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Volumn 103, Issue 5, 1999, Pages 691-696

Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1α

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHROPOIETIN; GLYCOLYTIC ENZYME; HELIX LOOP HELIX PROTEIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; UNCLASSIFIED DRUG; VASCULOTROPIN;

EID: 0033104847     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI5912     Document Type: Article
Times cited : (590)

References (47)
  • 1
    • 0014238190 scopus 로고
    • Circulatory adaptation to high altitude
    • Hultgren, H.N., and Grover, R.F. 1968. Circulatory adaptation to high altitude. Annu. Rev. Med. 19:119-152.
    • (1968) Annu. Rev. Med. , vol.19 , pp. 119-152
    • Hultgren, H.N.1    Grover, R.F.2
  • 2
    • 0031205387 scopus 로고    scopus 로고
    • Pulmonary hypertension: Newer concepts in diagnosis and management
    • Moraes, D., and Loscalzo, J. 1997. Pulmonary hypertension: newer concepts in diagnosis and management. Clin. Cardiol. 20:676-682.
    • (1997) Clin. Cardiol. , vol.20 , pp. 676-682
    • Moraes, D.1    Loscalzo, J.2
  • 3
    • 0030712990 scopus 로고    scopus 로고
    • Pulmonary circulation at high altitude
    • Naeije, R. 1997. Pulmonary circulation at high altitude. Respiration. 64:429-434.
    • (1997) Respiration , vol.64 , pp. 429-434
    • Naeije, R.1
  • 4
    • 0028844533 scopus 로고
    • a-receptor antagonism prevents and reverses chronic hypoxia-induced pulmonary hypertension in rat
    • A-receptor antagonism prevents and reverses chronic hypoxia-induced pulmonary hypertension in rat. Am. J. Phystol. 269:L690-L697.
    • (1995) Am. J. Phystol. , vol.269
    • DiCarlo, V.S.1
  • 6
    • 0028060499 scopus 로고
    • Enhanced endothelin-1 and endothelin receptor gene expression in chronic hypoxia
    • Li, H., et al. 1994. Enhanced endothelin-1 and endothelin receptor gene expression in chronic hypoxia. J. Appl. Physiol. 77:1451-1459.
    • (1994) J. Appl. Physiol. , vol.77 , pp. 1451-1459
    • Li, H.1
  • 7
    • 0018128776 scopus 로고
    • The effect of beta adrenergic blockade on pulmonary hypertension, nght ventricular hypertrophy and polycythaemia, induced in rats by intermittent high altitude hypoxia
    • Ostadal, B, et al. 1978. The effect of beta adrenergic blockade on pulmonary hypertension, nght ventricular hypertrophy and polycythaemia, induced in rats by intermittent high altitude hypoxia. Basic Res. Cardiol. 73:422-432.
    • (1978) Basic Res. Cardiol. , vol.73 , pp. 422-432
    • Ostadal, B.1
  • 8
    • 0018487516 scopus 로고
    • Rat pulmonary circulation after chronic hypoxia: Hemodynamics and structural features
    • Rabinovitch, M., Gamble, W., Nades, A.S., Miettinen, O.S., and Reid, L. 1979. Rat pulmonary circulation after chronic hypoxia: hemodynamics and structural features. Am. J. Physiol. 236:H818-H827.
    • (1979) Am. J. Physiol. , vol.236
    • Rabinovitch, M.1    Gamble, W.2    Nades, A.S.3    Miettinen, O.S.4    Reid, L.5
  • 9
    • 85047680838 scopus 로고
    • Effect of intermittent altitude hypoxia on the myocardium and lesser circulation in the rat
    • Widimsky, J., et al. 1973. Effect of intermittent altitude hypoxia on the myocardium and lesser circulation in the rat. Cardiovasc. Res. 7:798-808.
    • (1973) Cardiovasc. Res. , vol.7 , pp. 798-808
    • Widimsky, J.1
  • 10
    • 0032102283 scopus 로고    scopus 로고
    • Sustained pulmonary hypertension and right ventricular hypertrophy after chronic hypoxia in mice with congenital deficiency of nitric oxide synthase 3
    • Steudel, W., et al. 1998. Sustained pulmonary hypertension and right ventricular hypertrophy after chronic hypoxia in mice with congenital deficiency of nitric oxide synthase 3. J. Clin. Invest. 101:2468-2477.
    • (1998) J. Clin. Invest. , vol.101 , pp. 2468-2477
    • Steudel, W.1
  • 11
    • 0029936155 scopus 로고    scopus 로고
    • Inhibition of 5-lipoxygenase-activating protein (FLAP) reduces pulmonary vascular reactivity and pulmonary hypertension in hypoxic rats
    • Voelkel, N.F., et al. 1996. Inhibition of 5-lipoxygenase-activating protein (FLAP) reduces pulmonary vascular reactivity and pulmonary hypertension in hypoxic rats. J. Clin. Invest. 97:2491-2498.
    • (1996) J. Clin. Invest. , vol.97 , pp. 2491-2498
    • Voelkel, N.F.1
  • 12
    • 0029890251 scopus 로고    scopus 로고
    • Molecular basis of hypoxia-induced erythropoietin expression
    • Wang, G.L., and Semenza, G.L. 1996. Molecular basis of hypoxia-induced erythropoietin expression. Curr. Opin. Hematol. 3:156-162.
    • (1996) Curr. Opin. Hematol. , vol.3 , pp. 156-162
    • Wang, G.L.1    Semenza, G.L.2
  • 13
    • 0024538075 scopus 로고
    • Hemodynamic effects of arginine vasopressin in rats adapted to chronic hypoxia
    • Jin, H.K., et al. 1989. Hemodynamic effects of arginine vasopressin in rats adapted to chronic hypoxia. J. Appl. Physiol. 66:151-160.
    • (1989) J. Appl. Physiol. , vol.66 , pp. 151-160
    • Jin, H.K.1
  • 14
    • 0030763575 scopus 로고    scopus 로고
    • NO: COPD and beyond
    • Jones, A.T., and Evans, T.W. 1997. NO: COPD and beyond. Thorax. 52:S16-S21.
    • (1997) Thorax. , vol.52
    • Jones, A.T.1    Evans, T.W.2
  • 15
    • 0027527064 scopus 로고
    • NIP-121 is more effective than nifedipine in acutely reversing chronic hypoxic pulmonary hypertension
    • Oka, M., Morris, K.G., and McMurtry, I.F. 1993. NIP-121 is more effective than nifedipine in acutely reversing chronic hypoxic pulmonary hypertension. J. Appl. Physiol. 75:1074-1080.
    • (1993) J. Appl. Physiol. , vol.75 , pp. 1074-1080
    • Oka, M.1    Morris, K.G.2    McMurtry, I.F.3
  • 16
    • 0026468180 scopus 로고
    • A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
    • Semenza, G.L., and Wang, G.L. 1992. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol. Cell. Biol. 12:5447-5454.
    • (1992) Mol. Cell. Biol. , vol.12 , pp. 5447-5454
    • Semenza, G.L.1    Wang, G.L.2
  • 18
    • 0030792094 scopus 로고    scopus 로고
    • Oxygenregulated transferrin expression is mediated by hypoxia-inducible factor-1
    • Rolfs, A., Kvietikova, I., Gassmann, M., and Wenger, R.H. 1997. Oxygenregulated transferrin expression is mediated by hypoxia-inducible factor-1. J. Biol. Chem. 272:20055-20062.
    • (1997) J. Biol. Chem. , vol.272 , pp. 20055-20062
    • Rolfs, A.1    Kvietikova, I.2    Gassmann, M.3    Wenger, R.H.4
  • 19
    • 0029761644 scopus 로고    scopus 로고
    • Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
    • Forsythe, J.A., et al. 1996. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol. Cell. Biol. 16:4604-4613.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 4604-4613
    • Forsythe, J.A.1
  • 20
    • 0029103274 scopus 로고
    • Hypoxia regulates vascular endothelial growth factor gene expression in endothelial cells
    • Liu, Y., Cox, S.R. Morita, T., and Kourembanas, S. 1995. Hypoxia regulates vascular endothelial growth factor gene expression in endothelial cells. Circ. Res. 77:638-643.
    • (1995) Circ. Res. , vol.77 , pp. 638-643
    • Liu, Y.1    Cox, S.R.2    Morita, T.3    Kourembanas, S.4
  • 21
    • 0030751493 scopus 로고    scopus 로고
    • Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes: Flt-1, but not Flk-1, is upregulated by hypoxia
    • Gerber, H.-P., Condorelli, F., Park, J., and Ferrara, N. 1997. Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes: Flt-1, but not Flk-1, is upregulated by hypoxia. J. Biol. Chem. 272:23659-23667.
    • (1997) J. Biol. Chem. , vol.272 , pp. 23659-23667
    • Gerber, H.-P.1    Condorelli, F.2    Park, J.3    Ferrara, N.4
  • 22
    • 0028786601 scopus 로고
    • A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter
    • Melillo, G., et al. 1995. A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter. J. Exp. Med. 182:1683-1693.
    • (1995) J. Exp. Med. , vol.182 , pp. 1683-1693
    • Melillo, G.1
  • 23
    • 0031888729 scopus 로고    scopus 로고
    • Hypoxia induces type II NOS gene expression in pulmonary artery endothehal cells via HIF-1
    • Palmer, L.A., Semenza, G.L., Stoler, M.H., and Johns, R.A. 1998. Hypoxia induces type II NOS gene expression in pulmonary artery endothehal cells via HIF-1. Am. J. Physiol. 274:L212-L219.
    • (1998) Am. J. Physiol. , vol.274
    • Palmer, L.A.1    Semenza, G.L.2    Stoler, M.H.3    Johns, R.A.4
  • 24
    • 0031041377 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1 mediates transcriptional activation of heme oxygenase-1 gene in response to hypoxia
    • Lee, P.J., et al. 1997. Hypoxia-inducible factor 1 mediates transcriptional activation of heme oxygenase-1 gene in response to hypoxia. J. Biol. Chem. 272:5375-5381.
    • (1997) J. Biol. Chem. , vol.272 , pp. 5375-5381
    • Lee, P.J.1
  • 25
    • 0032576971 scopus 로고    scopus 로고
    • Hypoxia regulates expression of the endothelin-1 gene through a proximal hypoxia-inducible factor 1 binding site on the antisense strand
    • Hu, J., Discher, D.J., Bishopric, N.H., and Webster, K.A. 1998. Hypoxia regulates expression of the endothelin-1 gene through a proximal hypoxia-inducible factor 1 binding site on the antisense strand. Biochem. Biophys. Res. Commun. 245:894-899.
    • (1998) Biochem. Biophys. Res. Commun. , vol.245 , pp. 894-899
    • Hu, J.1    Discher, D.J.2    Bishopric, N.H.3    Webster, K.A.4
  • 26
    • 0031020097 scopus 로고    scopus 로고
    • Mechanisms by which oxygen regulates gene expression and cell-cell interaction in the vasculature
    • Kourembanas, S., Morita, T., Liu, Y., and Christou, H. 1997. Mechanisms by which oxygen regulates gene expression and cell-cell interaction in the vasculature. Kidney Int. 51:438-443.
    • (1997) Kidney Int. , vol.51 , pp. 438-443
    • Kourembanas, S.1    Morita, T.2    Liu, Y.3    Christou, H.4
  • 27
    • 0030023029 scopus 로고    scopus 로고
    • Chronic hypoxia upregulates endothelial and inducible NO synthase gene and protein expression in rat lung
    • Le Cras, T.D., Xue, C., Rengasamy, A., and Johns, R.A. 1996. Chronic hypoxia upregulates endothelial and inducible NO synthase gene and protein expression in rat lung. Am. J. Physiol. 270:L164-L170.
    • (1996) Am. J. Physiol. , vol.270
    • Le Cras, T.D.1    Xue, C.2    Rengasamy, A.3    Johns, R.A.4
  • 28
    • 0031919886 scopus 로고    scopus 로고
    • Polycythemic responses to hypoxia: Molecular and genetic mechanisms of chronic mountain sickness
    • Ou, L.C., et al. 1998. Polycythemic responses to hypoxia: molecular and genetic mechanisms of chronic mountain sickness. J. Appl. Physiol. 8:1242-1251.
    • (1998) J. Appl. Physiol. , vol.8 , pp. 1242-1251
    • Ou, L.C.1
  • 29
    • 0028940664 scopus 로고
    • Increased gene expression for VEGF and the VEGF receptors KDR/Flk and Flt in kings exposed to acute or to chronic hypoxia: Modulation of gene expression by nitric oxide
    • Tuder, R.M., Flook, B.E., and Voelkel, N.F. 1995. Increased gene expression for VEGF and the VEGF receptors KDR/Flk and Flt in Kings exposed to acute or to chronic hypoxia: modulation of gene expression by nitric oxide. J. Clin. Invest. 95:1798-1807.
    • (1995) J. Clin. Invest. , vol.95 , pp. 1798-1807
    • Tuder, R.M.1    Flook, B.E.2    Voelkel, N.F.3
  • 30
    • 0028816847 scopus 로고
    • Purification and characterization of hypoxia-inducible factor 1
    • Wang, G.L., and Semenza, G.L. 1995. Purification and characterization of hypoxia-inducible factor 1. J. Biol. Chem. 270:1230-1237.
    • (1995) J. Biol. Chem. , vol.270 , pp. 1230-1237
    • Wang, G.L.1    Semenza, G.L.2
  • 31
    • 0029944965 scopus 로고    scopus 로고
    • Dimerization, DNA binding, and transactivation properties of hypoxiainducible factor 1
    • Jiang, B.-H., Rue, E., Wang, G.L., Roe, R., and Semenza, G.L. 1996. Dimerization, DNA binding, and transactivation properties of hypoxiainducible factor 1. J. Biol. Chem. 271:17771-17778.
    • (1996) J. Biol. Chem. , vol.271 , pp. 17771-17778
    • Jiang, B.-H.1    Rue, E.2    Wang, G.L.3    Roe, R.4    Semenza, G.L.5
  • 32
    • 0025906014 scopus 로고
    • Cloning of a factor required for activity of the Ah (dioxin) receptor
    • Hoffman, E.C., et al. 1991. Cloning of a factor required for activity of the Ah (dioxin) receptor. Science. 252:954-958.
    • (1991) Science , vol.252 , pp. 954-958
    • Hoffman, E.C.1
  • 34
    • 0030460724 scopus 로고    scopus 로고
    • Hypoxia response elements in the aldolase a, enolase 1, and lactate dehydrogenase a gene promoters contain essential binding sites for hypoxia-mdudble factor 1
    • Semenza, G.L., et al. 1998. Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-mdudble factor 1. J. Biol. Chem. 271:32529-32537.
    • (1998) J. Biol. Chem. , vol.271 , pp. 32529-32537
    • Semenza, G.L.1
  • 35
    • 0031957221 scopus 로고    scopus 로고
    • Cardiac hypertrophy in chronically anemic fetal sheep: Increased vascularization is associated with increased myocardial expression of vascular endothelial growth factor and hypoxia-inducible factor 1
    • Martin, C., et al. Cardiac hypertrophy in chronically anemic fetal sheep: increased vascularization is associated with increased myocardial expression of vascular endothelial growth factor and hypoxia-inducible factor 1. Am. J. Obstet. Gynecol. 178:527-534.
    • Am. J. Obstet. Gynecol. , vol.178 , pp. 527-534
    • Martin, C.1
  • 36
    • 0031753986 scopus 로고    scopus 로고
    • Temporal, spatial, and oxygen-regulated expression of hypoxia-inducible factor 1 in the lung
    • Yu, A.Y., et al. 1998. Temporal, spatial, and oxygen-regulated expression of hypoxia-inducible factor 1 in the lung. Am. J. Physiol. 275:L818-L826.
    • (1998) Am. J. Physiol. , vol.275
    • Yu, A.Y.1
  • 37
    • 15444342958 scopus 로고    scopus 로고
    • 2 homeostasis by hypoxia-inducible factor 1α
    • 2 homeostasis by hypoxia-inducible factor 1α. Genes Dev. 12:149-162.
    • (1998) Genes Dev. , vol.12 , pp. 149-162
    • Iyer, N.V.1
  • 38
    • 0032100732 scopus 로고    scopus 로고
    • HIF-1α is required for solid rumor formation and embryonic vascularizarinn
    • Ryan, H.E., Lo, J., and Johnson, R.S. 1998. HIF-1α is required for solid rumor formation and embryonic vascularizarinn. EMBO J. 17:3005-3015.
    • (1998) EMBO J. , vol.17 , pp. 3005-3015
    • Ryan, H.E.1    Lo, J.2    Johnson, R.S.3
  • 40
    • 0029165211 scopus 로고
    • Pulmonary vascular adaptations to augmented polycythemia during chronic hypoxia
    • Petit, R.D., Warburton, R.R., Ou, L.C., and Hill, N.S. 1995. Pulmonary vascular adaptations to augmented polycythemia during chronic hypoxia. J. Appl. Physiol. 79:229-235.
    • (1995) J. Appl. Physiol. , vol.79 , pp. 229-235
    • Petit, R.D.1    Warburton, R.R.2    Ou, L.C.3    Hill, N.S.4
  • 41
    • 0031754373 scopus 로고    scopus 로고
    • Mersalyl is a novel inducer of vascular endothelial growth factor gene expression and hypoxia-inducible factor 1 activity
    • Agani, F., and Semenza, G.L. 1998. Mersalyl is a novel inducer of vascular endothelial growth factor gene expression and hypoxia-inducible factor 1 activity. Mol. Pharmacol. 54:749-754.
    • (1998) Mol. Pharmacol. , vol.54 , pp. 749-754
    • Agani, F.1    Semenza, G.L.2
  • 42
    • 0032169214 scopus 로고    scopus 로고
    • Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1α/ARNT
    • Zelzer, E., et al. 1998. Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1α/ARNT. EMBO J. 17:5085-5094.
    • (1998) EMBO J. , vol.17 , pp. 5085-5094
    • Zelzer, E.1
  • 43
    • 0031974197 scopus 로고    scopus 로고
    • Insulin-like growth factor II induced by hypoxia may contribute to angiogenesis of human hepatocellular carcinoma
    • Kim, K.W., et al. 1998. Insulin-like growth factor II induced by hypoxia may contribute to angiogenesis of human hepatocellular carcinoma. Cancer Res. 58:348-351.
    • (1998) Cancer Res. , vol.58 , pp. 348-351
    • Kim, K.W.1
  • 44
    • 0030733878 scopus 로고    scopus 로고
    • Hypoxia-induced changes in insulin-like growth factors and their binding proteins in pregnant rats
    • Tapanainen, P.J., et al. 1997. Hypoxia-induced changes in insulin-like growth factors and their binding proteins in pregnant rats. Horm. Res. 48:227-234.
    • (1997) Horm. Res. , vol.48 , pp. 227-234
    • Tapanainen, P.J.1
  • 45
    • 0031955609 scopus 로고    scopus 로고
    • Modulation of insulin-like growth factor (IGF) and IGF binding protein biosynthesis by hypoxia in cultured vascular endothelial cells
    • Tucci, M., et al. 1998. Modulation of insulin-like growth factor (IGF) and IGF binding protein biosynthesis by hypoxia in cultured vascular endothelial cells. J. Endocrinol. 157:13-24.
    • (1998) J. Endocrinol. , vol.157 , pp. 13-24
    • Tucci, M.1
  • 46
    • 0032544113 scopus 로고    scopus 로고
    • Hypoxia stimulates insulin-like growth factor binding protein 1 (IGFBP-1) gene expression in HepG2 cells: A possible model for IGFBP-1 expression in fetal hypoxia
    • Tazuke, S.I., et al. 1998. Hypoxia stimulates insulin-like growth factor binding protein 1 (IGFBP-1) gene expression in HepG2 cells: a possible model for IGFBP-1 expression in fetal hypoxia. Proc. Natl. Acad. Sci. USA. 95:10188-10193.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 10188-10193
    • Tazuke, S.I.1
  • 47
    • 0030635457 scopus 로고    scopus 로고
    • Endothelin receptor a antagonism prevents hypoxia-induced intrauterine growth restriction in the rat
    • Thaete, L.G., Neerhof, M.G., and Caplan, M.S. 1997. Endothelin receptor A antagonism prevents hypoxia-induced intrauterine growth restriction in the rat. Am. J. Obstet. Gynecol. 176:73-76.
    • (1997) Am. J. Obstet. Gynecol. , vol.176 , pp. 73-76
    • Thaete, L.G.1    Neerhof, M.G.2    Caplan, M.S.3


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