Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression

Nature

Volumn 414, Issue 6863, 2001, Pages 550-554

  Makino, Yuichi ^a,b   Cao, Renhai ^a   Svensson, Kristian ^c,d   Bertilsson, Göran ^c,e   Asman, Mikael ^a   Tanaka, Hirotoshi ^b   Cao, Yihai ^a   Berkenstam, Anders ^c,f   Poellinger, Lorenz ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSITY OF TOKYO   (Japan)

^c Pharmacia Corporation   (Sweden)

^d Leica Microsystems AB   (Sweden)

^e NeuroNova AB   (Sweden)

^f Karobia AB   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; OXYGEN; PROTEINS; TUMORS;

GENE EXPRESSIONS;

GENES;

ANTISENSE OLIGONUCLEOTIDE; HELIX LOOP HELIX PROTEIN;

BIOCHEMISTRY; HYPOXIA; PROTEIN;

ADAPTATION; ANGIOGENESIS; ANIMAL CELL; ARTICLE; CORNEA EPITHELIUM; GENE EXPRESSION REGULATION; GENE INDUCTION; HYPOXIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN;

AMINO ACID SEQUENCE; ANIMALS; ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR; CELL HYPOXIA; CEREBELLUM; CORNEA; COS CELLS; DNA-BINDING PROTEINS; ENDOTHELIAL GROWTH FACTORS; GENE EXPRESSION REGULATION; HELA CELLS; HELIX-LOOP-HELIX MOTIFS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LYMPHOKINES; MICE; MOLECULAR SEQUENCE DATA; NEOVASCULARIZATION, PHYSIOLOGIC; OXYGEN; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, ARYL HYDROCARBON; RECOMBINANT FUSION PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

ANIMALIA;

EID: 0035969508     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35107085     Document Type: Article

References (24)

1. Oxygen sensing and molecular adaptation to hypoxia
2. Mammalian oxygen sensing, signalling and gene regulation
3. Hidden Markov models in computational biology. Applications to protein modeling
4. 2 tension
5. A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1α regulates the VEGF expression and is potentially involved in lung and vascular development
6. Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells
7. HIF-1 and human disease: One highly involved factor
8. Regulation of the hypoxia-inducible transcription factor 1α by the ubiquitin-proteasome pathway
9. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
10. Induction of endothelial PAS domain protein-1 by hypoxia: Characterization and comparison with hypoxia-inducible factor-1α
11. Induction of phosphoglycerate kinase 1 gene expression by hypoxia. Roles of Arnt and HIF1α
12. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
13. The proinflammatory cytokines and arachidonic acid metabolites in human overnight tears: Homeostatic mechanisms
14. Diurnal variations in angiostatin in human tear fluid: A possible role in prevention of corneal neovascularization
15. Functional interference between hypoxia and dioxin signal transduction pathways: Competition for recruitment of the Arnt transcription factor
16. Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1α
17. Loss of PTEN facilitates HIF-1-mediated gene expression
18. PR 39, a peptide regulator of angiogenesis
19. Id helix-loop-helix protein in cell growth and differentiation
20. Multiple alignment using hidden Markov models
21. Mechanism of regulation of the hypoxia-inducible factor-1α by the von Hippel-Lindau tumor suppressor protein
22. Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction
23. Suppression of aniogenesis by a novel inhibitor, K1-5, generated by plasmin-mediated proteolysis