Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: Possible links between cell metabolism and stabilization of HIF

Journal of Biological Chemistry

Volumn 282, Issue 7, 2007, Pages 4524-4532

  Koivunen, Peppi ^a   Hirsilä, Maija ^a   Remes, Anne M ^a   Hassinen, Ilmo E ^a   Kivirikko, Kari I ^a   Myllyharju, Johanna ^a  

^a UNIVERSITY OF OULU   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

CELL METABOLISM; HYDROXYLASES; HYPOXIA INDUCIBLE FACTORS (HIFS); TRANSCRIPTIONAL ACTIVITY;

CATALYSIS; CITRIC ACID; ENZYME INHIBITION; METABOLISM; OXYGEN; PURIFICATION;

ENZYME KINETICS;

CITRIC ACID; ENZYME INHIBITOR; ERYTHROPOIETIN; ESTER; FUMARATE DIETHYL ESTER; FUMARATE HYDRATASE; FUMARIC ACID; FUMARIC ACID DIMETHYL ESTER; FUMARIC ACID ETHYL ESTER; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR ASPARAGINYL HYDROXYLASE; HYPOXIA INDUCIBLE FACTOR PROLYL 4 HYDROXYLASE; OXALOACETIC ACID; OXYGENASE; SMALL INTERFERING RNA; SUCCINIC ACID; UNCLASSIFIED DRUG; VASCULOTROPIN; ASPARTIC ACID 2 OXOGLUTARATE DEPENDENT DIOXYGENASE; ASPARTIC ACID 2-OXOGLUTARATE-DEPENDENT DIOXYGENASE; HIF1A PROTEIN, HUMAN; HISTONE ACETYLTRANSFERASE PCAF; MIXED FUNCTION OXIDASE; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; SUCCINATE DEHYDROGENASE; VASCULOTROPIN A;

ARTICLE; CARCINOGENESIS; CELL CULTURE; CELL METABOLISM; CITRIC ACID CYCLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME DEFICIENCY; ENZYME INHIBITION; FIBROBLAST; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN STABILITY; TRANSCRIPTION REGULATION; BIOSYNTHESIS; CELL LINE; CHEMISTRY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; NEOPLASM; PATHOLOGY;

CELL LINE; CITRIC ACID CYCLE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; ERYTHROPOIETIN; FIBROBLASTS; FUMARATE HYDRATASE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MIXED FUNCTION OXYGENASES; NEOPLASMS; P300-CBP TRANSCRIPTION FACTORS; PROCOLLAGEN-PROLINE DIOXYGENASE; SUCCINATE DEHYDROGENASE; TRANSCRIPTION, GENETIC; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 33947520506     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M610415200     Document Type: Article

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