Dichloroacetate, a metabolic modulator, prevents and reverses chronic hypoxic pulmonary hypertension in rats: Role of increased expression and activity of voltage-gated potassium channels

Circulation

Volumn 105, Issue 2, 2002, Pages 244-250

  Michelakis, Evangelos D ^a   McMurtry, M Sean ^a   Wu, Xi Chen ^a   Dyck, Jason R B ^a   Moudgil, Rohit ^a   Hopkins, Teresa A ^a   Lopaschuk, Gary D ^a   Puttagunta, Lakshmi ^a   Waite, Ross ^a   Archer, Stephen L ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Dichloroacetate; Hypertension, pulmonary; Ion channels; Kinases; Metabolism

Indexed keywords

DICHLOROACETIC ACID; PYRUVATE DEHYDROGENASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; ENZYME ACTIVITY; HEMODYNAMICS; HYPOXIA; ION TRANSPORT; LUNG VASCULAR RESISTANCE; MEMBRANE POTENTIAL; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PULMONARY HYPERTENSION; RAT; RECEPTOR DOWN REGULATION; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE;

ANIMALS; ANOXIA; CELLS, CULTURED; CHO CELLS; CHRONIC DISEASE; CRICETINAE; DELAYED RECTIFIER POTASSIUM CHANNELS; DICHLOROACETATE; ELECTRIC CONDUCTIVITY; ENZYME INHIBITORS; HEMODYNAMIC PROCESSES; HYPERTENSION, PULMONARY; IMMUNOBLOTTING; MALE; MUSCLE, SMOOTH, VASCULAR; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; PULMONARY ARTERY; PYRUVATE DEHYDROGENASE COMPLEX; RATS; RATS, SPRAGUE-DAWLEY; SHAB POTASSIUM CHANNELS;

EID: 0037080541     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/hc0202.101974     Document Type: Article

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