Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells

Journal of Biological Chemistry

Volumn 277, Issue 41, 2002, Pages 38205-38211

  Fukuda, Ryo ^a   Hirota, Kiichi ^b   Fan, Fan ^c   Jung, Young Do ^c   Ellis, Lee M ^a   Semenza, Gregg L ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS   (United States)

^c NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; ENZYMES; RNA; SYNTHESIS (CHEMICAL); TUMORS;

PROTEIN EXPRESSION;

HORMONES;

HYPOXIA INDUCIBLE FACTOR 1; INITIATION FACTOR 4E; INITIATION FACTOR 4E BINDING PROTEIN 1; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN SUBUNIT; REGULATOR PROTEIN; S6 KINASE; SOMATOMEDIN C; UBIQUITIN; UNCLASSIFIED DRUG; VASCULOTROPIN;

ARTICLE; CANCER CELL; CELL STIMULATION; COLON CANCER; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; HYPOXIA; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN MODIFICATION; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; TRANSACTIVATION; TRANSLATION REGULATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ANOXIA; CARCINOMA; CARRIER PROTEINS; COLONIC NEOPLASMS; ENDOTHELIAL GROWTH FACTORS; ENZYME INHIBITORS; EUKARYOTIC INITIATION FACTOR-4E; GENE EXPRESSION REGULATION; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INSULIN-LIKE GROWTH FACTOR I; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LYMPHOKINES; MAP KINASE KINASE 2; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; PHOSPHOPROTEINS; PROTEIN-TYROSINE KINASES; REPRESSOR PROTEINS; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; TRANSCRIPTION FACTORS; UBIQUITIN; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0037064010     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M203781200     Document Type: Article

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