rats: Role of increased expression and activity of voltage-gated potassium channels
-
Michelakis ED, McMurtry MS, Wu XC, Dyck JR, Moudgil R, Hopkins TA, Lopaschuk GD, Puttagunta L, Waite R, Archer SL. Dichloroacetate, a metabolic modulator, prevents and reverses chronic hypoxic pulmonary hypertension in rats: role of increased expression and activity of voltage-gated potassium channels. Circulation 105: 244-250, 2002.
-
(2002)
Circulation
, vol.105
, pp. 244-250
-
-
Michelakis, E.D.1
McMurtry, M.S.2
Wu, X.C.3
Dyck, J.R.4
Moudgil, R.5
Hopkins, T.A.6
Lopaschuk, G.D.7
Puttagunta, L.8
Waite, R.9
Archer, S.L.10
-
229
-
-
0026738217
-
Arterial chemoreceptor input to nucleus tractus solitarius
-
Mifflin SW. Arterial chemoreceptor input to nucleus tractus solitarius. Am J Physiol Regul Integr Comp Physiol 263: R368-R375, 1992.
-
(1992)
Am J Physiol Regul Integr Comp Physiol
, vol.263
-
-
Mifflin, S.W.1
-
230
-
-
0032749463
-
Hypoxia-induced activation of HIF-1: Role of HIF-1 α-Hsp90 interaction
-
Minet E, Mottet D, Michel G, Roland I, Raes M, Remacle J, Michiels C. Hypoxia-induced activation of HIF-1: role of HIF-1 α-Hsp90 interaction. FEBS Lett 460: 251-256, 1999.
-
(1999)
FEBS Lett
, vol.460
, pp. 251-256
-
-
Minet, E.1
Mottet, D.2
Michel, G.3
Roland, I.4
Raes, M.5
Remacle, J.6
Michiels, C.7
-
231
-
-
1642329821
-
Hypoxia-inducible factor-1-independent regulation of vascular endothelial growth factor by hypoxia in colon cancer
-
Mizukami Y, Li J, Zhang X, Zimmer MA, Iliopoulos O, Chung DC. Hypoxia-inducible factor-1-independent regulation of vascular endothelial growth factor by hypoxia in colon cancer. Cancer Res 64: 1765-1772, 2004.
-
(2004)
Cancer Res
, vol.64
, pp. 1765-1772
-
-
Mizukami, Y.1
Li, J.2
Zhang, X.3
Zimmer, M.A.4
Iliopoulos, O.5
Chung, D.C.6
-
232
-
-
67650531089
-
Genome-wide association of hypoxia-inducible factor (HIF)-1 α and HIF-2α DNA binding with expression profiling of hypoxia-inducible transcripts
-
Mole DR, Blancher C, Copley RR, Pollard PJ, Gleadle JM, Ragoussis J, Ratcliffe PJ. Genome-wide association of hypoxia-inducible factor (HIF)-1 α and HIF-2α DNA binding with expression profiling of hypoxia-inducible transcripts. J Biol Chem 284: 16767-16775, 2009.
-
(2009)
J Biol Chem
, vol.284
, pp. 16767-16775
-
-
Mole, D.R.1
Blancher, C.2
Copley, R.R.3
Pollard, P.J.4
Gleadle, J.M.5
Ragoussis, J.6
Ratcliffe, P.J.7
-
233
-
-
0036090048
-
2+ release from ryanodine-sensitive store contributes to mechanism of hypoxic vasoconstriction in rat lungs
-
2+ release from ryanodine-sensitive store contributes to mechanism of hypoxic vasoconstriction in rat lungs. J Appl Physiol 92: 527-534, 2002.
-
(2002)
J Appl Physiol
, vol.92
, pp. 527-534
-
-
Morio, Y.1
McMurtry, I.F.2
-
234
-
-
0037416792
-
HLF/HIF-2α is a key factor in retinopathy of prematurity in association with erythropoietin
-
Morita M, Ohneda O, Yamashita T, Takahashi S, Suzuki N, Nakajima O, Kawauchi S, Ema M, Shibahara S, Udono T, Tomita K, Tamai M, Sogawa K, Yamamoto M, Fujii-Kuriyama Y. HLF/HIF-2α is a key factor in retinopathy of prematurity in association with erythropoietin. EMBOJ 22: 1134-1146, 2003.
-
(2003)
EMBOJ
, vol.22
, pp. 1134-1146
-
-
Morita, M.1
Ohneda, O.2
Yamashita, T.3
Takahashi, S.4
Suzuki, N.5
Nakajima, O.6
Kawauchi, S.7
Ema, M.8
Shibahara, S.9
Udono, T.10
Tomita, K.11
Tamai, M.12
Sogawa, K.13
Yamamoto, M.14
Fujii-Kuriyama, Y.15
-
235
-
-
67649599147
-
Cellular and molecular basis of pulmonary arterial hypertension
-
Morrell NWAS, Archer SL, Dupuis J, Jones PL, MacLean MR, McMurtry IF, Stenmark KR, Thistlewaite PA, Weissmann N, Yuan JX, Weir EK. Cellular and molecular basis of pulmonary arterial hypertension. J Am Coll Cardiol 54: 2009.
-
(2009)
J Am Coll Cardiol
, pp. 54
-
-
Morrell, N.W.A.S.1
Archer, S.L.2
Dupuis, J.3
Jones, P.L.4
Maclean, M.R.5
McMurtry, I.F.6
Stenmark, K.R.7
Thistlewaite, P.A.8
Weissmann, N.9
Yuan, J.X.10
Weir, E.K.11
-
236
-
-
69949115589
-
Hypoxic activation of the unfolded protein response (UPR) induces expression of the metastasis-associated gene LAMP3
-
Mujcic H, Rzymski T, Rouschop KM, Koritzinsky M, Milani M, Harris AL, Wouters BG. Hypoxic activation of the unfolded protein response (UPR) induces expression of the metastasis-associated gene LAMP3. Radiother Oncol 92: 450-459, 2009.
-
(2009)
Radiother Oncol
, vol.92
, pp. 450-459
-
-
Mujcic, H.1
Rzymski, T.2
Rouschop, K.M.3
Koritzinsky, M.4
Milani, M.5
Harris, A.L.6
Wouters, B.G.7
-
237
-
-
0022970945
-
Preconditioning with ischemia: A delay of lethal cell injury in ischemic myocardium
-
Murry CE, Jennings RB, Reimer KA. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation 74: 1124-1136, 1986.
-
(1986)
Circulation
, vol.74
, pp. 1124-1136
-
-
Murry, C.E.1
Jennings, R.B.2
Reimer, K.A.3
-
238
-
-
59049086571
-
Intermittent hypoxia degrades HIF-2α via calpains resulting in oxidative stress: Implications for recurrent apnea-induced morbidities
-
Nanduri J, Wang N, Yuan G, Khan SA, Souvannakitti D, Peng YJ, Kumar GK, Garcia J A, Prabhakar NR. Intermittent hypoxia degrades HIF-2α via calpains resulting in oxidative stress: implications for recurrent apnea-induced morbidities. Proc Natl Acad Sci USA 106: 1199-1204,2009.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 1199-1204
-
-
Nanduri, J.1
Wang, N.2
Yuan, G.3
Khan, S.A.4
Souvannakitti, D.5
Peng, Y.J.6
Kumar, G.K.7
Garcia, J.A.8
Prabhakar, N.R.9
-
239
-
-
0033537701
-
Selective potentiation of peripheral chemoreflex sensitivity in obstructive sleep apnea
-
Narkiewicz K, van de Borne PJ, Pesek CA, Dyken ME, Montano N, Somers VK. Selective potentiation of peripheral chemoreflex sensitivity in obstructive sleep apnea. Circulation 99: 1183-1189, 1999.
-
(1999)
Circulation
, vol.99
, pp. 1183-1189
-
-
Narkiewicz, K.1
van de Borne, P.J.2
Pesek, C.A.3
Dyken, M.E.4
Montano, N.5
Somers, V.K.6
-
240
-
-
0035877163
-
Hypoxia-inducible factor 1-mediated inhibition of peroxisome proliferator-activated receptor a expression during hypoxia
-
Narravula S, Colgan SP. Hypoxia-inducible factor 1-mediated inhibition of peroxisome proliferator-activated receptor a expression during hypoxia. J Immunol 166: 7543-7548, 2001.
-
(2001)
J Immunol
, vol.166
, pp. 7543-7548
-
-
Narravula, S.1
Colgan, S.P.2
-
241
-
-
0343362699
-
Association of sleep-disordered breathing, sleep apnea, and hypertension in a large community-based study. Sleep Heart Health Study
-
Nieto FJ, Young TB, Lind BK, Shahar E, Samet JM, Redline S, D'Agostino RB, Newman AB, Lebowitz MD, Pickering TG. Association of sleep-disordered breathing, sleep apnea, and hypertension in a large community-based study. Sleep Heart Health Study. JAMA 283: 1829-1836,2000.
-
(2000)
JAMA
, vol.283
, pp. 1829-1836
-
-
Nieto, F.J.1
Young, T.B.2
Lind, B.K.3
Shahar, E.4
Samet, J.M.5
Redline, S.6
D'Agostino, R.B.7
Newman, A.B.8
Lebowitz, M.D.9
Pickering, T.G.10
-
242
-
-
0036468259
-
Early Growth Response-1 gene mediates up-regulation of epidermal growth factor receptor expression during hypoxia
-
Nishi H, Nishi KH, Johnson AC. Early Growth Response-1 gene mediates up-regulation of epidermal growth factor receptor expression during hypoxia. Cancer Res 62: 827-834, 2002.
-
(2002)
Cancer Res
, vol.62
, pp. 827-834
-
-
Nishi, H.1
Nishi, K.H.2
Johnson, A.C.3
-
243
-
-
0028859483
-
2-responsive sequences on the tyrosine hydroxylase gene
-
Norris ML, Millhorn DE. Hypoxia-induced protein binding to O2-responsive sequences on the tyrosine hydroxylase gene. J Biol Chem 270: 23774-23779, 1995.
-
(1995)
J Biol Chem
, vol.270
, pp. 23774-23779
-
-
Norris, M.L.1
Millhorn, D.E.2
-
244
-
-
33644866952
-
Hypoxia induces epithelial amphiregulin gene expression in a CREB-de-pendent manner
-
O'Reilly SM, Leonard MO, Kieran N, Comerford KM, Cummins E, Pouliot M, Lee SB, Taylor CT. Hypoxia induces epithelial amphiregulin gene expression in a CREB-de-pendent manner. Am J Physiol Cell Physiol 290: C592-C600, 2006.
-
(2006)
Am J Physiol Cell Physiol
, vol.290
-
-
O'Reilly, S.M.1
Leonard, M.O.2
Kieran, N.3
Comerford, K.M.4
Cummins, E.5
Pouliot, M.6
Lee, S.B.7
Taylor, C.T.8
-
245
-
-
0035941117
-
Hypoxia induces transcription factor ETS-1 via the activity of hypoxia-inducible factor-1
-
Oikawa M, Abe M, Kurosawa H, Hida W, Shirato K, Sato Y. Hypoxia induces transcription factor ETS-1 via the activity of hypoxia-inducible factor-1. Biochem Biophys Res Commun 289: 39-43, 2001.
-
(2001)
Biochem Biophys Res Commun
, vol.289
, pp. 39-43
-
-
Oikawa, M.1
Abe, M.2
Kurosawa, H.3
Hida, W.4
Shirato, K.5
Sato, Y.6
-
246
-
-
33744959141
-
Expression of vascular endothelial growth factor receptor 1 in bone marrow-derived mesenchymal cells is dependent on hypoxia-inducible factor 1
-
Okuyama H, Krishnamachary B, Zhou YF, Nagasawa H, Bosch-Marce M, Semenza GL. Expression of vascular endothelial growth factor receptor 1 in bone marrow-derived mesenchymal cells is dependent on hypoxia-inducible factor 1.J Biol Chem 281: 15554-15563,2006.
-
(2006)
J Biol Chem
, vol.281
, pp. 15554-15563
-
-
Okuyama, H.1
Krishnamachary, B.2
Zhou, Y.F.3
Nagasawa, H.4
Bosch-Marce, M.5
Semenza, G.L.6
-
247
-
-
0028847669
-
Endothelin-A receptor antagonist prevents acute hypoxia-induced pulmonary hypertension in the rat
-
Oparil S, Chen SJ, Meng QC, Elton TS, Yano M, Chen YF. Endothelin-A receptor antagonist prevents acute hypoxia-induced pulmonary hypertension in the rat. Am J Physiol Lung Cell Mol Physiol 268: L95-L100, 1995.
-
(1995)
Am J Physiol Lung Cell Mol Physiol
, vol.268
-
-
Oparil, S.1
Chen, S.J.2
Meng, Q.C.3
Elton, T.S.4
Yano, M.5
Chen, Y.F.6
-
248
-
-
0033673457
-
Normoxic stabilization of hypoxia-inducible factor-1 expression and activity: Redox-dependent effect of nitrogen oxides
-
Palmer LA, Gaston B, Johns RA. Normoxic stabilization of hypoxia-inducible factor-1 expression and activity: redox-dependent effect of nitrogen oxides. Mol Pharmacol 58: 1197-1203, 2000.
-
(2000)
Mol Pharmacol
, vol.58
, pp. 1197-1203
-
-
Palmer, L.A.1
Gaston, B.2
Johns, R.A.3
-
249
-
-
33644622570
-
HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
-
Papandreou I, Cairns RA, Fontana L, Lim AL, Denko NC. HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption. Cell Metab 3: 187-197, 2006.
-
(2006)
Cell Metab
, vol.3
, pp. 187-197
-
-
Papandreou, I.1
Cairns, R.A.2
Fontana, L.3
Lim, A.L.4
Denko, N.C.5
-
250
-
-
1642443176
-
Methods in optical oxygen sensing: Protocols and critical analyses
-
Papkovsky DB. Methods in optical oxygen sensing: protocols and critical analyses. Methods Enzymol 381: 715-735, 2004.
-
(2004)
Methods Enzymol
, vol.381
, pp. 715-735
-
-
Papkovsky, D.B.1
-
251
-
-
0038788826
-
Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1α (HIF-1 α): Role of cytoplasmic trapping of HIF-2α
-
Park SK, Dadak AM, Haase VH, Fontana L, Giaccia AJ, Johnson RS. Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1α (HIF-1 α): role of cytoplasmic trapping of HIF-2α. Mol Cell Biol 23: 4959-4971, 2003.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 4959-4971
-
-
Park, S.K.1
Dadak, A.M.2
Haase, V.H.3
Fontana, L.4
Giaccia, A.J.5
Johnson, R.S.6
-
252
-
-
0035783413
-
Selective cardiorespiratory and catecholaminergic areas express the hypoxia-inducible factor-1 α (HIF-1 α) under in vivo hypoxia in rat brainstem
-
Pascual O, Denavit-Saubie M, Dumas S, Kietzmann T, Ghilini G, Mallet J, Pequignot JM. Selective cardiorespiratory and catecholaminergic areas express the hypoxia-inducible factor-1 α (HIF-1 α) under in vivo hypoxia in rat brainstem. Eur J Neurosci 14: 1981-1991, 2001.
-
(2001)
Eur J Neurosci
, vol.14
, pp. 1981-1991
-
-
Pascual, O.1
Denavit-Saubie, M.2
Dumas, S.3
Kietzmann, T.4
Ghilini, G.5
Mallet, J.6
Pequignot, J.M.7
-
253
-
-
79952609061
-
Hypoxia-inducible factor 2α (HIF-2α) heterozygous-null mice exhibit exaggerated carotid body sensitivity to hypoxia, breathing instability, and hypertension
-
Peng YJ, Nanduri J, Khan SA, Yuan G, Wang N, Kinsman B, Vaddi DR, Kumar GK, Garcia JA, Semenza GL, Prabhakar NR. Hypoxia-inducible factor 2α (HIF-2α) heterozygous-null mice exhibit exaggerated carotid body sensitivity to hypoxia, breathing instability, and hypertension. Proc Natl Acad Sci USA 108: 3065-3070,2011.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 3065-3070
-
-
Peng, Y.J.1
Nanduri, J.2
Khan, S.A.3
Yuan, G.4
Wang, N.5
Kinsman, B.6
Vaddi, D.R.7
Kumar, G.K.8
Garcia, J.A.9
Semenza, G.L.10
Prabhakar, N.R.11
-
254
-
-
65549160457
-
NADPH oxidase is required for the sensory plasticity of the carotid body by chronic intermittent hypoxia
-
Peng YJ, Nanduri J, Yuan G, Wang N, Deneris E, Pendyala S, Natarajan V, Kumar GK, Prabhakar NR. NADPH oxidase is required for the sensory plasticity of the carotid body by chronic intermittent hypoxia. J Neurosci 29: 4903-4910, 2009.
-
(2009)
J Neurosci
, vol.29
, pp. 4903-4910
-
-
Peng, Y.J.1
Nanduri, J.2
Yuan, G.3
Wang, N.4
Deneris, E.5
Pendyala, S.6
Natarajan, V.7
Kumar, G.K.8
Prabhakar, N.R.9
-
255
-
-
0042691713
-
Induction of sensory long-term facilitation in the carotid body by intermittent hypoxia: Implications for recurrent apneas
-
Peng YJ, Overholt JL, Kline D, Kumar GK, Prabhakar NR. Induction of sensory long-term facilitation in the carotid body by intermittent hypoxia: implications for recurrent apneas. Proc Natl Acad Sci USA 100: 10073-10078,2003.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 10073-10078
-
-
Peng, Y.J.1
Overholt, J.L.2
Kline, D.3
Kumar, G.K.4
Prabhakar, N.R.5
-
256
-
-
1342283025
-
Effect of two paradigms of chronic intermittent hypoxia on carotid body sensory activity
-
Peng YJ, Prabhakar NR. Effect of two paradigms of chronic intermittent hypoxia on carotid body sensory activity. J Appl Physiol 96: 1236-1242, 2004.
-
(2004)
J Appl Physiol
, vol.96
, pp. 1236-1242
-
-
Peng, Y.J.1
Prabhakar, N.R.2
-
257
-
-
33751329032
-
Heterozygous HIF-1 α deficiency impairs carotid body-mediated systemic responses and reactive oxygen species generation in mice exposed to intermittent hypoxia
-
Peng YJ, Yuan G, Ramakrishnan D, Sharma SD, Bosch-Marce M, Kumar GK, Semenza GL, Prabhakar NR. Heterozygous HIF-1 α deficiency impairs carotid body-mediated systemic responses and reactive oxygen species generation in mice exposed to intermittent hypoxia. J Physiol 577: 705-716, 2006.
-
(2006)
J Physiol
, vol.577
, pp. 705-716
-
-
Peng, Y.J.1
Yuan, G.2
Ramakrishnan, D.3
Sharma, S.D.4
Bosch-Marce, M.5
Kumar, G.K.6
Semenza, G.L.7
Prabhakar, N.R.8
-
258
-
-
0021282007
-
Intact and sympathectomized carotid bodies of long-term hypoxic rats: A morphometric ultrastructural study
-
Pequignot JM, Hellstrom S, Johansson C. Intact and sympathectomized carotid bodies of long-term hypoxic rats: a morphometric ultrastructural study. J Neurocytol 13: 481-493, 1984.
-
(1984)
J Neurocytol
, vol.13
, pp. 481-493
-
-
Pequignot, J.M.1
Hellstrom, S.2
Johansson, C.3
-
259
-
-
38049173572
-
A gain-of-function mutation in the HIF2Α gene in familial erythrocytosis
-
Percy MJ, Furlow PW, Lucas GS, Li X, Lappin TR, McMullin MF, Lee FS. A gain-of-function mutation in the HIF2Α gene in familial erythrocytosis. N Engl J Med 358: 162-168, 2008.
-
(2008)
N Engl J Med
, vol.358
, pp. 162-168
-
-
Percy, M.J.1
Furlow, P.W.2
Lucas, G.S.3
Li, X.4
Lappin, T.R.5
McMullin, M.F.6
Lee, F.S.7
-
260
-
-
34447120059
-
Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs)
-
Peyssonnaux C, Zinkernagel AS, Schuepbach RA, Rankin E, Vaulont S, Haase VH, Nizet V, Johnson RS. Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs). J Clin Invest 117: 1926-1932,2007.
-
(2007)
J Clin Invest
, vol.117
, pp. 1926-1932
-
-
Peyssonnaux, C.1
Zinkernagel, A.S.2
Schuepbach, R.A.3
Rankin, E.4
Vaulont, S.5
Haase, V.H.6
Nizet, V.7
Johnson, R.S.8
-
261
-
-
0037423858
-
VEGFR-1-selective VEGF homologue PlGF is arteriogenic: Evidence for a monocyte-mediated mechanism
-
Pipp F, Heil M, Issbrucker K, Ziegelhoeffer T, Martin S, van den Heuvel J, Weich H, Fernandez B, Golomb G, Carmeliet P, Schaper W, Clauss M. VEGFR-1-selective VEGF homologue PlGF is arteriogenic: evidence for a monocyte-mediated mechanism. Circ Res 92: 378-385, 2003.
-
(2003)
Circ Res
, vol.92
, pp. 378-385
-
-
Pipp, F.1
Heil, M.2
Issbrucker, K.3
Ziegelhoeffer, T.4
Martin, S.5
van den Heuvel, J.6
Weich, H.7
Fernandez, B.8
Golomb, G.9
Carmeliet, P.10
Schaper, W.11
Clauss, M.12
-
262
-
-
53849121922
-
HIF-1 and ventilatory acclimatization to chronic hypoxia
-
Powell FL, Fu Z. HIF-1 and ventilatory acclimatization to chronic hypoxia. Respir Physiol Neurobiol 164: 282-287, 2008.
-
(2008)
Respir Physiol Neurobiol
, vol.164
, pp. 282-287
-
-
Powell, F.L.1
Fu, Z.2
-
264
-
-
0035061344
-
Oxygen sensing during intermittent hypoxia: Cellular and molecular mechanisms
-
Prabhakar NR. Oxygen sensing during intermittent hypoxia: cellular and molecular mechanisms. J Appl Physiol 90: 1986-1994, 2001.
-
(2001)
J Appl Physiol
, vol.90
, pp. 1986-1994
-
-
Prabhakar, N.R.1
-
265
-
-
33846253979
-
Systemic, cellular and molecular analysis of chemoreflex-mediated sympathoexcitation by chronic intermittent hypoxia
-
Prabhakar NR, Dick TE, Nanduri J, Kumar GK. Systemic, cellular and molecular analysis of chemoreflex-mediated sympathoexcitation by chronic intermittent hypoxia. Exp Physiol 92: 39-44, 2007.
-
(2007)
Exp Physiol
, vol.92
, pp. 39-44
-
-
Prabhakar, N.R.1
Dick, T.E.2
Nanduri, J.3
Kumar, G.K.4
-
266
-
-
25844440541
-
Cellular and molecular mechanisms associated with carotid body adaptations to chronic hypoxia
-
Prabhakar NRJacono FJ. Cellular and molecular mechanisms associated with carotid body adaptations to chronic hypoxia. High Alt Med Biol 6: 112-120, 2005.
-
(2005)
High Alt Med Biol
, vol.6
, pp. 112-120
-
-
Prabhakar, N.R.1
Jacono, F.J.2
-
267
-
-
0347363478
-
Peripheral chemoreceptors in health and disease
-
Prabhakar NR, Peng YJ. Peripheral chemoreceptors in health and disease. J Appl Physiol 96: 359-366, 2004.
-
(2004)
J Appl Physiol
, vol.96
, pp. 359-366
-
-
Prabhakar, N.R.1
Peng, Y.J.2
-
268
-
-
0030608521
-
Activation of nitric oxide synthase gene expression by hypoxia in central and peripheral neurons
-
Prabhakar NR, Pieramici SF, Premkumar DR, Kumar GK, Kalaria RN. Activation of nitric oxide synthase gene expression by hypoxia in central and peripheral neurons. Brain Res 43: 341-346, 1996.
-
(1996)
Brain Res
, vol.43
, pp. 341-346
-
-
Prabhakar, N.R.1
Pieramici, S.F.2
Premkumar, D.R.3
Kumar, G.K.4
Kalaria, R.N.5
-
269
-
-
0030937718
-
Activation of hypoxia-inducible factor-1: Definition of regulatory domains within the a subunit
-
Pugh CW, O'Rourke JF, Nagao M, Gleadle JM, Ratcliffe PJ. Activation of hypoxia-inducible factor-1: definition of regulatory domains within the a subunit. J Biol Chem 272: 11205-11214, 1997.
-
(1997)
J Biol Chem
, vol.272
, pp. 11205-11214
-
-
Pugh, C.W.1
O'Rourke, J.F.2
Nagao, M.3
Gleadle, J.M.4
Ratcliffe, P.J.5
-
270
-
-
0025885693
-
Functional analysis of an oxygen-regulated transcriptional enhancer lying 3' to the mouse erythropoietin gene
-
Pugh CW, Tan CC, Jones RW, Ratcliffe PJ. Functional analysis of an oxygen-regulated transcriptional enhancer lying 3' to the mouse erythropoietin gene. Proc Natl Acad Sci USA 88: 10553-10557, 1991.
-
(1991)
Proc Natl Acad Sci USA
, vol.88
, pp. 10553-10557
-
-
Pugh, C.W.1
Tan, C.C.2
Jones, R.W.3
Ratcliffe, P.J.4
-
271
-
-
0033521535
-
Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E
-
Pyronnet S, Imataka H, Gingras AC, Fukunaga R, Hunter T, Sonenberg N. Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E. EMBOJ 18:270-279, 1999.
-
(1999)
EMBOJ
, vol.18
, pp. 270-279
-
-
Pyronnet, S.1
Imataka, H.2
Gingras, A.C.3
Fukunaga, R.4
Hunter, T.5
Sonenberg, N.6
-
272
-
-
31544473721
-
Nitric oxide is a factor in the stabilization of hypoxia-inducible factor-1 α in cancer: Role of free radical formation
-
Quintero M, Brennan PA, Thomas GJ, Moncada S. Nitric oxide is a factor in the stabilization of hypoxia-inducible factor-1 α in cancer: role of free radical formation. Cancer Res 66: 770-774, 2006.
-
(2006)
Cancer Res
, vol.66
, pp. 770-774
-
-
Quintero, M.1
Brennan, P.A.2
Thomas, G.J.3
Moncada, S.4
-
273
-
-
16244416835
-
SiegelJM. Antioxidant responses to chronic hypoxia in the rat cerebellum and pons
-
Ramanathan L, Gozal D, SiegelJM. Antioxidant responses to chronic hypoxia in the rat cerebellum and pons. J Neurochem 93: 47-52, 2005.
-
(2005)
J Neurochem
, vol.93
, pp. 47-52
-
-
Ramanathan, L.1
Gozal, D.2
-
274
-
-
65249185780
-
Downregulation of miR-199a derepresses hypoxia-inducible factor-1 α and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes
-
Rane S, He M, Sayed D, Vashistha H, Malhotra A, Sadoshima J, Vatner DE, Vatner SF, Abdellatif M. Downregulation of miR-199a derepresses hypoxia-inducible factor-1 α and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes. Circ Res 104: 879-886, 2009.
-
(2009)
Circ Res
, vol.104
, pp. 879-886
-
-
Rane, S.1
He, M.2
Sayed, D.3
Vashistha, H.4
Malhotra, A.5
Sadoshima, J.6
Vatner, D.E.7
Vatner, S.F.8
Abdellatif, M.9
-
275
-
-
20744445650
-
Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma
-
Raval RR, Lau KW, Tran MG, Sowter HM, Mandriota SJ, Li JL, Pugh CW, Maxwell PH, Harris AL, Ratcliffe PJ. Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma. Mol Cell Biol 25: 5675-5686, 2005.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 5675-5686
-
-
Raval, R.R.1
Lau, K.W.2
Tran, M.G.3
Sowter, H.M.4
Mandriota, S.J.5
Li, J.L.6
Pugh, C.W.7
Maxwell, P.H.8
Harris, A.L.9
Ratcliffe, P.J.10
-
276
-
-
0035008770
-
Alterations in a redox oxygen sensing mechanism in chronic hypoxia
-
Reeve HL, Michelakis E, Nelson DP, Weir EK, Archer SL. Alterations in a redox oxygen sensing mechanism in chronic hypoxia. J Appl Physiol 90: 2249-2256, 2001.
-
(2001)
J Appl Physiol
, vol.90
, pp. 2249-2256
-
-
Reeve, H.L.1
Michelakis, E.2
Nelson, D.P.3
Weir, E.K.4
Archer, S.L.5
-
277
-
-
7444220066
-
Chronic intermittent hypoxia enhances cat chemosensory and ventilatory responses to hypoxia
-
Rey S, Del Rio R, Alcayaga J, Iturriaga R. Chronic intermittent hypoxia enhances cat chemosensory and ventilatory responses to hypoxia. J Physiol 560: 577-586, 2004.
-
(2004)
J Physiol
, vol.560
, pp. 577-586
-
-
Rey, S.1
Del Rio, R.2
Alcayaga, J.3
Iturriaga, R.4
-
278
-
-
73949085704
-
Synergistic effect of HIF-1 α gene therapy and HIF-1-activated bone marrow-derived angiogenic cells in a mouse model of limb ischemia
-
Rey S, Lee K, Wang CJ, Gupta K, Chen S, McMillan A, Bhise N, Levchenko A, Semenza GL. Synergistic effect of HIF-1 α gene therapy and HIF-1-activated bone marrow-derived angiogenic cells in a mouse model of limb ischemia. Proc Natl Acad Sci USA 106: 20399-20404, 2009.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 20399-20404
-
-
Rey, S.1
Lee, K.2
Wang, C.J.3
Gupta, K.4
Chen, S.5
McMillan, A.6
Bhise, N.7
Levchenko, A.8
Semenza, G.L.9
-
279
-
-
0033822011
-
Inhibition of sustained hypoxic vasoconstriction byY-27632 in isolated intrapulmonary arteries and perfused lung of the rat
-
Robertson TP, Dipp M, Ward JP, Aaronson PI, Evans AM. Inhibition of sustained hypoxic vasoconstriction byY-27632 in isolated intrapulmonary arteries and perfused lung of the rat. Br J Pharmacol 131: 5-9, 2000.
-
(2000)
Br J Pharmacol
, vol.131
, pp. 5-9
-
-
Robertson, T.P.1
Dipp, M.2
Ward, J.P.3
Aaronson, P.I.4
Evans, A.M.5
-
280
-
-
0028988958
-
Poor ventilatory response to mild hypoxia may inhibit acclimatization at moderate altitude in elderly patients after carotid surgery
-
Roeggla G, Roeggla M, Wagner A, Laggner AN. Poor ventilatory response to mild hypoxia may inhibit acclimatization at moderate altitude in elderly patients after carotid surgery. BrJ Sports Med 29: 110-112, 1995.
-
(1995)
BrJ Sports Med
, vol.29
, pp. 110-112
-
-
Roeggla, G.1
Roeggla, M.2
Wagner, A.3
Laggner, A.N.4
-
281
-
-
0030792094
-
Oxygen-regulated transferrin expression is mediated by hypoxia-inducible factor-1
-
Rolfs A, Kvietikova I, Gassmann M, Wenger RH. Oxygen-regulated transferrin expression is mediated by hypoxia-inducible factor-1.J Biol Chem 272: 20055-20062, 1997.
-
(1997)
J Biol Chem
, vol.272
, pp. 20055-20062
-
-
Rolfs, A.1
Kvietikova, I.2
Gassmann, M.3
Wenger, R.H.4
-
282
-
-
2442576104
-
Natural antisense transcripts of hypoxia-inducible factor 1α are detected in different normal and tumour human tissues
-
Rossignol F, Vache C, Clottes E. Natural antisense transcripts of hypoxia-inducible factor 1α are detected in different normal and tumour human tissues. Gene 299: 135-140, 2002.
-
(2002)
Gene
, vol.299
, pp. 135-140
-
-
Rossignol, F.1
Vache, C.2
Clottes, E.3
-
283
-
-
22044436344
-
2 sensing by chemoreceptors
-
Roux JC, Brismar H, Aperia A, Lagercrantz H. Developmental changes in HIF transcription factor in carotid body: relevance for O2 sensing by chemoreceptors. Pediatr Res 58: 53-57, 2005.
-
(2005)
Pediatr Res
, vol.58
, pp. 53-57
-
-
Roux, J.C.1
Brismar, H.2
Aperia, A.3
Lagercrantz, H.4
-
284
-
-
0037458830
-
Oxygen sensing by primary cardiac fibroblasts: A key role of p21(Waf1/Cip1/Sdi1)
-
Roy S, Khanna S, Bickerstaff AA, Subramanian SV, Atalay M, Bierl M, Pendyala S, Levy D, Sharma N, Venojarvi M, Strauch A, Orosz CG, Sen CK. Oxygen sensing by primary cardiac fibroblasts: a key role of p21(Waf1/Cip1/Sdi1). Circ Res 92: 264-271, 2003.
-
(2003)
Circ Res
, vol.92
, pp. 264-271
-
-
Roy, S.1
Khanna, S.2
Bickerstaff, A.A.3
Subramanian, S.V.4
Atalay, M.5
Bierl, M.6
Pendyala, S.7
Levy, D.8
Sharma, N.9
Venojarvi, M.10
Strauch, A.11
Orosz, C.G.12
Sen, C.K.13
-
285
-
-
0030961006
-
Hypoxia-inducible factor 1 α (HIF-1α) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes
-
Salceda S, Caro J. Hypoxia-inducible factor 1 α (HIF-1α) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes. J Biol Chem 272: 22642-22647, 1997.
-
(1997)
J Biol Chem
, vol.272
, pp. 22642-22647
-
-
Salceda, S.1
Caro, J.2
-
286
-
-
0034638623
-
Induction of hypoxia-inducible-factor 1 by nitric oxide is mediated via the PI3K pathway
-
Sandau KB, Faus HG, Brune B. Induction of hypoxia-inducible-factor 1 by nitric oxide is mediated via the PI3K pathway. Biochem Biophys Res Commun 278: 263-267, 2000.
-
(2000)
Biochem Biophys Res Commun
, vol.278
, pp. 263-267
-
-
Sandau, K.B.1
Faus, H.G.2
Brune, B.3
-
287
-
-
33947520124
-
P53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload
-
Sano M, Minamino T, Toko H, Miyauchi H, Orimo M, Qin Y, Akazawa H, Tateno K, Kayama Y, Harada M, Shimizu I, Asahara T, Hamada H, Tomita S, Molkentin JD, Zou Y, Komuro I. p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload. Nature 446: 444-448, 2007
-
(2007)
Nature
, vol.446
, pp. 444-448
-
-
Sano, M.1
Minamino, T.2
Toko, H.3
Miyauchi, H.4
Orimo, M.5
Qin, Y.6
Akazawa, H.7
Tateno, K.8
Kayama, Y.9
Harada, M.10
Shimizu, I.11
Asahara, T.12
Hamada, H.13
Tomita, S.14
Molkentin, J.D.15
Zou, Y.16
Komuro, I.17
-
288
-
-
0026638065
-
Augmented hypoxic ventilatory response in men at altitude
-
Sato M, Severinghaus JW, Powell FL, Xu FD, Spellman MJ Jr. Augmented hypoxic ventilatory response in men at altitude. J Appl Physiol 73: 101-107, 1992.
-
(1992)
J Appl Physiol
, vol.73
, pp. 101-107
-
-
Sato, M.1
Severinghaus, J.W.2
Powell, F.L.3
Xu, F.D.4
Spellman Jr., M.J.5
-
289
-
-
0031034814
-
Hypoxia induces cyclooxygen-ase-2 via the NF-kappaB p65 transcription factor in human vascular endothelial cells
-
Schmedtje JF Jr, Ji YS, Liu WL, DuBois RN, Runge MS. Hypoxia induces cyclooxygen-ase-2 via the NF-kappaB p65 transcription factor in human vascular endothelial cells. J Biol Chem 272: 601-608, 1997.
-
(1997)
J Biol Chem
, vol.272
, pp. 601-608
-
-
Schmedtje Jr., J.F.1
Ji, Y.S.2
Liu, W.L.3
Dubois, R.N.4
Runge, M.S.5
-
290
-
-
0024495050
-
Stimulation of erythropoietin gene transcription during hypoxia and cobalt exposure
-
Schuster SJ, Badiavas EV, Costa-Giomi P, Weinmann R, Erslev AJ, Caro J. Stimulation of erythropoietin gene transcription during hypoxia and cobalt exposure. Blood 73: 13-16, 1989.
-
(1989)
Blood
, vol.73
, pp. 13-16
-
-
Schuster, S.J.1
Badiavas, E.V.2
Costa-Giomi, P.3
Weinmann, R.4
Erslev, A.J.5
Caro, J.6
-
291
-
-
0023265719
-
Physiologic regulation and tissue localization of renal erythropoietin messenger RNA
-
Schuster SJ, Wilson JH, Erslev AJ, Caro J. Physiologic regulation and tissue localization of renal erythropoietin messenger RNA. Blood 70: 316-318, 1987.
-
(1987)
Blood
, vol.70
, pp. 316-318
-
-
Schuster, S.J.1
Wilson, J.H.2
Erslev, A.J.3
Caro, J.4
-
292
-
-
0344826529
-
_/_ mice
-
_/_ mice. Nat Genet 35: 331-340, 2003.
-
(2003)
Nat Genet
, vol.35
, pp. 331-340
-
-
Scortegagna, M.1
Ding, K.2
Oktay, Y.3
Gaur, A.4
Thurmond, F.5
Yan, L.J.6
Marck, B.T.7
Matsumoto, A.M.8
Shelton, J.M.9
Richardson, J.A.10
Bennett, M.J.11
Garcia, J.A.12
-
293
-
-
0041440036
-
The HIF family member EPAS1/HIF-2α is required for normal hematopoiesis in mice
-
Scortegagna M, Morris MA, Oktay Y, Bennett M, Garcia JA. The HIF family member EPAS1/HIF-2α is required for normal hematopoiesis in mice. Blood 102: 1634-1640, 2003.
-
(2003)
Blood
, vol.102
, pp. 1634-1640
-
-
Scortegagna, M.1
Morris, M.A.2
Oktay, Y.3
Bennett, M.4
Garcia, J.A.5
-
294
-
-
0035027828
-
Transcription factor HIF-1 is a necessary mediator of the Pasteur effect in mammalian cells
-
Seagroves TN, Ryan HE, Lu H, Wouters BG, Knapp M, Thibault P, Laderoute K, Johnson RS. Transcription factor HIF-1 is a necessary mediator of the Pasteur effect in mammalian cells. Mol Cell Biol 21: 3436-3444, 2001.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 3436-3444
-
-
Seagroves, T.N.1
Ryan, H.E.2
Lu, H.3
Wouters, B.G.4
Knapp, M.5
Thibault, P.6
Laderoute, K.7
Johnson, R.S.8
-
295
-
-
0021895269
-
Adrenomedullary function in the neonatal rat: Responses to acute hypoxia
-
Seidler FJ, Slotkin TA. Adrenomedullary function in the neonatal rat: responses to acute hypoxia. J Physiol 358: 1-16, 1985.
-
(1985)
J Physiol
, vol.358
, pp. 1-16
-
-
Seidler, F.J.1
Slotkin, T.A.2
-
296
-
-
19944433653
-
Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-α prolyl hydroxylase
-
Selak MA, Armour SM, MacKenzie ED, Boulahbel H, Watson DG, Mansfield KD, Pan Y, Simon MC, Thompson CB, Gottlieb E. Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-α prolyl hydroxylase. Cancer Cell 7: 77-85, 2005.
-
(2005)
Cancer Cell
, vol.7
, pp. 77-85
-
-
Selak, M.A.1
Armour, S.M.2
Mackenzie, E.D.3
Boulahbel, H.4
Watson, D.G.5
Mansfield, K.D.6
Pan, Y.7
Simon, M.C.8
Thompson, C.B.9
Gottlieb, E.10
-
297
-
-
0025012679
-
Human erythropoietin gene expression in transgenic mice: Multiple transcription initiation sites and cis-acting regulatory elements
-
Semenza GL, Dureza RC, Traystman MD, Gearhart JD, Antonarakis SE. Human erythropoietin gene expression in transgenic mice: multiple transcription initiation sites and cis-acting regulatory elements. Mol Cell Biol 10: 930-938, 1990.
-
(1990)
Mol Cell Biol
, vol.10
, pp. 930-938
-
-
Semenza, G.L.1
Dureza, R.C.2
Traystman, M.D.3
Gearhart, J.D.4
Antonarakis, S.E.5
-
298
-
-
0030460724
-
Hypoxia Response Elements In the Aldolase A, Enolase 1, and Lactate Dehydrogenase a Gene Promoters Contain Essential Binding Sites For Hypoxia-inducible Factor 1
-
Semenza GL, Jiang BH, Leung SW, Passantino R, Concordet JP, Maire P, Giallongo A Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1.J Biol Chem 271: 32529-32537, 1996.
-
(1996)
J Biol Chem
, vol.271
, pp. 32529-32537
-
-
Semenza, G.L.1
Jiang, B.H.2
Leung, S.W.3
Passantino, R.4
Concordet, J.P.5
Maire, P.6
Giallongo, A.7
-
299
-
-
0026072341
-
Cell-type-specific and hypoxia-inducible expression of the human erythropoietin gene in transgenic mice
-
Semenza GL, Koury ST, Nejfelt MK, Gearhart JD, Antonarakis SE. Cell-type-specific and hypoxia-inducible expression of the human erythropoietin gene in transgenic mice. Proc Natl Acad Sci USA 88: 8725-8729, 1991.
-
(1991)
Proc Natl Acad Sci USA
, vol.88
, pp. 8725-8729
-
-
Semenza, G.L.1
Koury, S.T.2
Nejfelt, M.K.3
Gearhart, J.D.4
Antonarakis, S.E.5
-
300
-
-
0026075610
-
Hypoxia-inducible nuclear factors bind to an enhancer element located 3' to the human erythropoietin gene
-
Semenza GL, Nejfelt MK, Chi SM, Antonarakis SE. Hypoxia-inducible nuclear factors bind to an enhancer element located 3' to the human erythropoietin gene. Proc Natl Acad Sci USA 88: 5680-5684, 1991.
-
(1991)
Proc Natl Acad Sci USA
, vol.88
, pp. 5680-5684
-
-
Semenza, G.L.1
Nejfelt, M.K.2
Chi, S.M.3
Antonarakis, S.E.4
-
301
-
-
0030585761
-
Assignment of the hypoxia-inducible factor 1 α gene to a region of conserved synteny on mouse chromosome 12 and human chromosome 14q
-
Semenza GL, Rue EA, Iyer NV, Pang MG, Kearns WG. Assignment of the hypoxia-inducible factor 1 α gene to a region of conserved synteny on mouse chromosome 12 and human chromosome 14q. Genomics 34: 437-439, 1996.
-
(1996)
Genomics
, vol.34
, pp. 437-439
-
-
Semenza, G.L.1
Rue, E.A.2
Iyer, N.V.3
Pang, M.G.4
Kearns, W.G.5
-
302
-
-
0024507117
-
Polycythemia in transgenic mice expressing the human erythropoietin gene
-
Semenza GL, Traystman MD, Gearhart JD, Antonarakis SE. Polycythemia in transgenic mice expressing the human erythropoietin gene. Proc Natl Acad Sci USA 86: 2301-2305, 1989.
-
(1989)
Proc Natl Acad Sci USA
, vol.86
, pp. 2301-2305
-
-
Semenza, G.L.1
Traystman, M.D.2
Gearhart, J.D.3
Antonarakis, S.E.4
-
303
-
-
0026468180
-
A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
-
Semenza GL, Wang GL. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol Cell Biol 12:5447-5454, 1992.
-
(1992)
Mol Cell Biol
, vol.12
, pp. 5447-5454
-
-
Semenza, G.L.1
Wang, G.L.2
-
304
-
-
0035148723
-
Sleep-disordered breathing and cardiovascular disease: Cross-sectional results of the Sleep Heart Health Study
-
Shahar E, Whitney CW, Redline S, Lee ET, Newman AB, Javier Nieto F, O'Connor GT, Boland LL, Schwartz JE, Samet JM. Sleep-disordered breathing and cardiovascular disease: cross-sectional results of the Sleep Heart Health Study. Am J Respir Crit Care Med 163: 19-25, 2001.
-
(2001)
Am J Respir Crit Care Med
, vol.163
, pp. 19-25
-
-
Shahar, E.1
Whitney, C.W.2
Redline, S.3
Lee, E.T.4
Newman, A.B.5
Javier Nieto, F.6
O'Connor, G.T.7
Boland, L.L.8
Schwartz, J.E.9
Samet, J.M.10
-
305
-
-
33751117499
-
HIF-1 regulates hypoxic induction of NHE1 expression and alkalinization of intracellular pH in pulmonary arterial myocytes
-
Shimoda LA, Fallon M, Pisarcik S, Wang J, Semenza GL. HIF-1 regulates hypoxic induction of NHE1 expression and alkalinization of intracellular pH in pulmonary arterial myocytes. Am J Physiol Lung Cell Mol Physiol 291: L941-L949, 2006.
-
(2006)
Am J Physiol Lung Cell Mol Physiol
, vol.291
-
-
Shimoda, L.A.1
Fallon, M.2
Pisarcik, S.3
Wang, J.4
Semenza, G.L.5
-
306
-
-
0034815688
-
Partial HIF-1 α deficiency impairs pulmonary arterial myocyte electrophysiological responses to hypoxia
-
Shimoda LA, Manalo DJ, Sham JS, Semenza GL, Sylvester JT. Partial HIF-1 α deficiency impairs pulmonary arterial myocyte electrophysiological responses to hypoxia. Am J Physiol Lung Cell Mol Physiol 281: L202-L208, 2001.
-
(2001)
Am J Physiol Lung Cell Mol Physiol
, vol.281
-
-
Shimoda, L.A.1
Manalo, D.J.2
Sham, J.S.3
Semenza, G.L.4
Sylvester, J.T.5
-
308
-
-
85047678002
-
Hypoxic preconditioning of ischaemic canine myocardium
-
Shizukuda Y, Mallet RT, Lee SC, Downey HF. Hypoxic preconditioning of ischaemic canine myocardium. Cardiovasc Res 26: 534-542, 1992.
-
(1992)
Cardiovasc Res
, vol.26
, pp. 534-542
-
-
Shizukuda, Y.1
Mallet, R.T.2
Lee, S.C.3
Downey, H.F.4
-
309
-
-
54049146968
-
The angiopoietin-2 gene of endothelial cells is up-regulated in hypoxia by a HIF binding site located in its first intron and by the central factors GATA-2 and Ets-1
-
Simon MP, Tournaire R, Pouyssegur J. The angiopoietin-2 gene of endothelial cells is up-regulated in hypoxia by a HIF binding site located in its first intron and by the central factors GATA-2 and Ets-1.J Cell Physiol 217: 809-818, 2008.
-
(2008)
J Cell Physiol
, vol.217
, pp. 809-818
-
-
Simon, M.P.1
Tournaire, R.2
Pouyssegur, J.3
-
310
-
-
77954319663
-
Genetic evidence for high-altitude adaptation in Tibet
-
Simonson TS, Yang Y, Huff CD, Yun H, Qin G, Witherspoon DJ, Bai Z, Lorenzo FR, Xing J, Jorde LB, Prchal JT, Ge R. Genetic evidence for high-altitude adaptation in Tibet. Science 329: 72-75, 2010.
-
(2010)
Science
, vol.329
, pp. 72-75
-
-
Simonson, T.S.1
Yang, Y.2
Huff, C.D.3
Yun, H.4
Qin, G.5
Witherspoon, D.J.6
Bai, Z.7
Lorenzo, F.R.8
Xing, J.9
Jorde, L.B.10
Prchal, J.T.11
Ge, R.12
-
311
-
-
67651098992
-
Endothelial deletion of hypoxia-inducible factor-2α (HIF-2α) alters vascular function and tumor angiogenesis
-
Skuli N, Liu L, Runge A, Wang T, Yuan L, Patel S, Iruela-Arispe L, Simon MC, Keith B. Endothelial deletion of hypoxia-inducible factor-2α (HIF-2α) alters vascular function and tumor angiogenesis. Blood 114: 469-477, 2009.
-
(2009)
Blood
, vol.114
, pp. 469-477
-
-
Skuli, N.1
Liu, L.2
Runge, A.3
Wang, T.4
Yuan, L.5
Patel, S.6
Iruela-Arispe, L.7
Simon, M.C.8
Keith, B.9
-
312
-
-
0029066386
-
Loss of neonatal hypoxia tolerance after prenatal nicotine exposure: Implications for sudden infant death syndrome
-
Slotkin TA, Lappi SE, McCook EC, Lorber BA, Seidler FJ. Loss of neonatal hypoxia tolerance after prenatal nicotine exposure: implications for sudden infant death syndrome. Brain Res Bull 38: 69-75, 1995.
-
(1995)
Brain Res Bull
, vol.38
, pp. 69-75
-
-
Slotkin, T.A.1
Lappi, S.E.2
McCook, E.C.3
Lorber, B.A.4
Seidler, F.J.5
-
313
-
-
33746398489
-
Mutation of von Hippel-Lindau tumour suppressor and human cardiopulmonary physiology
-
Smith TG, Brooks JT, Balanos GM, Lappin TR, Layton DM, Leedham DL, Liu C, Maxwell PH, McMullin MF, McNamara CJ, Percy MJ, Pugh CW, Ratcliffe PJ, Talbot NP, Treacy M, Robbins PA. Mutation of von Hippel-Lindau tumour suppressor and human cardiopulmonary physiology. PLoS Med 3: e290, 2006.
-
(2006)
PLoS Med
, vol.3
-
-
Smith, T.G.1
Brooks, J.T.2
Balanos, G.M.3
Lappin, T.R.4
Layton, D.M.5
Leedham, D.L.6
Liu, C.7
Maxwell, P.H.8
McMullin, M.F.9
McNamara, C.J.10
Percy, M.J.11
Pugh, C.W.12
Ratcliffe, P.J.13
Talbot, N.P.14
Treacy, M.15
Robbins, P.A.16
-
314
-
-
27644520812
-
Erythropoietin regulates hypoxic ventilation in mice by interacting with brainstem and carotid bodies
-
Soliz J, Joseph V, Soulage C, Becskei C, Vogel J, Pequignot JM, Ogunshola O, Gassmann M. Erythropoietin regulates hypoxic ventilation in mice by interacting with brainstem and carotid bodies. J Physiol 568: 559-571, 2005.
-
(2005)
J Physiol
, vol.568
, pp. 559-571
-
-
Soliz, J.1
Joseph, V.2
Soulage, C.3
Becskei, C.4
Vogel, J.5
Pequignot, J.M.6
Ogunshola, O.7
Gassmann, M.8
-
315
-
-
52149086125
-
Collaboration with the National Heart, Lung, and Blood Institute National Center on Sleep Disorders Research (National Institutes of Health)
-
Sleep apnea and cardiovascular disease: an American Heart Association/American College Of Cardiology Foundation Scientific Statement from the American Heart Association Council for High Blood Pressure Research Professional Education Committee, Council on Clinical Cardiology, Stroke Council, and Council On Cardiovascular Nursing
-
Somers VK, White DP, Amin R, Abraham WT, Costa F, Culebras A, Daniels S, Floras JS, Hunt CE, Olson LJ, Pickering TG, Russell R, Woo M, Young T. Sleep apnea and cardiovascular disease: an American Heart Association/American College Of Cardiology Foundation Scientific Statement from the American Heart Association Council for High Blood Pressure Research Professional Education Committee, Council on Clinical Cardiology, Stroke Council, and Council On Cardiovascular Nursing. In collaboration with the National Heart, Lung, and Blood Institute National Center on Sleep Disorders Research (National Institutes of Health). Circulation 118: 1080-1111, 2008.
-
(2008)
Circulation
, vol.118
, pp. 1080-1111
-
-
Somers, V.K.1
White, D.P.2
Amin, R.3
Abraham, W.T.4
Costa, F.5
Culebras, A.6
Daniels, S.7
Floras, J.S.8
Hunt, C.E.9
Olson, L.J.10
Pickering, T.G.11
Russell, R.12
Woo, M.13
Young, T.14
-
316
-
-
66349130218
-
Neonatal intermittent hypoxia leads to long-lasting facilitation of acute hypoxia-evoked catecholamine secretion from rat chromaffin cells
-
Souvannakitti D, Kumar GK, Fox A, Prabhakar NR. Neonatal intermittent hypoxia leads to long-lasting facilitation of acute hypoxia-evoked catecholamine secretion from rat chromaffin cells. J Neurophysiol 101: 2837-2846, 2009.
-
(2009)
J Neurophysiol
, vol.101
, pp. 2837-2846
-
-
Souvannakitti, D.1
Kumar, G.K.2
Fox, A.3
Prabhakar, N.R.4
-
317
-
-
77956202249
-
2+ channels and ryanodine receptors mediate the augmented exocytosis of catecholamines from intermittent hypoxia-treated neonatal rat chromaffin cells
-
2+ channels and ryanodine receptors mediate the augmented exocytosis of catecholamines from intermittent hypoxia-treated neonatal rat chromaffin cells. J Neurosci 30: 10763-10772, 2010.
-
(2010)
J Neurosci
, vol.30
, pp. 10763-10772
-
-
Souvannakitti, D.1
Nanduri, J.2
Yuan, G.3
Kumar, G.K.4
Fox, A.P.5
Prabhakar, N.R.6
-
318
-
-
0141988698
-
Predominant role of hypoxia-inducible transcription factor (Hif)-1 α versus Hif-2α in regulation of the transcriptional response to hypoxia
-
Sowter HM, Raval RR, Moore JW, Ratcliffe PJ, Harris AL. Predominant role of hypoxia-inducible transcription factor (Hif)-1 α versus Hif-2α in regulation of the transcriptional response to hypoxia. Cancer Res 63: 6130-6134, 2003.
-
(2003)
Cancer Res
, vol.63
, pp. 6130-6134
-
-
Sowter, H.M.1
Raval, R.R.2
Moore, J.W.3
Ratcliffe, P.J.4
Harris, A.L.5
-
319
-
-
33749345684
-
Hypoxia-induced pulmonary vascular remodeling: Cellular and molecular mechanisms
-
Stenmark KR, Fagan KA, Frid MG. Hypoxia-induced pulmonary vascular remodeling: cellular and molecular mechanisms. Circ Res 99: 675-691, 2006.
-
(2006)
Circ Res
, vol.99
, pp. 675-691
-
-
Stenmark, K.R.1
Fagan, K.A.2
Frid, M.G.3
-
320
-
-
0042926509
-
Regulation of hypoxia-inducible factor-1 α, vascular endothelial growth factor, and angiogenesis by an insulin-like growth factor-I receptor autocrine loop in human pancreatic cancer
-
Stoeltzing O, Liu W, Reinmuth N, Fan F, Parikh AA, Bucana CD, Evans DB, Semenza GL, Ellis LM. Regulation of hypoxia-inducible factor-1 α, vascular endothelial growth factor, and angiogenesis by an insulin-like growth factor-I receptor autocrine loop in human pancreatic cancer. AmJ Pathol 163: 1001-1011,2003.
-
(2003)
AmJ Pathol
, vol.163
, pp. 1001-1011
-
-
Stoeltzing, O.1
Liu, W.2
Reinmuth, N.3
Fan, F.4
Parikh, A.A.5
Bucana, C.D.6
Evans, D.B.7
Semenza, G.L.8
Ellis, L.M.9
-
321
-
-
85047685683
-
Ecto-5'-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia
-
Synnestvedt K, Furuta GT, Comerford KM, Louis N, Karhausen J, Eltzschig HK, Hansen KR, Thompson LF, Colgan SP. Ecto-5'-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia. J Clin Invest 110: 993-1002, 2002.
-
(2002)
J Clin Invest
, vol.110
, pp. 993-1002
-
-
Synnestvedt, K.1
Furuta, G.T.2
Comerford, K.M.3
Louis, N.4
Karhausen, J.5
Eltzschig, H.K.6
Hansen, K.R.7
Thompson, L.F.8
Colgan, S.P.9
-
322
-
-
0033588021
-
Transferrin receptor induction by hypoxia. HIF-1-mediated transcriptional activation and cell-specific post-transcrip-tional regulation
-
Tacchini L, Bianchi L, Bernelli-Zazzera A, Cairo G. Transferrin receptor induction by hypoxia. HIF-1-mediated transcriptional activation and cell-specific post-transcrip-tional regulation. J Biol Chem 274: 24142-24146, 1999.
-
(1999)
J Biol Chem
, vol.274
, pp. 24142-24146
-
-
Tacchini, L.1
Bianchi, L.2
Bernelli-Zazzera, A.3
Cairo, G.4
-
323
-
-
77956390760
-
Hypoxia and adrenergic function: Molecular mechanisms related to Egr-1 andSp1 αctivation
-
Tai TC, Wong-Faull DC, Claycomb R, Wong DL. Hypoxia and adrenergic function: molecular mechanisms related to Egr-1 andSp1 αctivation. Brain Res 1353: 14-27, 2010.
-
(2010)
Brain Res
, vol.1353
, pp. 14-27
-
-
Tai, T.C.1
Wong-Faull, D.C.2
Claycomb, R.3
Wong, D.L.4
-
324
-
-
85047677005
-
Acute ischaemic preconditioning and chronic hypoxia independently increase myocardial tolerance to ischaemia
-
Tajima M, Katayose D, Bessho M, Isoyama S. Acute ischaemic preconditioning and chronic hypoxia independently increase myocardial tolerance to ischaemia. Cardiovasc Res 28: 312-319, 1994.
-
(1994)
Cardiovasc Res
, vol.28
, pp. 312-319
-
-
Tajima, M.1
Katayose, D.2
Bessho, M.3
Isoyama, S.4
-
325
-
-
39849098721
-
SAG/ROC2/RBX2 is a HIF-1 target gene that promotes HIF-1 α ubiquitination and degradation
-
Tan M, Gu Q, He H, Pamarthy D, Semenza GL, Sun Y. SAG/ROC2/RBX2 is a HIF-1 target gene that promotes HIF-1 α ubiquitination and degradation. Oncogene 27: 1404-1411, 2008.
-
(2008)
Oncogene
, vol.27
, pp. 1404-1411
-
-
Tan, M.1
Gu, Q.2
He, H.3
Pamarthy, D.4
Semenza, G.L.5
Sun, Y.6
-
326
-
-
7944224442
-
Loss of HIF-1 α in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary fortumorigenesis
-
Tang N, Wang L, Esko J, Giordano FJ, Huang Y, Gerber HP, Ferrara N, Johnson RS. Loss of HIF-1 α in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary fortumorigenesis. Cancer Cell 6: 485-495, 2004.
-
(2004)
Cancer Cell
, vol.6
, pp. 485-495
-
-
Tang, N.1
Wang, L.2
Esko, J.3
Giordano, F.J.4
Huang, Y.5
Gerber, H.P.6
Ferrara, N.7
Johnson, R.S.8
-
327
-
-
0033516488
-
Critical role of cAMP response element binding protein expression in hypoxia-elicited induction of epithelial tumor necrosis factor-α
-
Taylor CT, Fueki N, Agah A, Hershberg RM, Colgan SP. Critical role of cAMP response element binding protein expression in hypoxia-elicited induction of epithelial tumor necrosis factor-α.J Biol Chem 274: 19447-19454, 1999.
-
(1999)
J Biol Chem
, vol.274
, pp. 19447-19454
-
-
Taylor, C.T.1
Fueki, N.2
Agah, A.3
Hershberg, R.M.4
Colgan, S.P.5
-
328
-
-
0026610144
-
Intravenous pretreatment with A1-selective adenosine analogs protects the heart against infarction
-
Thornton JD, Liu GS, Olsson RA, Downey JM. Intravenous pretreatment with A1-selective adenosine analogs protects the heart against infarction. Circulation 85: 659-665, 1992.
-
(1992)
Circulation
, vol.85
, pp. 659-665
-
-
Thornton, J.D.1
Liu, G.S.2
Olsson, R.A.3
Downey, J.M.4
-
329
-
-
0033585496
-
AHIF: A natural antisense transcript overexpressed in human renal cancer and during hypoxia
-
Thrash-Bingham CA, Tartof KD. aHIF: a natural antisense transcript overexpressed in human renal cancer and during hypoxia. J Natl Cancer Inst 91:143-151, 1999.
-
(1999)
J Natl Cancer Inst
, vol.91
, pp. 143-151
-
-
Thrash-Bingham, C.A.1
Tartof, K.D.2
-
330
-
-
0032213236
-
The hypoxia-re-sponsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development
-
Tian H, Hammer RE, Matsumoto AM, Russell DW, McKnight SL. The hypoxia-re-sponsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development. Genes Dev 12: 3320-3324, 1998.
-
(1998)
Genes Dev
, vol.12
, pp. 3320-3324
-
-
Tian, H.1
Hammer, R.E.2
Matsumoto, A.M.3
Russell, D.W.4
McKnight, S.L.5
-
331
-
-
0031020884
-
Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells
-
Tian H, McKnight SL, Russell DW. Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells. Genes Dev 11: 72-82, 1997.
-
(1997)
Genes Dev
, vol.11
, pp. 72-82
-
-
Tian, H.1
McKnight, S.L.2
Russell, D.W.3
-
332
-
-
58049216350
-
Differential dependence of hypoxia-inducible factors 1α and 2α on mTORC1 and mTORC2
-
Toschi A, Lee E, Gadir N, Ohh M, Foster DA. Differential dependence of hypoxia-inducible factors 1α and 2α on mTORC1 and mTORC2. J Biol Chem 283: 34495-34499, 2008.
-
(2008)
J Biol Chem
, vol.283
, pp. 34495-34499
-
-
Toschi, A.1
Lee, E.2
Gadir, N.3
Ohh, M.4
Foster, D.A.5
-
333
-
-
0037008770
-
Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway
-
Treins C, Giorgetti-Peraldi S, Murdaca J, Semenza GL, Van Obberghen E. Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway. J Biol Chem 277: 27975-27981, 2002.
-
(2002)
J Biol Chem
, vol.277
, pp. 27975-27981
-
-
Treins, C.1
Giorgetti-Peraldi, S.2
Murdaca, J.3
Semenza, G.L.4
van Obberghen, E.5
-
334
-
-
36148987611
-
Reactive oxygen species contribute to sleep apnea-induced hypertension in rats
-
Troncoso Brindeiro CM, daSilva AQ, Allahdadi KJ, Youngblood V, Kanagy NL. Reactive oxygen species contribute to sleep apnea-induced hypertension in rats. Am J Physiol Heart Circ Physiol 293: H2971-H2976, 2007.
-
(2007)
Am J Physiol Heart Circ Physiol
, vol.293
-
-
Troncoso Brindeiro, C.M.1
Dasilva, A.Q.2
Allahdadi, K.J.3
Youngblood, V.4
Kanagy, N.L.5
-
335
-
-
0034772039
-
Expression of angiogenesis-related molecules in plexiform lesions in severe pulmonary hypertension: Evidence for a process of disordered angiogenesis
-
Tuder RM, Chacon M, Alger L, Wang J, Taraseviciene-Stewart L, Kasahara Y, Cool CD, Bishop AE, Geraci M, Semenza GL, Yacoub M, Polak JM, Voelkel NF. Expression of angiogenesis-related molecules in plexiform lesions in severe pulmonary hypertension: evidence for a process of disordered angiogenesis.J Pathol 195: 367-374, 2001.
-
(2001)
J Pathol
, vol.195
, pp. 367-374
-
-
Tuder, R.M.1
Chacon, M.2
Alger, L.3
Wang, J.4
Taraseviciene-Stewart, L.5
Kasahara, Y.6
Cool, C.D.7
Bishop, A.E.8
Geraci, M.9
Semenza, G.L.10
Yacoub, M.11
Polak, J.M.12
Voelkel, N.F.13
-
336
-
-
2442544693
-
Prolonged hypoxia differentially regulates hypoxia-inducible factor (HIF)-1α and HIF-2α expression in lung epithelial cells: Implication of natural antisense HIF-1 α
-
Uchida T, Rossignol F, Matthay MA, Mounier R, Couette S, Clottes E, Clerici C. Prolonged hypoxia differentially regulates hypoxia-inducible factor (HIF)-1α and HIF-2α expression in lung epithelial cells: implication of natural antisense HIF-1 α. J Biol Chem 279: 14871-14878,2004.
-
(2004)
J Biol Chem
, vol.279
, pp. 14871-14878
-
-
Uchida, T.1
Rossignol, F.2
Matthay, M.A.3
Mounier, R.4
Couette, S.5
Clottes, E.6
Clerici, C.7
-
337
-
-
69949124669
-
Hypoxia-induced expression of carbonic anhydrase 9 is dependent on the unfolded protein response
-
Van den Beucken T, Koritzinsky M, Niessen H, Dubois L, Savelkouls K, Mujcic H, Jutten B, Kopacek J, Pastorekova S, van der Kogel AJ, Lambin P, Voncken W, Rouschop KM, Wouters BG. Hypoxia-induced expression of carbonic anhydrase 9 is dependent on the unfolded protein response. J Biol Chem 284: 24204-24212, 2009.
-
(2009)
J Biol Chem
, vol.284
, pp. 24204-24212
-
-
Van den Beucken, T.1
Koritzinsky, M.2
Niessen, H.3
Dubois, L.4
Savelkouls, K.5
Mujcic, H.6
Jutten, B.7
Kopacek, J.8
Pastorekova, S.9
van der Kogel, A.J.10
Lambin, P.11
Voncken, W.12
Rouschop, K.M.13
Wouters, B.G.14
-
338
-
-
0037423667
-
Local monocyte chemoattractant protein-1 therapy increases collateral artery formation in apolipoprotein E-deficient mice but induces systemic monocytic CD11b expression, neointimal formation, and plaque progression
-
Van Royen N, Hoefer I, Bottinger M, Hua J, Grundmann S, Voskuil M, Bode C, Schaper W, Buschmann I, Piek JJ. Local monocyte chemoattractant protein-1 therapy increases collateral artery formation in apolipoprotein E-deficient mice but induces systemic monocytic CD11b expression, neointimal formation, and plaque progression. Circ Res 92: 218-225, 2003.
-
(2003)
Circ Res
, vol.92
, pp. 218-225
-
-
van Royen, N.1
Hoefer, I.2
Bottinger, M.3
Hua, J.4
Grundmann, S.5
Voskuil, M.6
Bode, C.7
Schaper, W.8
Buschmann, I.9
Piek, J.J.10
-
339
-
-
0032211938
-
Pimonidazole: Anovel hypoxia marker for complementary study of tumor hypoxia and cell proliferation in cervical carcinoma
-
Varia MA, Calkins-Adams DP, Rinker LH, Kennedy AS, Novotny DB, Fowler WC Jr, Raleigh JA. Pimonidazole: anovel hypoxia marker for complementary study of tumor hypoxia and cell proliferation in cervical carcinoma. Gynecol Oncol 71: 270-277, 1998.
-
(1998)
Gynecol Oncol
, vol.71
, pp. 270-277
-
-
Varia, M.A.1
Calkins-Adams, D.P.2
Rinker, L.H.3
Kennedy, A.S.4
Novotny, D.B.5
Fowler Jr., W.C.6
Raleigh, J.A.7
-
340
-
-
0023582994
-
Biphasic ventilatory response of adult cats to sustained hypoxia has central origin
-
Vizek M, Pickett CK, Weil JV. Biphasic ventilatory response of adult cats to sustained hypoxia has central origin. J Appl Physiol 63: 1658-1664, 1987.
-
(1987)
J Appl Physiol
, vol.63
, pp. 1658-1664
-
-
Vizek, M.1
Pickett, C.K.2
Weil, J.V.3
-
341
-
-
0023575945
-
Increased carotid body hypoxic sensitivity during acclimatization to hypobaric hypoxia
-
Vizek M, Pickett CK, Weil JV. Increased carotid body hypoxic sensitivity during acclimatization to hypobaric hypoxia. J Appl Physiol 63: 2403-2410, 1987.
-
(1987)
J Appl Physiol
, vol.63
, pp. 2403-2410
-
-
Vizek, M.1
Pickett, C.K.2
Weil, J.V.3
-
342
-
-
13444259810
-
Abnormal monocyte recruitment and collateral artery formation in monocyte chemoattractant protein-1 deficient mice
-
Voskuil M, Hoefer IE, van Royen N, Hua J, de Graaf S, Bode C, Buschmann IR, Piek JJ. Abnormal monocyte recruitment and collateral artery formation in monocyte chemoattractant protein-1 deficient mice. Vasc Med 9: 287-292, 2004.
-
(2004)
Vasc Med
, vol.9
, pp. 287-292
-
-
Voskuil, M.1
Hoefer, I.E.2
van Royen, N.3
Hua, J.4
de Graaf, S.5
Bode, C.6
Buschmann, I.R.7
Piek, J.J.8
-
343
-
-
0029051439
-
2 tension
-
Wang GL, Jiang BH, Rue EA, Semenza GL. Hypoxia-inducible factor 1 is abasic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci USA 92: 5510-5514, 1995.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 5510-5514
-
-
Wang, G.L.1
Jiang, B.H.2
Rue, E.A.3
Semenza, G.L.4
-
344
-
-
0028816847
-
Purification and characterization of hypoxia-inducible factor
-
Wang GL, Semenza GL. Purification and characterization of hypoxia-inducible factor.J Biol Chem 270: 1230-1237, 1995.
-
(1995)
J Biol Chem
, vol.270
, pp. 1230-1237
-
-
Wang, G.L.1
Semenza, G.L.2
-
346
-
-
27644499187
-
Hypoxia induces a functionally significant and translationally efficient neuronal NO synthase mRNA variant
-
Ward ME, Toporsian M, Scott JA, Teoh H, Govindaraju V, Quan A, Wener AD, Wang G, Bevan SC, Newton DC, Marsden PA. Hypoxia induces a functionally significant and translationally efficient neuronal NO synthase mRNA variant. J Clin Invest 115: 3128-3139, 2005.
-
(2005)
J Clin Invest
, vol.115
, pp. 3128-3139
-
-
Ward, M.E.1
Toporsian, M.2
Scott, J.A.3
Teoh, H.4
Govindaraju, V.5
Quan, A.6
Wener, A.D.7
Wang, G.8
Bevan, S.C.9
Newton, D.C.10
Marsden, P.A.11
-
347
-
-
9444283176
-
Differentiating the functional role of hypoxia-inducible factor (HIF)-1α and HIF-2α (EPAS-1) by the use of RNA interference: Erythropoietin is a HIF-2α target gene in Hep3B and Kelly cells
-
Warnecke C, Zaborowska Z, Kurreck J, Erdmann VA, Frei U, Wiesener M, Eckardt KU. Differentiating the functional role of hypoxia-inducible factor (HIF)-1α and HIF-2α (EPAS-1) by the use of RNA interference: erythropoietin is a HIF-2α target gene in Hep3B and Kelly cells. FASEBJ 18: 1462-1464, 2004.
-
(2004)
FASEBJ
, vol.18
, pp. 1462-1464
-
-
Warnecke, C.1
Zaborowska, Z.2
Kurreck, J.3
Erdmann, V.A.4
Frei, U.5
Wiesener, M.6
Eckardt, K.U.7
-
348
-
-
0029982422
-
Nucleotide sequence, chromosomal assignment and mRNA expression of mouse hypoxia-inducible factor-1α
-
Wenger RH, Rolfs A, Marti HH, Guenet JL, Gassmann M. Nucleotide sequence, chromosomal assignment and mRNA expression of mouse hypoxia-inducible factor-1α. Biochem Biophys Res Commun 223: 54-59, 1996.
-
(1996)
Biochem Biophys Res Commun
, vol.223
, pp. 54-59
-
-
Wenger, R.H.1
Rolfs, A.2
Marti, H.H.3
Guenet, J.L.4
Gassmann, M.5
-
349
-
-
25844519550
-
HSP90 and the chaperoning of cancer
-
Whitesell L, Lindquist SL. HSP90 and the chaperoning of cancer. Nat Rev Cancer 5: 761-772, 2005.
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 761-772
-
-
Whitesell, L.1
Lindquist, S.L.2
-
350
-
-
39149127581
-
+ channel expression in pulmonary arterial myocytes
-
+ channel expression in pulmonary arterial myocytes. Am J Physiol Lung Cell Mol Physiol 294: L309-L318, 2008.
-
(2008)
Am J Physiol Lung Cell Mol Physiol
, vol.294
-
-
Whitman, E.M.1
Pisarcik, S.2
Luke, T.3
Fallon, M.4
Wang, J.5
Sylvester, J.T.6
Semenza, G.L.7
Shimoda, L.A.8
-
351
-
-
0030583293
-
In vivo expression of mRNAs encoding hypoxia-inducible factor 1
-
Wiener CM, Booth G, Semenza GL. In vivo expression of mRNAs encoding hypoxia-inducible factor 1. Biochem Biophys Res Commun 225: 485-488, 1996.
-
(1996)
Biochem Biophys Res Commun
, vol.225
, pp. 485-488
-
-
Wiener, C.M.1
Booth, G.2
Semenza, G.L.3
-
352
-
-
0037315337
-
Widespread hypoxia-inducible expression of HIF-2α in distinct cell populations of different organs
-
Wiesener MS, Jurgensen JS, Rosenberger C, Scholze CK, Horstrup JH, Warnecke C, Mandriota S, Bechmann I, Frei UA, Pugh CW, Ratcliffe PJ, Bachmann S, Maxwell PH, Eckardt KU. Widespread hypoxia-inducible expression of HIF-2α in distinct cell populations of different organs. FASEBJ 17: 271-273, 2003.
-
(2003)
FASEBJ
, vol.17
, pp. 271-273
-
-
Wiesener, M.S.1
Jurgensen, J.S.2
Rosenberger, C.3
Scholze, C.K.4
Horstrup, J.H.5
Warnecke, C.6
Mandriota, S.7
Bechmann, I.8
Frei, U.A.9
Pugh, C.W.10
Ratcliffe, P.J.11
Bachmann, S.12
Maxwell, P.H.13
Eckardt, K.U.14
-
353
-
-
0030025172
-
Trachealess encodes a bHLH-PAS protein that is an inducer of tracheal cell fates in Drosophila
-
Wilk R, Weizman I, Shilo BZ. trachealess encodes a bHLH-PAS protein that is an inducer of tracheal cell fates in Drosophila. Genes Dev 10: 93-102, 1996.
-
(1996)
Genes Dev
, vol.10
, pp. 93-102
-
-
Wilk, R.1
Weizman, I.2
Shilo, B.Z.3
-
354
-
-
1642565853
-
Identifying oxygen sensors by their photochemical action spectra
-
Wilson DF. Identifying oxygen sensors by their photochemical action spectra. Methods Enzymol 381: 690-704, 2004.
-
(2004)
Methods Enzymol
, vol.381
, pp. 690-704
-
-
Wilson, D.F.1
-
355
-
-
79151483728
-
Stress and adrenergic function: HIF1α, a potential regulatory switch
-
Wong DL, Tai TC, Wong-Faull DC, Claycomb R, Siddall BJ, Bell RA, Kvetnansky R. Stress and adrenergic function: HIF1α, a potential regulatory switch. Cell Mol Neuro-biol 30: 1451-1457,2010.
-
(2010)
Cell Mol Neuro-biol
, vol.30
, pp. 1451-1457
-
-
Wong, D.L.1
Tai, T.C.2
Wong-Faull, D.C.3
Claycomb, R.4
Siddall, B.J.5
Bell, R.A.6
Kvetnansky, R.7
-
356
-
-
70449991100
-
PI3K, Rho, and ROCK play a key role in hypoxia-induced ATP release and ATP-stimulated angiogenic responses in pulmonary artery vasava-sorum endothelial cells
-
Woodward HN, Anwar A, Riddle S, Taraseviciene-Stewart L, Fragoso M, Stenmark KR, Gerasimovskaya EV. PI3K, Rho, and ROCK play a key role in hypoxia-induced ATP release and ATP-stimulated angiogenic responses in pulmonary artery vasava-sorum endothelial cells. Am J Physiol Lung Cell Mol Physiol 297: L954-L964, 2009.
-
(2009)
Am J Physiol Lung Cell Mol Physiol
, vol.297
-
-
Woodward, H.N.1
Anwar, A.2
Riddle, S.3
Taraseviciene-Stewart, L.4
Fragoso, M.5
Stenmark, K.R.6
Gerasimovskaya, E.V.7
-
357
-
-
63449103705
-
Integrative analysis of HIF binding and transactivation reveals its role in maintaining histone methylation homeostasis
-
Xia X, Lemieux ME, Li W, Carroll JS, Brown M, Liu XS, Kung AL. Integrative analysis of HIF binding and transactivation reveals its role in maintaining histone methylation homeostasis. Proc Natl Acad Sci USA 106: 4260-4265, 2009.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 4260-4265
-
-
Xia, X.1
Lemieux, M.E.2
Li, W.3
Carroll, J.S.4
Brown, M.5
Liu, X.S.6
Kung, A.L.7
-
358
-
-
0033571167
-
Hypoxia-induced elevation in inter-leukin-8 expression by human ovarian carcinoma cells
-
Xu L, Xie K, Mukaida N, Matsushima K, Fidler IJ. Hypoxia-induced elevation in inter-leukin-8 expression by human ovarian carcinoma cells. Cancer Res 59: 5822-5829, 1999.
-
(1999)
Cancer Res
, vol.59
, pp. 5822-5829
-
-
Xu, L.1
Xie, K.2
Mukaida, N.3
Matsushima, K.4
Fidler, I.J.5
-
359
-
-
0034637541
-
Sp1 increases expression of cyclooxygenase-2 in hypoxic vascular endothelium. Implications for the mechanisms of aortic aneurysm and heart failure
-
Xu Q, Ji YS, Schmedtje JF. Sp1 increases expression of cyclooxygenase-2 in hypoxic vascular endothelium. Implications for the mechanisms of aortic aneurysm and heart failure. J Biol Chem 275: 24583-24589, 2000.
-
(2000)
J Biol Chem
, vol.275
, pp. 24583-24589
-
-
Xu, Q.1
Ji, Y.S.2
Schmedtje, J.F.3
-
360
-
-
78449239616
-
Induction of SENP1 in endothelial cells contributes to hypoxia-driven VEGF expression and angiogenesis
-
Xue Y, Zuoe Y, Zhang H, Kang X, Yue F, Yi Z, Liu M, Yeh ET, Chen G, Cheng J. Induction of SENP1 in endothelial cells contributes to hypoxia-driven VEGF expression and angiogenesis.J Biol Chem 285: 36682-36688, 2010.
-
(2010)
J Biol Chem
, vol.285
, pp. 36682-36688
-
-
Xue, Y.1
Zuoe, Y.2
Zhang, H.3
Kang, X.4
Yue, F.5
Yi, Z.6
Liu, M.7
Yeh, E.T.8
Chen, G.9
Cheng, J.10
-
361
-
-
0034533374
-
Egr-1, a master switch coordinating upregulation of divergent gene families underlying ischemic stress
-
Yan SF, Fujita T, Lu J, Okada K, ShanZou Y, Mackman N, Pinsky DJ, Stern DM. Egr-1, a master switch coordinating upregulation of divergent gene families underlying ischemic stress. Nat Med 6: 1355-1361, 2000.
-
(2000)
Nat Med
, vol.6
, pp. 1355-1361
-
-
Yan, S.F.1
Fujita, T.2
Lu, J.3
Okada, K.4
Shanzou, Y.5
Mackman, N.6
Pinsky, D.J.7
Stern, D.M.8
-
362
-
-
0034697028
-
Protein kinase C-betaand oxygen deprivation. A novel Egr-1-dependent pathway for fibrin deposition in hypoxemic vasculature
-
Yan SF, Lu J, Zou YS, Kisiel W, Mackman N, Leitges M, Steinberg S, Pinsky D, Stern D. Protein kinase C-betaand oxygen deprivation. A novel Egr-1-dependent pathway for fibrin deposition in hypoxemic vasculature. J Biol Chem 275: 11921-11928, 2000.
-
(2000)
J Biol Chem
, vol.275
, pp. 11921-11928
-
-
Yan, S.F.1
Lu, J.2
Zou, Y.S.3
Kisiel, W.4
Mackman, N.5
Leitges, M.6
Steinberg, S.7
Pinsky, D.8
Stern, D.9
-
363
-
-
13144257677
-
Tissue factortranscription driven by Egr-1 is a critical mechanism of murine pulmonary fibrin deposition in hypoxia
-
Yan SF, Zou YS, Gao Y, Zhai C, Mackman N, Lee SL, Milbrandt J, Pinsky D, Kisiel W, Stern D. Tissue factortranscription driven by Egr-1 is a critical mechanism of murine pulmonary fibrin deposition in hypoxia. Proc Natl Acad Sci USA 95: 8298-8303, 1998.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 8298-8303
-
-
Yan, S.F.1
Zou, Y.S.2
Gao, Y.3
Zhai, C.4
Mackman, N.5
Lee, S.L.6
Milbrandt, J.7
Pinsky, D.8
Kisiel, W.9
Stern, D.10
-
364
-
-
15144350613
-
Nuclear factor interleukin 6 motifs mediate tissue-specific gene transcription in hypoxia
-
Yan SF, Zou YS, Mendelsohn M, Gao Y, Naka Y, Du Yan S, Pinsky D, Stern D. Nuclear factor interleukin 6 motifs mediate tissue-specific gene transcription in hypoxia. J Biol Chem 272: 4287-4294, 1997.
-
(1997)
J Biol Chem
, vol.272
, pp. 4287-4294
-
-
Yan, S.F.1
Zou, Y.S.2
Mendelsohn, M.3
Gao, Y.4
Naka, Y.5
du Yan, S.6
Pinsky, D.7
Stern, D.8
-
365
-
-
33751074650
-
The Ah receptor
-
edited by Crews ST. Norwell, MA: Kluwer Academic
-
Yao G, Harstad E, Bradfield C. The Ah receptor. In: PAS Proteins: Regulators and Sensors of Development and Physiology, edited by Crews ST. Norwell, MA: Kluwer Academic, 2003, p. 149-182.
-
(2003)
PAS Proteins: Regulators and Sensors of Development and Physiology
, pp. 149-182
-
-
Yao, G.1
Harstad, E.2
Bradfield, C.3
-
366
-
-
0036261303
-
Augmentation of hypoxia-induced nitric oxide generation in the rat carotid body adapted to chronic hypoxia: An involvement of constitutive and inducible nitric oxide synthases
-
Ye JS, Tipoe GL, Fung PC, Fung ML. Augmentation of hypoxia-induced nitric oxide generation in the rat carotid body adapted to chronic hypoxia: an involvement of constitutive and inducible nitric oxide synthases. Pflügers Arch 444: 178-185, 2002.
-
(2002)
Pflügers Arch
, vol.444
, pp. 178-185
-
-
Ye, J.S.1
Tipoe, G.L.2
Fung, P.C.3
Fung, M.L.4
-
367
-
-
77954319020
-
Sequencing of 50 human exomes reveals adaptation to high altitude
-
Yi X, Liang Y, Huerta-Sanchez E, Jin X, Cuo ZX, Pool JE, Xu X, Jiang H, Vinckenbosch N, Korneliussen TS, Zheng H, Liu T, He W, Li K, Luo R, Nie X, Wu H, Zhao M, Cao H, Zou J, Shan Y, Li S, Yang Q, Asan Ni P, Tian G, Xu J, Liu X, Jiang T, Wu R, Zhou G, Tang M, Qin J, Wang T, Feng S, Li G, Huasang Luosang J, Wang W, Chen F, Wang Y, Zheng X, Li Z, Bianba Z, Yang G, Wang X, Tang S, Gao G, Chen Y, Luo Z, Gusang L, Cao Z, Zhang Q, Ouyang W, Ren X, Liang H, Huang Y, Li J, Bolund L, Kristiansen K, Li Y, Zhang Y, Zhang X, Li R, Yang H, Nielsen R, Wang J. Sequencing of 50 human exomes reveals adaptation to high altitude. Science 329: 75-78, 2010.
-
(2010)
Science
, vol.329
, pp. 75-78
-
-
Yi, X.1
Liang, Y.2
Huerta-Sanchez, E.3
Jin, X.4
Cuo, Z.X.5
Pool, J.E.6
Xu, X.7
Jiang, H.8
Vinckenbosch, N.9
Korneliussen, T.S.10
Zheng, H.11
Liu, T.12
He, W.13
Li, K.14
Luo, R.15
Nie, X.16
Wu, H.17
Zhao, M.18
Cao, H.19
Zou, J.20
Shan, Y.21
Li, S.22
Yang, Q.23
Asan Ni, P.24
Tian, G.25
Xu, J.26
Liu, X.27
Jiang, T.28
Wu, R.29
Zhou, G.30
Tang, M.31
Qin, J.32
Wang, T.33
Feng, S.34
Li, G.35
Huasang Luosang, J.36
Wang, W.37
Chen, F.38
Wang, Y.39
Zheng, X.40
Li, Z.41
Bianba, Z.42
Yang, G.43
Wang, X.44
Tang, S.45
Gao, G.46
Chen, Y.47
Luo, Z.48
Gusang, L.49
Cao, Z.50
Zhang, Q.51
Ouyang, W.52
Ren, X.53
Liang, H.54
Huang, Y.55
Li, J.56
Bolund, L.57
Kristiansen, K.58
Li, Y.59
Zhang, Y.60
Zhang, X.61
Li, R.62
Yang, H.63
Nielsen, R.64
Wang, J.65
more..
-
368
-
-
33748742457
-
Hypoxia-inducible factor-1 deficiency results in dysregu-lated erythropoiesis signaling and iron homeostasis in mouse development
-
Yoon D, Pastore YD, Divoky V, Liu E, Mlodnicka AE, Rainey K, Ponka P, Semenza GL, Schumacher A, Prchal JT. Hypoxia-inducible factor-1 deficiency results in dysregu-lated erythropoiesis signaling and iron homeostasis in mouse development. J Biol Chem 281: 25703-25711, 2006.
-
(2006)
J Biol Chem
, vol.281
, pp. 25703-25711
-
-
Yoon, D.1
Pastore, Y.D.2
Divoky, V.3
Liu, E.4
Mlodnicka, A.E.5
Rainey, K.6
Ponka, P.7
Semenza, G.L.8
Schumacher, A.9
Prchal, J.T.10
-
369
-
-
0031753986
-
Temporal, spatial, and oxygen-regulated expression of hypoxia-inducible factor-1 in the lung
-
Yu AY, Frid MG, Shimoda LA, Wiener CM, Stenmark K, Semenza GL. Temporal, spatial, and oxygen-regulated expression of hypoxia-inducible factor-1 in the lung. Am J Physiol Lung Cell Mol Physiol 275: L818-L826, 1998.
-
(1998)
Am J Physiol Lung Cell Mol Physiol
, vol.275
-
-
Yu, A.Y.1
Frid, M.G.2
Shimoda, L.A.3
Wiener, C.M.4
Stenmark, K.5
Semenza, G.L.6
-
370
-
-
0033104847
-
Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1α
-
Yu AY, Shimoda LA, Iyer NV, Huso DL, Sun X, McWilliams R, Beaty T, Sham JS, Wiener CM, Sylvester JT, Semenza GL. Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1α.J Clin Invest 103: 691-696, 1999.
-
(1999)
J Clin Invest
, vol.103
, pp. 691-696
-
-
Yu, A.Y.1
Shimoda, L.A.2
Iyer, N.V.3
Huso, D.L.4
Sun, X.5
McWilliams, R.6
Beaty, T.7
Sham, J.S.8
Wiener, C.M.9
Sylvester, J.T.10
Semenza, G.L.11
-
371
-
-
0035859692
-
HIF-1 α binding to VHL is regulated by stimulus-sensitive proline hydroxylation
-
Yu F, White SB, Zhao Q, Lee FS. HIF-1 α binding to VHL is regulated by stimulus-sensitive proline hydroxylation. Proc Natl Acad Sci USA 98: 9630-9635, 2001.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 9630-9635
-
-
Yu, F.1
White, S.B.2
Zhao, Q.3
Lee, F.S.4
-
372
-
-
79960697192
-
Hypoxia-inducible factor 1 mediates increased expression of NADPH oxidase-2 in response to intermittent hypoxia
-
Yuan G, Khan SA, Luo W, Nanduri J, Semenza GL, Prabhakar NR. Hypoxia-inducible factor 1 mediates increased expression of NADPH oxidase-2 in response to intermittent hypoxia. J Cell Physiol 226: 2925-2933, 2011.
-
(2011)
J Cell Physiol
, vol.226
, pp. 2925-2933
-
-
Yuan, G.1
Khan, S.A.2
Luo, W.3
Nanduri, J.4
Semenza, G.L.5
Prabhakar, N.R.6
-
373
-
-
14244256421
-
2+/calmodulin ki-nase-dependent activation of hypoxia inducible factor 1 transcriptional activity in cells subjected to intermittent hypoxia
-
2+/calmodulin ki-nase-dependent activation of hypoxia inducible factor 1 transcriptional activity in cells subjected to intermittent hypoxia. J Biol Chem 280: 4321-4328, 2005.
-
(2005)
J Biol Chem
, vol.280
, pp. 4321-4328
-
-
Yuan, G.1
Nanduri, J.2
Bhasker, C.R.3
Semenza, G.L.4
Prabhakar, N.R.5
-
374
-
-
54049088213
-
2+ signaling, prolyl hydroxylases, and mTOR
-
2+ signaling, prolyl hydroxylases, and mTOR.J Cell Physiol 217: 674-685, 2008.
-
(2008)
J Cell Physiol
, vol.217
, pp. 674-685
-
-
Yuan, G.1
Nanduri, J.2
Khan, S.3
Semenza, G.L.4
Prabhakar, N.R.5
-
376
-
-
0032169214
-
Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1 α/ARNT
-
Zelzer E, Levy Y, Kahana C, Shilo BZ, Rubinstein M, Cohen B. Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1 α/ARNT. EMBOJ 17: 5085-5094, 1998.
-
(1998)
EMBOJ
, vol.17
, pp. 5085-5094
-
-
Zelzer, E.1
Levy, Y.2
Kahana, C.3
Shilo, B.Z.4
Rubinstein, M.5
Cohen, B.6
-
377
-
-
25444437443
-
NADPH oxidase mediates hypersomnolence and brain oxidative injury in a murine model of sleep apnea
-
Zhan G, Serrano F, Fenik P, Hsu R, Kong L, Pratico D, Klann E, Veasey SC. NADPH oxidase mediates hypersomnolence and brain oxidative injury in a murine model of sleep apnea. Am J Respir Crit Care Med 172: 921-929, 2005.
-
(2005)
Am J Respir Crit Care Med
, vol.172
, pp. 921-929
-
-
Zhan, G.1
Serrano, F.2
Fenik, P.3
Hsu, R.4
Kong, L.5
Pratico, D.6
Klann, E.7
Veasey, S.C.8
-
378
-
-
43649104579
-
Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia
-
Zhang H, Bosch-Marce M, Shimoda LA, Tan YS, Baek JH, Wesley JB, Gonzalez FJ, Semenza GL. Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia. J Biol Chem 283: 10892-10903, 2008.
-
(2008)
J Biol Chem
, vol.283
, pp. 10892-10903
-
-
Zhang, H.1
Bosch-Marce, M.2
Shimoda, L.A.3
Tan, Y.S.4
Baek, J.H.5
Wesley, J.B.6
Gonzalez, F.J.7
Semenza, G.L.8
-
379
-
-
58149374576
-
Digoxin and other cardiac glycosides inhibit HIF-1 α synthesis and block tumor growth
-
Zhang H, Qian DZ, Tan YS, Lee K, Gao P, Ren YR, Rey S, Hammers H, Chang D, Pili R, Dang CV, Liu JO, Semenza GL. Digoxin and other cardiac glycosides inhibit HIF-1 α synthesis and block tumor growth. Proc Natl Acad Sci USA 105: 19579-19586, 2008.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 19579-19586
-
-
Zhang, H.1
Qian, D.Z.2
Tan, Y.S.3
Lee, K.4
Gao, P.5
Ren, Y.R.6
Rey, S.7
Hammers, H.8
Chang, D.9
Pili, R.10
Dang, C.V.11
Liu, J.O.12
Semenza, G.L.13
-
380
-
-
77955284188
-
The asparaginyl hydroxylase factor inhibiting HIF-1 α is an essential regulator of metabolism
-
Zhang N, Fu Z, Linke S, Chicher J, Gorman JJ, Visk D, Haddad GG, Poellinger L, Peet DJ, Powell F, Johnson RS. The asparaginyl hydroxylase factor inhibiting HIF-1 α is an essential regulator of metabolism. Cell Metab 11: 364-378, 2010.
-
(2010)
Cell Metab
, vol.11
, pp. 364-378
-
-
Zhang, N.1
Fu, Z.2
Linke, S.3
Chicher, J.4
Gorman, J.J.5
Visk, D.6
Haddad, G.G.7
Poellinger, L.8
Peet, D.J.9
Powell, F.10
Johnson, R.S.11
-
381
-
-
70349774464
-
Role of HIF-1 α in the regulation ACE and ACE2 expression in hypoxic human pulmonary artery smooth muscle cells
-
Zhang R, Wu Y, Zhao M, Liu C, Zhou L, Shen S, Liao S, Yang K, Li Q, Wan H. Role of HIF-1 α in the regulation ACE and ACE2 expression in hypoxic human pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 297: L631-L640, 2009.
-
(2009)
Am J Physiol Lung Cell Mol Physiol
, vol.297
-
-
Zhang, R.1
Wu, Y.2
Zhao, M.3
Liu, C.4
Zhou, L.5
Shen, S.6
Liao, S.7
Yang, K.8
Li, Q.9
Wan, H.10
-
382
-
-
1642443179
-
31P nuclear magnetic resonance spectroscopy and fiber-optic oxygen consumption measurements in perfused rat hearts
-
31P nuclear magnetic resonance spectroscopy and fiber-optic oxygen consumption measurements in perfused rat hearts. Methods Enzymol 381: 735-746, 2004.
-
(2004)
Methods Enzymol
, vol.381
, pp. 735-746
-
-
Zhao, P.1
Zhao, Y.2
Sherry, A.D.3
Pantano, P.4
-
383
-
-
0034654174
-
Modulation of hypoxia-inducible factor 1 α expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: Implications for tumor angiogenesis and therapeutics
-
Zhong H, Chiles K, Feldser D, Laughner E, Hanrahan C, Georgescu MM, Simons JW, Semenza GL. Modulation of hypoxia-inducible factor 1 α expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res 60: 1541-1545,2000.
-
(2000)
Cancer Res
, vol.60
, pp. 1541-1545
-
-
Zhong, H.1
Chiles, K.2
Feldser, D.3
Laughner, E.4
Hanrahan, C.5
Georgescu, M.M.6
Simons, J.W.7
Semenza, G.L.8
|