Transcription factor HIF-1 is a necessary mediator of the pasteur effect in mammalian cells

Molecular and Cellular Biology

Volumn 21, Issue 10, 2001, Pages 3436-3444

  Seagroves, T N ^a   Ryan, H E ^a   Lu, H ^a   Wouters, B G ^a   Knapp, M ^a   Thibault, P ^a   Laderoute, K ^a   Johnson, R S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; GLUCOSE; LACTIC ACID; OXYGEN; TRANSCRIPTION FACTOR;

ACIDOSIS; ADAPTATION; ANIMAL CELL; ARTICLE; CELL GROWTH; CONTROLLED STUDY; EMBRYO; FERMENTATION; GLYCOLYSIS; GROWTH RATE; HYPOXIA; MAMMAL CELL; MOUSE; NONHUMAN; PHOSPHORYLATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; CELL HYPOXIA; CELL LINE; DNA-BINDING PROTEINS; ENERGY METABOLISM; FIBROBLASTS; HYPOXIA-INDUCIBLE FACTOR 1; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MICE; NUCLEAR PROTEINS; OXYGEN; TRANSCRIPTION FACTORS;

ANIMALIA; MAMMALIA;

EID: 0035027828     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.21.10.3436-3444.2001     Document Type: Article

References (27)

1. The unique physiology of solid tumors: Opportunities (and problems) for cancer therapy
2. Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
3. Regulation of the erythropoietin gene
4. Oxygen-regulated control elements in the phosphoglycerate kinase I and lactate dehydrogenase A genes: Similarities with the erythropoietin 3′ enhancer
5. Hypoxic regulation of lactate dehydrogenase A. Interaction between hypoxia-inducible factor 1 and cAMP response elements
6. Causes and effects of heterogeneous perfusion in tumors
7. Modification of tumour glucose metabolism for therapeutic benefit
8. 2-dependent degradation domain via the ubiquitin-proteasome pathway
9. 2homeostasis by hypoxia-inducible factor 1 alpha
10. Cellular transformation and malignancy induced by fas require c-Jun
11. Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth
12. Identification of hypoxically inducible mRNAs in HeLa cells using differential-display PCR. Role of hypoxia-inducible factor-1
13. Intermediary metabolism of fast-growth tumor cells
14. The hypoxia inducible factor-1 alpha gene is required for embryogenesis and solid tumor formation
15. Hypoxia-inducible factor-1 alpha is a positive factor in solid tumor growth
16. Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes
17. Targeted insertion of exogenous DNA into the eukaryotic genome by the Cre recombinase
18. Regulation of proliferation-survival decisions during tumor cell hypoxia
19. Hypoxia-inducible factor 1 and the molecular physiology of oxygen homeostasis
20. Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia
21. General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia
22. Purification and characterization of hypoxia-inducible factor 1
23. Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1alpha/ARNT