메뉴 건너뛰기




Volumn 12, Issue 2, 1998, Pages 149-162

Cellular and developmental control of O2 homeostasis by hypoxia- inducible factor 1α

Author keywords

Cardiovascular development; Glycolysis; Knockout; Oxygen; VEGF

Indexed keywords

6 PHOSPHOFRUCTOKINASE; AROMATIC HYDROCARBON RECEPTOR; ENOLASE; ERYTHROPOIETIN; FRUCTOSE BISPHOSPHATE ALDOLASE; GLUCOSE; GLUCOSE 6 PHOSPHATE ISOMERASE; GLUCOSE TRANSPORTER; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; GLYCOLYTIC ENZYME; HEXOKINASE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; LACTATE DEHYDROGENASE; MESSENGER RNA; OXYGEN; PHOSPHOGLUCOMUTASE; PHOSPHOGLYCERATE KINASE; PYRUVATE KINASE; TRANSCRIPTION FACTOR; TRIOSEPHOSPHATE ISOMERASE; UNCLASSIFIED DRUG; VASCULOTROPIN;

EID: 15444342958     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.12.2.149     Document Type: Article
Times cited : (2165)

References (60)
  • 1
    • 0028126819 scopus 로고
    • Pit-1 determines cell types during development of the anterior pituitary gland: A model for transcriptional regulation of cell phenotypes in mammalian organogenesis
    • Andersen, B. and M.G. Rosenfeld. 1994. Pit-1 determines cell types during development of the anterior pituitary gland: A model for transcriptional regulation of cell phenotypes in mammalian organogenesis. J. Biol. Chem. 269:29335-29338.
    • (1994) J. Biol. Chem. , vol.269 , pp. 29335-29338
    • Andersen, B.1    Rosenfeld, M.G.2
  • 3
    • 0030806273 scopus 로고    scopus 로고
    • Conditional switching of vascular endothelial growth factor (VEGF) expression in tumors: Induction of endothelial cell shedding and regression of hemangioblastoma-like vessels by VEGF withdrawal
    • Benjamin, L.E. and E. Keshet. 1997. Conditional switching of vascular endothelial growth factor (VEGF) expression in tumors: Induction of endothelial cell shedding and regression of hemangioblastoma-like vessels by VEGF withdrawal. Proc. Natl. Acad. Sci 94: 8761-8766.
    • (1997) Proc. Natl. Acad. Sci , vol.94 , pp. 8761-8766
    • Benjamin, L.E.1    Keshet, E.2
  • 6
    • 0018119549 scopus 로고
    • Reversion of transformed glycolysis to normal by inhibition of protein synthesis in rat kidney cells infected with temperature-sensitive mutant of Rous sarcoma virus
    • Carroll, R.C., J.F. Ash, P.K. Vogt, and S.J. Singer. 1978. Reversion of transformed glycolysis to normal by inhibition of protein synthesis in rat kidney cells infected with temperature-sensitive mutant of Rous sarcoma virus. Proc. Natl. Acad. Sci. 75:5015-5019.
    • (1978) Proc. Natl. Acad. Sci. , vol.75 , pp. 5015-5019
    • Carroll, R.C.1    Ash, J.F.2    Vogt, P.K.3    Singer, S.J.4
  • 7
    • 0023277545 scopus 로고
    • Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
    • Chomczynski, P. and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162: 156-159.
    • (1987) Anal. Biochem. , vol.162 , pp. 156-159
    • Chomczynski, P.1    Sacchi, N.2
  • 8
    • 0027169125 scopus 로고
    • In vitro analysis of Ah receptor domains involved in ligand-activated transcription
    • Dolwick, K.M., H.I. Swanson, and C.A. Bradfield. 1993. In vitro analysis of Ah receptor domains involved in ligand-activated transcription. Proc. Natl. Acad. Sci. 90: 8566-8570.
    • (1993) Proc. Natl. Acad. Sci. , vol.90 , pp. 8566-8570
    • Dolwick, K.M.1    Swanson, H.I.2    Bradfield, C.A.3
  • 9
    • 0031000736 scopus 로고    scopus 로고
    • A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1α regulates VEGF expression and is potentially involved in lung and vascular development
    • Ema, M., S. Taya, N. Yokotani, K. Sogawa, Y. Matsuda, and Y. Fujii-Kuriyama. 1997. A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1α regulates VEGF expression and is potentially involved in lung and vascular development. Proc. Natl. Acad. Sci. 94: 4273-4278.
    • (1997) Proc. Natl. Acad. Sci. , vol.94 , pp. 4273-4278
    • Ema, M.1    Taya, S.2    Yokotani, N.3    Sogawa, K.4    Matsuda, Y.5    Fujii-Kuriyama, Y.6
  • 10
    • 0031039243 scopus 로고    scopus 로고
    • The biology of vascular endothelial growth factor
    • Ferrara, N. and T. Davis-Smyth. 1997. The biology of vascular endothelial growth factor. Endocr. Rev. 18: 4-25.
    • (1997) Endocr. Rev. , vol.18 , pp. 4-25
    • Ferrara, N.1    Davis-Smyth, T.2
  • 12
    • 0343683375 scopus 로고    scopus 로고
    • HRF, a putative basic helix-loop-helix-PAS-domain transcription factor is closely related to hypoxia-inducible factor-1α and developmentally expressed in blood vessels
    • Flamme, I., T. Frohlich, M. von Reutern, A. Kappel, A. Damert, and W. Risau. 1997. HRF, a putative basic helix-loop-helix-PAS-domain transcription factor is closely related to hypoxia-inducible factor-1α and developmentally expressed in blood vessels. Mech. Dev. 63: 51-60.
    • (1997) Mech. Dev. , vol.63 , pp. 51-60
    • Flamme, I.1    Frohlich, T.2    Von Reutern, M.3    Kappel, A.4    Damert, A.5    Risau, W.6
  • 13
  • 15
    • 0030963616 scopus 로고    scopus 로고
    • The hypoxic response: Huffing and HIFing
    • Guillemin, K. and M.A. Krasnow. 1997. The hypoxic response: Huffing and HIFing. Cell 89: 9-12.
    • (1997) Cell , vol.89 , pp. 9-12
    • Guillemin, K.1    Krasnow, M.A.2
  • 17
    • 0029928689 scopus 로고    scopus 로고
    • cDNA cloning and tissue-specific expression of a novel basic helix-loop-helix/PAS factor (Arnt2) with close sequence similarity to the aryl hydrocarbon receptor nuclear translocator (Arnt)
    • Hirose, K., M. Morita, M. Ema, J. Mimura, H. Hamada, H. Fujii, Y. Saijo, O. Gotoh, K. Sogawa, and Y. Fujii-Kuriyama. 1996. cDNA cloning and tissue-specific expression of a novel basic helix-loop-helix/PAS factor (Arnt2) with close sequence similarity to the aryl hydrocarbon receptor nuclear translocator (Arnt). Mol. Cell. Biol. 16: 1706-1713.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 1706-1713
    • Hirose, K.1    Morita, M.2    Ema, M.3    Mimura, J.4    Hamada, H.5    Fujii, H.6    Saijo, Y.7    Gotoh, O.8    Sogawa, K.9    Fujii-Kuriyama, Y.10
  • 20
    • 0030887045 scopus 로고    scopus 로고
    • Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signalling pathway
    • Hogenesch, J.B., W.K. Chan, V.H. Jackiw, R.C. Brown, Y.-Z. Gu, G.H. Perdew, and C.A. Bradfield. 1997. Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signalling pathway. J. Biol. Chem. 272: 8581-8593.
    • (1997) J. Biol. Chem. , vol.272 , pp. 8581-8593
    • Hogenesch, J.B.1    Chan, W.K.2    Jackiw, V.H.3    Brown, R.C.4    Gu, Y.-Z.5    Perdew, G.H.6    Bradfield, C.A.7
  • 21
    • 0029117223 scopus 로고
    • Hypoxiainduced transcriptional activation and increased mRNA stability of vascular endothelial growth factor in C6 glioma cells
    • Ikeda, E., M.G. Achen, G. Breier, and W. Risau. 1995. Hypoxiainduced transcriptional activation and increased mRNA stability of vascular endothelial growth factor in C6 glioma cells. J. Biol. Chem. 270:19761-19766.
    • (1995) J. Biol. Chem. , vol.270 , pp. 19761-19766
    • Ikeda, E.1    Achen, M.G.2    Breier, G.3    Risau, W.4
  • 22
    • 0029944965 scopus 로고    scopus 로고
    • Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1
    • Jiang, B.-H., E. Rue, G.L. Wang, R. Roe, and G.L. Semenza. 1996a. Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1. J. Biol Chem. 271: 17771-17778.
    • (1996) J. Biol Chem. , vol.271 , pp. 17771-17778
    • Jiang, B.-H.1    Rue, E.2    Wang, G.L.3    Roe, R.4    Semenza, G.L.5
  • 24
    • 0030659531 scopus 로고    scopus 로고
    • V-SRC induces expression of hypoxia-inducible factor 1 and transcription of genes encoding VEGF and enolase 1: Involvement of HIF-I in tumor progression
    • Jiang, B.-H., F. Agani, A. Passaniti, and G.L. Semenza. 1997a. V-SRC induces expression of hypoxia-inducible factor 1 and transcription of genes encoding VEGF and enolase 1: Involvement of HIF-I in tumor progression. Cancer Res. 57: 5328-5335.
    • (1997) Cancer Res. , vol.57 , pp. 5328-5335
    • Jiang, B.-H.1    Agani, F.2    Passaniti, A.3    Semenza, G.L.4
  • 25
    • 0030787469 scopus 로고    scopus 로고
    • Transactivation and inhibitory domains of hypoxia-inducible factor 1α Modulation of transcriptional activity by oxygen tension
    • Jiang, B.-H., J.Z. Zheng, S.W. Leung, R. Roe, and G.L. Semenza. 1997b. Transactivation and inhibitory domains of hypoxia-inducible factor 1α Modulation of transcriptional activity by oxygen tension. J. Biol Chem. 272: 19253-19260.
    • (1997) J. Biol Chem. , vol.272 , pp. 19253-19260
    • Jiang, B.-H.1    Zheng, J.Z.2    Leung, S.W.3    Roe, R.4    Semenza, G.L.5
  • 26
    • 0028846081 scopus 로고
    • Ethanol-induced teratogenesis: Free radical damage as a possible mechanism
    • Kotch, L.E., S.-Y. Chen, and K.K. Sulik. 1995. Ethanol-induced teratogenesis: Free radical damage as a possible mechanism. Teratology 52: 128-136.
    • (1995) Teratology , vol.52 , pp. 128-136
    • Kotch, L.E.1    Chen, S.-Y.2    Sulik, K.K.3
  • 27
    • 0030005755 scopus 로고    scopus 로고
    • The I.M.A.G.E. consortium: An integrated molecular analysis of genomes and their expression
    • Lennon, G., C. Auffray, M. Polymeropoulos, and M.B. Soares. 1996. The I.M.A.G.E. consortium: An integrated molecular analysis of genomes and their expression. Genomics 33: 151-152.
    • (1996) Genomics , vol.33 , pp. 151-152
    • Lennon, G.1    Auffray, C.2    Polymeropoulos, M.3    Soares, M.B.4
  • 28
    • 0029039195 scopus 로고
    • Transcriptional regulation of the rat vascular endothelial growth factor gene by hypoxia
    • Levy, A.P., N.S. Levy, S. Wegner, and M.A. Goldberg. 1995. Transcriptional regulation of the rat vascular endothelial growth factor gene by hypoxia. J. Biol. Chem. 270: 13333-13340.
    • (1995) J. Biol. Chem. , vol.270 , pp. 13333-13340
    • Levy, A.P.1    Levy, N.S.2    Wegner, S.3    Goldberg, M.A.4
  • 29
    • 0030044039 scopus 로고    scopus 로고
    • Post-transcriptional regulation of vascular endothelial growth factor by hypoxia
    • Levy, A.P., N.S. Levy, and M.A. Goldberg. 1996. Post-transcriptional regulation of vascular endothelial growth factor by hypoxia. J. Biol. Chem. 271: 2746-2753.
    • (1996) J. Biol. Chem. , vol.271 , pp. 2746-2753
    • Levy, A.P.1    Levy, N.S.2    Goldberg, M.A.3
  • 30
    • 0026708177 scopus 로고
    • Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
    • Li, E., T.H. Bestor, and R. Jaenisch. 1992. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 69:915-926.
    • (1992) Cell , vol.69 , pp. 915-926
    • Li, E.1    Bestor, T.H.2    Jaenisch, R.3
  • 31
    • 0030756325 scopus 로고    scopus 로고
    • Pericyte loss and microaneurysm formation in PDGF-B-deficient mice
    • Lindahl, P., B.R. Johansson, P. Leveen, and C. Betsholtz. 1997. Pericyte loss and microaneurysm formation in PDGF-B-deficient mice. Science 277: 242-245.
    • (1997) Science , vol.277 , pp. 242-245
    • Lindahl, P.1    Johansson, B.R.2    Leveen, P.3    Betsholtz, C.4
  • 32
    • 0029103274 scopus 로고
    • Hypoxia regulates vascular endothelial growth factor gene expression in endothelial cells
    • Liu, Y., S.R. Cox, T. Morita, and S. Kourembanas. 1995. Hypoxia regulates vascular endothelial growth factor gene expression in endothelial cells. Circ. Res. 77: 638-643.
    • (1995) Circ. Res. , vol.77 , pp. 638-643
    • Liu, Y.1    Cox, S.R.2    Morita, T.3    Kourembanas, S.4
  • 33
    • 0030943461 scopus 로고    scopus 로고
    • Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT
    • Maltepe, E., J.V. Schmidt, D. Baunoch, C.A. Bradfield, and C. Simon. 1997. Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT. Nature 386: 403-407.
    • (1997) Nature , vol.386 , pp. 403-407
    • Maltepe, E.1    Schmidt, J.V.2    Baunoch, D.3    Bradfield, C.A.4    Simon, C.5
  • 34
    • 0024296027 scopus 로고
    • Disruption of the proto-oncogene int- 2 in mouse embryo-derived stem cells: A general strategy for targeting mutations to non-selectable genes
    • Mansour, S.L., K.R. Thomas, and M.R. Capecchi. 1988. Disruption of the proto-oncogene int- 2 in mouse embryo-derived stem cells: A general strategy for targeting mutations to non-selectable genes. Nature 336: 348-352.
    • (1988) Nature , vol.336 , pp. 348-352
    • Mansour, S.L.1    Thomas, K.R.2    Capecchi, M.R.3
  • 35
    • 0031957221 scopus 로고    scopus 로고
    • Cardiac hypertrophy in chronically anemic sheep: Increased vascularization is associated with increased myocardial expression of vascular endothelial growth factor and hypoxia-inducible factor 1
    • in press
    • Martin, C., A.Y. Yu, B.-H. Jiang, L. Davis, D. Kimberly, A.R. Hohimer, and G.L. Semenza. 1997. Cardiac hypertrophy in chronically anemic sheep: Increased vascularization is associated with increased myocardial expression of vascular endothelial growth factor and hypoxia-inducible factor 1. Am. J. Obstet. Gynecol. (in press).
    • (1997) Am. J. Obstet. Gynecol.
    • Martin, C.1    Yu, A.Y.2    Jiang, B.-H.3    Davis, L.4    Kimberly, D.5    Hohimer, A.R.6    Semenza, G.L.7
  • 36
    • 0030740207 scopus 로고    scopus 로고
    • The murine Sim-2 gene product inhibits transcription by active repression and functional interference
    • Moffett, P., M. Reece, and J. Pelletier. 1997. The murine Sim-2 gene product inhibits transcription by active repression and functional interference. Mol. Cell. Biol. 17: 4933-4947.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 4933-4947
    • Moffett, P.1    Reece, M.2    Pelletier, J.3
  • 38
    • 0026691333 scopus 로고
    • GATA-binding transcription factors in hematopoietic cells
    • Orkin, S.H. 1992. GATA-binding transcription factors in hematopoietic cells. Blood 80: 575-581.
    • (1992) Blood , vol.80 , pp. 575-581
    • Orkin, S.H.1
  • 39
    • 0030937718 scopus 로고    scopus 로고
    • Activation of hypoxia-inducible factor 1: Definition of regulatory domains within the α subunit
    • Pugh, C.W., J.F. O'Rourke, M. Nagao, J.M. Gleadle, and P.J. Ratcliffe. 1997. Activation of hypoxia-inducible factor 1: Definition of regulatory domains within the α subunit. J. Biol. Chem. 272: 11205-11214.
    • (1997) J. Biol. Chem. , vol.272 , pp. 11205-11214
    • Pugh, C.W.1    O'Rourke, J.F.2    Nagao, M.3    Gleadle, J.M.4    Ratcliffe, P.J.5
  • 42
    • 0030588298 scopus 로고    scopus 로고
    • Absolute requirement of aryl hydrocarbon receptor nuclear translocator protein for gene activation by hypoxia
    • Salceda, S., I. Beck, and J. Caro. 1996. Absolute requirement of aryl hydrocarbon receptor nuclear translocator protein for gene activation by hypoxia. Arch. Biochem. Biophys. 334: 389-394.
    • (1996) Arch. Biochem. Biophys. , vol.334 , pp. 389-394
    • Salceda, S.1    Beck, I.2    Caro, J.3
  • 44
    • 0026468180 scopus 로고
    • A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
    • Semenza, G.L. and G.L. Wang. 1992. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol. Cell. Biol. 12: 5447-5454.
    • (1992) Mol. Cell. Biol. , vol.12 , pp. 5447-5454
    • Semenza, G.L.1    Wang, G.L.2
  • 45
    • 0028068606 scopus 로고
    • Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1
    • Semenza, G.L., P.H. Roth, H.-M. Fang, and G.L. Wang. 1994. Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1. J. Biol. Chem. 269: 23757-23763.
    • (1994) J. Biol. Chem. , vol.269 , pp. 23757-23763
    • Semenza, G.L.1    Roth, P.H.2    Fang, H.-M.3    Wang, G.L.4
  • 46
    • 0030460724 scopus 로고    scopus 로고
    • Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1
    • Semenza, G.L., B.-H. Jiang, S.W. Leung, R. Passantino, J.-P. Concordet, P. Maire, and A. Giallongo. 1996. Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1. J. Biol. Chem. 271: 32529-32537.
    • (1996) J. Biol. Chem. , vol.271 , pp. 32529-32537
    • Semenza, G.L.1    Jiang, B.-H.2    Leung, S.W.3    Passantino, R.4    Concordet, J.-P.5    Maire, P.6    Giallongo, A.7
  • 47
    • 0030021835 scopus 로고    scopus 로고
    • The mouse gene for vascular endothelial growth factor: Genomic structure, definition of the transcriptional unit, and characterization of transcriptional and post-transcriptional regulatory sequences
    • Shima, D.T., M. Kuroki, U. Deutsch, Y.-S. Ng, A.P. Adamis, and P.A. D'Amore. 1996. The mouse gene for vascular endothelial growth factor: Genomic structure, definition of the transcriptional unit, and characterization of transcriptional and post-transcriptional regulatory sequences. J. Biol. Chem. 271: 3877-3883.
    • (1996) J. Biol. Chem. , vol.271 , pp. 3877-3883
    • Shima, D.T.1    Kuroki, M.2    Deutsch, U.3    Ng, Y.-S.4    Adamis, A.P.5    D'Amore, P.A.6
  • 48
    • 0029082384 scopus 로고
    • Stabilization of vascular endothelial growth factor mRNA by hypoxia and hypoglycemia and coregulation with other ischemia-induced genes
    • Stein, I., M. Neeman, D. Shweiki, A. Itin, and E. Keshet. 1995. Stabilization of vascular endothelial growth factor mRNA by hypoxia and hypoglycemia and coregulation with other ischemia-induced genes. Mol. Cell. Biol. 15: 5363-5368.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 5363-5368
    • Stein, I.1    Neeman, M.2    Shweiki, D.3    Itin, A.4    Keshet, E.5
  • 49
    • 0031020884 scopus 로고    scopus 로고
    • Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells
    • Tian, H., S.L. McKnight, and D.W. Russell. 1997. Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells. Genes & Dev. 11: 72-82.
    • (1997) Genes & Dev. , vol.11 , pp. 72-82
    • Tian, H.1    McKnight, S.L.2    Russell, D.W.3
  • 50
    • 0028816847 scopus 로고
    • Purification and characterization of hypoxia-inducible factor 1
    • Wang, G.L. and G.L. Semenza. 1995. Purification and characterization of hypoxia-inducible factor 1. J. Biol. Chem. 270: 1230-1237.
    • (1995) J. Biol. Chem. , vol.270 , pp. 1230-1237
    • Wang, G.L.1    Semenza, G.L.2
  • 52
    • 0030839731 scopus 로고    scopus 로고
    • Yolk sac angiogenic defect and intra-embryonic apoptosis in mice lacking the Ets-related factor TEL
    • Wang, L.C., F. Kuo, Y. Fujiwara, D.G. Gilliland, T.R. Golub, and S.H. Orkin. 1997. Yolk sac angiogenic defect and intra-embryonic apoptosis in mice lacking the Ets-related factor TEL. EMBO J. 16: 4374-4383.
    • (1997) EMBO J. , vol.16 , pp. 4374-4383
    • Wang, L.C.1    Kuo, F.2    Fujiwara, Y.3    Gilliland, D.G.4    Golub, T.R.5    Orkin, S.H.6
  • 53
    • 11444255268 scopus 로고
    • On respiratory impairment in cancer cells
    • Warburg, O. 1956. On respiratory impairment in cancer cells. Science 124:269-270.
    • (1956) Science , vol.124 , pp. 269-270
    • Warburg, O.1
  • 54
    • 0028278325 scopus 로고
    • The oncogenic cysteine-rich LIM domain protein Rbtn2 is essential for erythroid development
    • Warren, A.J., W.H. Colledge, M.B.L. Carlton, M.J. Evans, A.J.H. Smith, and T.H. Rabbits. 1994. The oncogenic cysteine-rich LIM domain protein Rbtn2 is essential for erythroid development. Cell 78: 45-57.
    • (1994) Cell , vol.78 , pp. 45-57
    • Warren, A.J.1    Colledge, W.H.2    Carlton, M.B.L.3    Evans, M.J.4    Smith, A.J.H.5    Rabbits, T.H.6
  • 55
    • 0027738464 scopus 로고
    • The MyoD family and myogenesis: Redundancy, networks, and thresholds
    • Weintraub, H. 1993. The MyoD family and myogenesis: Redundancy, networks, and thresholds. Cell 75: 1241-1244.
    • (1993) Cell , vol.75 , pp. 1241-1244
    • Weintraub, H.1
  • 56
    • 1842416574 scopus 로고    scopus 로고
    • Oxygen(es) and the hypoxia-inducible factor 1
    • Wenger, R.H. and M. Gassmann. 1997. Oxygen(es) and the hypoxia-inducible factor 1. Biol Chem. 378:609-616.
    • (1997) Biol Chem. , vol.378 , pp. 609-616
    • Wenger, R.H.1    Gassmann, M.2
  • 57
    • 0029982422 scopus 로고    scopus 로고
    • Nucleotide sequence, chromosomal assignment, and mRNA expression of mouse hypoxia-inducible factor 1α
    • Wenger, R.H., A. Rolfs, H.H. Marti, J.-L. Guenet, and M. Gassmann. 1996. Nucleotide sequence, chromosomal assignment, and mRNA expression of mouse hypoxia-inducible factor 1α. Biochem. Biophys. Res. Commun. 223:54-59.
    • (1996) Biochem. Biophys. Res. Commun. , vol.223 , pp. 54-59
    • Wenger, R.H.1    Rolfs, A.2    Marti, H.H.3    Guenet, J.-L.4    Gassmann, M.5
  • 58
    • 0030916245 scopus 로고    scopus 로고
    • The mouse gene for hypoxia-inducible factor-la: Genomic organization, expression, and characterization of an alternative first exon and 5′ flanking sequence
    • Wenger, R.H., A. Rolfs, I. Kvietikova, P. Spielmann, D.R. Zimmermann, and M. Gassmann. 1997. The mouse gene for hypoxia-inducible factor-la: Genomic organization, expression, and characterization of an alternative first exon and 5′ flanking sequence. Eur. J. Biochem. 246:155-165.
    • (1997) Eur. J. Biochem. , vol.246 , pp. 155-165
    • Wenger, R.H.1    Rolfs, A.2    Kvietikova, I.3    Spielmann, P.4    Zimmermann, D.R.5    Gassmann, M.6
  • 59
    • 0030583293 scopus 로고    scopus 로고
    • In vivo expression of mRNAs encoding hypoxia-inducible factor 1
    • Wiener, C.M., G. Booth, and G.L. Semenza. 1996. In vivo expression of mRNAs encoding hypoxia-inducible factor 1. Biochem. Biophys. Res. Commun. 225: 485-488.
    • (1996) Biochem. Biophys. Res. Commun. , vol.225 , pp. 485-488
    • Wiener, C.M.1    Booth, G.2    Semenza, G.L.3
  • 60
    • 0029888061 scopus 로고    scopus 로고
    • The role of the aryl hydrocarbon receptor nuclear translocator (ARNT) in hypoxic induction of gene expression: Studies in ARNT-deficient cells
    • Wood, S.M., J.M. Gleadle, C.W. Pugh, O. Hankinson, and P.J. Ratcliffe. 1996. The role of the aryl hydrocarbon receptor nuclear translocator (ARNT) in hypoxic induction of gene expression: Studies in ARNT-deficient cells. J. Biol. Chem. 271: 15117-15123.
    • (1996) J. Biol. Chem. , vol.271 , pp. 15117-15123
    • Wood, S.M.1    Gleadle, J.M.2    Pugh, C.W.3    Hankinson, O.4    Ratcliffe, P.J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.