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Volumn 399, Issue 6733, 1999, Pages 271-275

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; UNCLASSIFIED DRUG; VON HIPPEL LINDAU PROTEIN;

EID: 0033587146     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/20459     Document Type: Article
Times cited : (4375)

References (30)
  • 2
    • 0029842459 scopus 로고    scopus 로고
    • Oxygen sensing and molecular adaptation to hypoxia
    • Bunn, H. F. & Poyton, R. O. Oxygen sensing and molecular adaptation to hypoxia. Physiol. Rev. 76, 839-885 (1996).
    • (1996) Physiol. Rev. , vol.76 , pp. 839-885
    • Bunn, H.F.1    Poyton, R.O.2
  • 3
    • 0032581277 scopus 로고    scopus 로고
    • Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
    • Carmeliet, P. et al. Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature 394, 485-90 (1998).
    • (1998) Nature , vol.394 , pp. 485-490
    • Carmeliet, P.1
  • 4
    • 0032568150 scopus 로고    scopus 로고
    • Stabilization of wild-type p53 by hypoxia-inducible factor 1α
    • An, W.G. et al. Stabilization of wild-type p53 by hypoxia-inducible factor 1α. Nature 392, 405-408 (1998).
    • (1998) Nature , vol.392 , pp. 405-408
    • An, W.G.1
  • 5
    • 0032493368 scopus 로고    scopus 로고
    • Regulation of hypoxia-inducible factor 1α is mediated by an oxygen-dependent domain via the ubiquitin-proteazome pathway
    • Huang, L. E., Gu, J., Schau, M. & Bunn, H. F. Regulation of hypoxia-inducible factor 1α is mediated by an oxygen-dependent domain via the ubiquitin-proteazome pathway. Proc. Natl Acad. Sci. USA 95, 7987-7992 (1998).
    • (1998) Proc. Natl Acad. Sci. USA , vol.95 , pp. 7987-7992
    • Huang, L.E.1    Gu, J.2    Schau, M.3    Bunn, H.F.4
  • 6
    • 0024273450 scopus 로고
    • Regulation of the erythropoietin gene: Evidence that the oxygen sensor is a heme protein
    • Goldberg, M. A., Dunning, S. P. & Bunn, H. F. Regulation of the erythropoietin gene: evidence that the oxygen sensor is a heme protein. Science 242, 1412-1415 (1988).
    • (1988) Science , vol.242 , pp. 1412-1415
    • Goldberg, M.A.1    Dunning, S.P.2    Bunn, H.F.3
  • 7
    • 0027136260 scopus 로고
    • Desferrioxamine induces erythropoietin gene expression and hypoxia-inducible factor 1 DNA-binding activity: Implications for models of hypoxia signal transduction
    • Wang, G. L. & Semenza, G. L. Desferrioxamine induces erythropoietin gene expression and hypoxia-inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction. Blood 82, 3610-3615 (1993).
    • (1993) Blood , vol.82 , pp. 3610-3615
    • Wang, G.L.1    Semenza, G.L.2
  • 9
    • 0030576517 scopus 로고    scopus 로고
    • Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
    • Hanahan, D. & Folkman, J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 86, 353-364 (1996).
    • (1996) Cell , vol.86 , pp. 353-364
    • Hanahan, D.1    Folkman, J.2
  • 10
    • 0026485002 scopus 로고
    • Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
    • Shweiki, D., Itin, A., Soffer, D. & Keshet, E. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 359, 843-845 (1992).
    • (1992) Nature , vol.359 , pp. 843-845
    • Shweiki, D.1    Itin, A.2    Soffer, D.3    Keshet, E.4
  • 11
    • 0345164318 scopus 로고    scopus 로고
    • The VHL tumour-suppressor gene paradigm
    • Kaelin, W. G. & Maher, E. R. The VHL tumour-suppressor gene paradigm. Trends Genet. 14, 423-426 (1998).
    • (1998) Trends Genet. , vol.14 , pp. 423-426
    • Kaelin, W.G.1    Maher, E.R.2
  • 12
    • 0029785838 scopus 로고    scopus 로고
    • Post-transcriptional regulation of vascular endothelial growth factor mRNA by the product of the VHL tumor suppressor gene
    • Gnarra, J. R. et al. Post-transcriptional regulation of vascular endothelial growth factor mRNA by the product of the VHL tumor suppressor gene. Proc. Natl Acad. Sci. USA 93, 10589-10594 (1996).
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 10589-10594
    • Gnarra, J.R.1
  • 14
    • 0033079597 scopus 로고    scopus 로고
    • Oncogenic alterations of metabolism
    • Dang, C. V. & Semenza, G. L. Oncogenic alterations of metabolism. Trends Biochem. Sci. 24, 68-72 (1999).
    • (1999) Trends Biochem. Sci. , vol.24 , pp. 68-72
    • Dang, C.V.1    Semenza, G.L.2
  • 15
    • 0029753008 scopus 로고    scopus 로고
    • Activation of hypoxia-inducible transcription factor depends primarily on redox-sensitive stabilization of its α subunit
    • Huang, L. E., Arany, Z., Livingston, D. M. & Bunn, H. F. Activation of hypoxia-inducible transcription factor depends primarily on redox-sensitive stabilization of its α subunit. J. Biol. Chem. 271, 32253-32259 (1996).
    • (1996) J. Biol. Chem. , vol.271 , pp. 32253-32259
    • Huang, L.E.1    Arany, Z.2    Livingston, D.M.3    Bunn, H.F.4
  • 16
    • 0032189844 scopus 로고    scopus 로고
    • Induction of endothelial PAS domain protein-1 by hypoxia: Characterization and comparison with hypoxia-inducible factor-1α
    • Wiesener, M. S. et al. Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1α. Blood 92, 2260-2268 (1998).
    • (1998) Blood , vol.92 , pp. 2260-2268
    • Wiesener, M.S.1
  • 17
    • 0029090338 scopus 로고
    • Tumour supression by the human von Hippel-Lindau gene product
    • Iliopoulos, O., Kibel, A., Gray, S. & Kaelin, W. G. Jr Tumour supression by the human von Hippel-Lindau gene product. Nature Med. 1, 822-826 (1995).
    • (1995) Nature Med. , vol.1 , pp. 822-826
    • Iliopoulos, O.1    Kibel, A.2    Gray, S.3    Kaelin W.G., Jr.4
  • 18
    • 0030961006 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1α (HIP-1α) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions
    • Salceda, S. & Caro, J. Hypoxia-inducible factor 1α (HIP-1α) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. J. Biol. Chem. 272, 22642-22647 (1997).
    • (1997) J. Biol. Chem. , vol.272 , pp. 22642-22647
    • Salceda, S.1    Caro, J.2
  • 19
    • 0030953635 scopus 로고    scopus 로고
    • The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins
    • Pause, A. et al. the von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins. Proc. Natl Acad. Sci. USA 94, 2156-2161 (1997).
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , pp. 2156-2161
    • Pause, A.1
  • 20
    • 0031907152 scopus 로고    scopus 로고
    • Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2
    • Lonergan, K. M. et al. Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2. Mol. Cell Biol. 18, 732-741 (1998).
    • (1998) Mol. Cell Biol. , vol.18 , pp. 732-741
    • Lonergan, K.M.1
  • 21
    • 0030816109 scopus 로고    scopus 로고
    • Hypoxia inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth
    • Maxwell, P. H. et al. Hypoxia inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth. Proc. Natl Acad. Sci. USA 94, 8104-8109 (1997).
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , pp. 8104-8109
    • Maxwell, P.H.1
  • 22
    • 0032169214 scopus 로고    scopus 로고
    • Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1α/ARNT
    • Zelzer, E. et al. Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1α/ARNT. EMBO J. 17, 5083-3094 (1998).
    • (1998) EMBO J. , vol.17 , pp. 5083-13094
    • Zelzer, E.1
  • 23
    • 0029126892 scopus 로고
    • Inhibition of transcription elongation by the VHL tumor suppressor protein
    • Duan, D. R. et al. Inhibition of transcription elongation by the VHL tumor suppressor protein. Science 269, 1402-1406 (1995).
    • (1995) Science , vol.269 , pp. 1402-1406
    • Duan, D.R.1
  • 24
    • 0032085240 scopus 로고    scopus 로고
    • The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix
    • Ohh, M. et al. The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix. Mol. Cell 1, 959-968 (1998).
    • (1998) Mol. Cell , vol.1 , pp. 959-968
    • Ohh, M.1
  • 25
    • 0032478823 scopus 로고    scopus 로고
    • Selection and analysis of a mutant cell line defective in the hypoxia-inducible factor-1 α-subunit (HIF-1α)
    • Wood, S. M. et al. Selection and analysis of a mutant cell line defective in the hypoxia-inducible factor-1 α-subunit (HIF-1α). J. Biol. Chem. 273, 8360-8368 (1998).
    • (1998) J. Biol. Chem. , vol.273 , pp. 8360-8368
    • Wood, S.M.1
  • 26
    • 0027970536 scopus 로고
    • Role of hydrogen peroxide in hypoxia-induced erythropoietin production
    • Fandrey, J., Frede, S. & Jelkmann, W. Role of hydrogen peroxide in hypoxia-induced erythropoietin production. Biochem. J. 303, 507-510 (1994).
    • (1994) Biochem. J. , vol.303 , pp. 507-510
    • Fandrey, J.1    Frede, S.2    Jelkmann, W.3
  • 27
    • 0032574765 scopus 로고    scopus 로고
    • Iron-dependent oxidation, ubiquitination, and degradation of iron regulatory protein 2: Implications for degradation of oxidized proteins
    • Iwai, K. et al. Iron-dependent oxidation, ubiquitination, and degradation of iron regulatory protein 2: implications for degradation of oxidized proteins. Proc. Natl Acad. Sci. USA 95, 4924-4928 (1998).
    • (1998) Proc. Natl Acad. Sci. USA , vol.95 , pp. 4924-4928
    • Iwai, K.1
  • 28
    • 0029994507 scopus 로고    scopus 로고
    • Effects of transition metals on the expression of the erythropoietin gene: Further evidence that the oxygen sensor is a heme protein
    • Ho, V. T. & Bunn, H. F. Effects of transition metals on the expression of the erythropoietin gene: further evidence that the oxygen sensor is a heme protein. Biochem. Biophys. Res. Commun. 223, 175-180 (1996).
    • (1996) Biochem. Biophys. Res. Commun. , vol.223 , pp. 175-180
    • Ho, V.T.1    Bunn, H.F.2
  • 29
    • 0032578458 scopus 로고    scopus 로고
    • Mitochondrial reactive oxygen species trigger hypoxia-induced transcription
    • Chandel, N. S. et al. Mitochondrial reactive oxygen species trigger hypoxia-induced transcription. Proc. Natl Acad. Sci. USA 95, 11715-11720 (1998).
    • (1998) Proc. Natl Acad. Sci. USA , vol.95 , pp. 11715-11720
    • Chandel, N.S.1
  • 30
    • 0027954044 scopus 로고
    • Mutations of the VHL tumour suppressor gene in renal carcinoma
    • Gnarra, J. R. et al. Mutations of the VHL tumour suppressor gene in renal carcinoma. Nature Genet. 7, 85-90 (1994).
    • (1994) Nature Genet. , vol.7 , pp. 85-90
    • Gnarra, J.R.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.