HIF-1 regulates hypoxic induction of NHE1 expression and alkalinization of intracellular pH in pulmonary arterial myocytes

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 291, Issue 5, 2006, Pages

  Shimoda, Larissa A ^a   Fallon, Michele ^a   Pisarcik, Sarah ^a   Wang, Jian ^a   Semenza, Gregg L ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Hypoxia inducible factor 1; Pulmonary arterial smooth muscle cell

Indexed keywords

CALCIUM; HYPOXIA INDUCIBLE FACTOR 1; MESSENGER RNA; SODIUM PROTON EXCHANGE PROTEIN 1;

ALKALINITY; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BREATHING MUSCLE; CONTROLLED STUDY; HOMEOSTASIS; HYPOXIA; MOUSE; MUSCLE CELL; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN EXPRESSION; SMOOTH MUSCLE FIBER;

ACID-BASE EQUILIBRIUM; ANIMALS; ANOXIA; CATION TRANSPORT PROTEINS; CELLS, CULTURED; GENE EXPRESSION; HOMEOSTASIS; HYDROGEN-ION CONCENTRATION; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MUSCLE, SMOOTH, VASCULAR; PULMONARY ARTERY; RATS; RATS, WISTAR; SODIUM-HYDROGEN ANTIPORTER;

EID: 33751117499     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00528.2005     Document Type: Article

References (51)

1. + exchanger (NHE5) highly expressed in brain. J Biol Chem 274: 4383-4388, 1999.
2. + exchanger isoforms to preimplantation development of the mouse. Mol Reprod Dev 50: 146-153, 1998.
3. + exchanger isoform, NHE3. Am J Physiol Cell Physiol 269: C198-C206, 1995.
4. + exchanger in A6 cells. Am J Physiol Cell Physiol 271: C1639-C1645, 1996.
5. + antiport activity, isoform expression, and localization in endothelial cells. Am J Physiol Lung Cell Mol Physiol 275: L442-L451, 1998.
6. DiCarlo VS, Chen SJ, Meng QC, Durand J, Yano M, Chen YF, and Oparil S. ETA-receptor antagonist prevents and reverses chronic hypoxia-induced pulmonary hypertension in rat. Am J Physiol Lung Cell Mol Physiol 269: L690-L697, 1995.
7. + exchanger gene during neuronal differentiation of embryonal carcinoma cells. J Biol Chem 270: 10420-10427, 1995.
8. + exchanger NHE1 gene and its 5′-flanking region. Mol Cell Biochem 210: 91-99, 2000.
9. Fagan KA, McMurtry I, and Rodman DM. Nitric oxide synthase in pulmonary hypertension: lessons from knockout mice. Physiol Res 49: 539-548, 2000.
10. + exchanger isoform NHE8. Am J Physiol Renal Physiol 284: F467-F473, 2003.
11. Hasuda K, Lee C, and Tannock IF. Antitumor activity of nigericin and 5-(N-ethyl-N-isopropyl)amiloride: an approach to therapy based on cellular acidification and the inhibition of regulation of intracellular pH. Oncol Res 6: 259-268, 1994.
12. Howell K, Preston RJ, and McLoughlin P. Chronic hypoxia causes angiogenesis in addition to remodelling in the adult rat pulmonary circulation. J Physiol 547: 133-145, 2003.
13. Hu J, Discher DJ, Bishopric NH, and Webster KA. Hypoxia regulates expression of the endothelin-1 gene through a proximal hypoxia-inducible factor-1 binding site on the antisense strand. Biochem Biophys Res Commun 245: 894-899, 1998.
14. Iyer NV, Kotch LE, Agani F, Leung SW, Laughner E, Wenger RH, Gassmann M, Gearhart JD, Lawler AM, Yu AY, and Semenza GL. Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha. Genes Dev 12: 149-162, 1998.
15. Jiang BH, Rue E, Wang GL, Roe R, and Semenza GL. Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1. J Biol Chem 271: 17771-17778, 1996.
16. Jones AT and Evans TW. NO: COPD and beyond. Thorax 52, Suppl 3: S16-S21, 1997.
17. Kallio PJ, Pongratz I, Gradin K, McGuire J, and Poellinger L. Activation of hypoxia-inducible factor 1alpha: posttranscriptional regulation and conformational change by recruitment of the Arnt transcription factor. Proc Natl Acad Sci USA 94: 5667-5672, 1997.
18. Kelly BD, Hackett SF, Hirota K, Oshima Y, Cai Z, Berg-Dixon S, Rowan A, Yan Z, Campochiaro PA, and Semenza GL. Cell type-specific regulation of angiogenic growth factor gene expression and induction of angiogenesis in nonischemic tissue by a constitutively active form of hypoxia-inducible factor 1. Circ Res 93: 1074-1081, 2003.
19. Kourembanas S, Morita T, Liu Y, and Christou H. Mechanisms by which oxygen regulates gene expression and cell-cell interaction in the vasculature. Kidney Int 51: 438-443, 1997.
20. Leach RM, Sheehan DW, Chacko VP, and Sylvester JT. Effects of hypoxia on energy state and pH in resting pulmonary and femoral arterial smooth muscles. Am J Physiol Lung Cell Mol Physiol 275: L1051-L1060, 1998.
21. Leach RM, Sheehan DW, Chacko VP, and Sylvester JT. Energy state, pH, and vasomotor tone during hypoxia in precontracted pulmonary and femoral arteries. Am J Physiol Lung Cell Mol Physiol 278: L294-L304, 2000.
22. + exchanger expression in vascular smooth muscle of spontaneously hypertensive and Wistar-Kyoto rats. Hypertension 24: 734-738, 1994.
23. Madden JA, Ray DE, Keller PA, and Kleinman JG. Ion exchange activity in pulmonary artery smooth muscle cells: the response to hypoxia. Am J Physiol Lung Cell Mol Physiol 280: L264-L271, 2001.
24. Meyrick B and Reid L. Normal postnatal development of the media of the rat hilar pulmonary artery and its remodeling by chronic hypoxia. Lab Invest 46: 505-514, 1982.
25. Miller RT, Counillon L, Pages G, Lifton RP, Sardet C, and Pouyssegur J. Structure of the 5′-flanking regulatory region and gene for the human growth factor-activatable Na/H exchanger NHE-1. J Biol Chem 266: 10813-10819, 1991.
26. Miyazaki E, Sakaguchi M, Wakabayashi S, Shigekawa M, and Mihara K. NHE6 protein possesses a signal peptide destined for endoplasmic reticulum membrane and localizes in secretory organelles of the cell. J Biol Chem 276: 49221-49227, 2001.
27. Nagaoka T, Fagan KA, Gebb SA, Morris KG, Suzuki T, Shimokawa H, McMurtry IF, and Oka M. Inhaled Rho kinase inhibitors are potent and selective vasodilators in rat pulmonary hypertension. Am J Respir Crit Care Med 171: 494-499, 2005.
28. + exchanger isoforms are distributed to Golgi and post-Golgi compartments and are involved in organelle pH regulation. J Biol Chem 280: 1561-1572, 2005.
29. + exchanger isoforms. Am J Physiol Cell Physiol 268: C283-C296, 1995.
30. + exchanger localized to the trans-Golgi network. J Biol Chem 276: 17387-17394, 2001.
31. + exchanger. J Biol Chem 273: 6951-6959, 1998.
32. Oka M, Morris KG, and McMurtry IF. NIP-121 is more effective than nifedipine in acutely reversing chronic pulmonary hypertension. J Appl Physiol 75: 1075-1080, 1993.
33. Orlowski J, Kandasamy RA, and Shull GE. Molecular cloning of putative members of the Na/H exchanger gene family. cDNA cloning, deduced amino acid sequence, and mRNA tissue expression of the rat Na/H exchanger NHE-1 and two structurally related proteins. J Biol Chem 267: 9331-9339, 1992.
34. Platoshyn O, Golovina VA, Bailey CL, Limsuwan A, Krick S, Juhaszova M, Seiden JE, Rubin LJ, and Yuan JX. Sustained membrane depolarization and pulmonary artery smooth muscle cell proliferation. Am J Physiol Cell Physiol 279: C1540-C1549, 2000.
35. Praetorius J, Andreasen D, Jensen BL, Ainsworth MA, Friis UG, and Johansen T. NHE1, NHE2, and NHE3 contribute to regulation of intracellular pH in murine duodenal epithelial cells. Am J Physiol Gastrointest Liver Physiol 278: G197-G206, 2000.
36. + exchanger, NHE1: structure, regulation, and cellular actions. Annu Rev Pharmacol Toxicol 42: 527-552, 2002.
37. + exchange and growth factors in pulmonary artery smooth muscle cell proliferation. Am J Respir Cell Mol Biol 14: 139-145, 1996.
38. Quinn DA, Du HK, Thompson BT, and Hales CA. Amiloride analogs inhibit chronic hypoxic pulmonary hypertension. Am J Respir Crit Care Med 157: 1263-1268, 1998.
39. + exchange in pulmonary arterial smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 289: L867-L874, 2005.
40. Salceda S and Caro J. Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes. J Biol Chem 272: 22642-22647, 1997.
41. Semenza GL. Hydroxylation of HIF-1: oxygen sensing at the molecular level. Physiology (Bethesda) 19: 176-182, 2004.
42. Shimoda LA, Manalo DJ, Sham JS, Semenza GL, and Sylvester JT. Partial HIF-1α deficiency impairs pulmonary arterial myocyte electrophysiological responses to hypoxia. Am J Physiol Lung Cell Mol Physiol 281: L202-L208, 2001.
43. 2+ by endothelin-1 in rat intrapulmonary arterial smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 278: L157-L164, 2000.
44. + exchanger in hypoxia/reoxygenation-induced neonatal rat cardiomyocyte apoptosis. Eur J Pharmacol 486: 121-131, 2004.
45. Sutter CH, Laughner E, and Semenza GL. Hypoxia-inducible factor 1alpha protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations. Proc Natl Acad Sci USA 97: 4748-4753, 2000.
46. 2+ entry and attenuates pulmonary artery smooth muscle cell proliferation. Am J Physiol Lung Cell Mol Physiol 283: L144-L155, 2002.
47. + exchanger isoform (NHE-3). J Biol Chem 267: 9340-9346, 1992.
48. Wang J, Semenza G, Sylvester JT, and Shimoda LA. HIF-1 regulates hypoxic-induction of canonical transient receptor potential (TRPC) channels in pulmonary arterial smooth muscle cells. FASEB J 19: A1278, 2005.
49. Wang Z, Orlowski J, and Shull GE. Primary structure and functional expression of a novel gastrointestinal isoform of the rat Na/H exchanger. J Biol Chem 268: 11925-11928, 1993.
50. Yu AY, Shimoda LA, Iyer NV, Huso DL, Sun X, McWilliams R, Beaty T, Sham JS, Wiener CM, Sylvester JT, and Semenza GL. Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1alpha. J Clin Invest 103: 691-696, 1999.
51. + exchanger gene family: structure and function studies. Am J Physiol Gastrointest Liver Physiol 269: G1-G11, 1995.