A bifunctional molecule that displays context-dependent cellular activity

Journal of the American Chemical Society

Volumn 125, Issue 25, 2003, Pages 7575-7580

  Braun, Patrick D ^a   Barglow, Katherine T ^a   Lin, Yun Ming ^a   Akompong, Thomas ^b   Briesewitz, Roger ^a   Ray, Gregory T ^a   Haldar, Kasturi ^b   Wandless, Thomas J ^a  

^a STANFORD UNIVERSITY   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; ENZYME INHIBITION; MOLECULES;

CONTEXT-DEPENDENT CELLULAR ACTIVITY;

PROTEINS;

1 (3,3 DIMETHYL 2 OXOPENTANOYL)PIPERIDINE 2 CARBOXYLIC ACID [1 [3 (4 TERT BUTOXYCARBONYL) 4 [4 [(2,4 DIAMINOPTERIDIN 6 YLMETHYL)METHYLAMINO]BENZOYLAMINO]BUTYRYLAMINO]PHENYL] 3 (3,4 DIMETHYLOXYPHENYL)PROPYL ESTER; DIHYDROFOLATE REDUCTASE; DIHYDROFOLATE REDUCTASE INHIBITOR; FK 506 BINDING PROTEIN; LIGAND; METHOTREXATE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CELL ACTIVITY; CELL MEMBRANE PERMEABILITY; COMPLEX FORMATION; CONTROLLED STUDY; CYTOTOXICITY; DRUG DESIGN; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; PLASMODIUM FALCIPARUM; PROTEIN PROTEIN INTERACTION; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; ANIMALS; ANTIMALARIALS; CELL LINE; FEMALE; FOLIC ACID ANTAGONISTS; HUMANS; KINETICS; LIGANDS; METHOTREXATE; MOLECULAR SEQUENCE DATA; PEPTIDYLPROLYL ISOMERASE; PLASMODIUM FALCIPARUM; TACROLIMUS BINDING PROTEINS; TETRAHYDROFOLATE DEHYDROGENASE; UTERUS;

EID: 0038546791     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja035176q     Document Type: Article

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