Crystal structure of Plasmodium falciparum thioredoxin reductase, a validated drug target

Biochemical and Biophysical Research Communications

Volumn 425, Issue 4, 2012, Pages 806-811

  Boumis, Giovanna ^a   Giardina, Giorgio ^a   Angelucci, Francesco ^b   Bellelli, Andrea ^a   Brunori, Maurizio ^a   Dimastrogiovanni, Daniela ^a,c   Saccoccia, Fulvio ^a   Miele, Adriana E ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b UNIVERSITY OF L'AQUILA   (Italy)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Malaria; Protein crystallography; Rational drug design; Thiol mediated redox metabolism; Thioredoxin reductase

Indexed keywords

THIOREDOXIN REDUCTASE;

ARTICLE; BINDING SITE; COMPUTER MODEL; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; DRUG TARGETING; NUCLEOTIDE SEQUENCE; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL;

ANTIMALARIALS; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; HUMANS; PLASMODIUM FALCIPARUM; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; THIOREDOXIN-DISULFIDE REDUCTASE;

APICOMPLEXA; MAMMALIA; PLASMODIUM (APICOMPLEXA); PLASMODIUM FALCIPARUM; PLASMODIUM PARASITES;

EID: 84865977017     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.07.156     Document Type: Article

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