Oxygen-sensitive reset of hypoxia-inducible factor transactivation response: Prolyl hydroxylases tune the biological normoxic set point

Free Radical Biology and Medicine

Volumn 40, Issue 12, 2006, Pages 2147-2154

  Khanna, Savita ^a   Roy, Sashwati ^a   Maurer, Mariah ^a   Ratan, Rajiv R ^b   Sen, Chandan K ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Ischemia; Oxygen; Reperfusion

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1; ISOENZYME; MERCURY; OXYGEN; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; SMALL INTERFERING RNA;

AMBIENT AIR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOLOGICAL ACTIVITY; BLOOD OXYGEN TENSION; BRAIN CORTEX; BRAIN OXYGEN TENSION; CATALYSIS; CELL FUNCTION; CONTROLLED STUDY; DOWN REGULATION; ENVIRONMENT; ENZYME ACTIVITY; ENZYME MECHANISM; EXPOSURE; GENE CONSTRUCT; GENETIC TRANSCRIPTION; HYDROXYLATION; HYPEROXIA; HYPOTHESIS; HYPOXIA; IN VIVO STUDY; MALE; MOUSE; NERVE CELL; NONHUMAN; OXYGEN SENSING; OXYGEN TISSUE LEVEL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN STABILITY; REGULATORY MECHANISM; REPORTER GENE; TRANSACTIVATION;

ANAEROBIOSIS; ANIMALS; BRAIN; CELL RESPIRATION; HYPOXIA-INDUCIBLE FACTOR 1; MALE; MICE; MICE, INBRED C57BL; NEURONS; OXYGEN; PARTIAL PRESSURE; PROCOLLAGEN-PROLINE DIOXYGENASE; RNA, MESSENGER; RNA, SMALL INTERFERING; TRANS-ACTIVATION (GENETICS);

EID: 33745164962     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2006.02.010     Document Type: Article

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