Redefining the role of de novo fatty acid synthesis in Plasmodium parasites

Trends in Parasitology

Volumn 25, Issue 12, 2009, Pages 545-550

  Tarun, Alice S ^a,c   Vaughan, Ashley M ^a   Kappe, Stefan H I ^a,b  

^a SEATTLE BIOMEDICAL RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 OXOACYL ACYL CARRIER PROTEIN SYNTHASE; ACETYL COENZYME A SYNTHETASE; ACYL CARRIER PROTEIN MALONYLTRANSFERASE; DIACYLGLYCEROL; FATTY ACID; LOW DENSITY LIPOPROTEIN; PHOSPHOLIPID; PYRUVATE DEHYDROGENASE; SATURATED FATTY ACID; THIOCTIC ACID; TRIACYLGLYCEROL; UNSATURATED FATTY ACID;

APICOPLAST; ARTICLE; BIOGENESIS; CELL COMMUNICATION; ENZYME METABOLISM; FATTY ACID SYNTHESIS; GENE EXPRESSION; LIFE CYCLE; LIPID TRANSPORT; LIVER DEVELOPMENT; MEROZOITE; NONHUMAN; PLASMODIUM;

ANIMALS; CULICIDAE; FATTY ACIDS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE KNOCKOUT TECHNIQUES; HUMANS; LIFE CYCLE STAGES; LIVER; MALARIA; PLASMODIUM;

PLASMODIUM PARASITES; PROKARYOTA;

EID: 70449100668     PISSN: 14714922     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pt.2009.09.002     Document Type: Article

References (33)

1. Grellier P., et al. Lipid traffic between high density lipoproteins and Plasmodium falciparum-infected red blood cells. J. Cell Biol. 112 (1991) 267-277
2. Ofulla A.V., et al. Cultivation of Plasmodium falciparum parasites in a serum-free medium. Am. J. Trop. Med. Hyg. 49 (1993) 335-340
3. Palacpac N.M., et al. Developmental-stage-specific triacylglycerol biosynthesis, degradation and trafficking as lipid bodies in Plasmodium falciparum-infected erythrocytes. J. Cell Sci. 117 (2004) 1469-1480
4. Vial H.J., et al. Phospholipid biosynthesis in synchronous Plasmodium falciparum cultures. J. Protozool. 29 (1982) 258-263
5. Mi-Ichi F., et al. Intraerythrocytic Plasmodium falciparum utilize a broad range of serum-derived fatty acids with limited modification for their growth. Parasitology 133 (2006) 399-410
6. Mi-Ichi F., et al. Oleic acid is indispensable for intraerythrocytic proliferation of Plasmodium falciparum. Parasitology 134 (2007) 1671-1677
7. Kohler S., et al. A plastid of probable green algal origin in Apicomplexan parasites. Science 275 (1997) 1485-1489
8. McFadden G.I., et al. Plastid in human parasites. Nature 381 (1996) 482
9. Gardner M.J., et al. Genome sequence of the human malaria parasite Plasmodium falciparum. Nature 419 (2002) 498-511
10. Ralph S.A., et al. Tropical infectious diseases: metabolic maps and functions of the Plasmodium falciparum apicoplast. Nat. Rev. Microbiol. 2 (2004) 203-216
11. Surolia N., and Surolia A. Triclosan offers protection against blood stages of malaria by inhibiting enoyl-ACP reductase of Plasmodium falciparum. Nat. Med. 7 (2001) 167-173
12. Goodman C.D., and McFadden G.I. Fatty acid biosynthesis as a drug target in apicomplexan parasites. Curr. Drug Targets 8 (2007) 15-30
13. Bozdech, Z. et al. (2003) The transcriptome of the intraerythrocytic developmental cycle of Plasmodium falciparum. PLoS Biol. 1, E5 DOI:10.1371/journal.pbio.0000005 (www.plosbiology.org)
14. Tarun A.S., et al. A combined transcriptome and proteome survey of malaria parasite liver stages. Proc. Natl. Acad. Sci. U. S. A. 105 (2008) 305-310
15. Zhou, Y. et al. (2008) Evidence-based annotation of the malaria parasite's genome using comparative expression profiling. PLoS ONE 3, e1570 DOI:10.1371/journal.pone.0001570 (www.plosone.org)
16. Vaughan A.M., et al. Type II fatty acid synthesis is essential only for malaria parasite late liver stage development. Cell Microbiol. 11 (2009) 506-520
17. Yu M., et al. The fatty acid biosynthesis enzyme FabI plays a key role in the development of liver-stage malarial parasites. Cell Host Microbe 4 (2008) 567-578
18. Paul K.S., et al. Multiple triclosan targets in Trypanosoma brucei. Eukaryot Cell 3 (2004) 855-861
19. Villalain J., et al. Membranotropic effects of the antibacterial agent Triclosan. Arch. Biochem. Biophys. 390 (2001) 128-136
20. Daily J.P., et al. Distinct physiological states of Plasmodium falciparum in malaria-infected patients. Nature 450 (2007) 1091-1095
21. Vaughan A.M., et al. Malaria parasite pre-erythrocytic stage infection: gliding and hiding. Cell Host Microbe 4 (2008) 209-218
22. Menard R., et al. Circumsporozoite protein is required for development of malaria sporozoites in mosquitoes. Nature 385 (1997) 336-340
23. Thathy V., et al. Levels of circumsporozoite protein in the Plasmodium oocyst determine sporozoite morphology. EMBO J. 21 (2002) 1586-1596
24. Mazumdar J., et al. Apicoplast fatty acid synthesis is essential for organelle biogenesis and parasite survival in Toxoplasma gondii. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 13192-13197
25. von Itzstein M., et al. Hot, sweet and sticky: the glycobiology of Plasmodium falciparum. Trends Parasitol. 24 (2008) 210-218
26. Foth B.J., et al. The malaria parasite Plasmodium falciparum has only one pyruvate dehydrogenase complex, which is located in the apicoplast. Mol. Microbiol. 55 (2005) 39-53
27. Gunther S., et al. Plasmodium falciparum: organelle-specific acquisition of lipoic acid. Int. J. Biochem. Cell. Biol. 41 (2009) 748-752
28. Gunther, S. et al. (2007) Apicoplast lipoic acid protein ligase B is not essential for Plasmodium falciparum. PLoS Pathog. 3, e189 DOI:10.1371/journal.ppat.0030189 (www.plospathogens.org)
29. Fujita M., and Jigami Y. Lipid remodeling of GPI-anchored proteins and its function. Biochim. Biophys. Acta 1780 (2008) 410-420
30. Bethke L.L., et al. Duplication, gene conversion, and genetic diversity in the species-specific acyl-CoA synthetase gene family of Plasmodium falciparum. Mol. Biochem. Parasitol. 150 (2006) 10-24
31. Mikolajczak S.A., et al. L-FABP is a critical host factor for successful malaria liver stage development. Int. J. Parasitol. 37 (2007) 483-489
32. Sharma A., et al. Crystal structure of soluble domain of malaria sporozoite protein UIS3 in complex with lipid. J. Biol. Chem. 283 (2008) 24077-24088
33. Mazumdar J., and Striepen B. Make it or take it: fatty acid metabolism of apicomplexan parasites. Eukaryot. Cell 6 (2007) 1727-1735