Normoxic stabilization of hypoxia-inducible factor-1 expression and activity: Redox-dependent effect of nitrogen oxides

Molecular Pharmacology

Volumn 58, Issue 6, 2000, Pages 1197-1203

  Palmer, Lisa A ^a   Gaston, Benjamin ^b   Johns, Roger A ^a  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1; NITROGEN OXIDE;

ALPHA CHAIN; ANIMAL CELL; CATTLE; CONFORMATIONAL TRANSITION; DNA BINDING; DRUG STABILITY; ENDOTHELIUM CELL; GENE EXPRESSION REGULATION; GENE TARGETING; GENETIC REGULATION; NONHUMAN; OXIDATION REDUCTION REACTION; OXYGEN TENSION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SHORT SURVEY; TARGET CELL;

EID: 0033673457     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.58.6.1197     Document Type: Short Survey

References (29)

1. Chemiluminescence headspace-gas analysis for determination of nitric oxide formation in biological systems
2. Nitric oxide and thiol groups
3. Umbilical arterial S-nitriothiols in stressed newborns: Role in perinatal circulatory transition
4. Regulation of angiogenic growth factor expression by hypoxia, transition metals, and chelating agents
5. The hypoxic response: Huffing and HIFing
6. Induction of heine oxygenase-1 as a response in sensing the signals evoked by distinct nitric oxide donors
7. Snitrosoglutathione as a substrate for gamma glutamyl transpeptidase
8. Structure of an E6-AP-Ubc H7 complex insights into ubiquitination by the E2-E3 enzyme cascade
9. Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of it's α subunit
10. 2-dependent degradation domain via the ubiquitinproteasome pathway
11. Inhibition of hypoxia-inducible factor 1 activation by carbon monoxide and nitric oxide: Implications for oxygen sensing and signaling
12. Regulation of ubiquitin-conjugating enzymes by glutathione following oxidative stress
13. S-nitrosohaemoglobin: Dynamic activity of blood involved in vascular control
14. NG-monomethyl L-arginine inhibits endothelium-derived relaxing factor-stimulate cyclic GMP accumulation in co-cultures of endothelial and vascular smooth muscle cells by an action specific to the endothelial cells
15. Activation of hypoxia-inducible factor 1α: Posttranscriptional regulation and conformational change by recruitment of Arnt transcription factor
16. 'NONOATES' (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: Convenient nitric oxide dosage forms
17. Hypoxia response element of the human vascular endothelial growth factor gene mediates transcriptional regulation by nitric oxide: Control of hypoxia-inducible factor-1 activity by nitric oxide
18. Hypoxia-inducible factor 1 mediated transcriptional activation of the heme oxygenase 1 gene in response to hypoxia
19. Carbon monoxide and nitric oxide suppress the hypoxia induction of vascular endothelial growth factor gene via the 5' enhancer
20. The tumor suppressor protein VHL targets hypoxia-inducible factors for oxygen dependent proteolysis
21. Nitric oxide assay using hemoglobin method
22. Hypoxia induced type II NOS gene expression in pulmonary artery endothelial cells via HIF-1
23. Angiogenesis: How a tumor adapts to hypoxia
24. Hypoxia inducible factor 1alpha (HIF-1 alpha) protein is rapidly degraded by the ubiquitin-proteosome system under normoxia conditions Its stabilization by hypoxia depends on redox-induced changes
25. Inhibition of hypoxia-inducible factor i activity by nitric oxide donors in hypoxia
26. Biochemistry of nitric oxide and its redox-activated forms
27. 2 tension
28. Purification and characterization of hypoxia-inducible factor 1
29. The role of the aryl hydrocarbon receptor nuclear translocator (ARNT) in hypoxic induction of gene expression: Studies in ARNT-deficient cells