메뉴 건너뛰기




Volumn 394, Issue 6692, 1998, Pages 485-490

Role of HIF-1α in hypoxiamediated apoptosis, cell proliferation and tumour angiogenesis

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; ENDOTHELIAL CELL GROWTH FACTOR; GLUCOSE; HIF1A PROTEIN, MOUSE; HYPOXIA INDUCIBLE FACTOR 1; LYMPHOKINE; NUCLEAR PROTEIN; OXYGEN; TRANSCRIPTION FACTOR; VASCULOTROPIN; VASCULOTROPIN A;

EID: 0032581277     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/28867     Document Type: Article
Times cited : (2291)

References (30)
  • 1
    • 0029842459 scopus 로고    scopus 로고
    • Oxygen sensing and molecular adaptation to hyopoxia
    • Bunn, H. F. & Poyton, R. O. Oxygen sensing and molecular adaptation to hyopoxia. Physiol. Rev. 76, 839-885 (1996).
    • (1996) Physiol. Rev. , vol.76 , pp. 839-885
    • Bunn, H.F.1    Poyton, R.O.2
  • 2
    • 1842416574 scopus 로고    scopus 로고
    • Oxygen(s) and the hypoxia-inducible factor-1
    • Wenger, R. H. & Gassmann, M. Oxygen(s) and the hypoxia-inducible factor-1. Biol. Chem. 378, 609-616 (1997).
    • (1997) Biol. Chem. , vol.378 , pp. 609-616
    • Wenger, R.H.1    Gassmann, M.2
  • 3
    • 0030200804 scopus 로고    scopus 로고
    • Transcriptional regulation by hypoxia-inducible factor-1
    • Semenza, G. L. Transcriptional regulation by hypoxia-inducible factor-1. Trends Cardiovasc. Med. 6, 151-157 (1996).
    • (1996) Trends Cardiovasc. Med. , vol.6 , pp. 151-157
    • Semenza, G.L.1
  • 4
    • 15444342958 scopus 로고    scopus 로고
    • 2 homeostasis by hypoxia-inducible factor-1α
    • 2 homeostasis by hypoxia-inducible factor-1α. Genes Dev. 12, 149-162 (1998).
    • (1998) Genes Dev. , vol.12 , pp. 149-162
    • Iyer, N.V.1
  • 5
    • 0030712335 scopus 로고    scopus 로고
    • Ischemia-driven angiogenesis
    • Dor, Y. & Keshet, E. Ischemia-driven angiogenesis. Trends Cardiovasc. Med. 7, 289-294 (1997).
    • (1997) Trends Cardiovasc. Med. , vol.7 , pp. 289-294
    • Dor, Y.1    Keshet, E.2
  • 7
    • 0028363519 scopus 로고
    • p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21
    • Toyoshima, H. & Hunter, T. p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21. Cell 78, 67-74 (1994).
    • (1994) Cell , vol.78 , pp. 67-74
    • Toyoshima, H.1    Hunter, T.2
  • 8
    • 0026632457 scopus 로고
    • Gadd45 and Gadd153 messenger RNA levels are increased during hypoxia and after exposure of cells to agents which elevate the levels of the glucose-regulated proteins
    • Price, B. D. & Calderwood, S. K. Gadd45 and Gadd153 messenger RNA levels are increased during hypoxia and after exposure of cells to agents which elevate the levels of the glucose-regulated proteins. Cancer Res. 52, 3814-3817 (1992).
    • (1992) Cancer Res. , vol.52 , pp. 3814-3817
    • Price, B.D.1    Calderwood, S.K.2
  • 9
    • 0027958873 scopus 로고
    • The glucose-regulated proteins (GRP78 and GRP94): Functions, gene regulation, and applications
    • Little, E., Ramakrishnan, M., Roy, B., Gazit, G. & Lee, A. S. The glucose-regulated proteins (GRP78 and GRP94): functions, gene regulation, and applications. Crit. Rev. Eukaryot. Gene Expr. 4, 1-18 (1994).
    • (1994) Crit. Rev. Eukaryot. Gene Expr. , vol.4 , pp. 1-18
    • Little, E.1    Ramakrishnan, M.2    Roy, B.3    Gazit, G.4    Lee, A.S.5
  • 10
    • 0032478823 scopus 로고    scopus 로고
    • Selection and analysis of a mutant cell line defective in the hypoxia inducible factor-1α subunit. Characterization of HIF-1α dependent and independent hypoxia-inducible gene expression
    • Wood, S. M. et al. Selection and analysis of a mutant cell line defective in the hypoxia inducible factor-1α subunit. Characterization of HIF-1α dependent and independent hypoxia-inducible gene expression. J. Biol. Chem. 273, 8360-8367 (1998).
    • (1998) J. Biol. Chem. , vol.273 , pp. 8360-8367
    • Wood, S.M.1
  • 11
    • 0029097316 scopus 로고
    • Molecular controls of growth arrest and apoptosis: p53-dependent and independent pathways
    • Liebermann, D. A., Hoffman, B. & Steinman, R. A. Molecular controls of growth arrest and apoptosis: p53-dependent and independent pathways. Oncogene 11, 199-210 (1995).
    • (1995) Oncogene , vol.11 , pp. 199-210
    • Liebermann, D.A.1    Hoffman, B.2    Steinman, R.A.3
  • 12
    • 0030866223 scopus 로고    scopus 로고
    • Multiple pathways control cell growth and transformation: Overlapping and independent activities of p53 and p21Cip1/WAF1/Sdi1
    • Cox, L. S. Multiple pathways control cell growth and transformation: overlapping and independent activities of p53 and p21Cip1/WAF1/Sdi1. J. Pathol. 183, 134-140 (1997).
    • (1997) J. Pathol. , vol.183 , pp. 134-140
    • Cox, L.S.1
  • 13
    • 0028110809 scopus 로고
    • Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status
    • Graeber, T. G. et al. Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status. Mol. Cell. Biol. 14, 6264-6277 (1994).
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 6264-6277
    • Graeber, T.G.1
  • 14
    • 0030665659 scopus 로고    scopus 로고
    • The role of the bcl-2/ced-9 gene family in cancer and general implications of defects in cell death control for tumorigenesis and resistance to chemotherapy
    • Strasser, A., Huang, D. C. & Vaux, D. L. The role of the bcl-2/ced-9 gene family in cancer and general implications of defects in cell death control for tumorigenesis and resistance to chemotherapy. Biochim. Biophys. Acta 1333, F151-178 (1997).
    • (1997) Biochim. Biophys. Acta , vol.1333
    • Strasser, A.1    Huang, D.C.2    Vaux, D.L.3
  • 15
    • 0030816109 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth
    • Maxwell, P. H. et al. Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth. Proc. Natl Acad. Sci. USA 94, 8104-8109 (1997).
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , pp. 8104-8109
    • Maxwell, P.H.1
  • 16
    • 0030943461 scopus 로고    scopus 로고
    • Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT
    • Maltepe, E., Schmidt, J. V., Baunoch, D., Bradfield, C. A. & Simon, C. M. Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT. Nature 386, 403-407 (1997).
    • (1997) Nature , vol.386 , pp. 403-407
    • Maltepe, E.1    Schmidt, J.V.2    Baunoch, D.3    Bradfield, C.A.4    Simon, C.M.5
  • 17
    • 0031918244 scopus 로고    scopus 로고
    • Regulation of proliferation-survival decisions during tumor cell hypoxia
    • Schmaltz, C., Harrigan Hardenbergh, P., Wells, A. & Fisher, D. E. Regulation of proliferation-survival decisions during tumor cell hypoxia. Mol. Cell. Biol. 18, 2845-2854 (1998).
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 2845-2854
    • Schmaltz, C.1    Harrigan Hardenbergh, P.2    Wells, A.3    Fisher, D.E.4
  • 19
    • 0028882315 scopus 로고
    • Cytokines inhibit p53-mediated apoptosis but not p53-mediated G1 arrest
    • Lin, Y. & Benchimol, S. Cytokines inhibit p53-mediated apoptosis but not p53-mediated G1 arrest. Mol. Cell. Biol. 15, 6045-6054 (1995).
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 6045-6054
    • Lin, Y.1    Benchimol, S.2
  • 20
    • 0030744577 scopus 로고    scopus 로고
    • The influence of tumor blood flow and microenvironmental factors on the efficacy of radiation, drugs and localized hyperthermia
    • Vaupel, P. The influence of tumor blood flow and microenvironmental factors on the efficacy of radiation, drugs and localized hyperthermia. Klin. Pädiatr. 209, 243-249 (1997).
    • (1997) Klin. Pädiatr. , vol.209 , pp. 243-249
    • Vaupel, P.1
  • 21
    • 0029949160 scopus 로고    scopus 로고
    • Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody
    • Yuan, F. et al. Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody. Proc. Natl Acad. Sci. USA 93, 14765-14770 (1996).
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 14765-14770
    • Yuan, F.1
  • 22
    • 0030025773 scopus 로고    scopus 로고
    • Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours
    • Graeber, T. G. et al. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature 379, 88-91 (1996).
    • (1996) Nature , vol.379 , pp. 88-91
    • Graeber, T.G.1
  • 23
    • 0030614893 scopus 로고    scopus 로고
    • 2 gradients in solid tumors in vivo: High-resolution measurements reveal a lack of correlation
    • 2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlation. Nature Med. 3, 177-182 (1997).
    • (1997) Nature Med. , vol.3 , pp. 177-182
    • Helmlinger, G.1    Yuan, F.2    Dellian, M.3    Jain, R.K.4
  • 24
    • 0032568150 scopus 로고    scopus 로고
    • Stabilization of wild-type p53 by hypoxia-inducible factor-1α
    • An, W. G. et al. Stabilization of wild-type p53 by hypoxia-inducible factor-1α. Nature 392, 405-408 (1998).
    • (1998) Nature , vol.392 , pp. 405-408
    • An, W.G.1
  • 25
    • 0029944965 scopus 로고    scopus 로고
    • Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor-1
    • Jiang, B. H., Rue, E., Wang, G. L., Roe, R. & Semenza, G. L. Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor-1. J. Biol. Chem. 271, 17771-17778 (1996).
    • (1996) J. Biol. Chem. , vol.271 , pp. 17771-17778
    • Jiang, B.H.1    Rue, E.2    Wang, G.L.3    Roe, R.4    Semenza, G.L.5
  • 26
    • 0343920277 scopus 로고    scopus 로고
    • Abnormal blood vessel development and lethality in embryos lacking a single vascular endothelial growth-factor allele
    • Carmeliet, P. et al. Abnormal blood vessel development and lethality in embryos lacking a single vascular endothelial growth-factor allele. Nature 380, 435-439 (1996).
    • (1996) Nature , vol.380 , pp. 435-439
    • Carmeliet, P.1
  • 27
    • 0031969258 scopus 로고    scopus 로고
    • Analysis of subcutaneous angiogenesis by gradient echo magnetic resonance imaging
    • Abramovitch, R., Frenkiel, D. & Neeman, M. Analysis of subcutaneous angiogenesis by gradient echo magnetic resonance imaging. Mag. Reson. Med. 39, 813-824 (1998).
    • (1998) Mag. Reson. Med. , vol.39 , pp. 813-824
    • Abramovitch, R.1    Frenkiel, D.2    Neeman, M.3
  • 28
    • 0028335405 scopus 로고
    • Effects of intra-arterial injection of colored microspheres on systemic hemodynamics and regional blood flow in rats
    • Kobayashi, N., Kobayashi, K., Kouno, K., Horinaka, S. & Yagi, S. Effects of intra-arterial injection of colored microspheres on systemic hemodynamics and regional blood flow in rats. Am. J. Physiol. 266, H1910-H1917 (1994).
    • (1994) Am. J. Physiol. , vol.266
    • Kobayashi, N.1    Kobayashi, K.2    Kouno, K.3    Horinaka, S.4    Yagi, S.5
  • 29
    • 0028784382 scopus 로고
    • Identification of hypoxia in cells and tissues of epigastric 9L rat glioma using EF5 (2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl) acetamide)
    • Evans, S. M. et al. Identification of hypoxia in cells and tissues of epigastric 9L rat glioma using EF5 (2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl) acetamide). Br. J. Cancer 72, 875-882 (1995).
    • (1995) Br. J. Cancer , vol.72 , pp. 875-882
    • Evans, S.M.1
  • 30
    • 0030842570 scopus 로고    scopus 로고
    • Involvement of u-PA in the anti-apoptotic activity of TGFβ for vascular smooth muscle cells
    • Herbert, J. M. & Carmeliet, P. Involvement of u-PA in the anti-apoptotic activity of TGFβ for vascular smooth muscle cells. FEBS Lett. 413, 401-404 (1997).
    • (1997) FEBS Lett. , vol.413 , pp. 401-404
    • Herbert, J.M.1    Carmeliet, P.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.