Downregulation of a tumor suppressor RECK by hypoxia through recruitment of HDAC1 and HIF-1α to reverse HRE site in the promoter

Biochimica et Biophysica Acta - Molecular Cell Research

Volumn 1803, Issue 5, 2010, Pages 608-616

  Lee, Kyung Ju ^a   Lee, Kwang Youl ^b   Lee, You Mie ^a  

^a Kyungpook National University   (South Korea)

^b Chonnam National University   (South Korea)

Author keywords

HDAC1; HIF 1 ; Hypoxia; RECK; Reverse HRE; Tumor suppressor silencing

Indexed keywords

1 BENZYL 3 (5 HYDROXYMETHYL 2 FURYL)INDAZOLE; HISTONE DEACETYLASE 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA RESPONSIVE ELEMENT; RECOMBINANT HYPOXIA RESPONSIVE ELEMENT 2; REVERSION INDUCING CYSTEINE RICH PROTEIN WITH KAZAL MOTIF PROTEIN; TRICHOSTATIN A; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BREAST CANCER; CANCER CELL; CANCER INVASION; CELL MIGRATION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DELETION MUTANT; DOWN REGULATION; GENE EXPRESSION REGULATION; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HYPOXIA; KNOCKOUT GENE; MOUSE; NONHUMAN; PRECIPITATION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN SECRETION; PROTEIN SYNTHESIS INHIBITION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANIMALS; ANOXIA; BLOTTING, WESTERN; CELLS, CULTURED; CHROMATIN IMMUNOPRECIPITATION; DOWN-REGULATION; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION; GENES, TUMOR SUPPRESSOR; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE INHIBITORS; HUMANS; HYDROXAMIC ACIDS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IMMUNOPRECIPITATION; KIDNEY; LUCIFERASES; MEMBRANE GLYCOPROTEINS; MICE; PROMOTER REGIONS, GENETIC; RESPONSE ELEMENTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 77951938407     PISSN: 01674889     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbamcr.2010.01.004     Document Type: Article

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