Induction of HIF-2α is dependent on mitochondrial O2 consumption in an O2-sensitive adrenomedullary chromaffin cell line

American Journal of Physiology - Cell Physiology

Volumn 294, Issue 6, 2008, Pages

  Brown, Stephen T ^a   Nurse, Colin A ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

Hypoxia inducible factor; Mitochondrial inhibition; Reactive oxygen species; RNA interference

Indexed keywords

ANTIMYCIN A1; CYANIDE; CYTOCHROME C OXIDASE; HYPOXIA INDUCIBLE FACTOR 2ALPHA; MESSENGER RNA; MITOCHONDRIAL DNA; MYXOTHIAZOL; OXYGEN; REACTIVE OXYGEN METABOLITE; RNA; ROTENONE; SHORT HAIRPIN RNA; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; ENDOTHELIAL PAS DOMAIN CONTAINING PROTEIN 1; ENDOTHELIAL PAS DOMAIN-CONTAINING PROTEIN 1; IRON SULFUR PROTEIN; RIESKE IRON-SULFUR PROTEIN; UBIQUINOL CYTOCHROME C REDUCTASE; UNCOUPLING PROTEIN;

ADRENAL MEDULLA; ANIMAL CELL; ARTICLE; CHROMAFFIN CELL; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; ENZYME SUBUNIT; HYPOXIA; MITOCHONDRIAL RESPIRATION; NONHUMAN; NUCLEOTIDE SEQUENCE; OXYGEN SENSING; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; ANIMAL; CELL HYPOXIA; CELL LINE; CYTOLOGY; DRUG EFFECT; GENETICS; METABOLISM; MITOCHONDRION; OXYGEN CONSUMPTION; TIME; UPREGULATION;

RATTUS;

ADRENAL MEDULLA; ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL HYPOXIA; CELL LINE; CHROMAFFIN CELLS; DNA, MITOCHONDRIAL; ELECTRON TRANSPORT COMPLEX III; ELECTRON TRANSPORT COMPLEX IV; IRON-SULFUR PROTEINS; MITOCHONDRIA; OXYGEN CONSUMPTION; RATS; REACTIVE OXYGEN SPECIES; RNA INTERFERENCE; TIME FACTORS; UNCOUPLING AGENTS; UP-REGULATION;

EID: 47249162090     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00007.2008     Document Type: Article

References (34)

1. Agani FH, Pichiule P, Chavez JC, LaManna JC. The role of mitochondria in the regulation of hypoxia-inducible factor 1 expression during hypoxia. J Biol Chem 275: 35863-35867, 2000.
2. Bell EL, Klimova TA, Eisenbart J, Moraes CT, Murphy MP, Budinger GR, Chandel NS. The Qo site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production. J Cell Biol 177: 1029-1036, 2007.
3. Borisov AB, Huang SK, Carlson BM. Remodeling of the vascular bed and progressive loss of capillaries in denervated skeletal muscle. Anat Rec 258: 292-304, 2000.
4. Brummelkamp TR, Bernards R, Agami R. Stable suppression of tumorigenicity by virus-mediated RNA interference. Cancer Cell 2: 243-247, 2002.
5. Brunelle JK, Bell EL, Quesada NM, Vercauteren K, Tiranti V, Zeviani M, Scarpulla RC, Chandel NS. Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation. Cell Metab 1: 409-414, 2005.
6. 2 sensing in immortalized adrenomedullary chromaffin cells. Am J Physiol Cell Physiol 294: C945-C956, 2008.
7. Cairns RA, Papandreou I, Sutphin PD, Denko NC. Metabolic targeting of hypoxia and HIF1 in solid tumors can enhance cytotoxic chemotherapy. Proc Natl Acad Sci USA 104: 9445-9450, 2007.
8. Chandel NS, Maltepe E, Goldwasser E, Mathieu CE, Simon MC, Schumacker PT. Mitochondrial reactive oxygen species trigger hypoxia-induced transcription. Proc Natl Acad Sci USA 95: 11715-11720, 1998.
9. 2 sensing. J Biol Chem 275: 25130-25138, 2000.
10. Doege K, Heine S, Jensen I, Jelkmann W, Metzen E. Inhibition of mitochondrial respiration elevates oxygen concentration but leaves regulation of hypoxia-inducible factor (HIF) intact. Blood 106: 2311-2317, 2005.
11. + channels in immortalised rat chromaffin-cell-derived MAH cells. J Physiol 545: 807-818, 2002.
12. Fedele AO, Whitelaw ML, Peet DJ. Regulation of gene expression by the hypoxia-inducible factors. Mol Interv 2: 229-243, 2002.
13. Fukuda R, Zhang H, Kim JW, Shimoda L, Dang CV, Semenza GL. HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells. Cell 129: 111-122, 2007.
14. Giegerich R, Meyer F, Schleiermacher C. GeneFisher-software support for the detection of postulated genes. Proc Int Conf Intell Syst Mol Biol 4: 68-77, 1996.
15. Guzy RD, Hoyos B, Robin E, Chen H, Liu L, Mansfield KD, Simon MC, Hammerling U, Schumacker PT. Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing. Cell Metab 1: 401-408, 2005.
16. Hagen T, Taylor CT, Lam F, Moncada S. Redistribution of intracellular oxygen in hypoxia by nitric oxide: effect on HIF1alpha. Science 302: 1975-1978, 2003.
17. 2-dependent degradation domain via the ubiquitin-proteasome pathway. Proc Natl Acad Sci USA 95: 7987-7992, 1998.
18. 2 tension. Am J Physiol Cell Physiol 271: C1172-C1180, 1996.
19. Lopez-Lazaro M. Hypoxia-inducible factor 1 as a possible target for cancer chemoprevention. Cancer Epidemiol Biomarkers Prev 15: 2332-2335, 2006.
20. Mansfield KD, Guzy RD, Pan Y, Young RM, Cash TP, Schumacker PT, Simon MC. Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-alpha activation. Cell Metab 1: 393-399, 2005.
21. Mansfield KD, Simon MC, Keith B. Hypoxic reduction in cellular glutathione levels requires mitochondrial reactive oxygen species. J Appl Physiol 97: 1358-1366, 2004.
22. Masson N, Willam C, Maxwell PH, Pugh CW, Ratcliffe PJ. Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation. EMBO J 20: 5197-5206, 2001.
23. Maxwell PH, Wiesener MS, Chang GW, Clifford SC, Vaux EC, Cockman ME, Wykoff CC, Pugh CW, Maher ER, Ratcliffe PJ. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 399: 271-275, 1999.
24. Schroedl C, McClintock DS, Budinger GR, Chandel NS. Hypoxic but not anoxic stabilization of HIF-1alpha requires mitochondrial reactive oxygen species. Am J Physiol Lung Cell Mol Physiol 283: L922-L931, 2002.
25. Seidler FJ, Slotkin TA. Adrenomedullary function in the neonatal rat: responses to acute hypoxia. J Physiol 358: 1-16, 1985.
26. 2, and the 3 PHDs: how animal cells signal hypoxia to the nucleus. Cell 107: 1-3, 2001.
27. Semenza GL. Hydroxylation of HIF-1: oxygen sensing at the molecular level. Physiology (Bethesda) 19: 176-182, 2004.
28. Slotkin TA, Seidler FJ. Adrenomedullary catecholamine release in the fetus and newborn: secretory mechanisms and their role in stress and survival. J Dev Physiol 10: 1-16, 1988.
29. Srinivas V, Leshchinsky I, Sang N, King MP, Minchenko A, Caro J. Oxygen sensing and HIF-1 activation does not require an active mitochondrial respiratory chain electron-transfer pathway. J Biol Chem 276: 21995-21998, 2001.
30. Tian H, Hammer RE, Matsumoto AM, Russell DW, McKnight SL. The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development. Genes Dev 12: 3320-3324, 1998.
31. Vaux EC, Metzen E, Yeates KM, Ratcliffe PJ. Regulation of hypoxia-inducible factor is preserved in the absence of a functioning mitochondrial respiratory chain. Blood 98: 296-302, 2001.
32. Wang GL, Jiang BH, Rue EA, Semenza GL. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci USA 92: 5510-5514, 1995.
33. Weir EK, Lopez-Barneo J, Buckler KJ, Archer SL. Acute oxygen-sensing mechanisms. N Engl J Med 353: 2042-2055, 2005.
34. Wenger RH. Mitochondria: oxygen sinks rather than sensors? Med Hypotheses 66: 380-383, 2006.