Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-α activation

Cell Metabolism

Volumn 1, Issue 6, 2005, Pages 393-399

  Mansfield, Kyle D ^a   Guzy, Robert D ^b   Pan, Yi ^a,c   Young, Regina M ^a,c   Cash, Timothy P ^a   Schumacker, Paul T ^b   Simon, M Celeste ^a,c  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME C; HYDROGEN PEROXIDE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; OXYGEN; OXYGENASE; REACTIVE OXYGEN METABOLITE; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; HIF1A PROTEIN, HUMAN; HYPOXIA INDUCIBLE FACTOR 2, ALPHA SUBUNIT; HYPOXIA-INDUCIBLE FACTOR 2, ALPHA SUBUNIT; MITOCHONDRIAL DNA; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; CELL ACTIVITY; CELL FUNCTION; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; EMBRYO CELL; HUMAN; HUMAN CELL; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; OXYGEN CONCENTRATION; OXYGEN SENSING; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN STABILITY; SIGNAL TRANSDUCTION; ANIMAL; ANOXIA; CELL CULTURE; DNA REPLICATION; METABOLISM; MITOCHONDRION; PHYSIOLOGY;

MAMMALIA; MURINAE;

ANIMALS; ANOXIA; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELLS, CULTURED; CYTOCHROMES C; DNA REPLICATION; DNA, MITOCHONDRIAL; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MICE; MITOCHONDRIA; OXYGEN; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

EID: 24144447915     PISSN: 15504131     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cmet.2005.05.003     Document Type: Article

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