-
1
-
-
23644435597
-
Genetic evidence for a tumor suppressor role of HIF-2alpha
-
Acker T., Diez-Juan A., Aragones J., Tjwa M., Brusselmans K., Moons L., Fukumura D., Moreno-Murciano M.P., Herbert J.M., Burger A., et al. Genetic evidence for a tumor suppressor role of HIF-2alpha. Cancer Cell 8 (2005) 131-141
-
(2005)
Cancer Cell
, vol.8
, pp. 131-141
-
-
Acker, T.1
Diez-Juan, A.2
Aragones, J.3
Tjwa, M.4
Brusselmans, K.5
Moons, L.6
Fukumura, D.7
Moreno-Murciano, M.P.8
Herbert, J.M.9
Burger, A.10
-
2
-
-
34248230733
-
Differential regulation of Foxo3a target genes in erythropoiesis
-
Bakker W.J., van Dijk T.B., Parren-van Amelsvoort M., Kolbus A., Yamamoto K., Steinlein P., Verhaak R.G., Mak T.W., Beug H., Lowenberg B., and von Lindern M. Differential regulation of Foxo3a target genes in erythropoiesis. Mol. Cell. Biol. 27 (2007) 3839-3854
-
(2007)
Mol. Cell. Biol.
, vol.27
, pp. 3839-3854
-
-
Bakker, W.J.1
van Dijk, T.B.2
Parren-van Amelsvoort, M.3
Kolbus, A.4
Yamamoto, K.5
Steinlein, P.6
Verhaak, R.G.7
Mak, T.W.8
Beug, H.9
Lowenberg, B.10
von Lindern, M.11
-
3
-
-
33747488399
-
PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR
-
Bernardi R., Guernah I., Jin D., Grisendi S., Alimonti A., Teruya-Feldstein J., Cordon-Cardo C., Simon M.C., Rafii S., and Pandolfi P.P. PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR. Nature 442 (2006) 779-785
-
(2006)
Nature
, vol.442
, pp. 779-785
-
-
Bernardi, R.1
Guernah, I.2
Jin, D.3
Grisendi, S.4
Alimonti, A.5
Teruya-Feldstein, J.6
Cordon-Cardo, C.7
Simon, M.C.8
Rafii, S.9
Pandolfi, P.P.10
-
4
-
-
0032900610
-
Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1
-
Bhattacharya S., Michels C.L., Leung M.K., Arany Z.P., Kung A.L., and Livingston D.M. Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1. Genes Dev. 13 (1999) 64-75
-
(1999)
Genes Dev.
, vol.13
, pp. 64-75
-
-
Bhattacharya, S.1
Michels, C.L.2
Leung, M.K.3
Arany, Z.P.4
Kung, A.L.5
Livingston, D.M.6
-
5
-
-
0034255036
-
Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia
-
Bruick R.K. Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia. Proc. Natl. Acad. Sci. USA 97 (2000) 9082-9087
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 9082-9087
-
-
Bruick, R.K.1
-
6
-
-
0033582929
-
Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
-
Brunet A., Bonni A., Zigmond M.J., Lin M.Z., Juo P., Hu L.S., Anderson M.J., Arden K.C., Blenis J., and Greenberg M.E. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96 (1999) 857-868
-
(1999)
Cell
, vol.96
, pp. 857-868
-
-
Brunet, A.1
Bonni, A.2
Zigmond, M.J.3
Lin, M.Z.4
Juo, P.5
Hu, L.S.6
Anderson, M.J.7
Arden, K.C.8
Blenis, J.9
Greenberg, M.E.10
-
7
-
-
12144290563
-
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
-
Brunet A., Sweeney L.B., Sturgill J.F., Chua K.F., Greer P.L., Lin Y., Tran H., Ross S.E., Mostoslavsky R., Cohen H.Y., et al. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 303 (2004) 2011-2015
-
(2004)
Science
, vol.303
, pp. 2011-2015
-
-
Brunet, A.1
Sweeney, L.B.2
Sturgill, J.F.3
Chua, K.F.4
Greer, P.L.5
Lin, Y.6
Tran, H.7
Ross, S.E.8
Mostoslavsky, R.9
Cohen, H.Y.10
-
8
-
-
0032581277
-
Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
-
Carmeliet P., Dor Y., Herbert J.M., Fukumura D., Brusselmans K., Dewerchin M., Neeman M., Bono F., Abramovitch R., Maxwell P., et al. Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature 394 (1998) 485-490
-
(1998)
Nature
, vol.394
, pp. 485-490
-
-
Carmeliet, P.1
Dor, Y.2
Herbert, J.M.3
Fukumura, D.4
Brusselmans, K.5
Dewerchin, M.6
Neeman, M.7
Bono, F.8
Abramovitch, R.9
Maxwell, P.10
-
9
-
-
16844386959
-
Targeted replacement of hypoxia-inducible factor-1alpha by a hypoxia-inducible factor-2alpha knock-in allele promotes tumor growth
-
Covello K.L., Simon M.C., and Keith B. Targeted replacement of hypoxia-inducible factor-1alpha by a hypoxia-inducible factor-2alpha knock-in allele promotes tumor growth. Cancer Res. 65 (2005) 2277-2286
-
(2005)
Cancer Res.
, vol.65
, pp. 2277-2286
-
-
Covello, K.L.1
Simon, M.C.2
Keith, B.3
-
10
-
-
33644513730
-
Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis
-
Cully M., You H., Levine A.J., and Mak T.W. Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis. Nat. Rev. Cancer 6 (2006) 184-192
-
(2006)
Nat. Rev. Cancer
, vol.6
, pp. 184-192
-
-
Cully, M.1
You, H.2
Levine, A.J.3
Mak, T.W.4
-
11
-
-
0032714189
-
Cloning and expression pattern of EPAS1 in the chicken embryo. Colocalization with tyrosine hydroxylase
-
Favier J., Kempf H., Corvol P., and Gasc J.M. Cloning and expression pattern of EPAS1 in the chicken embryo. Colocalization with tyrosine hydroxylase. FEBS Lett. 462 (1999) 19-24
-
(1999)
FEBS Lett.
, vol.462
, pp. 19-24
-
-
Favier, J.1
Kempf, H.2
Corvol, P.3
Gasc, J.M.4
-
12
-
-
19944371176
-
Bnip3L is induced by p53 under hypoxia, and its knockdown promotes tumor growth
-
Fei P., Wang W., Kim S.H., Wang S., Burns T.F., Sax J.K., Buzzai M., Dicker D.T., McKenna W.G., Bernhard E.J., and El-Deiry W.S. Bnip3L is induced by p53 under hypoxia, and its knockdown promotes tumor growth. Cancer Cell 6 (2004) 597-609
-
(2004)
Cancer Cell
, vol.6
, pp. 597-609
-
-
Fei, P.1
Wang, W.2
Kim, S.H.3
Wang, S.4
Burns, T.F.5
Sax, J.K.6
Buzzai, M.7
Dicker, D.T.8
McKenna, W.G.9
Bernhard, E.J.10
El-Deiry, W.S.11
-
13
-
-
4544227785
-
Abnormal angiogenesis in Foxo1 (Fkhr)-deficient mice
-
Furuyama T., Kitayama K., Shimoda Y., Ogawa M., Sone K., Yoshida-Araki K., Hisatsune H., Nishikawa S., Nakayama K., Nakayama K., et al. Abnormal angiogenesis in Foxo1 (Fkhr)-deficient mice. J. Biol. Chem. 279 (2004) 34741-34749
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 34741-34749
-
-
Furuyama, T.1
Kitayama, K.2
Shimoda, Y.3
Ogawa, M.4
Sone, K.5
Yoshida-Araki, K.6
Hisatsune, H.7
Nishikawa, S.8
Nakayama, K.9
Nakayama, K.10
-
14
-
-
3142749712
-
Long-lived Drosophila with overexpressed dFOXO in adult fat body
-
Giannakou M.E., Goss M., Junger M.A., Hafen E., Leevers S.J., and Partridge L. Long-lived Drosophila with overexpressed dFOXO in adult fat body. Science 305 (2004) 361
-
(2004)
Science
, vol.305
, pp. 361
-
-
Giannakou, M.E.1
Goss, M.2
Junger, M.A.3
Hafen, E.4
Leevers, S.J.5
Partridge, L.6
-
15
-
-
27844497945
-
FOXO transcription factors at the interface between longevity and tumor suppression
-
Greer E.L., and Brunet A. FOXO transcription factors at the interface between longevity and tumor suppression. Oncogene 24 (2005) 7410-7425
-
(2005)
Oncogene
, vol.24
, pp. 7410-7425
-
-
Greer, E.L.1
Brunet, A.2
-
16
-
-
4944246547
-
The role of hypoxia inducible factor 1 (HIF-1) in hypoxia induced apoptosis
-
Greijer A.E., and van der Wall E. The role of hypoxia inducible factor 1 (HIF-1) in hypoxia induced apoptosis. J. Clin. Pathol. 57 (2004) 1009-1014
-
(2004)
J. Clin. Pathol.
, vol.57
, pp. 1009-1014
-
-
Greijer, A.E.1
van der Wall, E.2
-
18
-
-
0036179376
-
Hypoxia links ATR and p53 through replication arrest
-
Hammond E.M., Denko N.C., Dorie M.J., Abraham R.T., and Giaccia A.J. Hypoxia links ATR and p53 through replication arrest. Mol. Cell. Biol. 22 (2002) 1834-1843
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 1834-1843
-
-
Hammond, E.M.1
Denko, N.C.2
Dorie, M.J.3
Abraham, R.T.4
Giaccia, A.J.5
-
19
-
-
0036359548
-
Hypoxia-a key regulatory factor in tumour growth
-
Harris A.L. Hypoxia-a key regulatory factor in tumour growth. Nat. Rev. Cancer 2 (2002) 38-47
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 38-47
-
-
Harris, A.L.1
-
20
-
-
0035846604
-
daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans
-
Henderson S.T., and Johnson T.E. daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans. Curr. Biol. 11 (2001) 1975-1980
-
(2001)
Curr. Biol.
, vol.11
, pp. 1975-1980
-
-
Henderson, S.T.1
Johnson, T.E.2
-
21
-
-
0035925098
-
Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects
-
Hockel M., and Vaupel P. Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects. J. Natl. Cancer Inst. 93 (2001) 266-276
-
(2001)
J. Natl. Cancer Inst.
, vol.93
, pp. 266-276
-
-
Hockel, M.1
Vaupel, P.2
-
22
-
-
33750630119
-
Recruitment of HIF-1alpha and HIF-2alpha to common target genes is differentially regulated in neuroblastoma: HIF-2alpha promotes an aggressive phenotype
-
Holmquist-Mengelbier L., Fredlund E., Lofstedt T., Noguera R., Navarro S., Nilsson H., Pietras A., Vallon-Christersson J., Borg A., Gradin K., et al. Recruitment of HIF-1alpha and HIF-2alpha to common target genes is differentially regulated in neuroblastoma: HIF-2alpha promotes an aggressive phenotype. Cancer Cell 10 (2006) 413-423
-
(2006)
Cancer Cell
, vol.10
, pp. 413-423
-
-
Holmquist-Mengelbier, L.1
Fredlund, E.2
Lofstedt, T.3
Noguera, R.4
Navarro, S.5
Nilsson, H.6
Pietras, A.7
Vallon-Christersson, J.8
Borg, A.9
Gradin, K.10
-
23
-
-
1542267804
-
Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification
-
Hosaka T., Biggs III W.H., Tieu D., Boyer A.D., Varki N.M., Cavenee W.K., and Arden K.C. Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification. Proc. Natl. Acad. Sci. USA 101 (2004) 2975-2980
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 2975-2980
-
-
Hosaka, T.1
Biggs III, W.H.2
Tieu, D.3
Boyer, A.D.4
Varki, N.M.5
Cavenee, W.K.6
Arden, K.C.7
-
24
-
-
0345491599
-
Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation
-
Hu C.J., Wang L.Y., Chodosh L.A., Keith B., and Simon M.C. Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation. Mol. Cell. Biol. 23 (2003) 9361-9374
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 9361-9374
-
-
Hu, C.J.1
Wang, L.Y.2
Chodosh, L.A.3
Keith, B.4
Simon, M.C.5
-
25
-
-
33646248422
-
Differential regulation of the transcriptional activities of hypoxia-inducible factor 1 alpha (HIF-1alpha) and HIF-2alpha in stem cells
-
Hu C.J., Iyer S., Sataur A., Covello K.L., Chodosh L.A., and Simon M.C. Differential regulation of the transcriptional activities of hypoxia-inducible factor 1 alpha (HIF-1alpha) and HIF-2alpha in stem cells. Mol. Cell. Biol. 26 (2006) 3514-3526
-
(2006)
Mol. Cell. Biol.
, vol.26
, pp. 3514-3526
-
-
Hu, C.J.1
Iyer, S.2
Sataur, A.3
Covello, K.L.4
Chodosh, L.A.5
Simon, M.C.6
-
26
-
-
0034940761
-
The Caenorhabditis elegans hif-1 gene encodes a bHLH-PAS protein that is required for adaptation to hypoxia
-
Jiang H., Guo R., and Powell-Coffman J.A. The Caenorhabditis elegans hif-1 gene encodes a bHLH-PAS protein that is required for adaptation to hypoxia. Proc. Natl. Acad. Sci. USA 98 (2001) 7916-7921
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 7916-7921
-
-
Jiang, H.1
Guo, R.2
Powell-Coffman, J.A.3
-
27
-
-
0242539698
-
The Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling
-
Junger M.A., Rintelen F., Stocker H., Wasserman J.D., Vegh M., Radimerski T., Greenberg M.E., and Hafen E. The Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling. J. Biol. 2 (2003) 20
-
(2003)
J. Biol.
, vol.2
, pp. 20
-
-
Junger, M.A.1
Rintelen, F.2
Stocker, H.3
Wasserman, J.D.4
Vegh, M.5
Radimerski, T.6
Greenberg, M.E.7
Hafen, E.8
-
28
-
-
2342597973
-
Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth
-
10.1371/journal.pbio.0000083
-
Kondo K., Kim W.Y., Lechpammer M., and Kaelin Jr. W.G. Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth. PLoS Biol. 1 (2003) E83 10.1371/journal.pbio.0000083
-
(2003)
PLoS Biol.
, vol.1
-
-
Kondo, K.1
Kim, W.Y.2
Lechpammer, M.3
Kaelin Jr., W.G.4
-
29
-
-
0037136563
-
Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress
-
Kops G.J., Dansen T.B., Polderman P.E., Saarloos I., Wirtz K.W., Coffer P.J., Huang T.T., Bos J.L., Medema R.H., and Burgering B.M. Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress. Nature 419 (2002) 316-321
-
(2002)
Nature
, vol.419
, pp. 316-321
-
-
Kops, G.J.1
Dansen, T.B.2
Polderman, P.E.3
Saarloos, I.4
Wirtz, K.W.5
Coffer, P.J.6
Huang, T.T.7
Bos, J.L.8
Medema, R.H.9
Burgering, B.M.10
-
30
-
-
0035140981
-
Regulation of p53 by hypoxia: dissociation of transcriptional repression and apoptosis from p53-dependent transactivation
-
Koumenis C., Alarcon R., Hammond E., Sutphin P., Hoffman W., Murphy M., Derr J., Taya Y., Lowe S.W., Kastan M., and Giaccia A. Regulation of p53 by hypoxia: dissociation of transcriptional repression and apoptosis from p53-dependent transactivation. Mol. Cell. Biol. 21 (2001) 1297-1310
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 1297-1310
-
-
Koumenis, C.1
Alarcon, R.2
Hammond, E.3
Sutphin, P.4
Hoffman, W.5
Murphy, M.6
Derr, J.7
Taya, Y.8
Lowe, S.W.9
Kastan, M.10
Giaccia, A.11
-
31
-
-
0034529914
-
Suppression of tumor growth through disruption of hypoxia-inducible transcription
-
Kung A.L., Wang S., Klco J.M., Kaelin W.G., and Livingston D.M. Suppression of tumor growth through disruption of hypoxia-inducible transcription. Nat. Med. 6 (2000) 1335-1340
-
(2000)
Nat. Med.
, vol.6
, pp. 1335-1340
-
-
Kung, A.L.1
Wang, S.2
Klco, J.M.3
Kaelin, W.G.4
Livingston, D.M.5
-
32
-
-
3142622930
-
Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway
-
Kung A.L., Zabludoff S.D., France D.S., Freedman S.J., Tanner E.A., Vieira A., Cornell-Kennon S., Lee J., Wang B., Wang J., et al. Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway. Cancer Cell 6 (2004) 33-43
-
(2004)
Cancer Cell
, vol.6
, pp. 33-43
-
-
Kung, A.L.1
Zabludoff, S.D.2
France, D.S.3
Freedman, S.J.4
Tanner, E.A.5
Vieira, A.6
Cornell-Kennon, S.7
Lee, J.8
Wang, B.9
Wang, J.10
-
33
-
-
0034920088
-
Activation of c-Jun NH2-terminal kinase/stress-activated protein kinase (JNK/SAPK) is critical for hypoxia-induced apoptosis of human malignant melanoma
-
Kunz M., Ibrahim S., Koczan D., Thiesen H.J., Kohler H.J., Acker T., Plate K.H., Ludwig S., Rapp U.R., Brocker E.B., et al. Activation of c-Jun NH2-terminal kinase/stress-activated protein kinase (JNK/SAPK) is critical for hypoxia-induced apoptosis of human malignant melanoma. Cell Growth Differ. 12 (2001) 137-145
-
(2001)
Cell Growth Differ.
, vol.12
, pp. 137-145
-
-
Kunz, M.1
Ibrahim, S.2
Koczan, D.3
Thiesen, H.J.4
Kohler, H.J.5
Acker, T.6
Plate, K.H.7
Ludwig, S.8
Rapp, U.R.9
Brocker, E.B.10
-
34
-
-
34247631690
-
The transcription factor HIF-1alpha plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis
-
Lum J.J., Bui T., Gruber M., Gordan J.D., DeBerardinis R.J., Covello K.L., Simon M.C., and Thompson C.B. The transcription factor HIF-1alpha plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis. Genes Dev. 21 (2007) 1037-1049
-
(2007)
Genes Dev.
, vol.21
, pp. 1037-1049
-
-
Lum, J.J.1
Bui, T.2
Gruber, M.3
Gordan, J.D.4
DeBerardinis, R.J.5
Covello, K.L.6
Simon, M.C.7
Thompson, C.B.8
-
35
-
-
0035969508
-
Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression
-
Makino Y., Cao R., Svensson K., Bertilsson G., Asman M., Tanaka H., Cao Y., Berkenstam A., and Poellinger L. Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression. Nature 414 (2001) 550-554
-
(2001)
Nature
, vol.414
, pp. 550-554
-
-
Makino, Y.1
Cao, R.2
Svensson, K.3
Bertilsson, G.4
Asman, M.5
Tanaka, H.6
Cao, Y.7
Berkenstam, A.8
Poellinger, L.9
-
36
-
-
7244238167
-
Shared transcriptional signature in Caenorhabditis elegans Dauer larvae and long-lived daf-2 mutants implicates detoxification system in longevity assurance
-
McElwee J.J., Schuster E., Blanc E., Thomas J.H., and Gems D. Shared transcriptional signature in Caenorhabditis elegans Dauer larvae and long-lived daf-2 mutants implicates detoxification system in longevity assurance. J. Biol. Chem. 279 (2004) 44533-44543
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 44533-44543
-
-
McElwee, J.J.1
Schuster, E.2
Blanc, E.3
Thomas, J.H.4
Gems, D.5
-
37
-
-
0034643331
-
AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1
-
Medema R.H., Kops G.J., Bos J.L., and Burgering B.M. AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1. Nature 404 (2000) 782-787
-
(2000)
Nature
, vol.404
, pp. 782-787
-
-
Medema, R.H.1
Kops, G.J.2
Bos, J.L.3
Burgering, B.M.4
-
38
-
-
0042092531
-
Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans
-
Murphy C.T., McCarroll S.A., Bargmann C.I., Fraser A., Kamath R.S., Ahringer J., Li H., and Kenyon C. Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature 424 (2003) 277-283
-
(2003)
Nature
, vol.424
, pp. 277-283
-
-
Murphy, C.T.1
McCarroll, S.A.2
Bargmann, C.I.3
Fraser, A.4
Kamath, R.S.5
Ahringer, J.6
Li, H.7
Kenyon, C.8
-
39
-
-
12944335299
-
DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells
-
Nasrin N., Ogg S., Cahill C.M., Biggs W., Nui S., Dore J., Calvo D., Shi Y., Ruvkun G., and Alexander-Bridges M.C. DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells. Proc. Natl. Acad. Sci. USA 97 (2000) 10412-10417
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 10412-10417
-
-
Nasrin, N.1
Ogg, S.2
Cahill, C.M.3
Biggs, W.4
Nui, S.5
Dore, J.6
Calvo, D.7
Shi, Y.8
Ruvkun, G.9
Alexander-Bridges, M.C.10
-
40
-
-
33846295218
-
FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis
-
Paik J.H., Kollipara R., Chu G., Ji H., Xiao Y., Ding Z., Miao L., Tothova Z., Horner J.W., Carrasco D.R., et al. FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis. Cell 128 (2007) 309-323
-
(2007)
Cell
, vol.128
, pp. 309-323
-
-
Paik, J.H.1
Kollipara, R.2
Chu, G.3
Ji, H.4
Xiao, Y.5
Ding, Z.6
Miao, L.7
Tothova, Z.8
Horner, J.W.9
Carrasco, D.R.10
-
41
-
-
3042779529
-
p53 cannot be induced by hypoxia alone but responds to the hypoxic microenvironment
-
Pan Y., Oprysko P.R., Asham A.M., Koch C.J., and Simon M.C. p53 cannot be induced by hypoxia alone but responds to the hypoxic microenvironment. Oncogene 23 (2004) 4975-4983
-
(2004)
Oncogene
, vol.23
, pp. 4975-4983
-
-
Pan, Y.1
Oprysko, P.R.2
Asham, A.M.3
Koch, C.J.4
Simon, M.C.5
-
42
-
-
0038788826
-
Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1alpha (HIF-1alpha): role of cytoplasmic trapping of HIF-2alpha
-
Park S.K., Dadak A.M., Haase V.H., Fontana L., Giaccia A.J., and Johnson R.S. Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1alpha (HIF-1alpha): role of cytoplasmic trapping of HIF-2alpha. Mol. Cell. Biol. 23 (2003) 4959-4971
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 4959-4971
-
-
Park, S.K.1
Dadak, A.M.2
Haase, V.H.3
Fontana, L.4
Giaccia, A.J.5
Johnson, R.S.6
-
43
-
-
0036651790
-
A novel mechanism of gene regulation and tumor suppression by the transcription factor FKHR
-
Ramaswamy S., Nakamura N., Sansal I., Bergeron L., and Sellers W.R. A novel mechanism of gene regulation and tumor suppression by the transcription factor FKHR. Cancer Cell 2 (2002) 81-91
-
(2002)
Cancer Cell
, vol.2
, pp. 81-91
-
-
Ramaswamy, S.1
Nakamura, N.2
Sansal, I.3
Bergeron, L.4
Sellers, W.R.5
-
44
-
-
0033984094
-
BNIP3 heterodimerizes with Bcl-2/Bcl-X(L) and induces cell death independent of a Bcl-2 homology 3 (BH3) domain at both mitochondrial and nonmitochondrial sites
-
Ray R., Chen G., Vande Velde C., Cizeau J., Park J.H., Reed J.C., Gietz R.D., and Greenberg A.H. BNIP3 heterodimerizes with Bcl-2/Bcl-X(L) and induces cell death independent of a Bcl-2 homology 3 (BH3) domain at both mitochondrial and nonmitochondrial sites. J. Biol. Chem. 275 (2000) 1439-1448
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 1439-1448
-
-
Ray, R.1
Chen, G.2
Vande Velde, C.3
Cizeau, J.4
Park, J.H.5
Reed, J.C.6
Gietz, R.D.7
Greenberg, A.H.8
-
45
-
-
10044276784
-
The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila
-
Reiling J.H., and Hafen E. The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila. Genes Dev. 18 (2004) 2879-2892
-
(2004)
Genes Dev.
, vol.18
, pp. 2879-2892
-
-
Reiling, J.H.1
Hafen, E.2
-
46
-
-
34447523460
-
Hypoxia-inducible factor-1alpha, a key factor in the keratinocyte response to UVB exposure
-
Rezvani H.R., Dedieu S., North S., Belloc F., Rossignol R., Letellier T., de Verneuil H., Taieb A., and Mazurier F. Hypoxia-inducible factor-1alpha, a key factor in the keratinocyte response to UVB exposure. J. Biol. Chem. 282 (2007) 16413-16422
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 16413-16422
-
-
Rezvani, H.R.1
Dedieu, S.2
North, S.3
Belloc, F.4
Rossignol, R.5
Letellier, T.6
de Verneuil, H.7
Taieb, A.8
Mazurier, F.9
-
47
-
-
0032100732
-
HIF-1 alpha is required for solid tumor formation and embryonic vascularization
-
Ryan H.E., Lo J., and Johnson R.S. HIF-1 alpha is required for solid tumor formation and embryonic vascularization. EMBO J. 17 (1998) 3005-3015
-
(1998)
EMBO J.
, vol.17
, pp. 3005-3015
-
-
Ryan, H.E.1
Lo, J.2
Johnson, R.S.3
-
48
-
-
0037189303
-
Regulation of hypoxic death in C. elegans by the insulin/IGF receptor homolog DAF-2
-
Scott B.A., Avidan M.S., and Crowder C.M. Regulation of hypoxic death in C. elegans by the insulin/IGF receptor homolog DAF-2. Science 296 (2002) 2388-2391
-
(2002)
Science
, vol.296
, pp. 2388-2391
-
-
Scott, B.A.1
Avidan, M.S.2
Crowder, C.M.3
-
49
-
-
0035027828
-
Transcription factor HIF-1 is a necessary mediator of the pasteur effect in mammalian cells
-
Seagroves T.N., Ryan H.E., Lu H., Wouters B.G., Knapp M., Thibault P., Laderoute K., and Johnson R.S. Transcription factor HIF-1 is a necessary mediator of the pasteur effect in mammalian cells. Mol. Cell. Biol. 21 (2001) 3436-3444
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 3436-3444
-
-
Seagroves, T.N.1
Ryan, H.E.2
Lu, H.3
Wouters, B.G.4
Knapp, M.5
Thibault, P.6
Laderoute, K.7
Johnson, R.S.8
-
50
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
Semenza G.L. Targeting HIF-1 for cancer therapy. Nat. Rev. Cancer 3 (2003) 721-732
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 721-732
-
-
Semenza, G.L.1
-
51
-
-
0036118562
-
Identification of a novel hypoxia-inducible factor 1-responsive gene, RTP801, involved in apoptosis
-
Shoshani T., Faerman A., Mett I., Zelin E., Tenne T., Gorodin S., Moshel Y., Elbaz S., Budanov A., Chajut A., et al. Identification of a novel hypoxia-inducible factor 1-responsive gene, RTP801, involved in apoptosis. Mol. Cell. Biol. 22 (2002) 2283-2293
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 2283-2293
-
-
Shoshani, T.1
Faerman, A.2
Mett, I.3
Zelin, E.4
Tenne, T.5
Gorodin, S.6
Moshel, Y.7
Elbaz, S.8
Budanov, A.9
Chajut, A.10
-
52
-
-
0035884701
-
HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors
-
Sowter H.M., Ratcliffe P.J., Watson P., Greenberg A.H., and Harris A.L. HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors. Cancer Res. 61 (2001) 6669-6673
-
(2001)
Cancer Res.
, vol.61
, pp. 6669-6673
-
-
Sowter, H.M.1
Ratcliffe, P.J.2
Watson, P.3
Greenberg, A.H.4
Harris, A.L.5
-
53
-
-
19944426515
-
Microvascular patterning is controlled by fine-tuning the Akt signal
-
Sun J.F., Phung T., Shiojima I., Felske T., Upalakalin J.N., Feng D., Kornaga T., Dor T., Dvorak A.M., Walsh K., and Benjamin L.E. Microvascular patterning is controlled by fine-tuning the Akt signal. Proc. Natl. Acad. Sci. USA 102 (2005) 128-133
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 128-133
-
-
Sun, J.F.1
Phung, T.2
Shiojima, I.3
Felske, T.4
Upalakalin, J.N.5
Feng, D.6
Kornaga, T.7
Dor, T.8
Dvorak, A.M.9
Walsh, K.10
Benjamin, L.E.11
-
54
-
-
0027762217
-
Chemosensory regulation of development in C. elegans
-
Thomas J.H. Chemosensory regulation of development in C. elegans. Bioessays 15 (1993) 791-797
-
(1993)
Bioessays
, vol.15
, pp. 791-797
-
-
Thomas, J.H.1
-
55
-
-
84966192535
-
The histological structure of some human lung cancers and the possible implications for radiotherapy
-
Thomlinson R.H., and Gray L.H. The histological structure of some human lung cancers and the possible implications for radiotherapy. Br. J. Cancer 9 (1955) 539-549
-
(1955)
Br. J. Cancer
, vol.9
, pp. 539-549
-
-
Thomlinson, R.H.1
Gray, L.H.2
-
56
-
-
0037134040
-
DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein
-
Tran H., Brunet A., Grenier J.M., Datta S.R., Fornace Jr. A.J., DiStefano P.S., Chiang L.W., and Greenberg M.E. DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein. Science 296 (2002) 530-534
-
(2002)
Science
, vol.296
, pp. 530-534
-
-
Tran, H.1
Brunet, A.2
Grenier, J.M.3
Datta, S.R.4
Fornace Jr., A.J.5
DiStefano, P.S.6
Chiang, L.W.7
Greenberg, M.E.8
-
57
-
-
2942726155
-
The ins and outs of FoxO shuttling: mechanisms of FoxO translocation and transcriptional regulation
-
Van Der Heide L.P., Hoekman M.F., and Smidt M.P. The ins and outs of FoxO shuttling: mechanisms of FoxO translocation and transcriptional regulation. Biochem. J. 380 (2004) 297-309
-
(2004)
Biochem. J.
, vol.380
, pp. 297-309
-
-
Van Der Heide, L.P.1
Hoekman, M.F.2
Smidt, M.P.3
-
58
-
-
33845724644
-
Partial rescue of defects in Cited2-deficient embryos by HIF-1alpha heterozygosity
-
Xu B., Doughman Y., Turakhia M., Jiang W., Landsettle C.E., Agani F.H., Semenza G.L., Watanabe M., and Yang Y.C. Partial rescue of defects in Cited2-deficient embryos by HIF-1alpha heterozygosity. Dev. Biol. 301 (2007) 130-140
-
(2007)
Dev. Biol.
, vol.301
, pp. 130-140
-
-
Xu, B.1
Doughman, Y.2
Turakhia, M.3
Jiang, W.4
Landsettle, C.E.5
Agani, F.H.6
Semenza, G.L.7
Watanabe, M.8
Yang, Y.C.9
-
59
-
-
0036679122
-
The essential role of Cited2, a negative regulator for HIF-1alpha, in heart development and neurulation
-
Yin Z., Haynie J., Yang X., Han B., Kiatchoosakun S., Restivo J., Yuan S., Prabhakar N.R., Herrup K., Conlon R.A., et al. The essential role of Cited2, a negative regulator for HIF-1alpha, in heart development and neurulation. Proc. Natl. Acad. Sci. USA 99 (2002) 10488-10493
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 10488-10493
-
-
Yin, Z.1
Haynie, J.2
Yang, X.3
Han, B.4
Kiatchoosakun, S.5
Restivo, J.6
Yuan, S.7
Prabhakar, N.R.8
Herrup, K.9
Conlon, R.A.10
-
60
-
-
0034050050
-
Loss of PTEN facilitates HIF-1-mediated gene expression
-
Zundel W., Schindler C., Haas-Kogan D., Koong A., Kaper F., Chen E., Gottschalk A.R., Ryan H.E., Johnson R.S., Jefferson A.B., et al. Loss of PTEN facilitates HIF-1-mediated gene expression. Genes Dev. 14 (2000) 391-396
-
(2000)
Genes Dev.
, vol.14
, pp. 391-396
-
-
Zundel, W.1
Schindler, C.2
Haas-Kogan, D.3
Koong, A.4
Kaper, F.5
Chen, E.6
Gottschalk, A.R.7
Ryan, H.E.8
Johnson, R.S.9
Jefferson, A.B.10
|