Pyruvate dehydrogenase complex activity controls metabolic and malignant phenotype in cancer cells

Journal of Biological Chemistry

Volumn 283, Issue 33, 2008, Pages 22700-22708

  McFate, Thomas ^a   Mohyeldin, Ahmed ^a   Lu, Huasheng ^a   Thakar, Jay ^a   Henriques, Jeremy ^a   Halim, Nader D ^a   Wu, Hong ^b   Schell, Michael J ^b   Tsz, Mon Tsang ^c   Teahan, Orla ^c   Zhou, Shaoyu ^d   Califano, Joseph A ^d,e,g   Nam, Ho Jeoung ^f   Harris, Robert A ^f   Verma, Ajay ^a,h  

^a Uniformed Services University of the Health Sciences and the Walter Reed National Military Medical Center   (United States)

^b UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

^d DEPARTMENT OF PATHOLOGY   (United States)

^e GREATER BALTIMORE MEDICAL CENTER   (United States)

^f INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g NONE   (United States)

^h MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CELL GROWTH; CELLS; CHEMICAL REACTIONS; ENZYMES; GLUCOSE; METABOLISM; METABOLITES; MILITARY OPERATIONS; NUCLEIC ACIDS; OXYGEN; PHOSPHORYLATION; RNA; TRANSCRIPTION; TRANSCRIPTION FACTORS; TUMORS;

CANCER CELLS; CANCER THERAPIES; CLINICAL OUTCOMES; GLUCOSE METABOLISMS; GLUCOSE OXIDATIONS; GLYCOLYTIC METABOLITES; HUMAN HEADS; HYPOXIC CELLS; INVASIVENESS; MALIGNANT PHENOTYPES; MALIGNANT PROGRESSIONS; METABOLIC ABNORMALITIES; METABOLIC PHENOTYPES; OXYGEN CONDITIONS; PYRUVATE DEHYDROGENASE COMPLEXES; PYRUVATE DEHYDROGENASE KINASES; PYRUVATE DEHYDROGENASES; REGULATED GENES; SQUAMOUS CELL CARCINOMATA; TUMOR GROWTHS;

ANIMAL CELL CULTURE;

HYPOXIA INDUCIBLE FACTOR 1ALPHA; PYRUVATE DEHYDROGENASE 1; PYRUVATE DEHYDROGENASE ALPHA SUBUNIT; PYRUVATE DEHYDROGENASE COMPLEX; UNCLASSIFIED DRUG; HIF1A PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL; CANCER INHIBITION; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENE; HEAD AND NECK CARCINOMA; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; PDK 1 GENE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SQUAMOUS CELL CARCINOMA; CANCER INVASION; CELL CULTURE; CELL DIVISION; CELL NUCLEUS; CYTOSOL; DRUG ANTAGONISM; ENZYMOLOGY; GLYCOLYSIS; HEAD AND NECK TUMOR; KINETICS; METABOLISM; PATHOLOGY;

CELL DIVISION; CELL NUCLEUS; CELL SURVIVAL; CYTOSOL; GLYCOLYSIS; HEAD AND NECK NEOPLASMS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; KINETICS; NEOPLASM INVASIVENESS; PYRUVATE DEHYDROGENASE COMPLEX; TUMOR CELLS, CULTURED;

EID: 53049087909     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M801765200     Document Type: Article

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