-
1
-
-
8344237449
-
Hydroxylation of HIF-1: Oxygen sensing at the molecular level
-
Bethesda
-
Semenza GL. Hydroxylation of HIF-1: oxygen sensing at the molecular level. Physiology (Bethesda). 2004;19:176-182.
-
(2004)
Physiology
, vol.19
, pp. 176-182
-
-
Semenza, G.L.1
-
3
-
-
0038037735
-
Regulation of angiogenesis by hypoxia: Role of the HIF system
-
Pugh CW, Ratcliffe PJ. Regulation of angiogenesis by hypoxia: role of the HIF system. Nat Med. 2003;9:677-684.
-
(2003)
Nat Med
, vol.9
, pp. 677-684
-
-
Pugh, C.W.1
Ratcliffe, P.J.2
-
4
-
-
0037490210
-
Hypoxia-inducible factor and its biomedical relevance
-
Huang LE, Bunn HF. Hypoxia-inducible factor and its biomedical relevance. J Biol Chem. 2003;278:19575-19578.
-
(2003)
J Biol Chem
, vol.278
, pp. 19575-19578
-
-
Huang, L.E.1
Bunn, H.F.2
-
5
-
-
0029944965
-
Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1
-
Jiang BH, Rue E, Wang GL, Roe R, Semenza GL. Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1. J Biol Chem. 1996;271:17771-17778.
-
(1996)
J Biol Chem
, vol.271
, pp. 17771-17778
-
-
Jiang, B.H.1
Rue, E.2
Wang, G.L.3
Roe, R.4
Semenza, G.L.5
-
6
-
-
0030937718
-
Activation of hypoxia-inducible factor-1; definition of regulatory domains within the α subunit
-
Pugh CW, O'Rourke JF, Nagao M, Gleadle JM, Ratcliffe PJ. Activation of hypoxia-inducible factor-1; definition of regulatory domains within the α subunit. J Biol Chem. 1997;272:11205-11214.
-
(1997)
J Biol Chem
, vol.272
, pp. 11205-11214
-
-
Pugh, C.W.1
O'Rourke, J.F.2
Nagao, M.3
Gleadle, J.M.4
Ratcliffe, P.J.5
-
7
-
-
0030787469
-
Transactivation and inhibitory domains of hypoxia-inducible factor 1alpha. Modulation of transcriptional activity by oxygen tension
-
Jiang BH, Zheng JZ, Leung SW, Roe R, Semenza GL. Transactivation and inhibitory domains of hypoxia-inducible factor 1alpha. Modulation of transcriptional activity by oxygen tension. J Biol Chem. 1997;272:19253-19260.
-
(1997)
J Biol Chem
, vol.272
, pp. 19253-19260
-
-
Jiang, B.H.1
Zheng, J.Z.2
Leung, S.W.3
Roe, R.4
Semenza, G.L.5
-
8
-
-
0029859510
-
Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension
-
Jiang BH, Semenza GL, Bauer C, Marti HH. Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension. Am J Physiol. 1996;271:C1172-C1180.
-
(1996)
Am J Physiol
, vol.271
-
-
Jiang, B.H.1
Semenza, G.L.2
Bauer, C.3
Marti, H.H.4
-
9
-
-
0032493368
-
2-dependent degradation domain via the ubiquitin-proteasome pathway
-
U S A
-
2-dependent degradation domain via the ubiquitin-proteasome pathway. Proc Natl Acad Sci U S A. 1998;95:7987-7992.
-
(1998)
Proc Natl Acad Sci
, vol.95
, pp. 7987-7992
-
-
Huang, L.E.1
Gu, J.2
Schau, M.3
Bunn, H.F.4
-
10
-
-
0030961006
-
Hypoxia-inducible factor 1α (HIF-1α) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes
-
Salceda S, Caro J. Hypoxia-inducible factor 1α (HIF-1α) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes. J Biol Chem. 1997;272:22642-22647.
-
(1997)
J Biol Chem
, vol.272
, pp. 22642-22647
-
-
Salceda, S.1
Caro, J.2
-
13
-
-
17944375360
-
C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
-
Epstein ACR, Gleadle JM, McNeill LA, et al. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell. 2001;107:43-54.
-
(2001)
Cell
, vol.107
, pp. 43-54
-
-
Epstein, A.C.R.1
Gleadle, J.M.2
McNeill, L.A.3
-
14
-
-
0035834409
-
A conserved family of prolyl-4-hydroxylases that modify HIF
-
Bruick RK, McKnight SL. A conserved family of prolyl-4-hydroxylases that modify HIF. Science. 2001;294:1337-1340.
-
(2001)
Science
, vol.294
, pp. 1337-1340
-
-
Bruick, R.K.1
McKnight, S.L.2
-
15
-
-
0035887011
-
FIH-1: A novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity
-
Mahon PC, Hirota K, Semenza GL. FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity. Genes Dev. 2001;15:2675-2686.
-
(2001)
Genes Dev
, vol.15
, pp. 2675-2686
-
-
Mahon, P.C.1
Hirota, K.2
Semenza, G.L.3
-
16
-
-
18544386401
-
Hypoxia inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family
-
Hewitson KS, McNeill LA, Riordan MV, et al. Hypoxia inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family. J Biol Chem. 2002;277:26351-26355.
-
(2002)
J Biol Chem
, vol.277
, pp. 26351-26355
-
-
Hewitson, K.S.1
McNeill, L.A.2
Riordan, M.V.3
-
17
-
-
0036469038
-
Asparagine hydroxylation of the HIF transactivation domain: A hypoxic switch
-
Lando D, Peet DJ, Whelan DA, Gorman JJ, Whitelaw ML. Asparagine hydroxylation of the HIF transactivation domain: a hypoxic switch. Science. 2002;295:858-861.
-
(2002)
Science
, vol.295
, pp. 858-861
-
-
Lando, D.1
Peet, D.J.2
Whelan, D.A.3
Gorman, J.J.4
Whitelaw, M.L.5
-
18
-
-
0027136260
-
Desferrioxamine induces erythropoietin gene expression and hypoxiainducible factor 1 DNA-binding activity: Implications for models of hypoxia signal transduction
-
Wang GL, Semenza GL. Desferrioxamine induces erythropoietin gene expression and hypoxiainducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction. Blood. 1993;82:3610-3615.
-
(1993)
Blood
, vol.82
, pp. 3610-3615
-
-
Wang, G.L.1
Semenza, G.L.2
-
19
-
-
0035910429
-
Identification of hypoxia-inducible factor 1 ancillary sequence and its function in vascular endothelial growth factor gene induction by hypoxia and nitric oxide
-
Kimura H, Weisz A, Ogura T, et al. Identification of hypoxia-inducible factor 1 ancillary sequence and its function in vascular endothelial growth factor gene induction by hypoxia and nitric oxide. J Biol Chem. 2001;276:2292-2298.
-
(2001)
J Biol Chem
, vol.276
, pp. 2292-2298
-
-
Kimura, H.1
Weisz, A.2
Ogura, T.3
-
20
-
-
0042469448
-
Nitric oxide impairs normoxic degradation of HIF-1α by inhibition of prolyl hydroxylases
-
Metzen E, Zhou J, Jelkmann W, Fandrey J, Brune B. Nitric oxide impairs normoxic degradation of HIF-1α by inhibition of prolyl hydroxylases. Mol Biol Cell. 2003;14:3470-3481.
-
(2003)
Mol Biol Cell
, vol.14
, pp. 3470-3481
-
-
Metzen, E.1
Zhou, J.2
Jelkmann, W.3
Fandrey, J.4
Brune, B.5
-
21
-
-
0038825680
-
2-Oxoglutarate analogue inhibitors of HIF prolyl hydroxylase
-
Mole DR, Schlemminger I, McNeill LA, et al. 2-oxoglutarate analogue inhibitors of HIF prolyl hydroxylase. Bioorg Med Chem Lett. 2003;13:2677-2680.
-
(2003)
Bioorg Med Chem Lett
, vol.13
, pp. 2677-2680
-
-
Mole, D.R.1
Schlemminger, I.2
McNeill, L.A.3
-
22
-
-
0037337061
-
The subtle side to hypoxia inducible factor (HIFα) regulation
-
Bilton RL, Booker GW. The subtle side to hypoxia inducible factor (HIFα) regulation. Eur J Biochem. 2003;270:791-798.
-
(2003)
Eur J Biochem
, vol.270
, pp. 791-798
-
-
Bilton, R.L.1
Booker, G.W.2
-
23
-
-
0033605676
-
Inhibition of hypoxia-inducible factor 1 activation by carbon monoxide and nitric oxide. Implications for oxygen sensing and signaling
-
Huang LE, Willmore WG, Gu J, Goldberg MA, Bunn HF. Inhibition of hypoxia-inducible factor 1 activation by carbon monoxide and nitric oxide. Implications for oxygen sensing and signaling. J Biol Chem. 1999;274:9038-9044.
-
(1999)
J Biol Chem
, vol.274
, pp. 9038-9044
-
-
Huang, L.E.1
Willmore, W.G.2
Gu, J.3
Goldberg, M.A.4
Bunn, H.F.5
-
24
-
-
0346027211
-
Regulation of hypoxia-inducible factor-1α by nitric oxide through mitochondria-dependent and -independent pathways
-
Mateo J, Garcia-Lecea M, Cadenas S, Hernandez C, Moncada S. Regulation of hypoxia-inducible factor-1α by nitric oxide through mitochondria- dependent and -independent pathways. Biochem J. 2003;376:537-544.
-
(2003)
Biochem J
, vol.376
, pp. 537-544
-
-
Mateo, J.1
Garcia-Lecea, M.2
Cadenas, S.3
Hernandez, C.4
Moncada, S.5
-
25
-
-
0348134741
-
Redistribution of intracellular oxygen in hypoxia by nitric oxide: Effect on HIF1alpha
-
Hagen T, Taylor CT, Lam F, Moncada S. Redistribution of intracellular oxygen in hypoxia by nitric oxide: effect on HIF1alpha. Science. 2003;302:1975-1978.
-
(2003)
Science
, vol.302
, pp. 1975-1978
-
-
Hagen, T.1
Taylor, C.T.2
Lam, F.3
Moncada, S.4
-
26
-
-
0032578458
-
Mitochondrial reactive oxygen species trigger hypoxia-induced transcription
-
U S A
-
Chandel NS, Maltepe E, Goldwasser E, Mathieu CE, Simon MC, Schumacker PT. Mitochondrial reactive oxygen species trigger hypoxia-induced transcription. Proc Natl Acad Sci U S A. 1998;95:11715-11720.
-
(1998)
Proc Natl Acad Sci
, vol.95
, pp. 11715-11720
-
-
Chandel, N.S.1
Maltepe, E.2
Goldwasser, E.3
Mathieu, C.E.4
Simon, M.C.5
Schumacker, P.T.6
-
27
-
-
0034682786
-
Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: A mechanism of O2 sensing
-
Chandel NS, McClintock DS, Feliciano CE, et al. Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing. J Biol Chem. 2000;275:25130-25138.
-
(2000)
J Biol Chem
, vol.275
, pp. 25130-25138
-
-
Chandel, N.S.1
McClintock, D.S.2
Feliciano, C.E.3
-
28
-
-
0035933716
-
Oxygen sensing and HIF-1 activation does not require an active mitochondrial respiratory chain electron-transfer pathway
-
Srinivas V, Leshchinsky I, Sang N, King MP, Minchenko A, Caro J. Oxygen sensing and HIF-1 activation does not require an active mitochondrial respiratory chain electron-transfer pathway. J Biol Chem. 2001;276:21995-21998.
-
(2001)
J Biol Chem
, vol.276
, pp. 21995-21998
-
-
Srinivas, V.1
Leshchinsky, I.2
Sang, N.3
King, M.P.4
Minchenko, A.5
Caro, J.6
-
29
-
-
0035880239
-
Regulation of hypoxia-inducible factor is preserved in the absence of a functioning mitochondrial respiratory chain
-
Vaux EC, Metzen E, Yeates KM, Ratcliffe PJ. Regulation of hypoxia-inducible factor is preserved in the absence of a functioning mitochondrial respiratory chain. Blood. 2001;98:296-302.
-
(2001)
Blood
, vol.98
, pp. 296-302
-
-
Vaux, E.C.1
Metzen, E.2
Yeates, K.M.3
Ratcliffe, P.J.4
-
30
-
-
0024448458
-
Human cells lacking mtDNA: Repopulation with exogenous mitochondria by complementation
-
King MP, Attardi G. Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementation. Science. 1989;246:500-503.
-
(1989)
Science
, vol.246
, pp. 500-503
-
-
King, M.P.1
Attardi, G.2
-
31
-
-
0027362262
-
Microelectrode measurements of pericellular PO2 in erythropoietin- producing human hepatoma cell cultures
-
Wolff M, Fandrey J, Jelkmann W. Microelectrode measurements of pericellular PO2 in erythropoietin-producing human hepatoma cell cultures. Am J Physiol. 1993;265:C1266-C1270.
-
(1993)
Am J Physiol
, vol.265
-
-
Wolff, M.1
Fandrey, J.2
Jelkmann, W.3
-
32
-
-
0032079903
-
Reductive metabolism of the hypoxia marker pimonidazole is regulated by oxygen tension independent of the pyridine nucleotide redox state
-
Arteel GE, Thurman RG, Raleigh JA. Reductive metabolism of the hypoxia marker pimonidazole is regulated by oxygen tension independent of the pyridine nucleotide redox state. Eur J Biochem. 1998;253:743-750.
-
(1998)
Eur J Biochem
, vol.253
, pp. 743-750
-
-
Arteel, G.E.1
Thurman, R.G.2
Raleigh, J.A.3
-
33
-
-
0032801526
-
Comparisons among pimonidazole binding, oxygen electrode measurements, and radiation response in C3H mouse tumors
-
Raleigh JA, Chou SC, Arteel GE, Horsman MR. Comparisons among pimonidazole binding, oxygen electrode measurements, and radiation response in C3H mouse tumors. Radiat Res. 1999;151:580-589.
-
(1999)
Radiat Res
, vol.151
, pp. 580-589
-
-
Raleigh, J.A.1
Chou, S.C.2
Arteel, G.E.3
Horsman, M.R.4
-
34
-
-
20144384861
-
Activation of hypoxia-inducible factor-1 in bacillary angiomatosis: Evidence for a role of hypoxia-inducible factor-1 in bacterial infections
-
Kempf VA, Lebiedziejewski M, Alitalo K, et al. Activation of hypoxia-inducible factor-1 in bacillary angiomatosis: evidence for a role of hypoxia-inducible factor-1 in bacterial infections. Circulation. 2005;111:1054-1062.
-
(2005)
Circulation
, vol.111
, pp. 1054-1062
-
-
Kempf, V.A.1
Lebiedziejewski, M.2
Alitalo, K.3
-
35
-
-
0035983324
-
Loss of HIF-2α and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice
-
Compernolle V, Brusselmans K, Acker T, et al. Loss of HIF-2α and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice. Nat Med. 2002;8:702-710.
-
(2002)
Nat Med
, vol.8
, pp. 702-710
-
-
Compernolle, V.1
Brusselmans, K.2
Acker, T.3
-
36
-
-
0037430244
-
GLUT-1 and CAIX as intrinsic markers of hypoxia in carcinoma of the cervix: Relationship to pimonidazole binding
-
Airley RE, Loncaster J, Raleigh JA, et al. GLUT-1 and CAIX as intrinsic markers of hypoxia in carcinoma of the cervix: relationship to pimonidazole binding. Int J Cancer. 2003;104:85-91.
-
(2003)
Int J Cancer
, vol.104
, pp. 85-91
-
-
Airley, R.E.1
Loncaster, J.2
Raleigh, J.A.3
-
37
-
-
4444229716
-
Inhibition of mitochondrial respiration by the anticancer agent 2-methoxyestradiol
-
Hagen T, D'Amico G, Quintero M, et al. Inhibition of mitochondrial respiration by the anticancer agent 2-methoxyestradiol. Biochem Biophys Res Commun. 2004;322:923-929.
-
(2004)
Biochem Biophys Res Commun
, vol.322
, pp. 923-929
-
-
Hagen, T.1
D'Amico, G.2
Quintero, M.3
-
39
-
-
0001559027
-
Oxygen requirements for liver cells in vitro
-
Stevens KM. Oxygen requirements for liver cells in vitro. Nature. 1965;206:199.
-
(1965)
Nature
, vol.206
, pp. 199
-
-
Stevens, K.M.1
-
40
-
-
0028988301
-
Pericellular PO2 and O2 consumption in monolayer cell cultures
-
Metzen E, Wolff M, Fandrey J, Jelkmann W. Pericellular PO2 and O2 consumption in monolayer cell cultures. Respir Physiol. 1995;100:101-106.
-
(1995)
Respir Physiol
, vol.100
, pp. 101-106
-
-
Metzen, E.1
Wolff, M.2
Fandrey, J.3
Jelkmann, W.4
-
41
-
-
0242408897
-
The regulated expression of erythropoietin by two human hepatoma cell lines
-
U S A
-
Goldberg MA, Glass GA, Cunningham JM, Bunn HF. The regulated expression of erythropoietin by two human hepatoma cell lines. Proc Natl Acad Sci U S A. 1987;84:7972-7976.
-
(1987)
Proc Natl Acad Sci
, vol.84
, pp. 7972-7976
-
-
Goldberg, M.A.1
Glass, G.A.2
Cunningham, J.M.3
Bunn, H.F.4
-
43
-
-
0043234538
-
Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor
-
Hirsilä M, Koivunen P, Günzler V, Kivirikko KI, Myllyharju J. Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor. J Biol Chem. 2003;278:30772-30780.
-
(2003)
J Biol Chem
, vol.278
, pp. 30772-30780
-
-
Hirsilä, M.1
Koivunen, P.2
Günzler, V.3
Kivirikko, K.I.4
Myllyharju, J.5
-
44
-
-
4544346656
-
JunD reduces tumor angiogenesis by protecting cells from oxidative stress
-
Gerald D, Berra E, Frapart YM, et al. JunD reduces tumor angiogenesis by protecting cells from oxidative stress. Cell. 2004;118:781-794.
-
(2004)
Cell
, vol.118
, pp. 781-794
-
-
Gerald, D.1
Berra, E.2
Frapart, Y.M.3
-
45
-
-
3042818863
-
Mitochondrial signals initiate the activation of c-Jun N-terminal kinase (JNK) by hypoxia-reoxygenation
-
Dougherty CJ, Kubasiak LA, Frazier DP, et al. Mitochondrial signals initiate the activation of c-Jun N-terminal kinase (JNK) by hypoxia- reoxygenation. FASEB J. 2004;18:1060-1070.
-
(2004)
FASEB J
, vol.18
, pp. 1060-1070
-
-
Dougherty, C.J.1
Kubasiak, L.A.2
Frazier, D.P.3
-
47
-
-
0000104045
-
Measurement of endothelial cell free radical generation: Evidence for a central mechanism of free radical injury in postischemic tissues
-
U S A
-
Zweier JL, Kuppusamy P, Lutty GA. Measurement of endothelial cell free radical generation: evidence for a central mechanism of free radical injury in postischemic tissues. Proc Natl Acad Sci U S A. 1988;85:4046-4050.
-
(1988)
Proc Natl Acad Sci
, vol.85
, pp. 4046-4050
-
-
Zweier, J.L.1
Kuppusamy, P.2
Lutty, G.A.3
-
48
-
-
17644426380
-
Oligomycin inhibits HIF-1α expression in hypoxic tumor cells
-
Gong Y, Agani FH. Oligomycin inhibits HIF-1α expression in hypoxic tumor cells. Am J Physiol Cell Physiol. 2005;288:C1023-C1029.
-
(2005)
Am J Physiol Cell Physiol
, vol.288
-
-
Gong, Y.1
Agani, F.H.2
|