HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

Cell Metabolism

Volumn 3, Issue 3, 2006, Pages 187-197

  Papandreou, Ioanna ^a   Cairns, Rob A ^a   Fontana, Lucrezia ^a   Lim, Ai Lin ^a   Denko, Nicholas C ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1; OXYGEN; PROTEIN KINASE; PYRUVATE DEHYDROGENASE; SMALL INTERFERING RNA; TIRAPAZAMINE;

ADAPTATION; ANIMAL CELL; APOPTOSIS; ARTICLE; CITRIC ACID CYCLE; CONTROLLED STUDY; CYTOTOXICITY; DNA MICROARRAY; DOWN REGULATION; DRUG ACTIVITY; ENZYME PHOSPHORYLATION; FIBROBLAST; FLOW CYTOMETRY; GENE EXPRESSION; GLYCOLYSIS; HUMAN; HUMAN CELL; HYPOXIA; INHIBITION KINETICS; MITOCHONDRION; NONHUMAN; OXIDATIVE PHOSPHORYLATION; OXYGEN CONSUMPTION; OXYGEN TENSION; PLASMID; PRIORITY JOURNAL; PROTEIN FUNCTION;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; APOPTOSIS; CELL HYPOXIA; CELLS, CULTURED; COMPUTATIONAL BIOLOGY; DOWN-REGULATION; GENOMICS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MICE; MICE, KNOCKOUT; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; OXYGEN CONSUMPTION; PROTEIN KINASES; UP-REGULATION;

ANIMALIA;

EID: 33644622570     PISSN: 15504131     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cmet.2006.01.012     Document Type: Article

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