Hypoxia inducible factor 1 mediates hypoxia-induced TRPC expression and elevated intracellular Ca 2+ in pulmonary arterial smooth muscle cells

Circulation Research

Volumn 98, Issue 12, 2006, Pages 1528-1537

  Wang, Jian ^a,b   Weigand, Letitia ^a,b   Lu, Wenju ^a,b   Sylvester, J T ^a,b   Semenza, Gregg L ^a,b   Shimoda, Larissa A ^a,b  

^a Institute for Cell Engineering   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Ca 2+ channels; Hypoxia; Hypoxia inducible factor 1; Hypoxic pulmonary vasoconstriction; Vascular smooth muscle

Indexed keywords

1 [2 (4 METHOXYPHENYL) 2 [3 (4 METHOXYPHENYL)PROPOXY]ETHYL] 1H IMIDAZOLE; CALCIUM CHANNEL; CALCIUM CHANNEL L TYPE; HYPOXIA INDUCIBLE FACTOR 1; MESSENGER RNA; PROTEIN; STORE OPERATED CALCIUM CHANNEL; TRANSIENT RECEPTOR POTENTIAL CHANNEL; TRANSIENT RECEPTOR POTENTIAL CHANNEL 1; TRANSIENT RECEPTOR POTENTIAL CHANNEL 4; TRANSIENT RECEPTOR POTENTIAL CHANNEL 6; UNCLASSIFIED DRUG; CALCIUM; CALCIUM CHANNEL BLOCKING AGENT; TRANSIENT RECEPTOR POTENTIAL CHANNEL C; TRANSIENT RECEPTOR POTENTIAL CHANNEL RELATED PROTEIN 1; TRANSIENT RECEPTOR POTENTIAL CHANNEL-RELATED PROTEIN 1; TRPC6 PROTEIN, HUMAN;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL CULTURE; CONTROLLED STUDY; EXTRACELLULAR CALCIUM; HYPOXIA; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PULMONARY ARTERY; PULMONARY HYPERTENSION; RAT; REGULATORY MECHANISM; SMOOTH MUSCLE FIBER; WILD TYPE; ANIMAL; ANOXIA; CHRONIC DISEASE; DRUG EFFECT; IN VITRO STUDY; INTRACELLULAR MEMBRANE; METABOLISM; OSMOLARITY; VASOCONSTRICTION;

ANIMALS; ANOXIA; CALCIUM; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; CELLS, CULTURED; CHRONIC DISEASE; HYPOXIA-INDUCIBLE FACTOR 1; INTRACELLULAR MEMBRANES; MICE; MYOCYTES, SMOOTH MUSCLE; OSMOLAR CONCENTRATION; PULMONARY ARTERY; RATS; TRPC CATION CHANNELS; VASOCONSTRICTION;

EID: 33746543743     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000227551.68124.98     Document Type: Article

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