The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

Nature

Volumn 399, Issue 6733, 1999, Pages 271-275

  Maxwell, Patrick H ^a   Wlesener, Michael S ^a   Chang, Gin Wen ^a   Clifford, Steven C ^b   Vaux, Emma C ^c   Cockman, Matthew E ^c   Wykoff, Charles C ^c   Pugh, Christopher W ^c   Maher, Eamonn R ^b   Ratcliffe, Peter J ^a,c  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^c JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; UNCLASSIFIED DRUG; VON HIPPEL LINDAU PROTEIN;

ANGIOGENESIS; APOPTOSIS; ARTICLE; CELL HYPOXIA; CELL LINE; COMPLEX FORMATION; CONTROLLED STUDY; GENE CONTROL; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; IRON CHELATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; TUMOR SUPPRESSOR GENE; VON HIPPEL LINDAU DISEASE;

CELL HYPOXIA; COBALT; CYSTEINE ENDOPEPTIDASES; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; GENES, TUMOR SUPPRESSOR; HELA CELLS; HIPPEL-LINDAU DISEASE; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IRON CHELATING AGENTS; LIGASES; MULTIENZYME COMPLEXES; NEOVASCULARIZATION, PATHOLOGIC; NUCLEAR PROTEINS; OXYGEN; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BINDING; PROTEINS; RESPONSE ELEMENTS; TRANSCRIPTION FACTORS; TRANSFECTION; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEINS; UBIQUITIN-PROTEIN LIGASES; VON HIPPEL-LINDAU TUMOR SUPPRESSOR PROTEIN;

EID: 0033587146     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/20459     Document Type: Article

References (30)

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