From polyps to people: A hIghly familiar response to hypoxia

Annals of the New York Academy of Sciences

Volumn 1177, Issue , 2009, Pages 19-29

  Hampton Smith, R J ^a   Peet, D J ^a  

^a UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

2 OG dependent dioxygenase; Acropora millepora; Caenorhabditis elegans; Drosophila melanogaster; FIH 1; HIF; Hypoxia; Invertebrates; PHD; Tribolium castaneum; VHL

Indexed keywords

HYPOXIA INDUCIBLE FACTOR; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; PROTEASOME;

CAENORHABDITIS ELEGANS; CONFERENCE PAPER; DROSOPHILA; GENE TARGETING; HYPOXIA; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYP; PROTEIN DEGRADATION;

ACROPORA MILLEPORA; ANTHOZOA; CAENORHABDITIS ELEGANS; COLEOPTERA; DROSOPHILA MELANOGASTER; INVERTEBRATA; MAMMALIA; METAZOA; TRIBOLIUM CASTANEUM;

EID: 70350380469     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2009.05035.x     Document Type: Conference Paper

References (44)

1. Choi, D.W. 1990. Cerebral hypoxia: some new approaches and unanswered questions. J. Neurosci. 10: 2493-2501.
2. Weir, E.K. et al. 2008. Mechanisms of oxygen sensing: a key to therapy of pulmonary hypertension and patent ductus arteriosus. Br. J. Pharmacol. 155: 300-307.
3. Semenza, G.L. 2000. HIF-1 and human disease: one highly involved factor. Genes Dev. 14: 1983-1991.
4. Wenger, R.H.,D.P. Stiehl &G. Camenisch. 2005. Integration of oxygen signaling at the consensus HRE. Sci. STKE 2005: re12.
5. Gorr, T.A.,M. Gassmann & P.Wappner. 2006. Sensing and responding to hypoxia via HIF in model invertebrates. J. Insect Physiol. 52: 349-364.
6. van Voorhies, W.A. & S. Ward. 2000. Broad oxygen tolerance in the nematode Caenorhabditis elegans. J. Exp. Biol. 203: 2467-2478.
7. Kaelin,W.G., Jr. & P.J. Ratcliffe. 2008. Oxygen sensing bymetazoans: the central role of theHIF hydroxylase pathway. Mol Cell. 30: 393-402.
8. Flashman, E. et al. 2008. Kinetic rationale for selectivity toward N- and C-terminal oxygen-dependent degradation domain substrates mediated by a loop region of hypoxia-inducible factor prolyl hydroxylases. J. Biol. Chem. 283: 3808-3815.
9. Masson, N. & P.J. Ratcliffe. 2003. HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O(2) levels. J. Cell Sci. 116: 3041-3049.
10. Koivunen, P. et al. 2004. Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4- hydroxylases. J. Biol. Chem. 279: 9899-9904.
11. Ehrismann, D. et al. 2007. Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay. Biochem. J. 401: 227-234.
12. Tsai, A.G., P.C. Johnson &M. Intaglietta. 2003. Oxygen gradients in the microcirculation. Physiol. Rev. 83: 933-963.
13. Epstein, A.C. et al. 2001. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell 107: 43-54.
14. Jiang, H., R. Guo & J.A. Powell-Coffman. 2001. The Caenorhabditis elegans hif-1 gene encodes a bHLHPAS protein that is required for adaptation to hypoxia. Proc. Natl. Acad. Sci. USA 98: 7916-7921.
15. Arquier, N. et al. 2006. Analysis of the hypoxiasensing pathway in Drosophila melanogaster. Biochem. J. 393: 471-480.
16. Bruick, R.K. & S.L. McKnight. 2001. A conserved family of prolyl-4-hydroxylases that modify HIF. Science 294: 1337-1340.
17. Lavista-Llanos, S. et al. 2002. Control of the hypoxic response in Drosophila melanogaster by the basic helix-loop-helix PAS protein similar. Mol. Cell Biol. 22: 6842-6853.
18. Bacon, N.C. et al. 1998. Regulation of theDrosophila bHLH-PAS protein Sima by hypoxia: functional evidence for homology with mammalian HIF-1 alpha. Biochem. Biophys. Res. Commun. 249: 811-816.
19. Lando, D. et al. 2002. FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor. Genes Dev. 16: 1466-1471.
20. Mahon, P.C.,K.Hirota &G.L. Semenza. 2001. FIH- 1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity. Genes Dev. 15: 2675-2686.
21. Bishop, T. et al. 2004. Genetic analysis of pathways regulated by the von Hippel-Lindau tumor suppressor in Caenorhabditis elegans. PLoS Biol. 2: e289.
22. Shen, C. et al. 2005. Roles of the HIF-1 hypoxia-inducible factor during hypoxia response in Caenorhabditis elegans. J. Biol. Chem. 280: 20580-20588.
23. Gorr, T.A. et al. 2003. Genome-wide computational screen for candidate HIF target genes in Drosophila melanogaster and Caenorhabditis elegans. In: Oxygen Sensing: Responses and Adaptation to Hypoxia, Vol.175. S. Lahiri, G.L. Semenza & N.R. Prabhakar, Eds.: 175-199. Marcel Dekker. New York.
24. Horowitz, A. & M. Simons. 2008. Branching morphogenesis. Circ. Res. 103: 784-795.
25. Centanin, L. et al. 2008. Cell autonomy of HIF effects in Drosophila: tracheal cells sense hypoxia and induce terminal branch sprouting. Dev. Cell. 14: 547-558.
26. Forsythe, J.A. et al. 1996. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol. Cell Biol. 16: 4604-4613.
27. Dayan, F. et al. 2006. The oxygen sensor factorinhibiting hypoxia-inducible factor-1 controls expression of distinct genes through the bifunctional transcriptional character of hypoxia-inducible factor1alpha. Cancer Res. 66: 3688-3698.
28. Cockman, M.E. et al. 2009. Proteomics-based identification of novel factor inhibiting hypoxia-inducible factor (FIH) substrates indicates widespread asparaginyl hydroxylation of ankyrin repeat domaincontaining proteins. Mol. Cell Proteomics 8: 535-546.
29. Harrison, J.F. & J.R. Lighton. 1998. Oxygensensitive flight metabolism in the dragonfly erythemis simplicicollis. J. Exp. Biol. 201 (Pt 11): 1739-1744.
30. Joos, B. et al. 1997. Effects of ambient oxygen tension on flight performance, metabolism, and water loss of the honeybee. Physiol. Zool. 70: 167-174.
31. Komai, Y. 2001. Direct measurement of oxygen partial pressure in a flying bumblebee. J. Exp. Biol. 204: 2999-3007.
32. Bracken, C.P.,M.L.Whitelaw & D.J. Peet. 2003. The hypoxia-inducible factors: key transcriptional regulators of hypoxic responses. Cell Mol. Life Sci. 60: 1376-1393.
33. Centanin, L., P.J. Ratcliffe & P. Wappner. 2005. Reversion of lethality and growth defects in Fatiga oxygen-sensor mutant flies by loss of hypoxiainducible factor-alpha/Sima. EMBO Rep. 6: 1070-1075.
34. Metzen, E. et al. 2005. Regulation of the prolyl hydroxylase domain protein 2 (phd2/egln-1) gene: identification of a functional hypoxia-responsive element. Biochem. J. 387: 711-717.
35. Pescador, N. et al. 2005. Identification of a functional hypoxia-responsive element that regulates the expression of the egl nine homologue 3 (egln3/phd3) gene. Biochem. J. 390: 189-197.
36. Gort, E.H. et al. 2008. The TWIST1 oncogene is a direct target of hypoxia-inducible factor-2alpha. Oncogene 27: 1501-1510.
37. Pan, D. et al. 2009. Twist-1 is a PPARdelta-inducible, negative-feedback regulator of PGC-1alpha in brown fat metabolism. Cell 137: 73-86.
38. Brugarolas, J. et al. 2004. Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex. Genes Dev. 18: 2893-2904.
39. Shoshani, T. et al. 2002. Identification of a novel hypoxia-inducible factor 1-responsive gene,RTP801, involved in apoptosis. Mol. Cell Biol. 22: 2283-2293.
40. Reiling, J.H.&E.Hafen. 2004.The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila. Genes Dev. 18: 2879-2892.
41. Firth, J.D., B.L. Ebert & P.J. Ratcliffe. 1995. Hypoxic regulation of lactate dehydrogenase A. Interaction between hypoxia-inducible factor 1 and cAMP response elements. J. Biol. Chem. 270: 21021-21027.
42. Gorr, T.A. et al. 2004. Regulation of Drosophila hypoxia-inducible factor (HIF) activity in SL2 cells: identification of a hypoxia-induced variant isoform of the HIFalpha homolog gene similar. J. Biol. Chem. 279: 36048-36058.
43. Takahashi, Y. et al. 2000. Hypoxic induction of prolyl 4-hydroxylase alpha (I) in cultured cells. J. Biol. Chem. 275: 14139-14146.
44. Ivanov, S.V. et al. 1998. Down-regulation of transmembrane carbonic anhydrases in renal cell carcinoma cell lines by wild-type von Hippel-Lindau transgenes. Proc. Natl. Acad. Sci. USA 95: 12596-12601.