Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor

Proceedings of the National Academy of Sciences of the United States of America

Volumn 99, Issue 21, 2002, Pages 13459-13464

  Ivan, Mircea ^a   Haberberger, Thomas ^b   Gervasi, David C ^b   Michelson, Kristen S ^b   Günzler, Volkmar ^b   Kondo, Keiichi ^a   Yang, Haifeng ^a   Sorokina, Irina ^c   Conaway, Ronald C ^c   Conaway, Joan W ^c   Kaelin Jr , William G ^a,d,e  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b FIBROGEN INC   (United States)

^c Stowers Medical Research Institute   (United States)

^d HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^e DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; GENE PRODUCT; HYPOXIA INDUCIBLE FACTOR 1; OXYGEN; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; PROLINE; PROTEIN SUBUNIT; TRANSCRIPTION FACTOR; UBIQUITIN; VASCULOTROPIN;

ARTICLE; CAENORHABDITIS ELEGANS; ENZYME INHIBITION; ENZYME PURIFICATION; HUMAN; HUMAN CELL; HYDROXYLATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN MODIFICATION; PROTEIN STABILITY; PROTEIN SYNTHESIS;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CAENORHABDITIS ELEGANS PROTEINS; CELL LINE; CLONING, MOLECULAR; DNA, COMPLEMENTARY; DNA-BINDING PROTEINS; DRUG STABILITY; ENZYME INHIBITORS; HELMINTH PROTEINS; HUMANS; HYDROXYLATION; HYPOXIA-INDUCIBLE FACTOR 1; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LIGASES; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; PROCOLLAGEN-PROLINE DIOXYGENASE; RABBITS; RECOMBINANT FUSION PROTEINS; RETICULOCYTES; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEINS; UBIQUITIN-PROTEIN LIGASES; VON HIPPEL-LINDAU TUMOR SUPPRESSOR PROTEIN;

CAENORHABDITIS; CAENORHABDITIS ELEGANS; MAMMALIA;

EID: 0037108807     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.192342099     Document Type: Article

References (39)

1. Maher, E. & Kaelin, W. G., Jr. (1997) Medicine (Baltimore) 76, 381-391.
2. Kondo, K. & Kaelin, W. G., Jr. (2001) Exp. Cell Res. 264, 117-125.
3. Cockman, M., Masson, N., Mole, D., Jaakkola, P., Chang, G., Clifford, S., Maher, E., Pugh, C., Ratcliffe, P. & Maxwell, P. (2000) J. Biol. Chem. 275, 25733-25741.
4. Kamura, T., Sato, S., Iwain, K., Czyzyk-Krzeska, M., Conaway, R. C. & Conaway, J. W. (2000) Proc. Natl. Acad. Sci. USA 97, 10430-10435.
5. Tanimoto, K., Makino, Y., Pereira, T. & Poellinger, L. (2000) EMBO J. 19, 4298-4309.
6. Ohh, M., Park, C. W., Ivan, M., Hoffman, M. A., Kim, T.-Y., Huang, L. E., Chau, V. & Kaelin, W. G., Jr. (2000) Nat. Cell Biol. 2, 423-427.
7. Semenza, G. (1999) Annu. Rev. Cell Dev. Biol. 15, 551-578.
8. Semenza, G. (2000) Genes Dev. 14, 1983-1991.
9. Wenger, R. (2000) J. Exp. Biol. 203, 1253-1263.
10. Ivan, M., Kondo, K., Yang, H., Kim, W., Valiando, J., Ohh, M., Salic, A., Asara, J., Lane, W. & Kaelin, W. G., Jr. (2001) Science 292, 464-468.
11. Jaakkola, P., Mole, D., Tian, Y., Wilson, M., Gielbert, J., Gaskell, S., Kriegsheim, A., Hebestreit, H., Mukherji, M., Schofield, C., et al. (2001) Science 292, 468-472.
12. Yu, F., White, S., Zhao, Q. & Lee, F. (2001) Proc. Natl. Acad. Sci. USA 98, 9630-9635.
13. Masson, N., Willam, C., Maxwell, P., Pugh, C. & Ratcliffe, P. (2001) EMBO J. 20, 5197-5206.
14. Kivirikko, K. I. & Myllyharju, J. (1998) Matrix Biol. 16, 357-368.
15. Schofield, C. J. & Zhang, Z. (1999) Curr. Opin. Struct. Biol. 9, 722-731.
16. Takahashi, Y., Takahashi, S., Shiga, Y., Yoshimi, T. & Miura, T. (2000). J. Biol. Chem. 275, 14139-14146.
17. Epstein, A., Gleadle, J., McNeill, L., Hewitson, K., O'Rourke, L, Mole, D., Mukherji, M., Metzen, E., Wilson, M., Dhanda, A., et al. (2001) Cell 107, 43-54.
18. Bruick, R. & McKnight, S. (2001) Science 294, 1337-1340.
19. Stebbins, C. E., Kaelin, W. G., Jr., & Pavletich, N. P. (1999) Science 284, 455-461.
20. Taylor, M. S. (2001) Gene 275, 125-132.
21. Trent, C., Tsuing, N. & Horvitz, H. R. (1983) Genetics 104, 619-647.
22. Aravind, L. & Koonin, E. V. (2001) Genome Biol. 2, research0007.1-0007.8.
23. Franklin, T., Morris, W., Edwards, P., Large, M. & Stephenson, R. (2001) Biochem. J. 353, 333-338.
24. Tschank, G., Raghunath, M., Gunzler, V. & Hanauske-Abel, H. M. (1987) Biochem. J. 248, 625-633.
25. Majamaa, K., Hanauske-Abel, H. M., Gunzler, V. & Kivirikko, K. I. (1984) Eur. J. Biochem. 138, 239-245.
26. Gunzler, V., Hanauske-Abel, H., Myllyla, R., Kaska, D., Hanauske, A. & Kivirikko, K. I. (1988) Biochem. J. 251, 365-372.
27. Baader, E., Tschank, G., Baringhaus, K., Burghard, H. & Gunzler, V. (1994) Biochem. J. 300, 525-530.
28. Lipscomb, E., Sarmiere, P., Crowder, R. & Freeman, R. (1999) J. Neurochem. 73, 429-432.
29. Lipscomb, E., Sarmiere, P. & Freeman, R. (2001) J. Biol. Chem. 276, 11775-11782.
30. Moschella, M., Menzies, K., Tsao, L., Lieb, M., Kohtz, J., Kohtz, D. & Taubman, M. (1999) Gene Expression 8, 59-66.
31. Wax, S., Tsao, L., Lieb, M., Fallon, J. & Taubman, M. (1996) Lab. Invest. 74, 797-808.
32. Wax, S., Rosenfiled, C. & Taubman, M. (1994) J. Biol. Chem. 269, 13041-13047.
33. Majamaa, K., Gunzler, V., Hanauske-Abel, H. M., Myllyla, R. & Kivirikko, K. I. (1986) J. Biol. Chem. 261, 7819-7823.
34. Lando, D., Peet, D., Whelan, D., Gorman, J. & Whitelaw, M. (2002) Science 295, 858-861.
35. Kaelin, W. G., Jr. (2002) Genes Dev. 16, 1441-1445.
36. Bruick, R. & McKnight, S. (2001) Genes Dev. 15, 2497-2502.
37. Carmeliet, P. (2000) Nat. Med. 6, 1102-1103.
38. Elson, D., Thurston, G., Huang, L., Ginzinger, D., McDonald, D., Johnson, R. & Arbeit, J. (2001) Genes Dev. 15, 2520-2532.
39. Nwogu, J. I., Geenen, D., Bean, M., Brenner, M. B., Huang, X. & Buttrick, P. M. (2001) Circulation 104, 2216-2221.