Discovery of gene function by expression profiling of the malaria parasite life cycle

Science

Volumn 301, Issue 5639, 2003, Pages 1503-1508

  Le Roch, Karine G ^a   Zhou, Yingyao ^b   Blair, Peter L ^c   Grainger, Muni ^d   Moch, J Kathleen ^c   Haynes, J David ^e   De la Vega, Patricia ^c   Holder, Anthony A ^d   Batalov, Serge ^b   Carucci, Daniel J ^c   Winzeler, Elizabeth A ^a,b  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

^c NAVAL MEDICAL RESEARCH CENTER   (United States)

^d NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^e WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MALARIA CONTROL; OLIGOMERS; PATHOLOGY; PROTEINS;

GENES CODES;

GENES;

GENETICS; LIFE CYCLE; MALARIA; PARASITE;

ARTICLE; CHROMOSOME STRUCTURE; DNA MICROARRAY; GENE; GENE EXPRESSION PROFILING; GENE FUNCTION; LIFE CYCLE; NONHUMAN; PATHOGENESIS; PLASMODIUM; PRIORITY JOURNAL; PROTEIN ANALYSIS;

ANIMALS; ANOPHELES; CELL CYCLE; CHROMOSOMES; CLUSTER ANALYSIS; ERYTHROCYTES; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, PROTOZOAN; HUMANS; LIFE CYCLE STAGES; LIVER; MALARIA, FALCIPARUM; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PLASMODIUM FALCIPARUM; PROTEOME; PROTOZOAN PROTEINS; RNA, MESSENGER; RNA, PROTOZOAN; SALIVARY GLANDS; SPOROZOITES; TRANSCRIPTION, GENETIC;

EUKARYOTA; PLASMODIUM FALCIPARUM; PROTOZOA;

EID: 0141633042     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1087025     Document Type: Article

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46. We thank H. Vial and J. Vinetz for critical reading of the manuscript and for helpful suggestions. This work was supported by a grant to E.A.W. from The Ellison Foundation. The sequence data were produced by the Plasmodium falciparum Sequencing Groups at the SangerInstitute(ftp://ftp.sanger.ac.uk/pub/databases/P.falciparum_sequences). The Institute for Genomic Research (www.tigr.org), and the Stanford DNA Sequencing and Technology Center (www-sequence. stanford.edu/group/malaria). The International Malaria Genome Sequencing Project was supported by awards from the Burroughs Wellcome Fund, the Wellcome Trust Fund, NIAID, and the U.S. Department of Defense. The opinions expressed are those of the authors and do not reflect the official policy of the Department of the Navy, the Department of Defense, or the U.S. government.