An Abnormal mitochondrial-hypoxia inducible factor-1α-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: Similarities to human pulmonary arterial hypertension

Circulation

Volumn 113, Issue 22, 2006, Pages 2630-2641

  Bonnet, Sébastien ^a   Michelakis, Evangelos D ^a   Porter, Christopher J ^c   Andrade Navarro, Miguel A ^c   Thébaud, Bernard ^a   Bonnet, Sandra ^a   Haromy, Alois ^a   Harry, Gwyneth ^a   Moudgil, Rohit ^a   McMurtry, M Sean ^a   Weir, E Kenneth ^b   Archer, Stephen L ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

Author keywords

Free radicals; Hypoxia; Ion channels; Mitochondrial membranes

Indexed keywords

CYTOCHROME C OXIDASE; DICHLOROACETIC ACID; ENZYME INHIBITOR; HYPOXIA INDUCIBLE FACTOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 3ALPHA; MANGANESE SUPEROXIDE DISMUTASE; OXYGEN; POTASSIUM CHANNEL KV 1.5; POTASSIUM ION; PYRUVATE DEHYDROGENASE KINASE INHIBITOR; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; VOLTAGE GATED POTASSIUM CHANNEL; HIF1A PROTEIN, RAT; POTASSIUM CHANNEL; SUPEROXIDE DISMUTASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAUSE OF DEATH; CHROMOSOME 1; CONTROLLED STUDY; DOPPLER ECHOCARDIOGRAPHY; ELECTRON TRANSPORT; ENZYME INHIBITION; HEART CATHETERIZATION; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOXIC CELL; MALE; MEMBRANE CHANNEL; MEMBRANE DAMAGE; MEMBRANE DEPOLARIZATION; MITOCHONDRIAL MEMBRANE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXYGEN SENSING; PATHOPHYSIOLOGY; POLYCYTHEMIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PULMONARY HYPERTENSION; RAT; RAT STRAIN; VOLTAGE CLAMP; ANIMAL; ANOXIA; CHEMISTRY; CHROMOSOME ABERRATION; COMPARATIVE STUDY; DRUG EFFECT; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; HEMODYNAMICS; MITOCHONDRION; PHYSIOLOGY; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT; ULTRASTRUCTURE; VASCULAR SMOOTH MUSCLE; VASOCONSTRICTION;

ANIMALS; ANOXIA; CHROMOSOME ABERRATIONS; CHROMOSOMES, HUMAN, PAIR 1; DICHLOROACETATE; ECHOCARDIOGRAPHY, DOPPLER; ELECTRON TRANSPORT COMPLEX IV; GENE EXPRESSION REGULATION; HEART CATHETERIZATION; HEMODYNAMIC PROCESSES; HUMANS; HYPERTENSION, PULMONARY; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MALE; MITOCHONDRIA; MUSCLE, SMOOTH, VASCULAR; OXYGEN; POTASSIUM CHANNELS; RATS; RATS, INBRED STRAINS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SUPEROXIDE DISMUTASE; VASOCONSTRICTION;

EID: 33745155785     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.105.609008     Document Type: Article

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