Targeting of HIF-α to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

Science

Volumn 292, Issue 5516, 2001, Pages 468-472

  Jaakkola, P ^a   Mole, D R ^a   Tian, Y M ^a   Wilson, M I ^a   Gielbert, J ^a   Gaskell, S J ^a   Von Kriegsheim, A ^a   Hebestreit, H F ^a   Mukherji, M ^a   Schofield, C J ^a   Maxwell, P H ^a   Pugh, C W ^a   Ratcliffe, P J ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHELATION; ENZYMES; GENES; HYDROXYLATION; IRON; TUMORS;

CELLULAR OXYGEN SENSOR;

OXYGEN;

HYPOXIA INDUCIBLE FACTOR 1; OXYGEN; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; PROLINE DERIVATIVE; PROTEIN SUBUNIT;

ARTICLE; BINDING SITE; HUMAN; HYDROXYLATION; HYPOXIA; IMMUNOSUPPRESSIVE TREATMENT; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN INTERACTION; SENSOR; SEQUENCE ANALYSIS; TRANSCRIPTION REGULATION; VON HIPPEL LINDAU DISEASE;

EID: 0035917808     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1059796     Document Type: Article

References (46)