Chemoreflexes - Physiology and clinical implications

Acta Physiologica Scandinavica

Volumn 177, Issue 3, 2003, Pages 377-384

  Kara, T ^a   Narkiewicz, K ^a   Somers, V K ^a  

^a MAYO CLINIC   (United States)

Author keywords

Apnoea; Blood pressure; Heart failure; Heart rate; Hypertension

Indexed keywords

ADRENERGIC SYSTEM; CAROTID BODY CHEMORECEPTOR; CHEMORECEPTOR REFLEX; CONFERENCE PAPER; HEART FAILURE; HUMAN; HYPERBARIC OXYGEN; HYPERCAPNIA; HYPERTENSION; HYPERVENTILATION; HYPOXEMIA; HYPOXIA; OBESITY; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; SLEEP APNEA SYNDROME; SYMPATHETIC TONE;

ANOXEMIA; BLOOD PRESSURE; CAROTID BODY; CHEMORECEPTORS; ELECTROCARDIOGRAPHY; HEART FAILURE, CONGESTIVE; HEART RATE; HUMANS; HYPERCAPNIA; HYPERTENSION; MUSCLES; OXYGEN; REFLEX; SLEEP APNEA, OBSTRUCTIVE; SYMPATHETIC NERVOUS SYSTEM;

EID: 0037342849     PISSN: 00016772     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-201X.2003.01083.x     Document Type: Conference Paper

References (51)

1. Abboud, F.M., Heistad, D.D., Mark, A.I. & Schmid, P.G. 1975. Differential responses of the coronary circulation and other vascular beds to chemoreceptor stimulation. In: M.J. Purves (ed.) The peripheral arterial chemoreceptors, pp. 427-447. Cambridge University Press, London.
2. Angell-James, J.E. & Daly, M. 1975. Some aspects of upper respiratory tract reflexes. Acta Otolaryngol (stockh) 79, 242.
3. Berger, A.J., Mitchell, R.A. & Severinghaus, J.W. 1977. Regulation of respiration. N Engl J Med 297, 92-97.
4. Calvelo, M.G., Abboud, F.M., Ballard, D.R. & Abdel-Sayed, W. 1970. Reflex vascular responses to stimulation of chemoreceptors with nicotine and cyanide. Circ Res 27, 259-276.
5. Chua, T.P., Clark, A.L., Amadi, A.A. & Coats, A.J.S. 1996. The relationship between chemosensitivity and the ventilatory response to exercise in chronic heart failure. J Am Coll Cardiol 27, 650-657.
6. Daly, M., Korner, P.I., Angell-James, J.E. et al. 1978. Cardiovascular-respiratory reflex interactions between carotid bodies and upper-airway receptors in the money. Am J Physiol 234, H293-H299.
7. Daly, M., Angell-James, J.E. & Elsner, R. 1979. Role of carotid-body chemoreceptors and their reflex interactions in bradycardia and cardiac arrest. Lancet 8119, 764-767.
8. Fukuda, Y., Sato, A. & Trzebski, A. 1987. Carotid chemoreceptor discharge responses to hypoxia and hypercapnia in normotensive and spontaneously hypertensive rats. J Auton Nerv Syst 19, 1-11.
9. 2. J Appl Physiol 35, 903-913.
10. Hanly, P.J. & Zuberi-Khokhar, N.S. 1996. Increased mortality associated with Cheyne-Stokes respiration in patients with congestive heart failure. Am J Respir Crit Care Med 153, 272-276.
11. 2. Chest 104, 1079-1084.
12. Hedner, J., Ejnell, H., Sellgren, J., Hedner, T. & Wallin, G. 1988. Is high and fluctuating muscle nerve sympathetic activity in the sleep apnoea syndrome of pathogenetic importance for the development of hypertension? J Hypertens 6 (Suppl 14), S529-S531.
13. Hedner, J.A., Wilcox, I., Laks, L., Grunstein, R.R. & Sullivan, C.E. 1992. A specific and potent pressor effect of hypoxia in patients with sleep apnea. Am Rev Respir Dis 146, 1240-1245.
14. Heistad, D.D., Abboud, F.M., Mark, A.L. & Schmid, P.G. 1974. Interaction of baroreceptor and chemoreceptor reflexes: modulation of the chemoreceptor reflex by changes in baroreceptor activity. J Clin Invest 53, 1226-1236.
15. Heistad, D.D., Abboud, F.M., Mark, A.L. & Schmid, P.G. 1975. Response of muscular and cutaneous vessels to physiologic stimulation of chemoreceptors. Proc Soc Exp Biol Med 148, 198-202.
16. Heistad, D.D., Abboud, F.M., Mark, A.L. & Schmid, P.G. 1975. Effect of baroreceptor activity on ventilatory response to chemoreceptor stimulation. J Appl Physiol 39, 411-416.
17. Honig, A. 1989. Peripheral arterial chemoreceptors and reflex control of sodium and water homeostasis. Am J Physiol 26, R1282-R1302.
18. Javaheri, S. 1999. A mechanism of central sleep apnea in patients with heart failure. N Engl J Med 341, 949-954.
19. Kales, A., Cadieux, R.J., Shaw, L.C. III, et al. 1984. Sleep apnea in a hypertensive population. Lancet 2, 1005-1008.
20. Kimoff, R.J., Brooks, D., Horner, R.L. et al. 1997. Ventilatory and arousal responses to hypoxia and hypercapnia in a canine model of obstructive sleep apnea. Am J Respir Crit Care Med 156, 886-894.
21. Lanfranchi, P.A., Braghiroli, A., Bosimini, E. et al. 1999. Prognostic value of nocturnal Cheyne-Stokes respiration in chronic heart failure. Circulation 99, 1435-1440.
22. Lavie, P., Ben-Yosef, R. & Rubin, A.E. 1984. Prevalence of sleep apnea syndrome among patients with essential hypertension. Am Heart J 108, 373.
23. Lugliani, R.B., Whipp, B.J., Seard, C. & Wasserman, K. 1971. Effect of bilateral carotid-body resection on ventilatory control at rest and during exercise in man. N Engl J Med 285, 1105-1111.
24. Luu, M., Stevenson, W.G., Stevenson, L.W. et al. 1989. Diverse mechanisms of unexpected cardiac arrest in advanced heart failure. Circulation 80, 1675-1680.
25. Malone, S., Liu, P.P., Holloway, R. et al. 1991. Obtsructive sleep apnea in patients with idiopathic dilated cardiomyopathy: effects of continuous positive airway pressure. Lancet 338, 1480-1484.
26. Narkiewicz, K., van de Borne, P.J.H., Montano, N. et al. 1998. The contribution of tonic chemoreflex activation to sympathetic activity and blood pressure in patients with obstructive sleep apnea. Circulation 97, 943-945.
27. Narkiewicz, K., Pesek, C.A., van de Borne, P.G.H., Kato, M. & Somers, V.K. 1999. Enhanced sympathetic and ventilatory responses to central chemoreflex activation in heart failure. Circulation 100, 262-267.
28. Narkiewicz, K., van de Borne, P.J.H., Pesek, C.A. et al. 1999. Selective potentiation of peripheral chemoreflex sensitivity in obstructive sleep apnea. Circulation 99, 1183-1189.
29. Naughton, M.T., Benard, D.C., Liu, P.P. et al. 1995. Effects of nasal CPAP on sympathetic activity in patients with heart failure and central sleep apnea. Am J Respir Crit Care Med 152, 473-479.
30. Peppard, P.E., Young, T., Palta, M. & Skatrud, J. 2000. Prospective study of the association between sleep-disordered breathing and hypertension. N Engl J Med 342, 1378-1384.
31. Ponikowski, P., Chua, T.P., Piepoli, M., Ondusova, D., Webb-Peploe, K., et al. 1997. Augmented peripheral chemosensitivity as a potential input to baroreflex impairment and autonomic imbalance in chronic heart failure. Circulation 96, 2586-2594.
32. Prabhakar, N.R. 2001. Oxygen sensing during intermittent hypoxia: cellular and molecular mechanisms. J Appl Physiol 90, 1986-1994.
33. Prabhakar, N.R. 2002. Sleep apneas: an oxidative stress? Am J Respir Crit Care Med 165, 859-860.
34. Przbylski, J., Trzebski, A., Czyzewski, T. & Jodkowski, J. 1982. Responses to hyperoxia, hypoxia, hypercapnia and almitrine in spontaneously hypertensive rats. Bull Eur Physiopathol Respir 18, 145-154.
35. Sin, D.D., Logan, A.G., Fitzgerald, F.S., Liu, P.P. & Bradley DT. 2000. Effects of continuous positive airway pressure on cardiovascular outcomes in heart failure patients with and without Cheyne-Stokes respiration. Circulation 102, 61-66.
36. Solin, P., Bergin, P., Richardson, M. et al. 1999. Influence of pulmonary capillary wedge pressure on central apnea in heart failure. Circulation 99, 1574-1579.
37. Somers, V.K., Zavala, D.C., Mark, A.L. & Abboud, F.M. 1989a. Influence of ventilation and hypocapnia on sympathetic nerve responses to hypoxia in normal humans. J Appl Physiol 67, 2095-2100.
38. Somers, V.K., Zavala, D.C., Mark, A.L. & Abboud, F.M. 1989b. Contrasting effects of hypoxia and hypercapnia on ventilation and sympathetic activity in humans. J Appl Physiol 67, 2101-2106.
39. Somers, V.K., Mark, A.L. & Abboud, F.M. 1991. Interaction of baroreceptor and chemoreceptor reflex control of sympathetic nerve activity in normal humans. J Clin Invest 87, 1953-1957.
40. Somers, V.K., Mark, A.L. & Abboud, F.M. 1988a. Potentiation of sympathetic nerve responses to hypoxia in borderline hypertensive subjects. Hypertension 11, 608-612.
41. Somers, V.K., Mark, A.L. & Abboud, F.M. 1988b. Sympathetic activation by hypoxia and hypercapnia - implications for sleep apnea. Clin Exp Hypertension A10 (Suppl. 1), 413-422.
42. Sun, S.Y., Wang, W., Zucker, I.H. & Schultz, H.D. 1999a. Enhanced peripheral chemoreflex function in conscious rabbits with pacing-induced heart failure. J Appl Physiol 86, 1264-1272.
43. Sun, S.Y., Wang, W., Zucker, I.H. & Schultz, H.D. 1999b. Enhanced activity of carotid body chemoreceptors in rabbits with heart failure: role of nitric oxide. J Appl Physiol 86, 1273-1282.
44. Trzebski, A., Tafil, M., Zoltowski, M. & Przybylski, J. 1982. Increased sensitivity of the arterial chemoreceptor drive in young men with mild hypertension. Cardiovasc Res 16, 163-172.
45. Vallbo, A.B., Hagbarth, K.-E., Torebjork, H.E. & Wallin, B.G. 1979. Somatosensory, proprioceptive, and sympathetic activity in human peripheral nerves. Physiol Rev 59, 919-957.
46. Wade, J.G., Larson, C.P. Jr, Hickey, R.F., Ehrenfield, W.K. & Severinghaus, J.W. 1970. Effect of carotid endarterectomy on carotid chemoreceptor and baroreceptor function in man. N Engl J Med 282, 823-829.
47. Wallin, G. 1983. Intraneural recording and autonomic function in man. In: R. Bannister, (ed.) Autonomic failure, pp. 36-51. Oxford University Press, London.
48. Wilcox, I., Grunstein, R.R., Hedner, J.A., et al. 1993. Effect of nasal continuous positive airway pressure during sleep on 24-hour blood pressure in obstructive sleep apnea. Sleep 16, 539-544.
49. Yamamoto, K., Iwase, S. & Mano T. 1992. Responses of muscle sympathetic nerve activity and cardiac output to the cold pressor test. Jpn J Physiol 42, 239-252.
50. van de Borne, P., Oren, R., Anderson, E.A., Mark, A.L. & Somers, V.K. 1996. Tonic chemoreflex activation does not contribute to elevated muscle sympathetic nerve activity in heart failure. Circulation 94, 1325-1328.
51. van de Borne, P., Oren, R., Abouassaly, C., Anderson, E. & Somers, V.K. 1998. Effect of Cheyne-Stokes respiration on muscle sympathetic nerve activity in severe congestive heart failure. Am J Cardiol 81, 432-436.