Aryl Hydrocarbon Nuclear Translocator (ARNT) Promotes Oxygen-independent Stabilization of Hypoxia-inducible Factor-1α by Modulating an Hsp90-dependent Regulatory Pathway

Journal of Biological Chemistry

Volumn 279, Issue 16, 2004, Pages 16128-16135

  Isaacs, Jennifer S ^a   Jung, Yun Jin ^a   Neckers, Len ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC HYDROCARBONS; CELLS; COMPLEXATION; DIMERS; SENSITIVITY ANALYSIS; TUMORS;

ARYL HYDROCARBONDS; FUNCTIONAL TRANSCRIPTION; HETERODIMERIC COMPLEX;

BIOCHEMISTRY;

ARYL HYDROCARBON NUCLEAR TRANSLOCATOR; CARRIER PROTEIN; GELDANAMYCIN; HEAT SHOCK PROTEIN 90; HYPOXIA INDUCIBLE FACTOR 1ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING SITE; CONTROLLED STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN STABILITY; REGULATORY MECHANISM; RNA INTERFERENCE; STEADY STATE;

ANIMALS; ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR; BENZOQUINONES; CELL LINE; DNA-BINDING PROTEINS; HSP90 HEAT-SHOCK PROTEINS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LACTAMS, MACROCYCLIC; NUCLEAR PROTEINS; OXYGEN; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; QUINONES; RECEPTORS, ARYL HYDROCARBON; SIGNAL TRANSDUCTION; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; UP-REGULATION;

ANIMALIA;

EID: 1942533543     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M313342200     Document Type: Article

References (33)

1. Iwai, K., Yamanaka, K., Kamura, T., Minato, N., Conaway, R. C., Conaway, J. W., Klausner, R. D., and Pause, A. (1999) Proc. Natl. Acad. Sci. 96, 12436-12441
2. Maxwell, P. H., Wiesener, M. S., Chang, G.-W., Clifford, S. C., Vaux, E. C., Cockman, M. E., Wykoff, C. C., Pugh, C. W., Maher, E. R., and Ratcliffe, P. J. (1999) Nature 399, 271-275
3. Ivan, M., Kondo, K., Yang, H., Kim, W., Valiando, J., Ohh, M., Salic, A., Asara, J. M., Lane, W. S., and Kaelin, W. G. (2001) Science 292, 464-468
4. Jaakkola, P., Mole, D. R., Tian, Y. M., Wilson, M. I., Gielbert, J., Gaskell, S. J., Kriegsheim, A., Hebestreit, H. F., Mukherji, M., Schofield, C. J., Maxwell, P. H., Pugh, C. W., and Ratcliffe, P. J. (2001) Science 292, 468-472
5. Masson, N., Willam, C., Maxwell, P. H., Pugh, C. W., and Ratcliffe, P. J. (2001) EMBO J. 20, 5197-5206
6. Zhong, H., De Marzo, A. M., Laughner, E., Lim, M., Hilton, D. A., Zagzag, D., Buechler, P., Isaacs, W. B., Semenza, G. L., and Simons, J. W. (1999) Cancer Res. 59, 5830-5835
7. Kaelin, W. G., Jr., and Maher, E. R. (1998) Trends Genet. 14, 423-426
8. Wiesener, M. S., Munchenhagen, P. M., Berger, I., Morgan, N. V., Roigas, J., Schwiertz, A., Jurgensen, J. S., Gruber, G., Maxwell, P. H., Loning, S. A., Frei, U., Maher, E. R., Grone, H. J., and Eckardt, K. U. (2001) Cancer Res. 61, 5215-5222
9. Gradin, K., McGuire, J., Wenger, R. H., Kvietikova, I., Whitelaw, M. L., Toftgard, R., Tora, L., Gassmann, M., and Poellinger, L. (1996) Mol. Cell. Biol. 16, 5221-5231
10. Buchner, J. (1999) Trends Biochem. Sci. 24, 136-141
11. Caplan, A. J. (1999) Trends Cell Biol. 9, 262-268
12. Hohfeld, J., Cyr, D. M., and Patterson, C. (2001) EMBO Rep. 2, 885-890
13. Whitesell, L., Mimnaugh, E. G., De Costa, B., Myers, C. E., and Neckers, L. M. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 8324-8328
14. Prodromou, C., Roe, S. M., O'Brien, R., Ladbury, J. E., Piper, P. W., and Pearl, L. H. (1997) Cell 90, 65-75
15. Schneider, C., Sepp-Lorenzino, L., Nimmesgern, E., Ouerfelli, O., Danishefsky, S., Rosen, N., and Hartl, F. U. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 14536-14541
16. Mimnaugh, E. G., Chavany, C., and Neckers, L. (1996) J. Biol. Chem. 271, 22796-22801
17. Maloney, A., and Workman, P. (2002) Expert Opin. Biol. Ther. 2, 3-24
18. Isaacs, J. S., Xu, W., and Neckers, L. (2003) Cancer Cell 3, 213-217
19. Isaacs, J. S., Jung, Y. J., Mimnaugh, E. G., Martinez, A., Cuttitta, F., and Neckers, L. M. (2002) J. Biol. Chem. 277, 29936-29944
20. McGuire, J., Coumailleau, P., Whitelaw, M. L., Gustafsson, J. A., and Poellinger, L. (1996) J. Biol. Chem. 270, 31353-31357
21. Antonsson, C., Whitelaw, M. L., McGuire, J., Gustafsson, J. A., and Poellinger, L. (1995) Mol. Cell. Biol. 15, 756-765
22. Fukunaga, B. N., Probst, M. R., Reisz-Porszasz, S., and Hankinson, O. (1995) J. Biol. Chem. 270, 29270-29278
23. Vos, M. D., Ellis, C. A., Bell, A., Birrer, M. J., and Clark, G. J. (2000) J. Biol. Chem. 275, 35669-35672
24. Minet, E., Mottet, D., Michel, G., Roland, I., Raes, M., Remacle, J., and Michiels, C. (1999) FEBS Lett. 460, 251-256
25. Hirose, K., Morita, M., Ema, M., Mimura, J., Hamada, H., Fujii, H., Saijo, Y., Gotoh, O., Sogawa, K., and Fujii-Kuriyama, Y. (1996) Mol. Cell. Biol. 16, 1706-1713
26. Maltepe, E., Keith, B., Arsham, A. M., Brorson, J. R., and Simon, M. C. (2000) Biochem. Biophys. Res. Commun. 273, 231-238
27. Cowden, K. D., and Simon, M. C. (2002) Biochem. Biophys. Res. Commun. 290, 1228-1236
28. Takahata, S., Sogawa, K., Kobayashi, A., Ema, M., Mimura, J., Ozaki, N., and Fujii-Kuriyama, Y. (1998) Biochem. Biophys. Res. Commun. 248, 789-794
29. Hogenesch, J. B., Gu, Y. Z., Jain, S., and Bradfield, C. A. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 5474-5479
30. Lees, M. J., and Whitelaw, M. L. (1999) Mol. Cell. Biol. 19, 5811-5822
31. Jiang, B. H., Rue, E., Wang, G. L., Roe, R., and Semenza, G. L. (1996) J. Biol. Chem. 271, 17771-17778
32. Mabjeesh, N. J., Post, D. E., Willard, M. T., Kaur, B., Van Meir, E. G., Simons, J. W., and Zhong, H. (2002) Cancer Res. 62, 2478-2482
33. Hogenesch, J. B., Chan, W. K., Jackiw, V. H., Brown, R. C., Gu, Y. Z., Pray-Grant, M., Perdew, G. H., and Bradfield, C. A. (1997) J. Biol. Chem. 272, 8581-8593