HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia

Cell Metabolism

Volumn 3, Issue 3, 2006, Pages 177-185

  Kim, Jung Whan ^a   Tchernyshyov, Irina ^a   Semenza, Gregg L ^a   Dang, Chi V ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL COENZYME A; ADENOSINE TRIPHOSPHATE; GLUCOSE; HYPOXIA INDUCIBLE FACTOR 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; LACTIC ACID; PROTEIN KINASE; PYRUVATE DEHYDROGENASE; PYRUVATE DEHYDROGENASE KINASE 1; PYRUVIC ACID; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL CULTURE; CELL GROWTH; CELL METABOLISM; CELL PROLIFERATION; CITRIC ACID CYCLE; CONTROLLED STUDY; DNA MICROARRAY; GENE ACTIVATION; GENE EXPRESSION; GLYCOLYSIS; HUMAN; HUMAN CELL; HYPOXIA; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; WESTERN BLOTTING;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; APOPTOSIS; CELL HYPOXIA; CELL SURVIVAL; FIBROBLASTS; GENE EXPRESSION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MICE; MODELS, BIOLOGICAL; PHOSPHORYLATION; PROTEIN KINASES; REACTIVE OXYGEN SPECIES;

EID: 33644614520     PISSN: 15504131     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cmet.2006.02.002     Document Type: Article

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