Hypoxic activation of the unfolded protein response (UPR) induces expression of the metastasis-associated gene LAMP3

Radiotherapy and Oncology

Volumn 92, Issue 3, 2009, Pages 450-459

  Mujcic, Hilda ^a,b   Rzymski, Tomasz ^c   Rouschop, Kasper M A ^a   Koritzinsky, Marianne ^a,b,d   Milani, Manuela ^c   Harris, Adrian L ^c   Wouters, Bradly G ^a,b,d,e  

^a MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY HEALTH NETWORK   (Canada)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d UNIVERSITY OF TORONTO   (Canada)

^e ONTARIO INSTITUTE FOR CANCER RESEARCH   (Canada)

Author keywords

ATF4; Hypoxia; Metastasis; UPR

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; BEVACIZUMAB; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INITIATION FACTOR 2ALPHA; LYSOSOME ASSOCIATED MEMBRANE PROTEIN; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 3; PROTEASOME INHIBITOR; PROTEIN KINASE; PROTEIN KINASE LIKE ENDOPLASMIC RETICULUM KINASE; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CANCER; CELL HYPOXIA; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; GENE EXPRESSION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; METASTASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA INTERFERENCE; TRANSCRIPTION REGULATION;

ANIMALS; ANOXIA; BLOTTING, WESTERN; BREAST NEOPLASMS; CELL LINE, TUMOR; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED BALB C; NEOPLASM METASTASIS; NEOPLASM PROTEINS; POLYMERASE CHAIN REACTION; PROBABILITY; PROTEIN ARRAY ANALYSIS; REFERENCE VALUES; RNA, SMALL INTERFERING; TRANSFECTION; TUMOR CELLS, CULTURED; TUMOR MARKERS, BIOLOGICAL; UNFOLDED PROTEIN RESPONSE;

EID: 69949115589     PISSN: 01678140     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.radonc.2009.08.017     Document Type: Article

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