Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1

Nature Medicine

Volumn 10, Issue 8, 2004, Pages 858-864

  Ceradini, Daniel J ^a   Kulkarni, Anita R ^a   Callaghan, Matthew J ^a   Tepper, Oren M ^a   Bastidas, Nicholas ^a   Kleinman, Mark E ^a   Capla, Jennifer M ^a   Galiano, Robert D ^a   Levine, Jamie P ^a   Gurtner, Geoffrey C ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; HYPOXIA INDUCIBLE FACTOR 1; STROMAL CELL DERIVED FACTOR 1;

ARTICLE; CELL ADHESION; CELL HYPOXIA; CELL MIGRATION; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; HUMAN; HUMAN CELL; IN SITU HYBRIDIZATION; ORGANOGENESIS; OXYGEN TISSUE LEVEL; PRIORITY JOURNAL; RECEPTOR BINDING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STEM CELL; TISSUE REPAIR;

ANALYSIS OF VARIANCE; ANIMALS; BONE MARROW; CELL ADHESION; CELL HYPOXIA; CELL MOVEMENT; CHEMOKINES, CXC; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; ENDOTHELIAL CELLS; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION; HYPOXIA-INDUCIBLE FACTOR 1; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IN SITU HYBRIDIZATION; ISCHEMIA; MICE; MICE, NUDE; NUCLEAR PROTEINS; PRECIPITIN TESTS; RECEPTORS, CXCR4; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STEM CELLS; TRANSCRIPTION FACTORS;

EID: 4043184065     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm1075     Document Type: Article

References (30)

1. Peled, A. et al. Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4. Science 283, 845-848 (1999).
2. + cells on vascular endothelium under shear flow. J. Clin. Invest. 104, 1199-1211 (1999).
3. McGrath, K.E., Koniski, A.D., Maltby, K.M., McGann, J.K. & Palis, J. Embryonic expression and function of the chemokine SDF-1 and its receptor, CXCR4. Dev. Biol. 213, 442-456 (1999).
4. + stem cell recruitment to the liver. J. Clin. Invest. 112, 160-169 (2003).
5. Askari, A.T. et al. Effect of stromal-cell-derived factor 1 on stem-cell homing and tissue regeneration in ischaemic cardiomyopathy. Lancet 362, 697-703 (2003).
6. Yamaguchi, J. et al. Stromal cell-derived factor-1 effects on ex vivo expanded endothelial progenitor cell recruitment for ischemic neovascularization. Circulation 107, 1322-1328 (2003).
7. Hitchon, C. et al. Hypoxia-induced production of stromal cell-derived factor 1 (CXCL12) and vascular endothelial growth factor by synovial fibroblasts. Arthritis Rheum. 46, 2587-2597 (2002).
8. Tepper, O.M. et al. Human endothelial progenitor cells from type II diabetics exhibit impaired proliferation, adhesion, and incorporation into vascular structures. Circulation 106, 2781-2786 (2002).
9. Amara, A. et al. Stromal cell-derived factor-1α associates with heparan sulfates through the first β-strand of the chemokine. J. Biol. Chem. 274, 23916-23925 (1999).
10. Semenza, G.L. Targeting HIF-1 for cancer therapy. Nat. Rev. Cancer 3, 721-732 (2003).
11. 2-dependent degradation domain via the ubiquitin-proteasome pathway. Proc. Natl. Acad. Sci. USA 95, 7987-7992 (1998).
12. Forsythe, J.A. et al. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol. Cell. Biol. 16, 4604-4613 (1996).
13. Campbell, J. et al. Chemokines and the arrest of lymphocytes rolling under flow conditions. Science 279, 381-384 (1998).
14. Reiss, K., Mentlein, R., Sievers, J. & Hartmann, D. Stromal cell-derived factor 1 is secreted by meningeal cells and acts as chemotactic factor on neuronal stem cells of the cerebellar external granular layer. Neuroscience 115, 295-305 (2002).
15. Ratajczak, M.Z. et al. Expression of functional CXCR4 by muscle satellite cells and secretion of SDF-1 by muscle-derived fibroblasts is associated with the presence of both muscle progenitors in bone marrow and hematopoietic stem/progenitor cells in muscles. Stem Cells 21, 363-371 (2003).
16. Kawamoto, A. et al. Therapeutic potential of ex vivo expanded endothelial progenitor cells for myocardial ischemia. Circulation 103, 634-637 (2001).
17. Asahara, T. et al. Isolation of putative progenitor endothelial cells for angiogenesis. Science 275, 964-967 (1997).
18. Hill, J.M. et al. Circulating endothelial progenitor cells, vascular function, and cardiovascular risk. N. Engl. J. Med. 348, 593-600 (2003).
19. Signoret, N. et al. Phorbol esters and SDF-1 induce rapid endocytosis and down modulation of the chemokine receptor CXCR4. J. Cell Biol. 139, 651-664 (1997).
20. Sweeney, E., Lortat-Jacob, H., Priestley, G., Nakamoto, B. & Papayannopoulou, T. Sulfated polysaccharides increase plasma levels of SDF-1 in monkeys and mice: involvement in mobilization of stem/progenitor cells, Blood 99, 44-51 (2002).
21. Hattori, K. et al. Plasma elevation of stromal cell-derived factor-1 induces mobilization of mature and immature hematopoietic progenitor and stem cells. Blood 97, 3354-3360 (2001).
22. Nagasawa, T. et al. Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1. Nature 382, 635-638 (1996).
23. Zou, Y., Kottmann, A., Kuroda, M., Taniuchi, I. & Littman, D. Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development. Nature 393, 595-599 (1998).
24. Harrison, J.S., Rameshwar, P., Chang, V. & Bandari, P. Oxygen saturation in the bone marrow of healthy volunteers. Blood 99, 394 (2002).
25. Staller, P. et al. Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL. Nature 425, 307-311 (2003).
26. Elson, D.A. et al. Induction of hypervascularity without leakage or inflammation in transgenic mice overexpressing hypoxia-inducible factor-1α. Genes Dev. 15, 2520-2532 (2001).
27. Rivard, A. et al. Age-dependent defect in vascular endothelial growth factor expression is associated with reduced hypoxia-inducible factor 1 activity. J. Biol. Chem. 275, 29643-29647 (2000).
28. Muller, A. et al. Involvement of chemokine receptors in breast cancer metastasis. Nature 410, 50-56 (2001).
29. Takahashi, T. et al. Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization. Nat. Med. 5, 434-438 (1999).
30. Dimmeler, S. et al. HMG-CoA reductase inhibitors (statins) increase endothelial progenitor cells via the PI 3-kinase/Akt pathway. J. Clin. Invest. 108, 391-397 (2001).