Acyclic nucleoside analogues as inhibitors of Plasmodium falciparum dUTPase

Journal of Medicinal Chemistry

Volumn 49, Issue 14, 2006, Pages 4183-4195

  Nguyen, Corinne ^a   Ruda, Gian Filippo ^a   Schipani, Alessandro ^a   Kasinathan, Ganasan ^a   Leal, Isabel ^b   Musso Buendia, Alexander ^b   Kaiser, Marcel ^c   Brun, Reto ^c   Ruiz Pérez, Luis M ^b   Sahlberg, Britt Louise ^d   Johansson, Nils Gunnar ^d   González Pacanowska, Dolores ^b   Gilbert, Ian H ^a,e  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b INSTITUTO DE PARASITOLOGÍA Y BIOMEDICINA LÓPEZ NEYRA   (Spain)

^c SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^d MEDIVIR AB   (Sweden)

^e UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1 (3 TERT BUTYLDIMETHYLSILYLOXYPROPYL)URACIL; 1 (3 TRIPHENYLSILYLOXYPROPYL)URACIL; 1 (3 TRITYLAMINOPROPYL)URACIL; 1 (3 TRITYLOXYPROPYL)URACIL; 1 (4 TRITYLOXY 2 BUTENYL)URACIL; 1 (5 TRIPHENYLSILYLOXYPENTYL)URACIL; 1 (5 TRITYLAMINOPENTYL)URACIL; 1 (5 TRITYLOXYPENTYL)URACIL; 1 [2 (AZIDOMETHYL) 4 (TRITYLOXY)BUTYL]URACIL; 1 [2 (BENZOYLOXYETHOXY)METHYL]URACIL; 1 [2 (HYDROXYETHOXY)METHYL]URACIL; 1 [2 (HYDROXYMETHYL) 4 (TRITYLOXY)BUTYL]URACIL; 1 [2 (TRITYLOXY)ETHOXYMETHYL]URACIL; 1 [4 (TERT BUTOXYCARBONYLAMINO) 3 (TRITYLOXYMETHYL)BUTYL]URACIL; 1 [4 ACETYLOXY 3 (TRITYLAMINOMETHYL)BUTYL]URACIL; 1 [4 HYDROXY 2 (TRITYLOXYMETHYL)BUTYL]URACIL; 1 [4 HYDROXY 3 (TRITYLAMINOMETHYL)BUTYL]URACIL; ACICLOVIR; ACYCLIC NUCLEOSIDE; ANTIMALARIAL AGENT; ARTEMISININ; C 6628; CHLOROQUINE; DEOXYURIDINE TRIPHOSPHATE PYROPHOSPHATASE; DEOXYURIDINE TRIPHOSPHATE PYROPHOSPHATASE INHIBITOR; PYRIMETHAMINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; DRUG POTENCY; ENZYME INHIBITION; MOLECULAR MODEL; NONHUMAN; NUCLEOTIDE METABOLISM; PLASMODIUM FALCIPARUM; RAT;

ANIMALS; ANTIMALARIALS; ERYTHROCYTES; HUMANS; MODELS, MOLECULAR; NUCLEOSIDES; PLASMODIUM FALCIPARUM; PYROPHOSPHATASES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TRITYL COMPOUNDS; URACIL;

EID: 33745832313     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm060126s     Document Type: Article

References (24)

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