메뉴 건너뛰기




Volumn 417, Issue 1, 2012, Pages 576-581

Investigation of a potential mechanism for the inhibition of SmTGR by Auranofin and its implications for Plasmodium falciparum inhibition

Author keywords

Auranofin; P. falciparum; S. mansoni; Thioredoxin Glutathione Reductase

Indexed keywords

AURANOFIN; BACTERIAL PROTEIN; GLUTATHIONE REDUCTASE; PLASMODIUM FALCIPARUM THIOREDOXIN REDUCTASE; SCHISTOSOMA MANSONI THIOREDOXIN GLUTATHIONE REDUCTASE; UNCLASSIFIED DRUG;

EID: 84855819421     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.12.009     Document Type: Article
Times cited : (34)

References (22)
  • 1
    • 53649096054 scopus 로고    scopus 로고
    • Malaria research in the post-genomic era
    • Winzeler E.A. Malaria research in the post-genomic era. Nature 2008, 455:751-756.
    • (2008) Nature , vol.455 , pp. 751-756
    • Winzeler, E.A.1
  • 2
    • 77952696164 scopus 로고    scopus 로고
    • Drug discovery: priming the antimalarial pipeline
    • Fidock D.A. Drug discovery: priming the antimalarial pipeline. Nature 2011, 465:297-298.
    • (2011) Nature , vol.465 , pp. 297-298
    • Fidock, D.A.1
  • 3
    • 77952704258 scopus 로고    scopus 로고
    • Thousands of chemical starting points for antimalarial lead identification
    • Gamo F.J., Sanz L.M., Vidal J., et al. Thousands of chemical starting points for antimalarial lead identification. Nature 2010, 465:305-310.
    • (2010) Nature , vol.465 , pp. 305-310
    • Gamo, F.J.1    Sanz, L.M.2    Vidal, J.3
  • 4
    • 34347264532 scopus 로고    scopus 로고
    • Thioredoxin glutathione reductase from Schistosoma mansoni: an essential parasite enzyme and a key drug target
    • Kuntz A.N., Davioud-Charvet E., Sayed A.A., et al. Thioredoxin glutathione reductase from Schistosoma mansoni: an essential parasite enzyme and a key drug target. PLoS Med. 2007, 4:e206.
    • (2007) PLoS Med. , vol.4
    • Kuntz, A.N.1    Davioud-Charvet, E.2    Sayed, A.A.3
  • 5
    • 47349121027 scopus 로고    scopus 로고
    • Glutathione reductase and thioredoxin reductase at the crossroad: the structure of Schistosoma mansoni thioredoxin glutathione reductase
    • Angelucci F., Miele A.E., Boumis G., et al. Glutathione reductase and thioredoxin reductase at the crossroad: the structure of Schistosoma mansoni thioredoxin glutathione reductase. Proteins 2008, 72:936-945.
    • (2008) Proteins , vol.72 , pp. 936-945
    • Angelucci, F.1    Miele, A.E.2    Boumis, G.3
  • 6
    • 77957793022 scopus 로고    scopus 로고
    • Mapping the catalytic cycle of Schistosoma mansoni thioredoxin glutathione reductase by X-ray crystallography
    • Angelucci F., Dimastrogiovanni D., Boumis G., et al. Mapping the catalytic cycle of Schistosoma mansoni thioredoxin glutathione reductase by X-ray crystallography. J. Biol. Chem 2010, 285:32557-32567.
    • (2010) J. Biol. Chem , vol.285 , pp. 32557-32567
    • Angelucci, F.1    Dimastrogiovanni, D.2    Boumis, G.3
  • 7
    • 0037135586 scopus 로고    scopus 로고
    • Thioredoxin reductase is essential for the survival of Plasmodium falciparum erythrocytic stages
    • Krnajski Z., Gilberger T.W., Walter R.D., et al. Thioredoxin reductase is essential for the survival of Plasmodium falciparum erythrocytic stages. J. Biol. Chem. 2002, 277:25970-25975.
    • (2002) J. Biol. Chem. , vol.277 , pp. 25970-25975
    • Krnajski, Z.1    Gilberger, T.W.2    Walter, R.D.3
  • 8
    • 40149085227 scopus 로고    scopus 로고
    • New uses for old drugs Auranofin, a clinically established antiarthritic metallodrug, exhibits potent antimalarial effects in vitro: Mechanistic and pharmacological implications
    • Sannella A.R., Casini A., Gabbiani C., et al. New uses for old drugs Auranofin, a clinically established antiarthritic metallodrug, exhibits potent antimalarial effects in vitro: Mechanistic and pharmacological implications. FEBS Lett. 2008, 582:844-847.
    • (2008) FEBS Lett. , vol.582 , pp. 844-847
    • Sannella, A.R.1    Casini, A.2    Gabbiani, C.3
  • 9
    • 79951861884 scopus 로고    scopus 로고
    • Bioinorganic and medicinal chemistry: aspects of gold(I)-protein complexes
    • Bhabak K.P., Bhuyan B.J., Mugesh G. Bioinorganic and medicinal chemistry: aspects of gold(I)-protein complexes. Dalton Trans 2011, 40:2099-2111.
    • (2011) Dalton Trans , vol.40 , pp. 2099-2111
    • Bhabak, K.P.1    Bhuyan, B.J.2    Mugesh, G.3
  • 10
    • 43249126995 scopus 로고    scopus 로고
    • Inhibition of cathepsin B by Au(I) complexes: a kinetic and computational study
    • Gunatilleke S.S., de Oliveira C.A., McCammon J.A., et al. Inhibition of cathepsin B by Au(I) complexes: a kinetic and computational study. J. Biol. Inorg. Chem. 2008, 13:555-561.
    • (2008) J. Biol. Inorg. Chem. , vol.13 , pp. 555-561
    • Gunatilleke, S.S.1    de Oliveira, C.A.2    McCammon, J.A.3
  • 12
    • 70350351432 scopus 로고    scopus 로고
    • Inhibition of Schistosoma mansoni thioredoxin-glutathione reductase by auranofin: structural and kinetic aspects
    • Angelucci F., Sayed A.A., Williams D.L., et al. Inhibition of Schistosoma mansoni thioredoxin-glutathione reductase by auranofin: structural and kinetic aspects. J. Biol. Chem. 2009, 284:28977-28985.
    • (2009) J. Biol. Chem. , vol.284 , pp. 28977-28985
    • Angelucci, F.1    Sayed, A.A.2    Williams, D.L.3
  • 13
    • 0027136282 scopus 로고
    • Comparative protein modelling by satisfaction of spatial restraints
    • Sali A., Blundell T.L. Comparative protein modelling by satisfaction of spatial restraints. J. Mol. Biol. 1993, 234:779-815.
    • (1993) J. Mol. Biol. , vol.234 , pp. 779-815
    • Sali, A.1    Blundell, T.L.2
  • 14
    • 33645504195 scopus 로고    scopus 로고
    • Identification of correct regions in protein models using structural alignment, and consensus information
    • Wallner B., Elofsson A. Identification of correct regions in protein models using structural alignment, and consensus information. Protein Sci. 2006, 15:900-913.
    • (2006) Protein Sci. , vol.15 , pp. 900-913
    • Wallner, B.1    Elofsson, A.2
  • 15
    • 54949097750 scopus 로고    scopus 로고
    • MetaMQAP: a meta-server for the quality assessment of protein models
    • Pawlowski M., Gajda M.J., Matlak R., et al. MetaMQAP: a meta-server for the quality assessment of protein models. BMC Bioinformatics 2008, 9:403.
    • (2008) BMC Bioinformatics , vol.9 , pp. 403
    • Pawlowski, M.1    Gajda, M.J.2    Matlak, R.3
  • 16
    • 70349932423 scopus 로고    scopus 로고
    • AutoDock4 and AutoDockTools4: automated docking with selective receptor flexibility
    • Morris G.M., Huey R., Lindstrom W., et al. AutoDock4 and AutoDockTools4: automated docking with selective receptor flexibility. J. Comput. Chem. 2009, 30:2785-2791.
    • (2009) J. Comput. Chem. , vol.30 , pp. 2785-2791
    • Morris, G.M.1    Huey, R.2    Lindstrom, W.3
  • 17
    • 52449135496 scopus 로고    scopus 로고
    • Organogold complexes probe a large beta-barrel cavity for human serum alpha1-acid glycoprotein
    • Zsila F., Bikadi Z., Hazai E., et al. Organogold complexes probe a large beta-barrel cavity for human serum alpha1-acid glycoprotein. Biochim. Biophys. Acta 2008, 1784:1106-1114.
    • (2008) Biochim. Biophys. Acta , vol.1784 , pp. 1106-1114
    • Zsila, F.1    Bikadi, Z.2    Hazai, E.3
  • 18
    • 21144455675 scopus 로고    scopus 로고
    • The functional role of selenocysteine (Sec) in the catalysis mechanism of large thioredoxin reductases: proposition of a swapping catalytic triad including a Sec-His-Glu state
    • Brandt W., Wessjohann L.A. The functional role of selenocysteine (Sec) in the catalysis mechanism of large thioredoxin reductases: proposition of a swapping catalytic triad including a Sec-His-Glu state. Chembiochem 2005, 6:386-394.
    • (2005) Chembiochem , vol.6 , pp. 386-394
    • Brandt, W.1    Wessjohann, L.A.2
  • 19
    • 0030725657 scopus 로고    scopus 로고
    • Identification and characterization of the functional amino acids at the active site of the large thioredoxin reductase from Plasmodium falciparum
    • Gilberger T.W., Walter R.D., Muller S. Identification and characterization of the functional amino acids at the active site of the large thioredoxin reductase from Plasmodium falciparum. J. Biol. Chem. 1997, 272:29584-29589.
    • (1997) J. Biol. Chem. , vol.272 , pp. 29584-29589
    • Gilberger, T.W.1    Walter, R.D.2    Muller, S.3
  • 20
    • 79959805617 scopus 로고    scopus 로고
    • Investigations of the catalytic mechanism of thioredoxin glutathione reductase from Schistosoma mansoni
    • Huang H.H., Day L., Cass C.L., et al. Investigations of the catalytic mechanism of thioredoxin glutathione reductase from Schistosoma mansoni. Biochemistry 2011, 50:5870-5882.
    • (2011) Biochemistry , vol.50 , pp. 5870-5882
    • Huang, H.H.1    Day, L.2    Cass, C.L.3
  • 21
    • 0034683041 scopus 로고    scopus 로고
    • First crystal structure of a medicinally relevant gold protein complex: unexpected binding of
    • Zou J., Taylor P., Dornan J., et al. First crystal structure of a medicinally relevant gold protein complex: unexpected binding of. Angew. Chem. Int. Ed. 2000, 39:2931-2934.
    • (2000) Angew. Chem. Int. Ed. , vol.39 , pp. 2931-2934
    • Zou, J.1    Taylor, P.2    Dornan, J.3
  • 22
    • 1542358787 scopus 로고    scopus 로고
    • Prediction and functional analysis of native disorder in proteins from the three kingdoms of life
    • Ward J.J., Sodhi J.S., McGuffin L.J., et al. Prediction and functional analysis of native disorder in proteins from the three kingdoms of life. J. Mol. Biol. 2004, 337:635-645.
    • (2004) J. Mol. Biol. , vol.337 , pp. 635-645
    • Ward, J.J.1    Sodhi, J.S.2    McGuffin, L.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.