HIF-1α induces genetic instability by transcriptionally downregulating MutSα expression

Molecular Cell

Volumn 17, Issue 6, 2005, Pages 793-803

  Koshiji, Minori ^a   To, Kenneth K W ^a   Hammer, Stefanie ^a   Kumamoto, Kensuke ^a   Harris, Adrian L ^b   Modrich, Paul ^c,d   Huang, L Eric ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

^d DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; MYC PROTEIN; PROTEIN MSH2; PROTEIN MSH6; PROTEIN P53; TRANSCRIPTION FACTOR SP1; DNA BINDING PROTEIN; G T MISMATCH BINDING PROTEIN; G-T MISMATCH-BINDING PROTEIN; HIF1A PROTEIN, HUMAN; MSH2 PROTEIN, HUMAN; MYC PROTEIN, HUMAN; ONCOPROTEIN; TRANSCRIPTION FACTOR;

ARTICLE; BASE MISPAIRING; CELL HYPOXIA; COLON CARCINOMA; CONTROLLED STUDY; DNA BINDING; DNA REPAIR; GENE LOSS; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IMMUNOCHEMISTRY; MICROSATELLITE INSTABILITY; MOLECULAR RECOGNITION; NUCLEOTIDE SEQUENCE; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SYNTHESIS INHIBITION; TRANSCRIPTION TERMINATION; CELL CULTURE; CHROMOSOMAL INSTABILITY; COLON TUMOR; DOWN REGULATION; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; PATHOLOGY; PROTEIN BINDING;

CELL HYPOXIA; CHROMOSOMAL INSTABILITY; COLONIC NEOPLASMS; DNA REPAIR; DNA-BINDING PROTEINS; DOWN-REGULATION; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MUTS HOMOLOG 2 PROTEIN; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MYC; SP1 TRANSCRIPTION FACTOR; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 15244344206     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molcel.2005.02.015     Document Type: Article

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