Egr-1, a master switch coordinating upregulation of divergent gene families underlying ischemic stress

Nature Medicine

Volumn 6, Issue 12, 2000, Pages 1355-1361

  Yan, Shi Fang ^a   Fujita, Tomoyuki ^a   Lu, Jiesheng ^a   Okada, Kenji ^a   Shan Zou, Yu ^a   Mackman, Nigel ^b   Pinsky, David J ^a   Stern, David M ^a  

^a Surgeons of Columbia University ^*  (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; CYTOKINE; INTERCELLULAR ADHESION MOLECULE 1; LIPOPOLYSACCHARIDE; TRANSCRIPTION FACTOR; VASCULOTROPIN;

ARTICLE; BLOOD CLOTTING; GENE CONTROL; GENE EXPRESSION; HYPOXIA; IMMUNE RESPONSE; ISCHEMIA; LUNG; MULTIGENE FAMILY; NONHUMAN; PRIORITY JOURNAL; REPERFUSION INJURY; STRESS;

ANIMALS; BLOOD COAGULATION FACTORS; CHEMOKINES; DNA-BINDING PROTEINS; EARLY GROWTH RESPONSE PROTEIN 1; ENDOTHELIAL GROWTH FACTORS; GENES, SWITCH; IMMEDIATE-EARLY PROTEINS; INTERCELLULAR ADHESION MOLECULE-1; LIPOPOLYSACCHARIDES; LUNG; LYMPHOKINES; MICE; MICE, MUTANT STRAINS; REPERFUSION INJURY; TRANSCRIPTION FACTORS; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS; ZINC FINGERS;

EID: 0034533374     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/82168     Document Type: Article

References (50)

1. Perspectives on oxygen sensing
2. Oxygen sensing and signaling: Impact on the regulation of physiologically important genes
3. Oxygen sensing, HIF-1 and the regulation of mammalian gene expression
4. Tissue factor transcription driven by Egr-1 is a critical mechanism of murine pulmonary fibrin deposition in hypoxia
5. A nerve growth factor induced gene encodes a possible transcriptional regulatory factor
6. Egr-1: Prototype of a zinc finger family of transcription factors
7. Egr-1 is essential for and restricts differentiation along the macrophage cell lineage
8. Hypoxia-associated induction of early growth response-1 gene expression
9. Potentiation of endogenous fibrinolysis and rescue from lung ischemia-reperfusion injury in IL-10-reconstituted IL-10 null mice
10. Proto-oncogene expression in porcine myocardium subjected to ischemia and reperfusion
11. Expression of two 'immediate early' genes, Egr-1 and c-fos, in response to renal ischemia and during compensatory renal hypertrophy in mice
12. Changes in gene expression after temporary renal ischemia
13. Luteinizing hormone deficiency and female infertility in mice lacking the transcription factor NGFI-A (Egr-1)
14. Role of the β2-integrins and immunoglobulin superfamily members in myocardial ischemia-reperfusion
15. Cardiac graft ICAM-1 and IL-1 expression mediate primary isograft failure and induction of ICAM-1 in organs remote from the site of transplantation
16. Prominent and sustained upregulation of gp130-signaling cytokines and the chemokine MIP-2 in murine renal ischemia-reperfusion injury
17. Role of endogenous nitric oxide in TNF-α and IL-1-β generation in hepatic ischemia-reperfusion
18. Potential mechanisms of IL-1 involvement in cerebral ischemia
19. The expression of proinflammatory cytokine mRNA in the sciatic-tibial nerve of ischemia-reperfusion injury
20. Chemokines
21. Through the looking glass: The diverse in vivo activities of chemokines
22. The ratio of ELR+ to ELR- CXC chemokines affects the lung and liver injury following hepatic ischemia/reperfusion in the rat
23. IL-10 inhibits pulmonary NF-kB activation and lung injury by hepatic ischemia-reperfusion
24. Chemokine involvement in hepatic ischemia/reperfusion injury in mice: Roles for MIP-2 and KC
25. Roles for C-X-C chemokines and C5a in lung injury after hindlimb ischemia-reperfusion
26. Differential and time-dependent expression of JE/MCP-1 mRNA by astrocytes and macrophages in rat brain: Effects of ischemia and peripheral LPS administration
27. Prolonged expression of IP-10 in ischemic cortex after permanent occlusion of the middle cerebral artery in rat
28. Fibrin-specific fibrinolysis
29. Regulation of PAI-1 gene expression in vivo
30. VEGF is a secreted angiogenic mitogen
31. VPF/VEGF, microvascular hyperpermeability, and angiogenesis
32. Rapid induction of VEGF gene expression after transient middle cerebral artery occlusion in rats
33. Early expression of angiogenesis factors in acute myocardial ischemia
34. VEGF antagonism reduces edema formation and tissue damage in ischemia/reperfusion injury in the mouse brain
35. Tissue destruction by neutrophils
36. Cytokines and endothelial cell biology
37. Tissue factor is induced by MCP-1 in human aortic smooth muscle and THP-1 cells
38. VEGF: A tumor-derived polypeptide that induces endothelial cell and monocyte procoagulant activity, and promotes monocyte migration
39. Transcriptional regulation of the ICAM-1 gene in antigen receptor- and phorbol ester-stimulated B lymphocytes: Role for transcription factor Egr-1
40. Activation of VEGF gene transcription by HIF-1
41. Egr-1 -induced endothelial gene expression: A common theme in vascular injury
42. NAB2, a corepressor of NGFI-A (EGR-1), and Krox20, is induced by proliferative, and differentiative stimuli
43. In vivo transfection of cis element 'decoy' against NF-kB binding site prevents myocardial infarction
44. NF-kB is activated and promotes cell death in focal cerebral ischemia
45. Inhibition of NF-kB activity and enhancement of apoptosis by neuropeptide CGRP
46. NF-kB inhibition causes spontaneous apoptosis in EB virus-transformed lymphoblastoid cells
47. Altered molecular response to adrenoreceptor-induced cardiac hypertrophy in Egr-1-deficient mice
48. M-CSF neutralization and Egr-1 deficiency prevent ovariectomy-induced bone loss
49. Lung myeloperoxidase as a measure of pulmonary leukostasis in rabbits
50. Detection of mRNA in tissue sections using DIG-labeled RNA and oligonucleotide probes