Structure of human FIH-1 reveals a unique active site pocket and interaction sites for HIF-1 and von Hippel-Lindau

Journal of Biological Chemistry

Volumn 278, Issue 9, 2003, Pages 7558-7563

  Lee, Cheolju ^a   Kim, Seung Jun ^a   Jeong, Dae Gwin ^a   Lee, Soon Mi ^a   Ryu, Seong Eon ^a  

^a Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CRYSTAL STRUCTURE; DISEASES; MOLECULAR STRUCTURE;

ISCHEMIC DISEASE;

BIOCHEMISTRY;

2 OXOGLUTARIC ACID; ASPARAGINE; DIMER; DIOXYGENASE; FACTOR INHIBITING HIF 1; HYPOXIA INDUCIBLE FACTOR 1; OXYGENASE; SOLVENT; UNCLASSIFIED DRUG; VON HIPPEL LINDAU PROTEIN; ALPHA-KETOGLUTARIC ACID; CLAVAMINATE SYNTHASE; COMPLEMENTARY DNA; HIF1AN PROTEIN, HUMAN; LIGASE; MIXED FUNCTION OXIDASE; REPRESSOR PROTEIN; TRANSCRIPTION FACTOR; TUMOR SUPPRESSOR PROTEIN; UBIQUITIN PROTEIN LIGASE; VHL PROTEIN, HUMAN;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CELL HYPOXIA; COMPLEX FORMATION; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG SELECTIVITY; DRUG STRUCTURE; GENE DELETION; HUMAN; HUMAN CELL; HYDROXYLATION; MOLECULAR MODEL; OPTICAL RESOLUTION; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN INTERACTION; PROTEIN STRUCTURE; REGULATORY MECHANISM; STRUCTURE ANALYSIS; TRANSCRIPTION REGULATION; VON HIPPEL LINDAU DISEASE; AMINO ACID SEQUENCE; ANOXIA; BIOLOGICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; DIMERIZATION; GENE LIBRARY; METABOLISM; MOLECULAR CLONING; MOLECULAR GENETICS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; ANOXIA; BINDING SITES; CLONING, MOLECULAR; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; DNA, COMPLEMENTARY; GENE LIBRARY; HUMANS; HYDROXYLATION; KETOGLUTARIC ACIDS; LIGASES; MIXED FUNCTION OXYGENASES; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; REPRESSOR PROTEINS; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEINS; UBIQUITIN-PROTEIN LIGASES; VON HIPPEL-LINDAU TUMOR SUPPRESSOR PROTEIN;

EID: 0037470162     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M210385200     Document Type: Article

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