Predominant role of hypoxia-inducible transcription factor (Hif)-1α versus Hif-2α in regulation of the transcriptional response to hypoxial

Cancer Research

Volumn 63, Issue 19, 2003, Pages 6130-6134

  Sowter, Heidi M ^a   Raval, Raju ^b   Moore, John ^a   Ratcliffe, Peter J ^b   Harris, Adrian L ^a  

^a JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; RNA; UNCLASSIFIED DRUG;

ARTICLE; BREAST CANCER; CELL MIGRATION; CELL TYPE; CLINICAL PATHWAY; CONTROLLED STUDY; CORRELATION ANALYSIS; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; HYPOXIA; KIDNEY CANCER; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; TUMOR CELL LINE; TUMOR VASCULARIZATION;

BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BREAST NEOPLASMS; CARCINOMA, RENAL CELL; CELL HYPOXIA; CELL LINE, TUMOR; CELL MOVEMENT; ENDOTHELIUM, VASCULAR; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; KIDNEY NEOPLASMS; RNA, SMALL INTERFERING; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSFECTION;

EID: 0141988698     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Hoeckel, M., and Vaupel, P. Biological consequences of tumor hypoxia. Semin. Oncol., 28: 36-41, 2001.
2. Semenza, G. L. HIF-1 and tumor progression: pathophysiology and therapeutics. Trends Mol. Med., 8: S62-S67, 2002.
3. Pugh, C. W., and Ratcliffe, P. J. Regulation of angiogenesis by hypoxia: role of the HIF system. Nat. Med., 9: 677-684, 2003.
4. Wiesener, M. S., Turley, H., Allen, W. E., Willam, C., Eckhardt, K. U., Talks, K. L., Wood, S. M., Gatter, K. C., Harris, A. L., Pugh, C. W., Ratcliffe, P. J., and Maxwell, P. H. Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1 α. Blood, 92: 2260-2268, 1998.
5. Ema, M., Hirota, K., Mimura, J., Abe, H., Yodoi, J., Sogawa, K., Peollinger, L., and Fujii-Kuriyama, Y. Molecular mechanisms of transcription activation by HLF and HIFI a in response to hypoxia: their stabilisation and redox signal-induced interaction with CBP/p300. EMBO J., 18: 1905-1914, 1999.
6. Brusselmanns, K., Bono, F., Maxwell, P. H., Dor, Y., Dewerchin, M., Collen, D., Herbert, J-M., and Carmeliet, P. Hypoxia-inducible factor-2α is involved in the apoptotic response to hypoglycemia but not to hypoxia. J. Biol. Chem., 276: 39192-39196, 2001.
7. Rosenberger, C., Mandriota, S., Jurgensen, J. S., Wiesner, M. S., Horstrup, J. H., Frei, U., Ratcliffe, P. J., Maxwell, P. H., Bachmann, S., and Eckardt, K. U. Expression of hypoxia-inducible factor-1α and -2α in hypoxic and ischemic rat kidneys. J. Am. Soc. Nephrol., 13: 1974-1976, 2002.
8. Maranchie, J. K., Vasselli, J. R., Riss, J., Bonifacino, J. S., Linehan, W. M., and Klausner, R. D. The contribution of VHL substrate binding and HIF-1α to the phenotype of VHL loss in renal cell carcinoma. Cancer Cell, 1: 247-255, 2002.
9. Kondo, K., Klco, J., Nakamuri, E., Lechpammer, M., and Kaelin, W. G. Inhibition of HIF is necessary for tumor suppression by the von Hippel Lindau protein. Cancer Cell, 1: 237-246, 2002.
10. Blancher, C., Moore, J. W., Talks, K. L., Houlbrook, S., and Harris, A. L. Relationship of hypoxia-inducible factor (HIF)-1α and HIF-2α expression to vascular endothelial growth factor induction and hypoxia survival in human breast cancer cell lines. Cancer Res., 60: 7106-7113, 2000.
11. Elbashir, S. M., Harborth, J., Lendeckel, W., Yalcin, A., Weber, K., and Tuschl, T. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature (Lond.), 411: 494-498, 2001.
12. Chomczynski, P., and Sacchi, N. Single step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem., 162: 156-159, 1987.
13. Wykoff, C. C., Beasley, N. J. P., Watson, P. H., Turner, K. J., Pastorek, J., Sibtain, A., Wilson, G. D., Turley, H., Talks, K., Maxwell, P. H., Pugh, C. W., Ratcliffe. P. J., and Harris, A. L. Hypoxia-inducible expression of tumor-associated carbonic anhydrases. Cancer Res., 60: 7075-7083, 2000.
14. Ray, R., Chen, G., Vande Velde, C., Cizeau, J., Hoon Park, J. H., Reed, J. C., Gietz, R. D., and Greenberg, A. H. BNIP3 heterodimerizes with Bcl-2/Bcl-XL and induces cell death independent of a Bcl-2 homology 3 (BH3) domain at both mitochondrial and nonmitochondrial sites. J. Biol. Chem., 275: 1439-1448, 2000.
15. Sowter, H. M., Ratcliffe, P. J., Watson, P., Greenberg, A. H., and Harris, A. L. HIF-I-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors. Cancer Res. 61: 6669-6673, 2001.
16. Krishnamachary, B., Berg-Dixon, S., Kelly, B., Agani, F., Feldser, D., Ferreira, G., Iyer, N., LaRusch, J., Pak, B., Taghavi, P., and G. L. S. Regulation of colon carcinoma cell invasion by hypoxia-inducible factor 1. Cancer Res., 63: 1138-1143, 2003.
17. Ryan, H. E., Poloni, M., McNulty, W., Elson, D., Gassmann, M., Arbeit, J. M., and Johnson, R. S. Hypoxia-inducible factor-1α is a positive factor in solid tumor growth. Cancer Res., 60: 4010-4015, 2000.
18. Mandriota, S. J., Turner, K. J., Davies, D. R., Murray, P. G., Morgan, N. V., Sowter, H. M., Wykoff, C. C., Maher, E. R., Harris, A. L., Ratcliffe, P. J., and Maxwell, P. H. HIF inactivation identifies early lesions in VHL kidneys: evidence for site specific tumor suppressor function in the nephron. Cancer Cell, 1: 459-468, 2002.
19. Kreig, M., Haas, R., Brauch, H., Acker, T., Flamme, I., and Plate, K. H. Up-regulation of hypoxia-inducible factors HIF-1α and HIF-2α under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss function. Oncogene, 19: 5435-5443, 2000.
20. Maxwell, P. H., Dachs, G., Gleadle, J. M., Nicholls, L. G., Harris, A. L., Stratford, I. J., Hankinson, O., Pugh, C. W., and Ratcliffe, P. J. Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth. Proc. Natl. Acad. Sci. USA, 94: 8104-8109, 1997.