Antioxidant vitamin C improves endothelial function in obstructive sleep apnea

American Journal of Respiratory and Critical Care Medicine

Volumn 173, Issue 8, 2006, Pages 897-901

  Grebe, Mathias ^a   Eisele, Hans Joachim ^a   Weissmann, Norbert ^a   Schaefer, Christian ^a   Tillmanns, Harald ^a   Seeger, Werner ^a   Schulz, Richard ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

Cardiovascular disease; Endothelial dysfunction; Obstructive sleep apnea; Oxidative stress

Indexed keywords

ANTIOXIDANT; ASCORBIC ACID;

ADULT; ARTICLE; BRACHIAL ARTERY; BRONCHODILATATION; CELL FUNCTION; CLINICAL ARTICLE; CONTROLLED STUDY; DEMOGRAPHY; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; FEMALE; HUMAN; MALE; OXIDATIVE STRESS; POLYSOMNOGRAPHY; PRIORITY JOURNAL; SLEEP APNEA SYNDROME; ULTRASOUND;

ADMINISTRATION, SUBLINGUAL; ANTIOXIDANTS; ASCORBIC ACID; BRACHIAL ARTERY; ENDOTHELIUM, VASCULAR; FEMALE; HUMANS; INJECTIONS, INTRAVENOUS; MALE; MIDDLE AGED; NITROGLYCERIN; POLYSOMNOGRAPHY; SLEEP APNEA, OBSTRUCTIVE; TREATMENT OUTCOME; VASODILATION; VASODILATOR AGENTS;

EID: 33645514937     PISSN: 1073449X     EISSN: 1073449X     Source Type: Journal    
DOI: 10.1164/rccm.200508-1223OC     Document Type: Article

References (26)

1. Peppard PE, Young T, Palta M, Skatrud J. Prospective study of the association between sleep-disordered breathing and hypertension. N Engl J Med 2000;342:1378-1384.
2. Shahar E, Whitney CW, Redline S, Lee ET, Newman AB, Nieto FJ, O'Connor GT, Boland LL, Schwartz JE, Samet JM. Sleep-disordered breathing and cardiovascular disease: cross-sectional results from the Sleep Heart Health Study. Am J Respir Crit Care Med 2001;163:19-25.
3. Schulz R. The vascular micromilieu in obstructive sleep apnoea. Eur Respir J 2005;25:780-782.
4. Schulz R, Mahmoudi S, Hattar K, Sibelius U, Olschewski H, Mayer K, Seeger W, Grimminger F. Enhanced release of superoxide from polymorphonuclear neutrophils in obstructive sleep apnea: impact of CPAP therapy. Am J Respir Crit Care Med 2000;162:566-570.
5. Dyugovskaya L, Lavie P, Lavie L. Increased adhesion molecules expression and production of reactive oxygen species in leukocytes of sleep apnea patients. Am J Respir Crit Care Med 2002;165:934-939.
6. Schulz R, Schmidt D, Blum A, Lopes-Ribeiro X, Lücke C, Mayer K, Olschewski H, Seeger W, Grimminger F. Decreased plasma levels of nitric oxide derivatives in obstructive sleep apnoea: response to CPAP therapy. Thorax 2000;55:1046-1051.
7. Ip MS, Lam B, Chan LY, Zheng L, Tsang KWT, Fung PCW, Lam WK. Circulating nitric oxide is suppressed in obstructive sleep apnea and is reversed by nasal continuous positive airway pressure. Am J Respir Crit Care Med 2000;162:2166-2171.
8. Lavie L, Vishnevsky A, Lavie P. Evidence for lipid peroxidation in obstructive sleep apnea. Sleep 2004;27:123-128.
9. Ip MS, Tse HF, Lam B, Tsang KW, Lam WK. Endothelial function in obstructive sleep apnea and response to treatment. Am J Respir Crit Care Med 2004;169:348-353.
10. Celermajer DS, Sorensen KE, Gooch VM, Spiegelhalter BJ, Miller OI, Sullivan ID, Lloyd JU, Deanfield JE. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet 1992;340:1111-1115.
11. Joannides R, Haefeli WE, Linder L, Richard V, Bakkali EH, Thuillez C, Lüscher TF. Nitric oxide is responsible for flow-dependent dilatation of human peripheral conduit arteries in vivo. Circulation 1995;91:1314-1319.
12. Anderson TJ, Uehata A, Gerhard MD, Meredith IT, Knab S, Delagrange D, Lieberman EH, Ganz P, Creager MA, Yeung AC, et al. Close relation of endothelial function in the human coronary and peripheral circulations. J Am Coll Cardiol 1995;26:1235-1241.
13. Ting HH, Timimi FK, Boles KS, Creager SJ, Ganz P, Creager MA. Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin dependent diabetes mellitus. J Clin Invest 1996;97:22-28.
14. Ting HH, Timimi FK, Haley EA, Roddy MA, Ganz P, Creager MA. Vitamin C improves endothelium-dependent vasodilation in forearm resistance vessels of humans with hypercholesterolemia. Circulation 1997;95:2617-2622.
15. Taddei S, Virdis A, Ghiadoni L, Magagna A, Salvetti A. Vitamin C improves endothelium-dependent vasodilation by restoring nitric oxide activity in essential hypertension. Circulation 1998;97:2222-2229.
16. Ellis GR, Anderson RA, Lang D, Blackman DJ, Morris RH, Morris-Thurgood J, McDowell IF, Jackson SK, Lewis MJ, Frenneaux MP. Neutrophil superoxide anion-generating capacity, endothelial function and oxidative stress in chronic heart failure: effects of short-and long-term vitamin C therapy. J Am Coll Cardiol 2000;36:1474-1482.
17. Shankar SS, Steinberg HO. Obesity and endothelial dysfunction. Semin Vasc Med 2005;5:56-64.
18. Nieto FJ, Herrington DM, Redline S, Benjamin EJ, Robbins JA. Sleep apnea and markers of vascular endothelial function in a large community sample of older adults. Am J Respir Crit Care Med 2004;169:354-360.
19. Benjamin EJ, Larson MG, Keyes MJ, Mitchell GF, Vasan RS, Keaney JF Jr, Lehman BT, Fan S, Osypiuk E, Vita JA. Clinical correlates and heritability of flow-mediated dilation in the community. Circulation 2004;109:613-619.
20. Faulx MD, Larkin EK, Hoit BD, Aylor JE, Wright AT, Redline S. Sex influences endothelial function in sleep-disordered breathing. Sleep 2004;27:1113-1120.
21. Ohike Y, Kozaki K, Iijima K, Eto M, Kojima T, Ohga E, Santa T, Imai K, Hashimoto M, Yoshizumi M, et al. Amelioration of vascular endothelial dysfunction in obstructive sleep apnea syndrome by nasal continuous positive airway pressure: possible involvement of nitric oxide and asymmetric NG, NG-dimethylarginine. Circ J 2005;69:221-226.
22. Sherman DL, Keaney JF Jr, Biegelsen ES, Duffy SJ, Coffman JD, Vita JA. Pharmacological concentrations of ascorbic acid are required for the beneficial effect on endothelial vasomotor tone in hypertension. Hypertension 2000;35:936-941.
23. Carlson JT, Hedner J, Elam M, Ejnell H, Sellgren J, Wallin BG. Augmented resting sympathetic activity in awake patients with obstructive sleep apnea. Chest 1993;103:1763-1768.
24. Phillips BG, Narkiewicz K, Pesek CA, Haynes WG, Dyken ME, Somers VK. Effects of obstructive sleep apnea on endothelin-1 and blood pressure. J Hypertens 1999;17:61-66.
25. GISSI-Prevenzione Investigators. Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Lancet 1999;354:447-455.
26. Stephens NG, Parsons A, Brown MJ, Schofield PM, Kelly F, Cheeseman K, Mitchinson M. Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS). Lancet 1996;347:781-786.