Role of oxidants in NF-κB activation and TNF-α gene transcription induced by hypoxia and endotoxin

Journal of Immunology

Volumn 165, Issue 2, 2000, Pages 1013-1021

  Chandel, Navdeep S ^a,b   Trzyna, Wendy C ^a   McClintock, David S ^a   Schumacker, Paul T ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ENDOTOXIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; REACTIVE OXYGEN METABOLITE; ROTENONE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; GENETIC TRANSCRIPTION; HYPOXIA; MACROPHAGE; MITOCHONDRION; MOUSE; MULTIPLE ORGAN FAILURE; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM;

EID: 0034661990     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.165.2.1013     Document Type: Article

References (48)

1. Bone, R. C., R. A. Balk, F. B. Cerra, R. P. Dellinger, A. M. Fein, W. A. Knaus, R. M. Schein, and W. J. Sibbald. 1992. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Chest 101:1644.
2. Beal, A. L., and F. B. Cerra. 1994. Multiple organ failure syndrome in the 1990s: systemic inflammatory response and organ dysfunction. JAMA 271:226.
3. Parrillo, J. E. Pathogenetic mechanisms of septic shock. 1993. N. Engl. J. Med. 328:1471.
4. Bone, R. C. The pathogenesis of sepsis. 1991. Ann. Intern. Med. 115:457.
5. Natanson, C., R. L. Danner, R. J. Elin, J. M. Hosseini, K.W. Peart, S. M. Banks, T. J. MacVittie, R. I. Walker, and I. E. Parrillo. 1989. Role of endotoxemia in cardiovascular dysfunction and mortality: Escherichia coli and Staphylococcus aureus challenges in a canine model of human septic shock. J. Clin. Invest. 83:243.
6. Wright, S. D., R. A. Ramos, P. S. Tobias, R. J. Ulevitch, and J. C. Mathison. 1990. CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science 249:1431.
7. Gallay, P., D. Heumann, D. Le Roy, C. Barras, and M. P. Glauser. 1994. Mode of action of anti-lipopolysaccharide-binding protein antibodies for prevention of endotoxemic shock in mice. Proc. Natl. Acad. Sci. USA 91:7922.
8. Goeddel, D. V. 1999. Signal transduction by tumor necrosis factor: the Parker B. Francis Lectureship. Chest 116:69.
9. Natanson, C., P. W. Eichenholz, R. L. Danner, P. Q. Eichacker, W. D. Hoffman, G. C. Kuo, S. M. Banks, T. J. MacVittie, and J. E. Parrillo. 1989. Endotoxin and tumor necrosis factor challenges in dogs simulate the cardiovascular profile of human septic shock. J. Exp. Med. 169:823.
10. Marino, M. W., A. Dunn, D. Grail, M. Inglese, Y. Noguchi, E. Richards, A. Jungbluth, H. Wada, M. Moore, B. Williamson, S. Basu, and L. J. Old. 1997. Characterization of tumor necrosis factor-deficient mice. Proc. Natl. Acad. Sci. USA 94:8093.
11. Barnes, P. J., and M. Karin. 1997. Nuclear factor-κB: a pivotal transcription factor in chronic inflammatory diseases. N. Engl. J. Med. 336:1066.
12. Ghezzi, P., C. A. Dinarello, M. Bianchi, M. E Rosandich, J. E. Repine, and C. W. White. 1991. Hypoxia increases production of interleukin-1 and tumor necrosis factor by human mononuclear cells. Cylokine 3:189.
13. West, M. A., and C. Wilson. 1996. Hypoxic alterations in cellular signal transduction in shock and sepsis. New Horiz. 4:168.
14. S. L. Hempel, M. M. Monick, and G. W. Hunninghake. 1996. Effect of hypoxia on release of IL-1 and TNFα by human alveolar macrophages. Am. J. Respir. Cell Mol. Biol. 14:170.
15. Ghosh, S., M. J. May, and E. B. Kopp. 1998. NF-B and Rel proteins: evolutionarily conserved mediators of immune responses. Annu. Rev. Immunol. 16:225.
16. Leeper-Woodford, S. K., and K. Detmer. 1999. Acute hypoxia increases alveolar macrophage tumor necrosis factor activity and alters NF-κB expression. Am. J. Physiol. 276.-L909.
17. Koong, A. C., E. Y Chen, and A. J. Giaccia. 1994. Hypoxia causes the activation of nuclear factor KB through the phosphorylation of IicBa on tyrosine residues. Cancer Res. 54:1425.
18. Matsui, H., Y. Ihara, Y. Fujio, K. Kunisada, S. Akira, T. Kishimoto, and K. Yamauchi-Takihara. 1999. Induction of interleukin (IL)-6 by hypoxia is mediated by nuclear factor (NF)-κB and NF-IL6 in cardiac myocytes. Cardiovasc. Res. 42:104.
19. Gozal, E., N. Simakajornboon, and D. Gozal. 1998. NF-κB induction during in vivo hypoxia in dorsocaudal brain stem of rat: effect of MK-801 and L-NAME. J. Appl. Physiol. 85:372.
20. Taylor, C. T., N. Fueki, A. Agah, R. M. Hershberg, and S. P. Colgan. 1999. Critical role of cAMP response element binding protein expression in hypoxia-elicited induction of epithelial tumor necrosis factor-α. J. Biol. Chem. 274:19447.
21. Baeuerle, P. A., and D. Baltimore. 1996 NF-κB: ten years after. Cell 87:13.
22. Verma, I. M., J. K. Stevenson, E. M. Schwarz, D. Van Antwerp, and S. Miyamoto. 1995. Rel/NF-κB/IκB family: intimate tales of association and dissociation. Genes Dev. 9:2723.
23. Stancovski, I., and D. Baltimore. 1997. NF-κB activation: the IκB kinase revealed? Cell 91:299.
24. Schreck, R., P. Rieber, and P. A. Baeuerle. 1991. Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-κB transcription factor and HIV-I. EMBO J. 10:2247.
25. Sen, C. K., and L. Packer. 1996. Antioxidant and redox regulation of gene transcription. FASEB J. 10:709.
26. Muraoka, K., K. Shimizu, X. Sun, Y. K. Zhang, T. Tani, T. Hashimoto, M. Yagi, I. Miyazaki, and K. Yamamoto. 1997. Hypoxia, but not reoxygenation, induces interleukin 6 gene expression through NF-κB activation. Transplantation 63:466.
27. Ginn-Pease, M. E., and R. L. Whisler. 1998. Redox signals and NF-κB activation in T cells. Free Radic. Biol. Med. 25:346.
28. Chandel, N. S., E. Maltepe, E. Goldwasser, C. E. Mathieu, M. C. Simon, and P. T. Schumacker. 1998. Mitochondrial reactive oxygen species trigger hypoxiainduced transcription. Proc. Natl. Acad. Sci. USA 95:11715.
29. 2+ dependence, and differential half-site recognition. J. Biol. Chem. 266:252.
30. Fransen, L., R. Mueller, A. Marmenout, J. Tavernier, J. Van der Heyden, E. Kawashima, A. Chollet, R. Tizard, H. van Heuverswyn, A. van Vliet, M. R. Ruysschaert, and W. Fiers. 1985. Molecular cloning of mouse tumour necrosis factor cDNA and its eukaryotic expression. Nucleic Adds Res.13:4417.
31. Pattanaik, U., and K. Prasad. 1996. Endotoxemia and oxidative stress. Ann. NY Acad. Sci. 793:506.
32. Bass, D. A., J. W. Parce, L. R. Dechatelet, P. Szejda, M. C. Seeds, and M. Thomas. 1983. J. Immunol. 130:1910.
33. Tiku, M. L., J. B. Liesch, and F. M. Robertson. 1990. Production of hydrogen peroxide by rabbit articular chondrocytes. Enhancement by cytokines. J. Immunol. 145:690.
34. Li, Y., and M. A. Trush. 1998. Diphenyleneiodonium, an NAD(P)H oxidase inhibitor, also potently inhibits mitochondrial reactive oxygen species production. Biochem. Biophys. Res. Commun. 253:295.
35. Majander, A., M. Finel, and M. Wikstrom. 1994. Diphenyleneiodonium inhibits reduction of iron-sulfur clusters in the mitochondrial NADH-ubiquinone oxidoreductase (complex I). J. Biol. Chem. 269:21037.
36. Carter, W. O., P. K. Narayanan, and J. P. Robinson. 1994. Intracellular hydrogen peroxide and superoxide anion detection in endothelial cells. J. Leukocyte Biol. 55:253.
37. Schreck, R., B. Meier, D. N. Mannel, W. Droge, and P. A. Baeuerle. 1992 Dithiocarbamates as potent inhibitors of nuclear factor κB activation in intact cells. J. Exp. Med. 175:1181.
38. Ziegler-Heitbrock, H. W., T. Sternsdorf, J. Liese, B. Belohradsky, C. Weber, A. Wedel, R. Schreck, P. A. Bauerle, and M. Strobel. 1993. Pyrrolidine dithiocarbamate inhibits NF-κB mobilization and TNFα production in human monocytes. J. Immunol. 151:6986.
39. Muller, J. M., H. W. Ziegler-Heitbrock, and P. A. Baeuerle. 1993. Nuclear factor κB, a mediator of lipopolysaccharide effects. Immunobiology 187:233.
40. Han, J., J. D. Lee, L. Bibbs, and R. J. Ulevitch. 1994. A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science 265:808.
41. Schreck, R., K. Albermann, and P. A. Baeuerle. 1992. Nuclear factor κB: an oxidative stress-responsive transcription factor of eukaryotic cells. Free Radic. Res. Commun. 17:221.
42. Li, N., and M. Karin. 1999. Is NF-κB the sensor of oxidative stress? FASEB J. 13:1137.
43. 2 and antioxidants have opposite effects on activation of NF-κB and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor. EMBO J. 12:2005.
44. Blackwell, T. S., T. R. Blackwell, E. P. Holden, B. W. Christman, and J. W. Christman. 1996. In vivo antioxidant treatment suppresses nuclear factor-κB activation and neutrophilic lung inflammation. J. Immunol. 157:1630.
45. Suter, P. M., G. Domenighetti, M. D. Schaller, M. C. Laverriere, R. Ritz, and C. Perret. 1994. N-Acetylcysteine enhances recovery from acute lung injury in man: a randomized, double-blind, placebo-controlled clinical study. Chest 105:190.
46. Jepsen, S., P. Herlevsen, P. Knudsen, M. I. Bud, and N. O. Klausen. 1992. Antioxidant treatment with N-acetylcysteine during adult respiratory distress syndrome: a prospective, randomized, placebo-controlled study. Crit. Care Med. 20:918.
47. Camhi, S. L., J. Alam, G. W. Wiegand, B. Y. Chin, and A. M. Choi. 1998. Transcriptional activation of the HO-1 gene by lipopolysaccharide is mediated by 5′ distal enhancers: role of reactive oxygen intermediates and AP-1, Am. J. Respir. Cell Mol. Biol. 18:226.
48. K. Schulze-Osthoff, R. Beyaert, V. Vandevoorde, G. Haegeman, and W. Fiers. 1993. Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene-inductive effects of TNFα. EMBO J. 12:3095.