From crystal to compound: Structure-based antimalarial drug discovery

Biochemical Journal

Volumn 461, Issue 3, 2014, Pages 349-369

  Drinkwater, Nyssa ^a   Mcgowan, Sheena ^a  

^a MONASH UNIVERSITY   (Australia)

Author keywords

Antimalarial; Drug discovery; Malaria; Plasmodium falciparum; Structural biology

Indexed keywords

AMODIAQUINE; ANTIFUNGAL AGENT; ANTIINFECTIVE AGENT; ANTIMALARIAL AGENT; APICAL MEMBRANE ANTIGEN 1; ARGINASE; ASPARTIC PROTEINASE; DEOXYURIDINE TRIPHOSPHATE PYROPHOSPHATASE; DIHYDROFOLATE REDUCTASE; DIHYDROOROTATE DEHYDROGENASE; DIPEPTIDYL PEPTIDASE I; FOSMIDOMYCIN; GLYCOGEN SYNTHASE KINASE 3; HEMOGLOBIN; METHIONYL AMINOPEPTIDASE; PLASMEPSIN I; PLASMEPSIN II; PLASMEPSIN IV; PRIMAQUINE; PROTEINASE; PURINE NUCLEOSIDE DERIVATIVE; PURINE NUCLEOSIDE PHOSPHORYLASE; RECEPTOR; RHOPTRY NECK PROTEIN 2; SINEFUNGIN; SUBTILISIN LIKE SERINE PROTEASE 1; THIOREDOXIN REDUCTASE; THYMIDYLATE SYNTHASE; UNCLASSIFIED DRUG;

AUTOPHAGY; BINDING AFFINITY; COMBINATORIAL CHEMISTRY; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DRUG RESISTANCE; DRUG STRUCTURE; FATTY ACID SYNTHESIS; GAMETOCYTE; HUMAN; HYDROGEN BOND; LIFE CYCLE; MALARIA; MALARIA CONTROL; MEDICINE; MEMBRANE TRANSPORT; MEROZOITE; NONHUMAN; NUCLEIC ACID SYNTHESIS; PARASITE DEVELOPMENT; PARASITE SURVIVAL; PARASITE VIABILITY; PLASMODIUM; PRIORITY JOURNAL; PROTEIN MODIFICATION; PROTEIN PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION; SPOROZOITE; STRUCTURAL GENOMICS; X RAY CRYSTALLOGRAPHY;

ANIMALS; ANTIMALARIALS; DRUG DISCOVERY; DRUG RESISTANCE, MULTIPLE; HUMANS; LIFE CYCLE STAGES; MODELS, BIOLOGICAL; MOLECULAR STRUCTURE; PLASMODIUM FALCIPARUM; PROTOZOAN PROTEINS;

EID: 84904090309     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20140240     Document Type: Review

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